Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KRT7P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:52898678-52900056  UCSC
Coordinates (T2T) chr12:52863264-52864642  UCSC
Coordinates (hg19) chr12:53292462-53293840  UCSC
Strand -
Parental Sequence XM_011538325.2
Parental seq. overlap 757 bp
Parental seq. overlap (%) 33.2%
Genomic Region Intragenic (KRT8)
Retrocopy Summary KRT7P1, located on chr12:52898678-52900056, is a retrocopy of the parental gene KRT7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KRT7
Full Name keratin 7
Also known as CK7|K2C7|K7|SCL
Coordinate chr12:52233243-52252667
Strand +
Gene summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus KRT7P1
Chimpanzee Pan troglodytes Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KRT7P1
CTTAGTCTCATTTAATTTGAGCTGGGGGGAGTCAGCCTAGGTGGTGGTGGGGAGGACCCTGAGGGAGGGTGGGAGCACGGGAGAAGAGAAGGCATACCCAACCTGACCTACTTACCTGTCCCCTACCCCACAGAGGGCTTCCCTGGAGGCCGCCATTGCAGATGCCGAGCAGCGTGGAGAGCTGGCCATTAAGGATGCCAACGCCAAGTTGTCCGAGCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGGACATGGCGCGGCAGCTGCGTGAGTACCAGGAGCTGATGAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCGGGAGCTGCAGTCCCAGATCTCGGACACATCTGTGGTGCTGTCCATGGACAACAGCCGCTCCCTGGACATGGACAGCATCATTGCTGAGGTCAAGGCACAGTACGAGGATATTGCCAACCGCAGCCGGGCTGAGGCTGAGAGCATGTACCAGATCAAGTATGAGGAGCTGCAGAGCCTGGCTGGGAAGCACGGGGATGACCTGCGGCGCACAAAGACTGAGATCTCTGAGATGAACCGGAACATCAGCCGGCTCCAGGCTGAGATTGAGGGCCTCAAAGGCCAGGTATGGGCCGGGTTGGGGGTGGGAGGGGTTCCTTGGACACATCCTGGTGAGAGGAGATAATGTAGGAAGAGTGAAGTTTCTGGGAGTCGGGGAAGGAATCCTAGACCAGGGTTCAGGAGTTGGAGGGGCAGCCACAGTTCAGCTTCTCAGTCTGCTTCTGAGAAGCAAAGGGATGCAGGGAAGGTCCCTTGGGCCAGGACAGAGGTGAAAGGGGACTGGGGCAGGTATGTTGGGGCTCGTGATACATGCTCCCAAGCCTGCTTTAATCAGTCATATGCATCAGGGTAAGGTTGAGCTCTGCTGCTTTAAGGAAAGTCTAGAACCCAGGGATCTAGTCCAGTTAGGGTAGGGGGACCTTACAGTGTCGCAGGTGAGAAGGGTGTGGAGGGGAAGCACCTGGAAACTGCTCATGTCTCCCTGATCTGCTTCCTTAGTCTCGt
>XM_011538325.2
AGCGAGTGCGCGCTCCTCCTCGCCCGCCGCTAGGTCCATCCCGGCCCAGCCACCATGTCCATCCACTTCAGCTCCCCGGTATTCACCTCGCGCTCAGCCGCCTTCTCGGGCCGCGGCGCCCAGGTGCGCCTGAGCTCCGCTCGCCCCGGCGGCCTTGGCAGCAGCAGCCTCTACGGCCTCGGCGCCTCACGGCCGCGCGTGGCCGTGCGCTCTGCCTATGGGGGCCCGGTGGGCGCCGGCATCCGCGAGGTCACCATTAACCAGAGCCTGCTGGCCCCGCTGCGGCTGGACGCCGACCCCTCCCTCCAGCGGGTGCGCCAGGAGGAGAGCGAGCAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATCGACAAGGTGCGGTTTCTGGAGCAGCAGAACAAGCTGCTGGAGACCAAGTGGACGCTGCTGCAGGAGCAGAAGTCGGCCAAGAGCAGCCGCCTCCCAGACATCTTTGAGGCCCAGATTGCTGGCCTTCGGGGTCAGCTTGAGGCACTGCAGGTGGATGGGGGCCGCCTGGAGGCGGAGCTGCGGAGCATGCAGGATGTGGTGGAGGACTTCAAGAATAAGTACGAAGATGAAATTAACCACCGCACAGCTGCTGAGAATGAGTTTGTGGTGCTGAAGAAGGATGTGGATGCTGCCTACATGAGCAAGGTGGAGCTGGAGGCCAAGGTGGATGCCCTGAATGATGAGATCAACTTCCTCAGGACCCTCAATGAGACGGAGTTGACAGAGCTGCAGTCCCAGATCTCCGACACATCTGTGGTGCTGTCCATGGACAACAGTCGCTCCCTGGACCTGGACGGCATCATCGCTGAGGTCAAGGCGCAGTATGAGGAGATGGCCAAATGCAGCCGGGCTGAGGCTGAAGCCTGGTACCAGACCAAGTTTGAGACCCTCCAGGCCCAGGCTGGGAAGCATGGGGACGACCTCCGGAATACCCGGAATGAGATTTCAGAGATGAACCGGGCCATCCAGAGGCTGCAGGCTGAGATCGACAACATCAAGAACCAGCGTGCCAAGTTGGAGGCCGCCATTGCCGAGGCTGAGGAGCGTGGGGAGCTGGCGCTCAAGGATGCTCGTGCCAAGCAGGAGGAGCTGGAAGCCGCCCTGCAGCGGGGCAAGCAGGATATGGCACGGCAGCTGCGTGAGTACCAGGAACTCATGAGCGTGAAGCTGGCCCTGGACATCGAGATCGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAGAGCCGagtctgcaaactacggccacatgcaggcttcctgtttgtcaatcaagttttcttggaacccagtcataccgcttccttcaagtattgcctttggctgtggctgctttacatgacaacggagtggagcagttgaggcagagactacatggcccacgagcctaaagtttttactatctgaagctctaagaaaaagtttgcctgcccAGAACCCCAAGCTGTTATTTCAGGACCCACAAAATGGATTACTTACAGACATTTACAGCACCAACGCCCTCACACAACCTTATAGGGAAAGCAAAGAGACAGAAATTAGTTGTGGGGAGCAAAGCTGGTGAAATCTGTTTAACCTGCAAATTCTCTCCTCCAATTAGCGTTGATGCACATTCCAAGTAAATAATATGCAGACATGCTCCTGGGTGTTGAAGCACTGCAGCACTGCCTGGGGGAAACTGAGGGGACACCCTCCCCACAGCTGTGGTCCTCACCTCTGCTCCTCGCCCTCCAGCAGGCGCCTGTAGGTGGCGATCTCAAAGTCCAGGCCAGCTTGGAGTTCATCACCTCCTGGTACTCCCTGATCAGGCAGGCCATGTCCTGCTTGGCCTTCTGCAGGGCACCCTCCAGCTCGGCCAGCTTGCAGCGGGCATCACTGAGGGCCGCCTCACCCTGCTGCTCAGACTGGGCCACCGCGGCCTCCAGCTTGGAGTTCTGGGAGGCAAGGGAGGGTTATTAAGGATCTCTGTTCTGGCTTCAGGGTCAGAGGCCAGGTAACCACTGACCACTGACTAGCAGAAGAAAAAGAGGCCTTGTCTATTTGTTAGGCCAGGGGTTGCAAATTAGTGCTCCCAGGCATGTTTgcacagtgtcttcaattttggaaatttaacacaataa

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