RCPedia: Rtcs

Summary

Retrocopy Name	FGD6P1	Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr12:49013748-49014325 UCSC
Coordinates (T2T)	chr12:48975920-48976497 UCSC
Coordinates (hg19)	chr12:49407531-49408108 UCSC
Strand	-
Parental Sequence	NM_018351.4
Parental seq. overlap	231 bp
Parental seq. overlap (%)	2.5%
Genomic Region	Intragenic (PRKAG1)
Retrocopy Summary	FGD6P1, located on chr12:49013748-49014325, is a retrocopy of the parental gene FGD6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	FGD6
Full Name	FYVE, RhoGEF and PH domain containing 6
Also known as	ZFYVE24
Coordinate	chr12:95076749-95217467
Strand	-
Gene summary	Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	FGD6P1
Bonobo	Pan paniscus	FGD6P1
Gorilla	Gorilla gorilla	FGD6P1
Gibbon	Nomascus leucogenys	FGD6P1
Green monkey	Chlorocebus sabaeus	FGD6P1
Crab-eating macaque	Macaca fascicularis	FGD6P1
Rhesus	Macaca mulatta	FGD6P1
Baboon	Papio anubis	FGD6P1
Golden snub-nosed monkey	Rhinopithecus roxellana	FGD6P1
Orangutan	Pongo abelii	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>FGD6P1
TTTACAAAAATGAACACTGCCAAGATAAACCCAACCAAACTCTTCATCAGTTATAAGAAATTATTTTGTTAGGTATACGTAGTTTTTTAAAAATTTGTTTTTTCAAGTATGTTATTTATTAAAATTTTGATGTAATGCTCGTTCAGCTCAGAAGTGGATAGAAGCATTTCTGGAAGGCACAATATTGTAGCAGTATTGGTTTCTTCTCTTCTGTGATTCCAGAGAGGTAGAATTTCATCAGAATGGAGTAAATACATTCAAAAATTTTATAAAAATg

>NM_018351.4
GCTAGTGCTCGCCCGCCCGACCCCGGCGGCTCGCGCCCGGGAGCGCCGCAGGGTCGCTAGAGTCGGCCGCGTCCTTTGTGTGGCGCTCAGGCTGCGCCGCGGGGCGGCGGGACGGAATGTGGGCGCTGCGGGGGCTTTTCTCTCCTACCCGAACTGTGGGAACAATGGACTGAAAGGGGAAGATGGATTGAGGGGCCGAGCGGGGAAGCGAGCTGCACCGGGGAATCATGACTTCTGCAGCCGAGATAAAGAAGCCACCAGTGGCCCCCAAGCCCAAGTTTGTTGTGGCAAATAATAAGCCAGCCCCACCTCCTATTGCACCTAAACCCGACATTGTGATTTCTAGTGTTCCACAGTCGACAAAGAAAATGAAACCAGCAATAGCCCCAAAACCAAAAGTCCTGAAGACCTCACCTGTTCGAGAGATTGGGCAGTCGCCATCAAGGAAAATCATGTTGAACCTGGAAGGGCATAAACAGGAATTAGCTGAAAGCACTGACAACTTTAATTGTAAATATGAAGGCAATCAGAGCAATGATTATATTTCACCAATGTGTTCCTGCAGTTCTGAGTGTATCCATAAGCTGGGCCATAGAGAGAATTTGTGTGTAAAGCAGCTTGTTTTAGAGCCCCTGGAAATGAATGAAAATTTAGAAAACAGTAAAATTGATGAGACTTTGACTATAAAAACTAGGAGTAAATGTGATTTGTATGGTGAAAAAGCCAAGAACCAGGGTGGGGTTGTTTTAAAGGCAAGCGTTTTAGAAGAGGAGCTCAAAGATGCCTTAATACACCAAATGCCACCTTTTATTTCTGCACAGAAGCACAGGCCCACAGACAGCCCAGAAATGAATGGTGGCTGTAATTCAAATGGACAATTCAGAATTGAATTTGCGGATTTGTCACCTTCCCCATCCAGCTTTGAAAAAGTTCCTGATCATCACAGTTGCCACTTACAGCTTCCTAGTGATGAATGTGAACATTTTGAAACTTGCCAGGATGACAGTGAAAAAAGCAATAATTGCTTTCAGTCATCTGAACTAGAGGCTCTGGAAAATGGGAAAAGGAGTACTTTAATATCTTCAGATGGAGTTAGTAAGAAATCAGAAGTCAAAGACCTTGGTCCCTTAGAAATTCATTTAGTACCATATACCCCAAAATTTCCAACTCCCAAGCCCAGAAAGACACGAACTGCTCGTCTGTTACGCCAAAAGTGTGTAGATACTCCTAGTGAAAGCACTGAAGAACCGGGGAATTCAGACAGTAGCTCTTCCTGTCTTACTGAAAATAGTTTGAAAATCAATAAAATCAGTGTTCTGCATCAGAATGTTTTGTGTAAGCAGGAACAGGTGGATAAAATGAAGCTAGGAAATAAAAGTGAATTGAATATGGAATCCAACAGTGATGCACAGGACTTAGTCAATTCACAGAAAGCCATGTGTAATGAAACAACTTCCTTTGAAAAAATGGCACCTTCTTTTGATAAAGACTCTAATTTGAGTTCTGACAGCACAACTGTAGATGGTTCTAGTATGTCGCTTGCTGTGGACGAAGGGACCGGTTTTATAAGATGTACTGTATCTATGAGCCTGCCTAAGCAGCTCAAATTAACTTGCAATGAACATTTGCAATCTGGGAGAAACCTGGGAGTTTCTGCCCCTCAAATGCAAAAGGAATCTGTTATAAAAGAGGAAAATTCTCTACGAATTGTCCCCAAAAAACCTCAAAGACATAGCTTGCCTGCTACAGGAGTGCTTAAAAAGGCTGCCTCCGAGGAGCTTTTGGAAAAAAGTTCTTATCCTTCAAGTGAAGAAAAAAGTTCAGAGAAGAGTCTAGAAAGAAATCACCTTCAGCATTTGTGTGCCCAAAACCGTGGTGTGTCATCCTCCTTTGATATGCCTAAACGGGCTTCAGAAAAGCCAGTGTGGAAGTTACCTCATCCTATTTTACCCTTTTCAGGGAACCCAGAATTCTTAAAGTCTGTCACCGTATCGTCAAACAGTGAGCCTTCAACAGCCCTAACCAAGCCCAGAGCAAAATCGTTATCTGCTATGGATGTGGAAAAGTGCACTAAGCCTTGCAAAGACTCTACAAAGAAAAACTCTTTTAAAAAGTTGCTCAGCATGAAACTGTCCATCTGTTTCATGAAGAGTGACTTTCAAAAATTTTGGTCCAAGAGTAGCCAACTCGGAGACACCACCACAGGCCACCTCTCCAGTGGGGAGCAGAAGGGGATTGAAAGTGATTGGCAAGGCTTGTTGGTAGGAGAGGAGAAGAGAAGTAAACCCATCAAGGCATATTCCACAGAAAACTATAGCCTGGAATCTCAAAAGAAGAGGAAGAAGTCTCGGGGCCAGACCAGTGCAGCTAATGGTCTGAGAGCTGAGTCTTTGGATGACCAAATGCTCTCCCGGGAGTCATCATCTCAGGCACCTTACAAGTCTGTTACAAGCCTCTGTGCACCGGAGTATGAAAATATACGCCATTATGAGGAAATACCAGAGTACGAGAACTTGCCATTTATTATGGCTATACGGAAAACTCAAGAGTTGGAATGGCAGAATTCCAGCAGCATGGAGGACGCTGATGCAAATGTGTATGAGGTAGAAGAGCCGTATGAAGCTCCAGATGGCCAGCTGCAGCTTGGACCCAGACATCAGCATTCCAGTTCAGGAGCATcccaggaggaacagaatgatcttggtcttggtgaccttccctctgatgaggaggaaatcatcaacagttctgatgAAGATGATGTCAGCTCTGAGTCAAGTAAAGGAGAGCCTGACCCACTGGAAGATAAACAGGATGAAGATAATGGAATGAAAAGTAAAGTTCATCATATTGCCAAGGAGATCATGAGCTCAGAGAAAGTGTTTGTGGATGTGTTAAAACTTTTGCATATTGATTTCCGGGATGCAGTAGCTCATGCTTCCAGGCAACTTGGGAAACCAGTGATTGAGGACCGGATTCTAAATCAGATCCTATACTACTTGCCTCAGCTGTATGAGCTCAACCGGGATCTCTTGAAGGAACTGGAGGAAAGAATGTTGCACTGGACTGAACAACAAAGAATTGCTGATATCTTTGTAAAGAAGGGACCATATCTAAAAATGTATTCCACATACATCAAAGAATTTGATAAGAATATAGCCTTGCTGGATGAACAGTGCAAGAAAAATCCAGGTTTTGCTGCTGTTGTTAGAGAATTTGAGATGAGCCCTCGCTGTGCTAATCTGGCCCTCAAGCACTACCTGCTCAAGCCGGTTCAGAGGATCCCCCAGTACAGGCTGTTGCTGACAGATTATTTGAAGAATCTCATAGAAGATGCTGGAGATTACAGAGACACTCAAGATGCCCTTGCTGTTGTTATAGAGGTAGCCAACCACGCCAATGACACCATGAAGCAAGGAGACAACTTTCAGAAACTTATGCAAATTCAGTACAGCTTAAATGGACACCATGAAATTGTGCAGCCTGGTCGGGTTTTTCTCAAAGAAGGAATTCTGATGAAGCTGTCTCGGAAAGTGATGCAACCTCGAATGTTTTTCCTGTTTAATGATGCCCTGCTGTATACAACACCAGTGCAGTCTGGGATGTATAAACTGAACAACATGCTCTCACTGGCTGGAATGAAGGTCAGAAAACCTACCCAAGAAGCCTATCAGAATGAATTAAAGATTGAAAGTGTAGAACGTTCCTTCATTCTCTCAGCCAGTTCTGCCACAGAAAGGGATGAATGGCTAGAAGCGATTTCCAGGGCAATAGAAGAGTATGCCAAGAAAAGAATCACCTTCTGTCCTAGTAGGAGTCTTGATGAGGCAGACTCAGAAAATAAAGAAGAAGTTAGTCCTCTTGGATCGAAGGCTCCCATCTGGATTCCTGATACCAGAGCCACAATGTGTATGATCTGCACAAGCGAATTCACTCTCACCTGGAGACGACACCACTGCCGGGCCTGTGGAAAGATTGTATGCCAAGCTTGTTCGTCTAATAAGTATGGCTTAGATTACCTGAAAAATCAACCAGCAAGAGTATGTGAACATTGTTTCCAAGAACTGCAGAAATTAGATCACCAGCACTCCCCTAGGATTGGATCTCCTGGAAATCACAAATCTCCTTCAAGTGCCTTATCATCAGTCTTACATAGCATTCCATCAGGGAGGAAACAGAAAAAAATCCCAGCTGCTCTCAAAGAAGTATCAGCAAACACAGAGGATTCTTCTATGAGTGGCTACTTGTACAGATCAAAGGGCAATAAAAAACCCTGGAAACACTTTTGGTTTGTCATAAAAAATAAAGTACTATATACATATGCTGCAAGTGAGGACGTGGCCGCTTTGGAGAGTCAGCCTTTATTAGGATTCACTGTTATTCAAGTTAAAGATGAGAATTCCGAGTCTAAAGTATTTCAGTTACTGCACAAAAACATGTTATTTTATGTATTCAAAGCAGAGGATGCTCATTCGGCTCAGAAGTGGATAGAAGCATTTCAGGAAGGCACAATATTGTAGCAGTATTGGTTTCATCTCTTCTGTGATTCCAAAGAGGTGGAATTTCATCAGAATGGAGTAAATGCAATTCAAAAATTGTATAAAAATGAACACTGCCAAGATAAAGCCAACCAGACCCTTCATCAAAGAAATTGTTTTGTTAGGTATAAGCAATTTTTAAAAGGTGTTTGTTTTTTCATTTATGTTATTTATTAAAATTTTGATGTTTACTTAATGGTCAGAATTATTTCTGAGACACACTGAATTCTAAAGTACCATTTCTTTAGAGACCAGAAAAACTATCTTAATACTGTATACTGTATTAACTATTCGTGACATAGTTCACACTGTTTTCTTACCTTACATTGTAACAATCTTACTGGTGGAAAGTCTTTGTAAGGAAAAAACACATAGCAAGGAGCAAATTTCCACAAAGTGCTTGGTTTAGGAATTGTGATTATTATAAAACTGCTGATGAAAAAAATGCATGTCTTTGAATCAATAAACTTGGGTGAATATTTGTATCTTTTAGTGGAAAAACATGGCCAGCTTCTACCTCAGTAACTGTGAACTGAAATTTCAGTAAATTATCTAAAGTATTTCTGTTGTTAGGTACCTCTTTGGCAGGAGTTAATATTACATCATCAAAGAATTATAGCAAAGAGATAGAATCTGAATTTTTTAAAACTGTGAGTAGGAATGAAGATGTTTTTATTTGCAGAATACCACAAATAACCAACTCTTCCGGCTTTTAAGTCCAATCTTTTAAAAAATCTACCACTTCGAAACAAACATAAATGTATCATTTTTTAAAATAGCAAAATATAGCAAGCATTATGTCACATAATATTCCCTGCTATTATAAGAGTTCTGAGCCCAAGTCAATGATGATATTTGTATCTATAAGTAATGTTACATTTCCAAAAATATTGTGCATTACAAATGGAACTGGAATTACTATATCAGAAAAGCATAATTATAAGCCAGTAATAACTGAAATTCTATAGTATTCATTTTCAAAAGGTCTTTTTCTGCCAGTTTGTGATATCCTCCCTCCTAATTAAAAAAAAAAACAACAAATCCTTTCTCTATAAGCAGCTATCAGCACACCTCCTTAGGAAAGATTTAGATTCATAATTCTGGTGCACTTACTGTTTAACATATGAACTACCTTGCACATACAATTGTTGATTAGCAGAAGAAAATGAAATAACACTGTGATAAAAGCCATCCCTGATGTTCACAATACACAATTTATTAACTAAGTTTAAACTATAAATTATCTTAACTgccatgagcggtggctcacacctacaatctcagcattttgggaggccgaggccgttggaccacctgaggtcaggagatcgagaccagcctggccaatatggtgaaaccccatctctattaaaaatacaagaattagccggtcgtggtggtacatggctgtagtcctagctattcagcaggctgaggcaggagcatcgcttgaacccaggaggcagaggttgcagtgagccgagatggtgccactgcactccagcctgggatgacagagcgagactccatctcaaaaaaaaaaaaaaaaaaaaaaTTGAACAGCAAGGTTATCCATATAATATTTCTTTAAAGGGTACAAGAATTTTCCTTTCTGCCTCTAAATAAAGGATTTCCTAATTCAGTGTGATCCTTAACAGCAACCATGAGGATTACTGAGTGCCTTTCTGGGGCCTTTTGAATGCTGTTTGGTACAGCACCAGAGTCCCTACTAGATCTAGAGTTGGCTGCTATAGTTTTTTGTGGCGATTTTTTGCCATGGAGTCATTTGAACCTCATACACAATCCTAACATGCCATCCCCTTTCTGTCATAGCAGGTACACTAAAATTTCTTTGTAGCTCAATTTTATATAATCAAGATCACATAAATAAGGCTTCCATGTTAGAATCGTTGCAGTTTTTAGTGTATTCCTTTTTGGAGGCTAAAGTTGTACCTTATAAACTGTTTCTGCGTCTGGCATTTAGCAAGACAAGTTATTTGGGTTTTCTTTCCCTCCTCTTGAGCTCTCAGCCTTCTGACTACAAGGTTTGGCTTAAGCCTTATAATCTAAAAAATATCAGCCAGGCTATTCTATCTTCTAAGACCTGGCTGAATCATGAGCCAGTTCTAAATCTAAAGAGAGTGAGAGAGGGAAGAAATCTGGCACAAACTTACAGTCTCTTTAATTACATGTAAAATGCATGTGACTGTATTACCTATTGGCTTAGCCCCATGGAGGGTTTAGAAAAATGTGTAGTCTTTGTGGAAGCTATCCAATTATCCTTCTCCCAAAAAGATGTTTTAAATGTGGAATAGTATTACATTCCCCTGCCCCTTTATGAGTCCTTCATAACTTACTAAAGCTGACCAATTGTTATTTATGTAACCTGGCTCATTCATTGTCAACTAAGAACCTAATTATATGCAATTTATTGTAAAAAAAGCTATAAAAATATATTTTGCTAGTATTTTAGAGGAAAAATGATATTGGGCACAGTCTATAAATGGGGAGAAAAGTTAAGTAGTATCTAGATTCCAAGGATACTATATTTATTATACAGATATGTGTGCCTGTGCTTCCATCAAACCCTTTTTCAGGTATCTCCTTTTAATTCATAAGGAGGAAAGAGTAGGGCATTTATAAAGCTAAGCTAAAAATGATGCTAAGCATAACGTAGATGAGACGCCAGGCTGAACCAGGGGAAGGCTGGCATTGTTAGTGTCCCCAACTAGCAGTCCACCTTTATCTGTGGCAGCTATAAATGTACAGGACCCATCAGAGTCCTAAGAAAATGAGAGTAATTATCTCTGGCATCATCCACATTTCCGACTCTTTCCAATCTCTTTTCCCTTTTTCTGTAATGTACCCAGCATCCCCCTATTGTATTTTGGTTGCCCAAGATTCTTGATTCTTTGAGTGTGTAGTAGCATTTCTTAAAATGAGATCATCAGACCAACCCTTGATTCACATGAAAGCTGTAATGACACAACAAAGAGAAGGCGACAGTTTTAAAGTATAATTGTCAGCCAAATGTGTATTTTATATTTGGTTCATAGAATATATCTAGATGTGGGGAAAGTCTCCTATTTGGTAATTTAGTTAAAATGTAAATGTTATATCACAGCATATGTTGGTATGTTTTGGAGTGTGCTTCCATTGTGCTCAGCTTTTGAAAAGTTTGAAATCCACTTTAGTCAAATGTAGTCAATGGGATTTCCAGAGATACATATTGTTTTTCTTAGTGTACCACACACTCCTTGAAGGCAGATACTGTACTTAATATATCACTGTCTTCCATAATACTGCCCTAGGtctttttagtttttaagagaccgggtctcgctatgtttcccatgctgaactcaaatgcctgggcttaagcaatcctcccacctcagcctctggagtagctgggactacaggggcatgcaccaccaggcctggcTTCCTAGGAGGGTCTTTAAAGAGAAAATATTTGTTCAATTGAAAACAGGATTCTTGTCATCTACAACTCCAACACAGCCTGAAAATATCCACATTATAACCTGGACCTTAGACCTACTTtctccactatcctgcaaagctacatctgtaactacctattggctatctatatgagtcctcaagcatctcagactttacatgaataaaactcaacttccttcccattcaaatctgttTATTTTCTTCTGTAAGAGAAAGATACCATTTGAGACTCCAGAATCTGCCTCTAACTCTCAACAAGACTCTGCAATTACTCAAGTATCCTTTCCATCCTCATTGCCCTGCTGTTATTACATAGGCCCTGGTTCAAGTCCTTGTTACTTGTTCCCATTATTGCAATAACTTCTAATTCCAATGCCGTTGTGTGATCCCATTTTAAACACGGCCAGAGCAGTCTTCCAACAACATAGCTCTAATCTAGTTTCATCCCCACTTTTACATGCCTCAGTGGCTTTCCCAGTGACTTGGCATGGAACACGTCCTCAGTTGCCATACATTCCAGCTAACTCTTACCCAACCTTTCTTTGTTCACACAGTTTCCTTTTCCTTCCTCATTGACCCATCCGCATCTCTGTTTATCCAAGACTTCTCTGTGATAGCTGACCCTTAGTCTTTCTCTCCCCTATTCCTCCAGACTAGATCCTGTCTCCTTCCTGCAGCCCCGACACAGCCTTCAGTTCATATCTTTTGCATGATGCTTAGCACCTTCTATCCCTAAGGACAACTTACTCATTTGAGATTTCTGGCAGGGTACCTTGCATGCAGTGGACACTCAGTATTTGCTGAATTAAATTCCTTCCTATGGATCCCTTCTGATTTTTTTTAAGTGCCTCTAATACACATATCATTCTAGGGCTCATGCCACTTTTAATGTCATTTTCTAAAGGAAAATCTTATCTATGATATTTTCCCTTATAAGAGATAGTTGTTTTGAGTAGGGTTTTTTAAAAGATAAAGGTAGTAGGAAATTTTTTAAAGCCTAAATATCAAATTCCTTTCCCTTTGGAGTTGGGGGAAGGAATGAAGGGGGAGCAACTTGCTCTTTCATATGAGTTGGTCATAGCATGTAAGAACCAATCTTGAAATATCGTTTTTTTTTTAATGGCTTATAATGTATTTCTAGAAATACTTTGTACTTAAAATGATAACAGTTTGTATCTTTTTGTCCATATATACTTTATAAATAAAAAAATTAGCATTGTAAATAATGTTAATATGTATTTATACAAAATAAATTTACTATAATATA

>NM_018351.4 

GCTAGTGCTCGCCCGCCCGACCCCGGCGGCTCGCGCCCGGGAGCGCCGCAGGGTCGCTAGAGTCGGCCGCGTCCTTTGTGTGGCGCTCAGGCTGCGCCGCGGGGCGGCGGGACGGAATGTGGGCGCTGCGGGGGCTTTTCTCTCCTACCCGAACTGTGGGAACAATGGACTGAAAGGGGAAGATGGATTGAGGGGCCGAGCGGGGAAGCGAGCTGCACCGGGGAATCATGACTTCTGCAGCCGAGATAAAGAAGCCACCAGTGGCCCCCAAGCCCAAGTTTGTTGTGGCAAATAATAAGCCAGCCCCACCTCCTATTGCACCTAAACCCGACATTGTGATTTCTAGTGTTCCACAGTCGACAAAGAAAATGAAACCAGCAATAGCCCCAAAACCAAAAGTCCTGAAGACCTCACCTGTTCGAGAGATTGGGCAGTCGCCATCAAGGAAAATCATGTTGAACCTGGAAGGGCATAAACAGGAATTAGCTGAAAGCACTGACAACTTTAATTGTAAATATGAAGGCAATCAGAGCAATGATTATATTTCACCAATGTGTTCCTGCAGTTCTGAGTGTATCCATAAGCTGGGCCATAGAGAGAATTTGTGTGTAAAGCAGCTTGTTTTAGAGCCCCTGGAAATGAATGAAAATTTAGAAAACAGTAAAATTGATGAGACTTTGACTATAAAAACTAGGAGTAAATGTGATTTGTATGGTGAAAAAGCCAAGAACCAGGGTGGGGTTGTTTTAAAGGCAAGCGTTTTAGAAGAGGAGCTCAAAGATGCCTTAATACACCAAATGCCACCTTTTATTTCTGCACAGAAGCACAGGCCCACAGACAGCCCAGAAATGAATGGTGGCTGTAATTCAAATGGACAATTCAGAATTGAATTTGCGGATTTGTCACCTTCCCCATCCAGCTTTGAAAAAGTTCCTGATCATCACAGTTGCCACTTACAGCTTCCTAGTGATGAATGTGAACATTTTGAAACTTGCCAGGATGACAGTGAAAAAAGCAATAATTGCTTTCAGTCATCTGAACTAGAGGCTCTGGAAAATGGGAAAAGGAGTACTTTAATATCTTCAGATGGAGTTAGTAAGAAATCAGAAGTCAAAGACCTTGGTCCCTTAGAAATTCATTTAGTACCATATACCCCAAAATTTCCAACTCCCAAGCCCAGAAAGACACGAACTGCTCGTCTGTTACGCCAAAAGTGTGTAGATACTCCTAGTGAAAGCACTGAAGAACCGGGGAATTCAGACAGTAGCTCTTCCTGTCTTACTGAAAATAGTTTGAAAATCAATAAAATCAGTGTTCTGCATCAGAATGTTTTGTGTAAGCAGGAACAGGTGGATAAAATGAAGCTAGGAAATAAAAGTGAATTGAATATGGAATCCAACAGTGATGCACAGGACTTAGTCAATTCACAGAAAGCCATGTGTAATGAAACAACTTCCTTTGAAAAAATGGCACCTTCTTTTGATAAAGACTCTAATTTGAGTTCTGACAGCACAACTGTAGATGGTTCTAGTATGTCGCTTGCTGTGGACGAAGGGACCGGTTTTATAAGATGTACTGTATCTATGAGCCTGCCTAAGCAGCTCAAATTAACTTGCAATGAACATTTGCAATCTGGGAGAAACCTGGGAGTTTCTGCCCCTCAAATGCAAAAGGAATCTGTTATAAAAGAGGAAAATTCTCTACGAATTGTCCCCAAAAAACCTCAAAGACATAGCTTGCCTGCTACAGGAGTGCTTAAAAAGGCTGCCTCCGAGGAGCTTTTGGAAAAAAGTTCTTATCCTTCAAGTGAAGAAAAAAGTTCAGAGAAGAGTCTAGAAAGAAATCACCTTCAGCATTTGTGTGCCCAAAACCGTGGTGTGTCATCCTCCTTTGATATGCCTAAACGGGCTTCAGAAAAGCCAGTGTGGAAGTTACCTCATCCTATTTTACCCTTTTCAGGGAACCCAGAATTCTTAAAGTCTGTCACCGTATCGTCAAACAGTGAGCCTTCAACAGCCCTAACCAAGCCCAGAGCAAAATCGTTATCTGCTATGGATGTGGAAAAGTGCACTAAGCCTTGCAAAGACTCTACAAAGAAAAACTCTTTTAAAAAGTTGCTCAGCATGAAACTGTCCATCTGTTTCATGAAGAGTGACTTTCAAAAATTTTGGTCCAAGAGTAGCCAACTCGGAGACACCACCACAGGCCACCTCTCCAGTGGGGAGCAGAAGGGGATTGAAAGTGATTGGCAAGGCTTGTTGGTAGGAGAGGAGAAGAGAAGTAAACCCATCAAGGCATATTCCACAGAAAACTATAGCCTGGAATCTCAAAAGAAGAGGAAGAAGTCTCGGGGCCAGACCAGTGCAGCTAATGGTCTGAGAGCTGAGTCTTTGGATGACCAAATGCTCTCCCGGGAGTCATCATCTCAGGCACCTTACAAGTCTGTTACAAGCCTCTGTGCACCGGAGTATGAAAATATACGCCATTATGAGGAAATACCAGAGTACGAGAACTTGCCATTTATTATGGCTATACGGAAAACTCAAGAGTTGGAATGGCAGAATTCCAGCAGCATGGAGGACGCTGATGCAAATGTGTATGAGGTAGAAGAGCCGTATGAAGCTCCAGATGGCCAGCTGCAGCTTGGACCCAGACATCAGCATTCCAGTTCAGGAGCATcccaggaggaacagaatgatcttggtcttggtgaccttccctctgatgaggaggaaatcatcaacagttctgatgAAGATGATGTCAGCTCTGAGTCAAGTAAAGGAGAGCCTGACCCACTGGAAGATAAACAGGATGAAGATAATGGAATGAAAAGTAAAGTTCATCATATTGCCAAGGAGATCATGAGCTCAGAGAAAGTGTTTGTGGATGTGTTAAAACTTTTGCATATTGATTTCCGGGATGCAGTAGCTCATGCTTCCAGGCAACTTGGGAAACCAGTGATTGAGGACCGGATTCTAAATCAGATCCTATACTACTTGCCTCAGCTGTATGAGCTCAACCGGGATCTCTTGAAGGAACTGGAGGAAAGAATGTTGCACTGGACTGAACAACAAAGAATTGCTGATATCTTTGTAAAGAAGGGACCATATCTAAAAATGTATTCCACATACATCAAAGAATTTGATAAGAATATAGCCTTGCTGGATGAACAGTGCAAGAAAAATCCAGGTTTTGCTGCTGTTGTTAGAGAATTTGAGATGAGCCCTCGCTGTGCTAATCTGGCCCTCAAGCACTACCTGCTCAAGCCGGTTCAGAGGATCCCCCAGTACAGGCTGTTGCTGACAGATTATTTGAAGAATCTCATAGAAGATGCTGGAGATTACAGAGACACTCAAGATGCCCTTGCTGTTGTTATAGAGGTAGCCAACCACGCCAATGACACCATGAAGCAAGGAGACAACTTTCAGAAACTTATGCAAATTCAGTACAGCTTAAATGGACACCATGAAATTGTGCAGCCTGGTCGGGTTTTTCTCAAAGAAGGAATTCTGATGAAGCTGTCTCGGAAAGTGATGCAACCTCGAATGTTTTTCCTGTTTAATGATGCCCTGCTGTATACAACACCAGTGCAGTCTGGGATGTATAAACTGAACAACATGCTCTCACTGGCTGGAATGAAGGTCAGAAAACCTACCCAAGAAGCCTATCAGAATGAATTAAAGATTGAAAGTGTAGAACGTTCCTTCATTCTCTCAGCCAGTTCTGCCACAGAAAGGGATGAATGGCTAGAAGCGATTTCCAGGGCAATAGAAGAGTATGCCAAGAAAAGAATCACCTTCTGTCCTAGTAGGAGTCTTGATGAGGCAGACTCAGAAAATAAAGAAGAAGTTAGTCCTCTTGGATCGAAGGCTCCCATCTGGATTCCTGATACCAGAGCCACAATGTGTATGATCTGCACAAGCGAATTCACTCTCACCTGGAGACGACACCACTGCCGGGCCTGTGGAAAGATTGTATGCCAAGCTTGTTCGTCTAATAAGTATGGCTTAGATTACCTGAAAAATCAACCAGCAAGAGTATGTGAACATTGTTTCCAAGAACTGCAGAAATTAGATCACCAGCACTCCCCTAGGATTGGATCTCCTGGAAATCACAAATCTCCTTCAAGTGCCTTATCATCAGTCTTACATAGCATTCCATCAGGGAGGAAACAGAAAAAAATCCCAGCTGCTCTCAAAGAAGTATCAGCAAACACAGAGGATTCTTCTATGAGTGGCTACTTGTACAGATCAAAGGGCAATAAAAAACCCTGGAAACACTTTTGGTTTGTCATAAAAAATAAAGTACTATATACATATGCTGCAAGTGAGGACGTGGCCGCTTTGGAGAGTCAGCCTTTATTAGGATTCACTGTTATTCAAGTTAAAGATGAGAATTCCGAGTCTAAAGTATTTCAGTTACTGCACAAAAACATGTTATTTTATGTATTCAAAGCAGAGGATGCTCATTCGGCTCAGAAGTGGATAGAAGCATTTCAGGAAGGCACAATATTGTAGCAGTATTGGTTTCATCTCTTCTGTGATTCCAAAGAGGTGGAATTTCATCAGAATGGAGTAAATGCAATTCAAAAATTGTATAAAAATGAACACTGCCAAGATAAAGCCAACCAGACCCTTCATCAAAGAAATTGTTTTGTTAGGTATAAGCAATTTTTAAAAGGTGTTTGTTTTTTCATTTATGTTATTTATTAAAATTTTGATGTTTACTTAATGGTCAGAATTATTTCTGAGACACACTGAATTCTAAAGTACCATTTCTTTAGAGACCAGAAAAACTATCTTAATACTGTATACTGTATTAACTATTCGTGACATAGTTCACACTGTTTTCTTACCTTACATTGTAACAATCTTACTGGTGGAAAGTCTTTGTAAGGAAAAAACACATAGCAAGGAGCAAATTTCCACAAAGTGCTTGGTTTAGGAATTGTGATTATTATAAAACTGCTGATGAAAAAAATGCATGTCTTTGAATCAATAAACTTGGGTGAATATTTGTATCTTTTAGTGGAAAAACATGGCCAGCTTCTACCTCAGTAACTGTGAACTGAAATTTCAGTAAATTATCTAAAGTATTTCTGTTGTTAGGTACCTCTTTGGCAGGAGTTAATATTACATCATCAAAGAATTATAGCAAAGAGATAGAATCTGAATTTTTTAAAACTGTGAGTAGGAATGAAGATGTTTTTATTTGCAGAATACCACAAATAACCAACTCTTCCGGCTTTTAAGTCCAATCTTTTAAAAAATCTACCACTTCGAAACAAACATAAATGTATCATTTTTTAAAATAGCAAAATATAGCAAGCATTATGTCACATAATATTCCCTGCTATTATAAGAGTTCTGAGCCCAAGTCAATGATGATATTTGTATCTATAAGTAATGTTACATTTCCAAAAATATTGTGCATTACAAATGGAACTGGAATTACTATATCAGAAAAGCATAATTATAAGCCAGTAATAACTGAAATTCTATAGTATTCATTTTCAAAAGGTCTTTTTCTGCCAGTTTGTGATATCCTCCCTCCTAATTAAAAAAAAAAACAACAAATCCTTTCTCTATAAGCAGCTATCAGCACACCTCCTTAGGAAAGATTTAGATTCATAATTCTGGTGCACTTACTGTTTAACATATGAACTACCTTGCACATACAATTGTTGATTAGCAGAAGAAAATGAAATAACACTGTGATAAAAGCCATCCCTGATGTTCACAATACACAATTTATTAACTAAGTTTAAACTATAAATTATCTTAACTgccatgagcggtggctcacacctacaatctcagcattttgggaggccgaggccgttggaccacctgaggtcaggagatcgagaccagcctggccaatatggtgaaaccccatctctattaaaaatacaagaattagccggtcgtggtggtacatggctgtagtcctagctattcagcaggctgaggcaggagcatcgcttgaacccaggaggcagaggttgcagtgagccgagatggtgccactgcactccagcctgggatgacagagcgagactccatctcaaaaaaaaaaaaaaaaaaaaaaTTGAACAGCAAGGTTATCCATATAATATTTCTTTAAAGGGTACAAGAATTTTCCTTTCTGCCTCTAAATAAAGGATTTCCTAATTCAGTGTGATCCTTAACAGCAACCATGAGGATTACTGAGTGCCTTTCTGGGGCCTTTTGAATGCTGTTTGGTACAGCACCAGAGTCCCTACTAGATCTAGAGTTGGCTGCTATAGTTTTTTGTGGCGATTTTTTGCCATGGAGTCATTTGAACCTCATACACAATCCTAACATGCCATCCCCTTTCTGTCATAGCAGGTACACTAAAATTTCTTTGTAGCTCAATTTTATATAATCAAGATCACATAAATAAGGCTTCCATGTTAGAATCGTTGCAGTTTTTAGTGTATTCCTTTTTGGAGGCTAAAGTTGTACCTTATAAACTGTTTCTGCGTCTGGCATTTAGCAAGACAAGTTATTTGGGTTTTCTTTCCCTCCTCTTGAGCTCTCAGCCTTCTGACTACAAGGTTTGGCTTAAGCCTTATAATCTAAAAAATATCAGCCAGGCTATTCTATCTTCTAAGACCTGGCTGAATCATGAGCCAGTTCTAAATCTAAAGAGAGTGAGAGAGGGAAGAAATCTGGCACAAACTTACAGTCTCTTTAATTACATGTAAAATGCATGTGACTGTATTACCTATTGGCTTAGCCCCATGGAGGGTTTAGAAAAATGTGTAGTCTTTGTGGAAGCTATCCAATTATCCTTCTCCCAAAAAGATGTTTTAAATGTGGAATAGTATTACATTCCCCTGCCCCTTTATGAGTCCTTCATAACTTACTAAAGCTGACCAATTGTTATTTATGTAACCTGGCTCATTCATTGTCAACTAAGAACCTAATTATATGCAATTTATTGTAAAAAAAGCTATAAAAATATATTTTGCTAGTATTTTAGAGGAAAAATGATATTGGGCACAGTCTATAAATGGGGAGAAAAGTTAAGTAGTATCTAGATTCCAAGGATACTATATTTATTATACAGATATGTGTGCCTGTGCTTCCATCAAACCCTTTTTCAGGTATCTCCTTTTAATTCATAAGGAGGAAAGAGTAGGGCATTTATAAAGCTAAGCTAAAAATGATGCTAAGCATAACGTAGATGAGACGCCAGGCTGAACCAGGGGAAGGCTGGCATTGTTAGTGTCCCCAACTAGCAGTCCACCTTTATCTGTGGCAGCTATAAATGTACAGGACCCATCAGAGTCCTAAGAAAATGAGAGTAATTATCTCTGGCATCATCCACATTTCCGACTCTTTCCAATCTCTTTTCCCTTTTTCTGTAATGTACCCAGCATCCCCCTATTGTATTTTGGTTGCCCAAGATTCTTGATTCTTTGAGTGTGTAGTAGCATTTCTTAAAATGAGATCATCAGACCAACCCTTGATTCACATGAAAGCTGTAATGACACAACAAAGAGAAGGCGACAGTTTTAAAGTATAATTGTCAGCCAAATGTGTATTTTATATTTGGTTCATAGAATATATCTAGATGTGGGGAAAGTCTCCTATTTGGTAATTTAGTTAAAATGTAAATGTTATATCACAGCATATGTTGGTATGTTTTGGAGTGTGCTTCCATTGTGCTCAGCTTTTGAAAAGTTTGAAATCCACTTTAGTCAAATGTAGTCAATGGGATTTCCAGAGATACATATTGTTTTTCTTAGTGTACCACACACTCCTTGAAGGCAGATACTGTACTTAATATATCACTGTCTTCCATAATACTGCCCTAGGtctttttagtttttaagagaccgggtctcgctatgtttcccatgctgaactcaaatgcctgggcttaagcaatcctcccacctcagcctctggagtagctgggactacaggggcatgcaccaccaggcctggcTTCCTAGGAGGGTCTTTAAAGAGAAAATATTTGTTCAATTGAAAACAGGATTCTTGTCATCTACAACTCCAACACAGCCTGAAAATATCCACATTATAACCTGGACCTTAGACCTACTTtctccactatcctgcaaagctacatctgtaactacctattggctatctatatgagtcctcaagcatctcagactttacatgaataaaactcaacttccttcccattcaaatctgttTATTTTCTTCTGTAAGAGAAAGATACCATTTGAGACTCCAGAATCTGCCTCTAACTCTCAACAAGACTCTGCAATTACTCAAGTATCCTTTCCATCCTCATTGCCCTGCTGTTATTACATAGGCCCTGGTTCAAGTCCTTGTTACTTGTTCCCATTATTGCAATAACTTCTAATTCCAATGCCGTTGTGTGATCCCATTTTAAACACGGCCAGAGCAGTCTTCCAACAACATAGCTCTAATCTAGTTTCATCCCCACTTTTACATGCCTCAGTGGCTTTCCCAGTGACTTGGCATGGAACACGTCCTCAGTTGCCATACATTCCAGCTAACTCTTACCCAACCTTTCTTTGTTCACACAGTTTCCTTTTCCTTCCTCATTGACCCATCCGCATCTCTGTTTATCCAAGACTTCTCTGTGATAGCTGACCCTTAGTCTTTCTCTCCCCTATTCCTCCAGACTAGATCCTGTCTCCTTCCTGCAGCCCCGACACAGCCTTCAGTTCATATCTTTTGCATGATGCTTAGCACCTTCTATCCCTAAGGACAACTTACTCATTTGAGATTTCTGGCAGGGTACCTTGCATGCAGTGGACACTCAGTATTTGCTGAATTAAATTCCTTCCTATGGATCCCTTCTGATTTTTTTTAAGTGCCTCTAATACACATATCATTCTAGGGCTCATGCCACTTTTAATGTCATTTTCTAAAGGAAAATCTTATCTATGATATTTTCCCTTATAAGAGATAGTTGTTTTGAGTAGGGTTTTTTAAAAGATAAAGGTAGTAGGAAATTTTTTAAAGCCTAAATATCAAATTCCTTTCCCTTTGGAGTTGGGGGAAGGAATGAAGGGGGAGCAACTTGCTCTTTCATATGAGTTGGTCATAGCATGTAAGAACCAATCTTGAAATATCGTTTTTTTTTTAATGGCTTATAATGTATTTCTAGAAATACTTTGTACTTAAAATGATAACAGTTTGTATCTTTTTGTCCATATATACTTTATAAATAAAAAAATTAGCATTGTAAATAATGTTAATATGTATTTATACAAAATAAATTTACTATAATATA

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