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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PFDN5P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:222641301-222641849  UCSC
Coordinates (T2T) chr1:221875041-221875589  UCSC
Coordinates (hg19) chr1:222814643-222815191  UCSC
Strand -
Parental Sequence NM_002624.4
Parental seq. overlap 494 bp
Parental seq. overlap (%) 81.7%
Genomic Region Intragenic (MIA3)
Retrocopy Summary PFDN5P1, located on chr1:222641301-222641849, is a retrocopy of the parental gene PFDN5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PFDN5
Full Name prefoldin subunit 5
Also known as MM-1|MM1|PFD5
Coordinate chr12:53295542-53299450
Strand +
Gene summary This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PFDN5P1
Bonobo Pan paniscus PFDN5P1
Orangutan Pongo abelii PFDN5P1
Gibbon Nomascus leucogenys PFDN5P1
Green monkey Chlorocebus sabaeus PFDN5P1
Crab-eating macaque Macaca fascicularis PFDN5P1
Rhesus Macaca mulatta PFDN5P1
Baboon Papio anubis PFDN5P1
Golden snub-nosed monkey Rhinopithecus roxellana PFDN5P3
Marmoset Callithrix jacchus PFDN5P8
Gorilla Gorilla gorilla Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PFDN5P1
ATCACAGAGATGAATCTGCCGCAGCTAGAAATGCTCAAGAACCAGCTGGACCAGGAAATGGAGTTCTTGTCCACCTCCATTGCCCAGCTCAAAGTGGTACAGACCAAGTATGTAGAAGCCAAGGACTGTCTGAACATGCTGAGCGAGAACAATGAGGGAAGAGAATTACTCCTCCCACTGACGAGTTTAATATATGTCCCTGAGAAGCTGCATGATGTGGAACATGTGCTCATTGATGTAGGAACTGGGTACTATGTAGATAAGATAGCCGAGGATGCCAAGGACTTCTTGAAGAGGAAGACAGACTTCCTAACCAAGCAGATAGAGAAAATCCACCAGCTCTCCAGGAGCACACCATGCTGTCATGGAAATGATGAGCCAGACGATTCAGCAGCCCAGAGCCCTGGGGGCAGCTCAGGCTACTGCTAAGACCTGAAGAATCTGTTGCAGAAATGGGGCAGAGGGATACCCCTTGGGCATGGCTTCCTGGTGCCAGGGAAGGGAAGGGTCTTATATTTAATGCCAGTAAATGTGCCAGCTGGGCAGAAA
>NM_002624.4
CTCTTCGTTAAGTCGGCCTTCCCAACATGGCGCAGTCTATTAACATCACGGAGCTGAATCTGCCGCAGCTAGAAATGCTCAAGAACCAGCTGGACCAGGAAGTGGAGTTCTTGTCCACGTCCATTGCTCAGCTCAAAGTGGTACAGACCAAGTATGTGGAAGCCAAGGACTGTCTGAACGTGCTGAACAAGAGCAACGAGGGGAAAGAATTACTCGTCCCACTGACGAGTTCTATGTATGTCCCTGGGAAGCTGCATGATGTGGAACACGTGCTCATCGATGTGGGAACTGGGTACTATGTAGAGAAGACAGCTGAGGATGCCAAGGACTTCTTCAAGAGGAAGATAGATTTTCTAACCAAGCAGATGGAGAAAATCCAACCAGCTCTTCAGGAGAAGCACGCCATGAAACAGGCCGTCATGGAAATGATGAGTCAGAAGATTCAGCAGCTCACAGCCCTGGGGGCAGCTCAGGCTACTGCTAAGGCCTGAGAGTTTTTGCAGAAATGGGGCAGAGGGACACCCTTTGGGCGTGGCTTCCTGGTGATGGGAAGGGTCTTGTGTTTTAATGCCAATAAATGTGCCAGCTGGGCAGAA

Publications

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