Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name YWHAQP10
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:56871681-56874266  UCSC
Coordinates (T2T) chr12:56839569-56842154  UCSC
Coordinates (hg19) chr12:57265465-57268050  UCSC
Strand +
Parental Sequence NM_006826.4
Parental seq. overlap 1796 bp
Parental seq. overlap (%) 81%
Genomic Region Intergenic
Retrocopy Summary YWHAQP10, located on chr12:56871681-56874266, is a retrocopy of the parental gene YWHAQ. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name YWHAQ
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Also known as 14-3-3|1C5|HS1
Coordinate chr2:9583967-9630997
Strand -
Gene summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla YWHAQP4
Orangutan Pongo abelii YWHAQP4
Gibbon Nomascus leucogenys YWHAQP6
Golden snub-nosed monkey Rhinopithecus roxellana YWHAQP7
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>YWHAQP10
TGCCACGGAGAAGACGGAGCTGATCCTAGAAGGCCAAGCTGGCTGAGCTGGCCAGATGGTACGACTACATCACTACCTGGGTGAAGGCTGTGACAGAGCAGGGCACCAAGCTGTTCAATGAGGAGCTCAACCTGCTTTCAGTGGCCTACACATACATGGTCAGGGGATCACAGGTCTGCCTAGAGGGTCACCTTGAGCATTGAGCAGAAAACTGTTACCTCCGACAAGAAGTTGCAGCTGATTAAGGGCTATCAGGAGAAAGTAGAGTCTGAGCTGAGATCCATCTGTACCACAGTCCTGGAATTGCTGGATGAGTATTTAATAGCTGATGCAACTAATCCAGAGAGTAAGGTCTTCTAATTGAAAATGAAGGGAGATTACTTCCTGTACCTTGCCGAAGTTGCAAGTGGTGATGATTGAAAACAAGATAGATAATTCCCAAGGAGCTTACCAAGAAGTATTTGATATAAGCAAGAAAGAGAGTCAACTCACCCACCCAATCTACCTGGGGCTTGCTCTTAACTTTTCTGTATTTTACTGTGAGACCCTTAATAATGCAGAGCTCACCTGCATGCTGAATAAAACAGATACACTGCAGAACTTGATACACGGAATGAAGATTCATACAAAGACAGCACCCTTATCTGCTTAGAGACAACCTAACACTATGGATATCAGACAGTGCAAGGAAGAATGTGATGCAGTAGAAGGGGCTGAAAACTAAATGCATAAAGAGTGTCATCCTTCCTCCCTTCAAGAAACCTTTTTATGCATCTCCTTTCCTTATTCCACTTGAATTTCCTATAGCAAAGAAACCCATTCATGTGCTTGGAATTAACTGTTTATAGCTTTTTCACACTGCATCTTTGGGAAAATGCCATTCCCTGATTTGTGTTTGTCTTGGCCTTCCTGATGTGCAGTTACTGCTGTAGAAAAGCATTCATAGCTTAATTTCATATAAACTTAAGTACCTTCCAAATGCTTATGTAGAGGACTAAAAAATGTATCTGGTATTTAAGTAATCTGAACCAGTTTTGCAAATGACTGTGTTTTGTATTACTGTGGAGATATAAAAATGTAGTTAATTATAATTTAAAGAATGTTCGTGTTCGATGTAACGTCTTAATTTCTACATTCCCTCCCTTACTCTTTGGGGGTTTCTTCTCAATAATCAACTTTTCCATGCTCTTAATGTATTCTTTTTAGTAGAAATCCAGAAATATCAGATTGAATGGAAAAGCGCTTGCCATTTCTGGGTTGAGGTGTCACAAATTGAAATGTCTCCTATATCACATATTATGGAGGTCATGTGAATCTGTGGAAAGAGTAAATAAGAGTTTCCTTATTCACTCTTCATATGCTGCTGTTTAAGTTGGCAGCTTTCCTTCCCAATAAAAATTCATTTACACTTCCTGCCTTTATAGTTCTGGTATCTACTTTACTATGTAATAGAAGTAGCATGTTGCTGCCAGAATACTAGCATTTCTTTTGGCAAACTGAAGTACATGTCACTTCTTAACACACTAGAAAGGGGAAACAAAGCACACAAGTCCAAGTCTAAAACTTTAGTACATTTCTATGCAGATTTGTGTATATGTAAGGAGGTGTCCTGTTTGTCTAGTGATTGTTATTTAGTTGGACAACTATTGTGTGTTGCTCGTCATTGACTGAAGTCCCAAAAAAGTCTTGTGAAAATGTTATGCCCTATGTAACAGCAGAATAACATAAAATAAAATTAaTATAAACCATTTACTATGGCTTTGTAACAATTGCATATTCCTATATTAAGGGACAGGTGAATTTACTACTTTCTAAAGTTTATTGATAATTCCCTTTTGTGTAAAATGTGGTAGTGATACCTATATTTCTGCATCATGATATACTTGTCTAGGGATGCCTGGACATGTATAAGATTGGACTGCATTTCTTAGAATGTTTTACTATAGATCAGTCTCCTGGGCTATCTCTTCCTCAGACATAAATGATATCTGGTTAAGTGTTATGTGAAATAAAGTGAACATTTTAAAACT
>NM_006826.4
AAAGCCAAAAGCAGATCAAAGTGGTGGGACTCGCGTCGCGGCCGCGGAGACGTGAAGCTCTCGAGGCTCCTCCCGCTGCGGGTCGGCGCTCGCCCTCGCTCTCCTCGCCCTCCGCCCCGGCCCCGGCCCCGCGCCCGCCATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGCAGTGACCGAGCAGGGCGCCGAGCTGTCCAACGAGGAGCGCAACCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGGGTCATCTCTAGCATCGAGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAGGACTATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCACCACGGTGCTGGAATTGTTGGATAAATATTTAATAGCCAATGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAAATGAAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCGTGTGGTGATGATCGAAAACAAACGATAGATAATTCCCAAGGAGCTTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATGCAACCCACACACCCAATCCGCCTGGGGCTTGCTCTTAACTTTTCTGTATTTTACTATGAGATTCTTAATAACCCAGAGCTTGCCTGCACGCTGGCTAAAACGGCTTTTGATGAGGCCATTGCTGAACTTGATACACTGAATGAAGACTCATACAAAGACAGCACCCTCATCATGCAGTTGCTTAGAGACAACCTAACACTTTGGACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCAGAAGGGGCTGAAAACTAAATCCATACAGGGTGTCATCCTTCTTTCCTTCAAGAAACCTTTTTACACATCTCCATTCCTTATTCCACTTGGATTTCCTATAGCAAAGAAACCCATTCATGTGTATGGAATCAACTGTTTATAGTCTTTTCACACTGCAGCTTTGGGAAAACTTCATTCCTTGATTTGTGTTTGTCTTGGCCTTCCTGGTGTGCAGTACTGCTGTAGAAAAGTATTAATAGCTTCATTTCATATAAACATAAGTAACTCCCAAACACTTATGTAGAGGACTAAAAATGTATCTGGTATTTAAGTAATCTGAACCAGTTCTGCAAGTGACTGTGTTTTGTATTACTGTGAAAATAAGAAAATGTAGTTAATTACAATTTAAAGAGTATTCCACATAACTTCTTAATTTCTACATTCCCTCCCTTACTCTTCGGGGGTTTCCTTTCAGTAAGCAACTTTTCCATGCTCTTAATGTATTCCTTTTTAGTAGGAATCCGGAAGTATTAGATTGAATGGAAAAGCACTTGCCATCTCTGTCTAGGGGTCACAAATTGAAATGGCTCCTGTATCACATACGGAGGTCTTGTGTATCTGTGGCAACAGGGAGTTTCCTTATTCACTCTTTATTTGCTGCTGTTTAAGTTGCCAACCTCCCCTCCCAATAAAAATTCACTTACACCTCCTGCCTTTGTAGTTCTGGTATTCACTTTACTATGTGATAGAAGTAGCATGTTGCTGCCAGAATACAAGCATTGCTTTTGGCAAATTAAAGTGCATGTCATTTCTTAATACACTAGAAAGGGGAAATAAATTAAAGTACACAAGTCCAAGTCTAAAACTTTAGTACTTTTCCATGCAGATTTGTGCACATGTGAGAGGGTGTCCAGTTTGTCTAGTGATTGTTATTTAGAGAGTTGGACCACTATTGTGTGTTGCTAATCATTGACTGTAGTCCCAAAAAAGCCTTGTGAAAATGTTATGCCCTATGTAACAGCAGAGTAACATAAAATAAAAGTACATTTTATAAACCATTTACTATGGCTTTGTAACAATTGCATACCCATATTTTAAGGGACAGGTGAATTTACTACTTTCTAAAGTTTATTGATACTTCCCTTTTATGTAAAATGTAGTAGTGATACCTATATTTCCACATTGTGCATTGTGACACACTTGTCTAGGGATGCCTGGAAGTGTATAAAATTGGACTGCATTTCTTAGAGTGTTTTACTATAGATCAGTCTCATGGGCCATCTCTTCCTCAGATGTAAATGATATCTGGTTAAGTGTTATATGGAATAAAGTGGACATTTTAAAACTAGCAAAGTTAA

Publications

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