Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name STMN1P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:31714889-31715874  UCSC
Coordinates (T2T) chr12:31591737-31592722  UCSC
Coordinates (hg19) chr12:31867823-31868808  UCSC
Strand -
Parental Sequence NM_005563.4
Parental seq. overlap 879 bp
Parental seq. overlap (%) 60.7%
Genomic Region Intergenic
Retrocopy Summary STMN1P1, located on chr12:31714889-31715874, is a retrocopy of the parental gene STMN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name STMN1
Full Name stathmin 1
Also known as C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN
Coordinate chr1:25884179-25906880
Strand -
Gene summary This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes STMN1P2
Bonobo Pan paniscus STMN1P2
Gorilla Gorilla gorilla STMN1P2
Orangutan Pongo abelii STMN1P2
Gibbon Nomascus leucogenys STMN1P2
Crab-eating macaque Macaca fascicularis STMN1P2
Rhesus Macaca mulatta STMN1P2
Marmoset Callithrix jacchus STMN1P6
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>STMN1P1
AGAGTGTGGTCAGGTGGCTCAGATCTAGCAGAGTTTTCCTTATCCCAGTGGATTTTGTAGAATACACTGCCAGTCTCTTGTCTTTCATTCATCATGGCTACTTCTGATATCCAGGTGAAAGCACTGGAGAAGTGTGCCTCAGGCTAGGCTTTTGAACTGATTCTCAGATACCATCAAAAGAATCCATCCCAGAGTTCCTTATTTCCCCTCCAAAGAAGAAAGATCTTTCCCTGGAGGAAATTCAGAATAAATCAGAAGCTTCAGAAGAAAGACACAAGCCCTGCGAAGCTGAGGCCTTGAAGCAGCTTGCTGAAAAATGAGAGCAGGAGAAAGAAGTGCTTCAGAAATCAATAAAAGAACAGCTTCAGTGAAATAGCAGAAGAGAAACTGACCCACAAAATGGAAGCTAACAAAGAGAACAGGAAGGCGCAAATGACTACCACACTGGAGTGTTTGCAGAGAAAGATAAGCACGTTGAAGAAATGCGGAAGAGCAAAGAATCCAGAGATCCTGGTGATGAGGCTGAAGCTGACTAATTTGTTCTAAGAACTGACTTTCTCCCCGCTCTTCTTCCTAGATATTCAGACTATACTGGCCAGTGTCATTTTATTTTTTGCTCCTGACAAATATTCTAGAAGCTGATGTAGGACTAGATAGGTAAATCCAGCCTGTACAATGTTGTTTTAGGAGCTAAAGGGAAGAAACTGAAAGAGTTTTACTCTTTTTCTAAAATGTTGGTCTTTCTAACATAGCTATTTTTCTTGTTGCATCTTTGCTACTTCAGTACACTTGGGTTAATGGCTAGTACTGTACTGGCTTTGTGAAACATATTTGTGAAAAGAGTATGTAGTGGCTTCTTTTGAACTGTTTGATACGGAATATTTGTTCATTTTTTAATCCCAATTCTGTCCTAATTTTACCAGATGCTACTGGACTTGAATGGTTAATAAAATTGCACAATGTTGTTGGTGGCAGTGACTTCTTTC
>NM_005563.4
AGAGTGTGGTCAGGCGGCTCGGACTGAGCAGGACTTTCCTTATCCCAGTTGATTGTGCAGAATACACTGCCTGTCGCTTGTCTTCTATTCACCATGGCTTCTTCTGATATCCAGGTGAAAGAACTGGAGAAGCGTGCCTCAGGCCAGGCTTTTGAGCTGATTCTCAGCCCTCGGTCAAAAGAATCTGTTCCAGAATTCCCCCTTTCCCCTCCAAAGAAGAAGGATCTTTCCCTGGAGGAAATTCAGAAGAAATTAGAAGCTGCAGAAGAAAGACGCAAGTCCCATGAAGCTGAGGTCTTGAAGCAGCTGGCTGAGAAACGAGAGCACGAGAAAGAAGTGCTTCAGAAGGCAATAGAAGAGAACAACAACTTCAGTAAAATGGCAGAAGAGAAACTGACCCACAAAATGGAAGCTAATAAAGAGAACCGAGAGGCACAAATGGCTGCCAAACTGGAACGTTTGCGAGAGAAGGATAAGCACATTGAAGAAGTGCGGAAGAACAAAGAATCCAAAGACCCTGCTGACGAGACTGAAGCTGACTAATTTGTTCTGAGAACTGACTTTCTCCCCATCCCCTTCCTAAATATCCAAAGACTGTACTGGCCAGTGTCATTTTATTTTTTCCCTCCTGACAAATATTTTAGAAGCTAATGTAGGACTGTATAGGTAGATCCAGATCCAGACTGTAAGATGTTGTTTTAGGGGCTAAAGGGGAGAAACTGAAAGTGTTTTACTCTTTTTCTAAAGTGTTGGTCTTTCTAATGTAGCTATTTTTCTTGTTGCATCTTTTCTACTTCAGTACACTTGGTGTACTGGGTTAATGGCTAGTACTGTATTGGCTCTGTGAAAACATATTTGTGAAAAGAGTATGTAGTGGCTTCTTTTGAACTGTTAGATGCTGAATATCTGTTCACTTTTCAATCCCAATTCTGTCCCAATCTTACCAGATGCTACTGGACTTGAATGGTTAATAAAACTGCACAGTGCTGTTGGTGGCAGTGACTTCTTTTGAGTTAGGTTAATAAATCAAGCCATAGAGCCCCTCCTGGTTGATACTTGTTCCAGATGGGGCCTTTGGGGCTGGTAGAAATACCCAACGCACAAATGACCGCACGTTCTCTGCCCCGTTTCTTGCCCCAGTGTGGTTTGCATTGTCTCCTTCCACAATGACTGCTTTGTTTGGATGCCTCAGCCCAGGTCAGCTGTTACTTTCTTTCAGATGTTTATTTGCAAACAACCATTTTTTGTTCTGTGTCCCTTTTAAAAGGCAGATTAAAAGCACAAGCGTGTTTCTAGAGAACAGTTGAGAGAGAATCTCAAGATTCTACTTGGTGGTTTGCTTGCTCTACGTTACAGGTGGGGCATGTCCTCATCCTTTCCTGCCATAAAAGCTATGACACGAGAATCAGAATATTAATAAAACTTTATGTACTGCTGTAGCAA

Publications

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