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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FKBP3P2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:236285842-236286265  UCSC
Coordinates (T2T) chr1:235688118-235688541  UCSC
Coordinates (hg19) chr1:236449142-236449565  UCSC
Strand -
Parental Sequence NM_002013.4
Parental seq. overlap 378 bp
Parental seq. overlap (%) 29%
Genomic Region Intergenic
Retrocopy Summary FKBP3P2, located on chr1:236285842-236286265, is a retrocopy of the parental gene FKBP3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FKBP3
Full Name FKBP prolyl isomerase 3
Also known as FKBP-25|FKBP-3|FKBP25|PPIase
Coordinate chr14:45115292-45134481
Strand -
Gene summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FKBP3P1
Bonobo Pan paniscus FKBP3P1
Gorilla Gorilla gorilla FKBP3P1
Orangutan Pongo abelii FKBP3P1
Gibbon Nomascus leucogenys FKBP3P1
Green monkey Chlorocebus sabaeus FKBP3P3
Crab-eating macaque Macaca fascicularis FKBP3P1
Rhesus Macaca mulatta FKBP3P1
Baboon Papio anubis FKBP3P1
Golden snub-nosed monkey Rhinopithecus roxellana FKBP3P2
Marmoset Callithrix jacchus FKBP3P4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FKBP3P2
GGGAGATGTTGTTCAAGGCTGGTATACAGGAACACTACAGGATGGGACTGTTTTTGATACTAATATTCAAACAAGTTCAAAAAAGAAAAATACCAATACCAAGCCTTTAAGTTTTAAGGTCAGAGTAGGCAAAGTTATCACAGGATGGGATGAAGCACTGTTGACTGGGTAAAGGAGAAAAGCCTCGATTGAAGAGTGAAGCAGAATGGGCTTATGCAAAGAAAGGGCAGCCTGAAGCCAAAATTCCACTAAATACAAAGTTCGTTTCTGAAGTGGAATTAGTGGATACTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATCAGCAACAGTGATAAAACTTGGCCTTAAAGAAACTTACGTAACTAACTAGAGTTTGTTACTATTGGAAGGGAAGAGTCACCTGGAAAATTCAGAGTTAAA
>NM_002013.4
AGTAAAGCGGAGGCAGCGGGGGAAGATGGCGGCGGCCGTTCCACAGCGGGCGTGGACCGTGGAGCAGCTGCGCAGTGAGCAGCTGCCCAAGAAGGACATTATCAAGTTTCTGCAGGAACACGGTTCAGATTCGTTTCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCCTATAACCATCTTTTTGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAAGATAAACCCAAAGAAACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACCAACTTTCCCAAAAAGGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGTGCAAAGAAGAAGAAAAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATGAGTAAAGGAGAAAAGGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCAAAACTCACTTTTGAAGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGCCTTGAAGAAATTTACACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTTACTTGGTCCCAGCTTTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGAACTTTTTCCTTTTACCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTAATATATTATTGTTCTGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCTGTATAATGAGAAGGCAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTTAGAAAAGGTGTACTTCAAAACCAATGAGCCACTAATAAAGGTGAACATAAGGTTAATATTACTAATTGATCCCCCCAAAATAAATTCATAAACAATTA

Publications

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