Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PAIP2P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:48557131-48557353  UCSC
Coordinates (T2T) chr12:48519138-48519360  UCSC
Coordinates (hg19) chr12:48950914-48951136  UCSC
Strand +
Parental Sequence NM_001033112.3
Parental seq. overlap 190 bp
Parental seq. overlap (%) 12.9%
Genomic Region Intergenic
Retrocopy Summary PAIP2P1, located on chr12:48557131-48557353, is a retrocopy of the parental gene PAIP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PAIP2
Full Name poly(A) binding protein interacting protein 2
Also known as PAIP-2|PAIP2A
Coordinate chr5:139341850-139369717
Strand +
Gene summary Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PAIP2P1
Bonobo Pan paniscus PAIP2P1
Gorilla Gorilla gorilla PAIP2P1
Orangutan Pongo abelii PAIP2P1
Gibbon Nomascus leucogenys PAIP2P1
Rhesus Macaca mulatta PAIP2P1
Golden snub-nosed monkey Rhinopithecus roxellana PAIP2P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PAIP2P1
aCTGTTTCCAAGAAATGCTGAAGGGGAAGAACATGAGTAGTTTATTCCGGTTCAAGACTTCCCACGAACTGTGGACCAAGTCCAAGACCAGTTGAATGACCTTATTATCAATGATGACTCCTCTCTAAAAGACCCTGTGATCCACAGCAATCAATCCAAATGCAGAGGAGTTTGCTCCTGGGGTGAAGTACTCACATATTTGAGCAGATGGGGTTCTCTTTTG
>NM_001033112.3
GGCGGGCTCTTGGCGTCTTGGGGGAACGCTGCAACCGTCGACGGGCCTGATCAGAAGATCGTCTTTCTCCCGTTTCTTCGCCATCGCTACCCCTTATTTTTGGTTGTATTGCAGCTCATGCCCTGGAAAAAAGAACCTTTGGGGTTAAAAACGACAACCAACATCAGCCATGAAAGATCCAAGTCGCAGCAGTACTAGCCCAAGCATCATCAATGAAGATGTGATTATTAACGGTCATTCTCATGAAGATGACAATCCATTTGCAGAGTACATGTGGATGGAAAATGAAGAAGAATTCAACAGACAAATAGAAGAGGAGTTATGGGAAGAAGAATTTATTGAACGCTGTTTCCAAGAAATGCTGGAAGAGGAAGAAGAGCATGAATGGTTTATTCCAGCTCGAgatctcccacaaactatggaccaaatccaagaccagtttaatgaccttgttatcagtgatggctcttctctggaagatcttgtgGTCAAGAGCAATCTGAATCCAAATGCAAAGGAGTTTGTTCCTGGGGTGAAGTACGGAAATATTTGAGTAGACGGGGCCCTCTTTTGGTGGATGTAGCACAATTTCCACACTGTGAAGGCAGTATTAGAAGACTTAATTGTAAAAGCTCTCTTGTCACTGTGTTACACTTATGCATTGCCAAAGTTTTTGTTAGTCTTGCATGCTTAATAAAAGTGCTGAGACTGTTACTAAGTAAAAAGCTGTCAAACATTTACTGAAAATAGAATTGGCCCCATGGCTTGATGTGAAGACAGCAAGGAAAGAAGCACCAGTCAAGTTGTGAACAAGCACCAAATTAAAAGACCTAAACCTTACCAAATTGTCTTTTTTTGAGGCTAATCTATCACTTGTTAATGTCTAAACTTTAAAATCAGTACATTTAATTTGAGTTCCAACTGTTAAGCATATTTCTCAGACTTAAATTTGATTATGTCCCCATCAAAAAGAATCTCCATTTTCTGAAGGTCTGTTAGTTAATTTGAGATAATTTGTTAAAGGCAAGTATGTCATATTACTGAGGCTACAAGTTAGTCAGCAGATGAGTGCCAGTCCAGCCTTTTCTGGTATGTTATTGTTAGAAATATTGAGTTCTAATGTTACATCTGAGGAAGTATGTAATTTGAGAATTGTAACTTCTAAGGGATTCACTGCATCATAGCTATGCCTGTATGGAGTCTAACATATGACCAATACCAACCCATAATCCAGCTGAACAAAGATACTGTAACATGATTTGAGTGGTGCTTTTCCTTGCTTTGTTAACCATCACGAGAGTCTGCAGCACAACTTTTAACAAAGCTAGAACAGTTTTGGCTTCTTAAACTTCATATTTGGGTAGGTTAAGCTGCCATACGTGTTCAGTGTGAATAGTGTTTAAGTTGAAAATATTGTAAAAAAATTATATTTTTTCAAAAATATTTAAAAAAATAAATAATAGTAGAACTGA

Publications

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