Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNAJB6P6
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:224660557-224661904  UCSC
Coordinates (T2T) chr1:223849357-223850704  UCSC
Coordinates (hg19) chr1:224848259-224849606  UCSC
Strand -
Parental Sequence NM_005494.3
Parental seq. overlap 1182 bp
Parental seq. overlap (%) 74.9%
Genomic Region Intragenic (CNIH3)
Retrocopy Summary DNAJB6P6, located on chr1:224660557-224661904, is a retrocopy of the parental gene DNAJB6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJB6
Full Name DnaJ heat shock protein family (Hsp40) member B6
Also known as DJ4|DnaJ|HHDJ1|HSJ-2|HSJ2|LGMD1D|LGMD1E|LGMDD1|MRJ|MSJ-1
Coordinate chr7:157337004-157417439
Strand +
Gene summary This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJB6P1
Bonobo Pan paniscus DNAJB6P1
Gorilla Gorilla gorilla DNAJB6P1
Orangutan Pongo abelii DNAJB6P2
Gibbon Nomascus leucogenys DNAJB6P4
Green monkey Chlorocebus sabaeus DNAJB6P12
Crab-eating macaque Macaca fascicularis DNAJB6P2
Rhesus Macaca mulatta DNAJB6P2
Baboon Papio anubis DNAJB6P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104671759P4
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJB6P6
TTCCAATAATCTGATAAAATGTGGTGGATTACTATGAAGTTCTAGGCATGCAGACATGCCTTACCGGAGGATATTAAAATGACATATCAGAAACTGGCACTGAAGTGGCACCAAGATAAAAATCCTGAGAATAAAGCAGCAGAGAGAAAATTCAAACAAGTAGCCGAGACGTGAGGTGCTGTCAGATGCTAGAAAATAAGATAGCTTAATTTATATTAAACCAGAAGGAGGATTAAATGGTAGAGGACGTGGCGGAAGTCATTTTGACAATCATTTGAGTTTGTCATCACATTTCATAACGTAGATGATGTCTTCAGGGAATTTTTTGGTGGAAGAGACCCATTTCCATTTACCTACTTTGAAAATCTATTTGAGGACTTCTTTGGGAATCAAAGGGGTCCCCAAGGGAGCAGAAGCTGAGGGATGGGTTGTTTTTCTCAGCATTCAGTAGATTTCTATACCTTGGAAGTGGATTTTCTTCTTTTGAGACAGGATTTACTTCATTCTCGTCACTAGGTCACAGGGGACTCATTCTCTTCCACATCATTTGGTGGTAGTGGGATGGGCAACTTCAAATGTGTATCAACTTCTACTGAAATGGTTAATGGCAAAAAAATTACTAAAAAAAGGATTGTCAAGAATGGTCAAGAAAGAGCAGAAGTTGAAGAAGAGGGCCAGTTAAAGTCCTTAACGATACATGGTGAGGAGCAGCAGCTGTGCTTGGATAACCAGGAATTCAATGCACACACTTAACAGAAATGTTAACCTAAACAAGCACCATTTGAGGATTAACAAAAACAGTTTTTGAAGATATCCAGTGAACTCGACTTTCAGTATAATTGTACCTAAAGTATTTATAAACAGCTTCTCAGAGCTCCTATTTGTCATAGACTTTTGAGTTTATTGTTGGGACCACAAAATAGGACTTTTTGTTTTAAAAATTGATGTAAATATCTGTATGCACTTTGCTTTTTTATTAAACATACTCCAAGGTGAGCCTTGACTCTTCAGTGGTAGGACAAGATTGTACACTAACACCAGCATGGATCTGCTTTTCCATCACGTCTGCAAATGTGAGCCAAGCAGTGTCAGCCTGTTATGACGTTAATATTGCCAGGATAAGCCTTCTATAGAAACAATTTCATTTTTTTCAGTGTTTAGTAGTGAAAGATATTAATGCGTTAATGGTAATATACTTCTGGCTTAATATAAATTAAGGATGTTTTCTACTTGTGCATAAATGCTGGCAATTTGGTAGGTCTTGACAATTGTTTAAACATGCAACGTTAAGCTTGGGTTTTAAAAAAGTAAAGCTGGTAAGCTGGGTCTTTGTCATTTGCTTTAAAAC
>NM_005494.3
CTGTTTGTTGTTGGAGAAAGGAGAGAAAGGAAAGCGCGAGGAGCCGCCGCCACCACCAGCGCAGCAGTCCTGGAGCTGTGAGGAGATTCGGGCCGTCACCCTGCCTCCCCTGCGTCCCGCCACCGGCCGCTTCTGTCCTCGGACCCATTCCAACAATCTCGTAAAACATGGTGGATTACTATGAAGTTCTAGGCGTGCAGAGACATGCCTCACCCGAGGATATTAAAAAGGCATATCGGAAACTGGCACTGAAGTGGCATCCAGATAAAAATCCTGAGAATAAAGAAGAAGCAGAGAGAAAATTCAAGCAAGTAGCGGAGGCATATGAAGTGCTGTCGGATGCTAAGAAACGGGACATCTATGACAAATATGGCAAAGAAGGATTAAATGGTGGAGGAGGAGGTGGAAGTCATTTTGACAGTCCATTTGAATTTGGCTTCACATTCCGTAACCCAGATGATGTCTTCAGGGAATTTTTTGGTGGAAGGGACCCATTTTCATTTGACTTCTTTGAAGACCCTTTTGAGGACTTCTTTGGGAATCGAAGGGGTCCCCGAGGAAGCAGAAGCCGAGGGACGGGGTCGTTTTTCTCTGCGTTCAGTGGATTTCCGTCTTTTGGAAGTGGATTTTCTTCTTTTGATACAGGATTTACTTCATTTGGGTCACTAGGTCACGGGGGCCTCACTTCATTCTCTTCCACGTCATTTGGTGGTAGTGGCATGGGCAACTTCAAATCGATATCAACTTCAACTAAAATGGTTAATGGCAGAAAAATCACTACAAAGAGAATTGTCGAGAACGGTCAAGAAAGAGTAGAAGTTGAAGAAGATGGCCAGTTAAAGTCCTTAACAATAAATGGTAAGGAGCAGCTGCTGCGCTTGGATAACAAGTAATTCAACGCACGCACTTAACAGAAATGTTAAACTATAACAAGCACCATTTGAGGATTAACAGGAACATTTTTTTGAAGATTTCAAACGAACTCGACTTTCAGTATAATTGTACCTAAAGTATTTATAAACAGCTCATCGGAGCCTCTATTTGTCATAGACTTTTGAGTTGATTGTTGGGACCACATAATAGGACCATTTTTTTTTTGTCTTTAAAATTGTTGTAAATCTCTGTATGCACTTTGCTTTTTTATTAAACGTACTCCAAGGTGAGTCTTGACTCTTTAGTGTAGGACAAGATTGTACACTAACACCAGCATGGACCTGCTTTTCATTGTGTCTGAAATGTGAGCCACGTAGTGTCGGCCTGCTGTGAAGTTAACATTGCCAGGACGATTCTTCTACAGAAATAATTTCAATTTTTTTCAGTATTTAGTAGTGAAAGATATTAATACATTAATGGTAATACATTTCTGGTTTAATATAAATTAAGGATGTTTTCTAGTTGTGCATGAATGCTGGCAACTTAGTAAGTTTTGACAATTGTTTAAATATGTAATGTTAAGCTTAGGTTTAAAAAAGTAAAGCTGGTAAACTGGGTCTTTGTCATTTGCTTTaaaaaaaaaaaaaaagaaaataaaTGCGAATGTGTTGGTGCATTCTTCCTGAGTGGGATCTGGA

Publications

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