Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAB13P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:55979973-55981067  UCSC
Coordinates (T2T) chr12:55947036-55948130  UCSC
Coordinates (hg19) chr12:56373757-56374851  UCSC
Strand -
Parental Sequence NM_002870.5
Parental seq. overlap 843 bp
Parental seq. overlap (%) 65%
Genomic Region Intragenic (RAB5B)
Retrocopy Summary RAB13P1, located on chr12:55979973-55981067, is a retrocopy of the parental gene RAB13. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAB13
Full Name RAB13, member RAS oncogene family
Also known as GIG4
Coordinate chr1:153981650-153990644
Strand -
Gene summary This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAB13P1
Bonobo Pan paniscus RAB13P1
Gorilla Gorilla gorilla RAB13P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAB13P1
TGCCTCAGGCTTCAGACCTTACCTGGGTTTTCAGGGCAAACATAAATGTAAATACACTGATTTATTCTGTTACTAGATCAGGTTTTAGGGTCCTGCAAAGGGCTAGCTCGGCACTACACTAGGGAATTTGCTCCTGTTCTGTCACTTGTCATGGTCTTTCTTGGTATTAAAGGCCACCATTTGCACCCCCATCCCTTCCCCGGCTCCCCCGGTGTCCGCCATGGCCAAAGCCTACGACCACCTCTTCAAGTTGCTGCTGATCGGGGACTCGGGGGTGGGCAAGACTTGTCTGATCATTCGCTTTGCAGAGGACAACTTCAACAACACTTACATCTCCACCATCGGAATTGATTTCAAGATCCGCACTGTGGATATAGAGGGGAAGAAGATCAAACTACAAGTCTGGGACACAGCTGGCCAAGAGCGGTTCAAGACAATAACTACTGCCTACTACCGTGGAGCCATGGGCATTATCCTAGCATACGACATCACGGATGAGAAATCTTTCGAGAATATTCAGAACTGGATGAAAAGCATCATGGAGAATGCCTCAGCTGGGGTGGAGCACCTCTTGCTAGGGAACAAATGTGACATGGAGGCCAAGAGGAAGGTGCAGAAGGAGCAGGCCGATAAGTTGGCTCGAGAGCATGGAATCCGATTTTTCGAAACTAGTGCTAAATCCAGTATGAATGTGGATGAGGCTTTTAGTTCCCTGGCCCGGGACATCTTGCTCAAGTCAGGAGGCCGGAGATCAGGAAACGGCAACAAGCCTCCCAGTACTGACCTGAAAACTTGTGACATAAAGAACACCAACAAGTGCTCCCTGAGCTGAGGACCCTTTCTTGCCTCCCCACCCCGGAAGCTGAACCTGAGGGAGACAACAGCAGAGGGAGTGAGCAGGGGAGAAATAGCAGAGGGGCTTGGAGGGACACATAGGTAGATGGTAAAGAGAATGAGGAGAAAAAGGAGAAAAGGGAAAAGCAGAAAGGAAAAGAAGGAAAa
>NM_002870.5
CTTCCTGGCCTGGGCTCCGTGCCGCTCTGTTTGCCAACCGTCCAGTCCCGCCTACCAGTGCCGGGCGCTCCCCACCCCTCCCCCGGCTCCCCCGGTGTCCGCCATGGCCAAAGCCTACGACCACCTCTTCAAGTTGCTGCTGATCGGGGACTCGGGGGTGGGCAAGACTTGTCTGATCATTCGCTTTGCAGAGGACAACTTCAACAACACTTACATCTCCACCATCGGAATTGATTTCAAGATCCGCACTGTGGATATAGAGGGGAAGAAGATCAAACTACAAGTCTGGGACACGGCTGGCCAAGAGCGGTTCAAGACAATAACTACTGCCTACTACCGTGGAGCCATGGGCATTATCCTAGTATACGACATCACGGATGAGAAATCTTTCGAGAATATTCAGAACTGGATGAAAAGCATCAAGGAGAATGCCTCGGCTGGGGTGGAGCGCCTCTTGCTGGGGAACAAATGTGACATGGAGGCCAAGAGGAAGGTGCAGAAGGAGCAGGCCGATAAGTTGGCTCGAGAGCATGGAATCCGATTTTTCGAAACTAGTGCTAAATCCAGTATGAATGTGGATGAGGCTTTTAGTTCCCTGGCCCGGGACATCTTGCTCAAGTCAGGAGGCCGGAGATCAGGAAACGGCAACAAGCCTCCCAGTACTGACCTGAAAACTTGTGACAAGAAGAACACCAACAAGTGCTCCCTGGGCTGAGGACCCTTTCTTGCCTCCCCACCCCGGAAGCTGAACCTGAGGGAGACAACGGCAGAGGGAGTGAGCAGGGGAGAAATAGCAGAGGGGCTTGGAGGGTCACATAGGTAGATGGTAAAGAGAATGAGGAGAAAAAGGAGAAAAGGGAAAAGCAGAAAGGAAAAAAAGGAAgagagaggaagggagaagggagaggaatgaattgaggaagtgaaagaaggcaaggaggtaggaagagagggaggaggaaaggaaggagagaTGCCTCAGGCTTCAGACCTTACCTGGGTTTTCAGGGCAAACATAAATGTAAATACACTGATTTATTCTGTTACTAGATCAGGTTTTAGGGTCCTGCAAAAGGCTAGCTCGGCACTACACTAGGGAATTTGCTCCTGTTCTGTCACTTGTCATGGTCTTTCTTGGTATTAAAGGCCACCATTTGCACAAAT

Publications

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