Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PARK7P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:49595148-49596256  UCSC
Coordinates (T2T) chr12:49557409-49558517  UCSC
Coordinates (hg19) chr12:49988931-49990039  UCSC
Strand +
Parental Sequence NM_001123377.2
Parental seq. overlap 709 bp
Parental seq. overlap (%) 64.3%
Genomic Region Intragenic (FAM186B)
Retrocopy Summary PARK7P1, located on chr12:49595148-49596256, is a retrocopy of the parental gene PARK7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PARK7
Full Name Parkinsonism associated deglycase
Also known as DJ-1|DJ1|GATD2|HEL-S-67p
Coordinate chr1:7961711-7985505
Strand +
Gene summary The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PARK7P2
Bonobo Pan paniscus PARK7P2
Gorilla Gorilla gorilla PARK7P2
Orangutan Pongo abelii PARK7P2
Gibbon Nomascus leucogenys PARK7P2
Green monkey Chlorocebus sabaeus PARK7P1
Crab-eating macaque Macaca fascicularis PARK7P3
Rhesus Macaca mulatta PARK7P3
Baboon Papio anubis PARK7P3
Golden snub-nosed monkey Rhinopithecus roxellana PARK7P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PARK7P1
TTGGCTAAAGGAGCAGAGGAAATGGAGACGGTCATCCTGTAGATGTCATGAGGCAAGCTGGGATTAAGGTCACCATTGCAGGTCTGGCTGGAAAAGACCCAGTACAGTGTAGCCTTGATGTTTTCATTTGTCCTGATGCCAGTCTTGAAGATGCAAAAAAAGAGGGACCATATGACATAGTAGTTCTACCAGGAGGTAATCTGGGTGCACAGAATTTACCTGAGTCTGCTTCTGTGAAGGAGATACTAAAGGAGCAGGAAAACCAGAAGGGCCTTATAGCCACTATCTGTGCAGGTCCTACTGCTCTGATGGCTCATGAGATCAGTTTTGGAAGTAAAGTTACAACACTCCCGCTTGCTAAGGACAAAATGATGAATGGAAGCCATTACACCTACTCTGAGAATCGTGTGGAAAAGGACGGCCTGAAATTCTTATAAGCCCAGGGCCTAGGACCAGCTTTGAGTTTGTGATTACAATTGTTGAAGCCCTGAGCAGCAAGGAGATGGCAGCTCAAGTGAAGGCTCCACTAGTTCTTAAAGACTAGAGCAGCAAGTaGACTAGAGCAGCGAAATGTGACGATCACTTAGAGAAACAGGCCATTAGGAATCCATTCTCACTGTGTTCGCTCTAGACAAAACAATGGTAGATTAATGTGTTCAGAAGCCACCGTCATTACTGCTTTTGCCGAAGTATAGTTGTGAAGTCACAACTACACAGAGATTTCTCAACCTACAAAGTGTGTCTGTACATTTCTTTTTTTTAATAAGCCTTGTTTGCAGAATAAACAAGGCATTTAGCAAACTA
>NM_001123377.2
gcgtTCATTTTCAGCCTGGTGTGGGGCTTGTAAACATATAACATAAAAATGGCTTCCAAAAGAGCTCTGGTCATCCTGGCTAAAGGAGCAGAGGAAATGGAGACGGTCATCCCTGTAGATGTCATGAGGCGAGCTGGGATTAAGGTCACCGTTGCAGGCCTGGCTGGAAAAGACCCAGTACAGTGTAGCCGTGATGTGGTCATTTGTCCTGATGCCAGCCTTGAAGATGCAAAAAAAGAGGGACCATATGATGTGGTGGTTCTACCAGGAGGTAATCTGGGCGCACAGAATTTATCTGAGTCTGCTGCTGTGAAGGAGATACTGAAGGAGCAGGAAAACCGGAAGGGCCTGATAGCCGCCATCTGTGCAGGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAATGGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCAGCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGAGCAGCGAACTGCGACGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAATGTGTTCAGAAGTCGCTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATACATTTCTAAGCCTTGTTTGCAGAATAAACAGGGCATTTAGCAAACTACTGATTGTTTCTTGTTTTGTCTCTCATTTCTTTTGTGAAATTAAATTCCGTATCACCTTCATTTGCAGCTCTTAACTGTCCATATGGCACTGAAATAAAAGAACAGTGACCACATTTTACACAGCAAGGAGGAAAGGCATACAAACAGAATTTAAGAGGCTTGTGATTTTCTCTGCTTATTAGCTGTGTGTTTTTAATGTGCTATTAAAAAATACCAATGAGg

Publications

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