Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPS26P80
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:50217678-50217869  UCSC
Coordinates (T2T) chr12:50180777-50180968  UCSC
Coordinates (hg19) chr12:50611461-50611652  UCSC
Strand -
Parental Sequence NM_001029.5
Parental seq. overlap 165 bp
Parental seq. overlap (%) 14.5%
Genomic Region Intragenic (LIMA1)
Retrocopy Summary RPS26P80, located on chr12:50217678-50217869, is a retrocopy of the parental gene RPS26. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPS26
Full Name ribosomal protein S26
Also known as DBA10|S26|eS26
Coordinate chr12:56041918-56044697
Strand +
Gene summary This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPS26P36
Bonobo Pan paniscus RPS26P36
Gorilla Gorilla gorilla RPS26P33
Gibbon Nomascus leucogenys RPS26P17
Crab-eating macaque Macaca fascicularis RPS26P31
Rhesus Macaca mulatta RPS26P30
Baboon Papio anubis RPS26P24
Marmoset Callithrix jacchus POLR2DP2
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPS26P80
GAGGCTGCGGCAGTCAGCGATATTTCTGAAGTGAGCGTCCTAGATGCCTGTGTACTTCCCAGGCTGGATGTGAAGCTACATTACTGTGTGAGTTGTGCCATTCACAGCACGGTAGTCAGGAATCAAGGTCATGAAGCCCACAAGGATCGAACACCTTCCCCCCACTGTAGACCTGCGGGTGCTGCCCCACGA
>NM_001029.5
GATTTTCTTCCGCCATCCGGCTAAATAGTCCCATGTGCACTTTGTTCCATGGATAAATAAACACTAGGAACGCATTTCCACCCTAGATTTCAGCAGAAATGCTGAATGTAAAGGAATATTTGAGTAAAGTGAGTTGCCGTTCTTGAAGCCCGTCTCCTAAGGATTCTCCCGGTGTCCGCGTAGGGATCTCATGCTATATAGGAGGGCCCTGCCAGGCACCGTCTCCTCTCTCCGGTCCGTGCCTCCAAGATGACAAAGAAAAGAAGGAACAATGGTCGTGCCAAAAAGGGCCGCGGCCACGTGCAGCCTATTCGCTGCACTAACTGTGCCCGATGCGTGCCCAAGGACAAGGCCATTAAGAAATTCGTCATTCGAAACATAGTGGAGGCCGCAGCAGTCAGGGACATTTCTGAAGCGAGCGTCTTCGATGCCTATGTGCTTCCCAAGCTGTATGTGAAGCTACATTACTGTGTGAGTTGTGCAATTCACAGCAAAGTAGTCAGGAATCGATCTCGTGAAGCCCGCAAGGACCGAACACCCCCACCCCGATTTAGACCTGCGGGTGCTGCCCCACGTCCCCCACCAAAGCCCATGTAAGGAGCTGAGTTCTTAAAGACTGAAGACAGGCTATTCTCTGGAGAAAAATAAAATGGAAATTGTACTTAATATTGCATGTTAAGTGTATCTGTGCCAGATAAGGTGGGGATTTTGTGTGTTAGACCAAGTGTGAAGTGACACACATTATTTTCATGGGGAAGAAAGCTTATTCATGTAATTTAAtttttttcttttttttttttttttttttgagacggagtctttgtcgcccaagctgaattgcagtggcgtgatctcagctcactgcaacctccgtctcccgggttcaagtgattctcctgcctcagcttcttgagtagctgggattacaggtgtctgccaccatgcctggttaatttttgtatttttggtagagatggggtttcactatgttgtccaggctggtcttgaacttctgacctcagttaatccaccagccttggcctcccaaagtgctgggattacaggcttgagccacctcgcctagcTATTTATGTAAATTAAACTTTAATTGTGGTCGTATGGTTGGCCTCACAATTCGCA

Publications

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