Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PKP2P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:6477668-6482180  UCSC
Coordinates (T2T) chr12:6488017-6492529  UCSC
Coordinates (hg19) chr12:6586834-6591346  UCSC
Strand +
Parental Sequence NM_001005242.3
Parental seq. overlap 3938 bp
Parental seq. overlap (%) 92.5%
Genomic Region Intergenic
Retrocopy Summary PKP2P1, located on chr12:6477668-6482180, is a retrocopy of the parental gene PKP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PKP2
Full Name plakophilin 2
Also known as ARVD9
Coordinate chr12:32790755-32896777
Strand -
Gene summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13. [provided by RefSeq, May 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PKP2P1
Orangutan Pongo abelii PKP2P1
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PKP2P1
CGCGAGTCCCAAGGCAAGCGAGCGGCTGGGTCGCCCCCACCGGCCCCATGGCAGCCCCCGGGGCCCCAGCTGAGTACGGCTACATCCGGACCATCTTGGGCCAGCAGATCCTGGGACAACTGGACAGCTCCAGCCTGGCGCTGCCCTCTGAGGCCAAGCTGAAGCTGGCTGGGAGCAGCGGCCGCGGCAGCCAGTCAAGAGCCTGCGGATCCAGGAGCAGGTGCAGCAGATCCTCGCCCGGAAGGGCCGCAGCTCCGTGGGCAACGGAAATCTTCACCGAACCAGCAGTGTTCCTGAGTATGTCTACAACCTACACTTGGTTGAAAATGATTTTGTTGGAGGCCGTTCCCCTGTTCCTAAAACCTATTACATGCTAAAGGCTGGCACAACTGCCACTTATGAAGGTCGCTGGGGAAGAGGAACAGCACAGTACAGCTCCCAGAAGTCCGTGGAAGAAAGGTATTTGAGGCATCCTCTGAGGAGACTGGAGATTTCTCCTGACAGCAGCCCGGAGAGGGCTCACTACACGCACAGCGATTACCAGTACAGCCAGAGAAGCCAGGCTGGGCACACCCTGCACCACCAAGAAAGCAGGCGGGCCGCCTTCCTGGTGCCACCGAGATATGATCGTTCTGAGATCGCGGGGGTCCGCCGTACTGGCACCACAAGCAGGCAGCACCACTTTGACACCACAGGCAGTACCAGCGTGGCTCTGTTAGTGACACCGTTTTTGACAGCATCCCTGCCAACCCGGCCCTGCTCACGTACCCCAGGCCAGGGACCAGCCGCAGCATGGGCAACCTCTTGGAGAAAGAGAACTACCTGAGGGCAGGGCTCACCGTCGGCCAGGTCAGGCCGCTGGTGCCCCTGCGGCCCCTCACTCAGAACAGGGCTTCCAGGTCCTCCTGGCACCGGAGCTCCTTCCACAGCACCCGCACACCGAGGAAAGCTGGGCCCAGTGTTGCCGTGGATTCCAGCGGGAGGAGAGCGCACTTGACCGTCGGCCAGGCAGCGGCAGGGGGAAGTGGGAATCTTCTCACCCAGAGAAGCACTGACTCCCAGCTGGGGAATGCAGACATGGAGATGACTCTGGAGCGAGCAGGGAGTATGCTCGATGCAGACCAGATGCCGCCGTCCAGGATTTCTGCCGCAGCCACTTTCATACAGCACGAGTGCTTCCAGAAATCTGAAGCTGGGAAGAGGGTTAACCAGTTTTGTGGCATCCCCAAGCTTCTGCAGCTCCTAAAAGTTCAGAATGAAGATGTTCAGCGAGCTGTGTGGGGGGCCTTGAGAAACTTACTATTTGAAGACAATGACAACAAATTGGAGGTGGCTGAACTAAATGGGGTAACTCGGCTGCTCCAGGTGCTGAAGCAAACCAGAGTCTTGGAGACTAAAAAACAACTAACAGGTTTGCTGTGGAATTTGTCATCTAATGACAAACTCAAGAATCTCATGATAACAGAAGCATTGCTTATGCTGACCGAGAATATAATCATCTCCTTTTCTGGATGGCCTGAAGGAGACTACCCAAAAGCGAATGGTTTGCTCGATTTTGACACAGTCTACAACCCACTGGATGTCTAAGAAACATGAGTGCTGCTGGCCCTGATAGGAGAAAAGCAATGAGAAGATGTGACCGACTCATTGACTCACTGGTCCATTATGTCAGAGGAACCATTGCGGATTACCAGCCAGATGACAAGGCCACGGAGAATTGTGTGCACATTCTTCATAACCTCTCCTACCAGCTGGAGGTAGAGCTCCCAGAGAAATATTCCCAGAATATCTATATTCAAAACCCAAATGTCCAGACTAACAACAAAAGTATTGGATGTTTTGGCAGTCGAAGCAGGAAACTAAAAGAGCAATACTAGGACATGCCGATGCCAGAGGAAAAGAGCAACCCCAAGGGCGTGGAGTGGCTGTGACACTCCATTGTGATAAGGATGTATCTGTCCTTGATCGCCAAGAGTGTCCCAAACTACACACAGGAAGCCTCCTTAGGCGCTCTCCAGAACCTCACAGCCGGAAGTGGACCAATGCCGACATCAGTGGCTCAGACAGTCGTCCAGAAGGAAAATGGCCTGCAGCACACCCGAAAGATGGTGCATGTCAGTGACCCAAGTGTGAAAAAGACAGCCAACTTGCTGCTGAGGAATCTGTCCCAGAATCTTTCTCTGCAGAATAAAATTGCCAAAGAAACTCTCCCCAGTTTGGTCTCCATCATTCCTGATACAGTCCCGAGTACTGACCTTCTCATTGAAACTACAGCCTCTGCCTGTTACATGTTGAACAACGTAATCCAAAACAGTTACCAGAATGCACAGCGCCTTCCGAATACCGGGGGCATCCAGAAAATTATGACCATCAGTGCAGGCGATGCCTATGCCTCCAACAAAGCAAGTAAAGCTGCTTCCATCCTCCTGTATTCTCTGTAGGCACACACGGAACTCCATCATGCCTACAAGAAGGCTCAGTTTAAGAAGACAGATTTTGTCAACAGCTGGACTGTCAAAGCCTACCACTCCCTTAAAGACTGAGGAAAATGACGAAGTATTCTCAGCTGCAAAAAAATCCCACAGGAAAACACCTATTTTTCTACTACCCAGCCCAAGAAACCTCAAAAGCATGCCTCGTTTCTATCATTTTCTATTTCCATGGTCCCCCGAATCCAGAAAACAAGTACAACATAATCTTATGAGTCTTCCAGAAGACTTTTGCAAGCTTGCCACCAGTAGATACTGGTCACAGGCTCTACAAATAGTGGTCTTTGTTATTAGGGCTTATGGTGCATGGCCTCCTGGAACCAAAATGTGAATTCATGTGGAATGGACTTTGATCCAATAAATAAGGAAAGAAGTTGTTGCATTACTGGGATTTTAAAAGCTTGATTTACATTTATATTCCTTTTCTAGTTCCCATGTTTTGTCACTCATGTGCACATTGCTTCACCATTGGGCCATGAGTATATTGTTCTGTAGTGTTGAAACAGAATGGAAATGACAAGAAATATCTGCAGTTATCCAGGAGAAAGTATAATGGCAAAATTATTTGTTTCTTTGTTTACTTTGTGCTCGTTTTTATCTCCTTAGGTTTTTTTCCTCTGATTTTTAAATAAACTTAAGAAATTTAGATTACAGAGTATGCATGACTGTAAGAAAAAGAAATTGAGAGGAAGTGATCATAGCAAATTAAAGAAACCTTTTTCTCCCAAAACTTCTTTTCCCCAGAGAAAGGCAACTGTGATTATAAAGTTTAACCTTCCCCCAAACACTGAATGAATGAGATTTTTGCTCCGGAAATACTTTACCTATAACAACACCATTAAATCCAAATCTCTTCTAAACAATGGCATTCCGTGTAATGCCTTTCCTGGACAcTTCTGTATTTTTTAGGCCACTGCCCTGGACTAGTGGAAGAATGGACTCTAGTCTTTATCTGCAAGAGGAACTAAGGCCTTCTATCAGACTGCCCGGCCAGCCTGGGGCACTGAAAATACAGCTCATTTTAATGAGTTACATTATCAACCAGCTTTGCCCAGCATTTAAGAAATATCACAGGGCCACTAAATCTCATATGATCTTCTTCAAGCCATTATTTTAATTCAAGAAAACTCTAGAGAAAAAAGTGAAGAAGTCATGTTGAAGAAGATATAAGAATGTGTCAAGACCATACAGAAATGATATGAGAAATACTGGTGTTTTAAAAGGTGACATCATCCAGTGAAATGAATCTATATTAAATGTTATTTTAACTGCATTATGATTAAAACCATTCATATAGAGTTAGTCTTCACAACTACTATTCTGTTATATTTTGTTTTTTTTTTTTTAAATCTGACAACGTTTGTCATAAGTAAGATAAGGAAAAAAACTCTTCAACTCCTTTTGGCCAGAAAAGTGTAATAGAAAATAAATGTTGAATATGTACTTAAGTCTTTATTATATTTGAAACTTAAATTTTTTTTCAGTTTTAAAAGCTGAATGAAGATAGCTTAGGTAACTAACCTAGTTCAAAATGAAATTTAGATACCAATTTTTAAAATACTGGAGAGAATTTATATGTCTTTTTCCAGAGTTCTGATAATAAGCATTTGGAGTGCATTCATTCCTCCAGATAATAAATGTATGTTCAAGAACTTTTTGTGTTTTTTAAGACATTAATAGAGTCTTCAATAATATTAAATACAAAA
>NM_001005242.3
GCGAGTCCAGAGGCAGGCGAGCAGCTCGGTCGCCCCCACCGGCCCCATGGCAGCCCCCGGCGCCCCAGCTGAGTACGGCTACATCCGGACCGTCCTGGGCCAGCAGATCCTGGGACAACTGGACAGCTCCAGCCTGGCGCTGCCCTCCGAGGCCAAGCTGAAGCTGGCGGGGAGCAGCGGCCGCGGCGGCCAGACAGTCAAGAGCCTGCGGATCCAGGAGCAGGTGCAGCAGACCCTCGCCCGGAAGGGCCGCAGCTCCGTGGGCAACGGAAATCTTCACCGAACCAGCAGTGTTCCTGAGTATGTCTACAACCTACACTTGGTTGAAAATGATTTTGTTGGAGGCCGTTCCCCTGTTCCTAAAACCTATGACATGCTAAAGGCTGGCACAACTGCCACTTATGAAGGTCGCTGGGGAAGAGGAACAGCACAGTACAGCTCCCAGAAGTCCGTGGAAGAAAGGTCCTTGAGGCATCCTCTGAGGAGACTGGAGATTTCTCCTGACAGCAGCCCGGAGAGGGCTCACTACACGCACAGCGATTACCAGTACAGCCAGAGAAGCCAGGCTGGGCACACCCTGCACCACCAAGAAAGCAGGCGGGCCGCCCTCCTAGTGCCACCGAGATATGCTCGTTCCGAGATCGTGGGGGTCAGCCGTGCTGGCACCACAAGCAGGCAGCGCCACTTTGACACATACCACAGACAGTACCAGCATGGCTCTGTTAGCGACACCGTTTTTGACAGCATCCCTGCCAACCCGGCCCTGCTCACGTACCCCAGGCCAGGGACCAGCCGCAGCATGGGCAACCTCTTGGAGAAGGAGAACTACCTGACGGCAGGGCTCACTGTCGGGCAGGTCAGGCCGCTGGTGCCCCTGCAGCCCGTCACTCAGAACAGGGCTTCCAGGTCCTCCTGGCATCAGAGCTCCTTCCACAGCACCCGCACGCTGAGGGAAGCTGGGCCCAGTGTCGCCGTGGATTCCAGCGGGAGGAGAGCGCACTTGACTGTCGGCCAGGCGGCCGCAGGGGGAAGTGGGAATCTGCTCACTGAGAGAAGCACTTTCACTGACTCCCAGCTGGGGAATGCAGACATGGAGATGACTCTGGAGCGAGCAGTGAGTATGCTCGAGGCAGACCACATGCTGCCATCCAGGATTTCTGCTGCAGCTACTTTCATACAGCACGAGTGCTTCCAGAAATCTGAAGCTCGGAAGAGGGTTAACCAGCTTCGTGGCATCCTCAAGCTTCTGCAGCTCCTAAAAGTTCAGAATGAAGACGTTCAGCGAGCTGTGTGTGGGGCCTTGAGAAACTTAGTATTTGAAGACAATGACAACAAATTGGAGGTGGCTGAACTAAATGGGGTACCTCGGCTGCTCCAGGTGCTGAAGCAAACCAGAGACTTGGAGACTAAAAAACAAATAACAGGTTTGCTGTGGAATTTGTCATCTAATGACAAACTCAAGAATCTCATGATAACAGAAGCATTGCTTACGCTGACGGAGAATATCATCATCCCCTTTTCTGGGTGGCCTGAAGGAGACTACCCAAAAGCAAATGGTTTGCTCGATTTTGACATATTCTACAACGTCACTGGATGCCTAAGAAACATGAGTTCTGCTGGCGCTGATGGGAGAAAAGCGATGAGAAGATGTGACGGACTCATTGACTCACTGGTCCATTATGTCAGAGGAACCATTGCAGATTACCAGCCAGATGACAAGGCCACGGAGAATTGTGTGTGCATTCTTCATAACCTCTCCTACCAGCTGGAGGCAGAGCTCCCAGAGAAATATTCCCAGAATATCTATATTCAAAACCGGAATATCCAGACTGACAACAACAAAAGTATTGGATGTTTTGGCAGTCGAAGCAGGAAAGTAAAAGAGCAATACCAGGACGTGCCGATGCCGGAGGAAAAGAGCAACCCCAAGGGCGTGGAGTGGCTGTGGCATTCCATTGTTATAAGGATGTATCTGTCCTTGATCGCCAAAAGTGTCCGCAACTACACACAAGAAGCATCCTTAGGAGCTCTGCAGAACCTCACGGCCGGAAGTGGACCAATGCCGACATCAGTGGCTCAGACAGTTGTCCAGAAGGAAAGTGGCCTGCAGCACACCCGAAAGATGCTGCATGTTGGTGACCCAAGTGTGAAAAAGACAGCCATCTCGCTGCTGAGGAATCTGTCCCGGAATCTTTCTCTGCAGAATGAAATTGCCAAAGAAACTCTCCCTGATTTGGTTTCCATCATTCCTGACACAGTCCCGAGTACTGACCTTCTCATTGAAACTACAGCCTCTGCCTGTTACACATTGAACAACATAATCCAAAACAGTTACCAGAATGCACGCGACCTTCTAAACACCGGGGGCATCCAGAAAATTATGGCCATTAGTGCAGGCGATGCCTATGCCTCCAACAAAGCAAGTAAAGCTGCTTCCGTCCTTCTGTATTCTCTGTGGGCACACACGGAACTGCATCATGCCTACAAGAAGGCTCAGTTTAAGAAGACAGATTTTGTCAACAGCCGGACTGCCAAAGCCTACCACTCCCTTAAAGACTGAGGAAAATGACAAAGTATTCTCGGCTGCAAAAATCCCCAAAGGAAAACACCTATTTTTCTACTACCCAGCCCAAGAAACCTCAAAAGCATGCCTTGTTTCTATCCTTCTCTATTTCCGTGGTCCCCTGAATCCAGAAAACAAATAGAACATAATTTTATGAGTCTTCCAGAAGACCTTTGCAAGTTTGCCACCAGTAGATACCGGCCACAGGCTCGACAAATAGTGGTCTTTGTTATTAGGGCTTATGGTACATGGCTTCCTGGAATCAAAATGTGAATTCATGTGGAAGGGACATTAATCCAATAAATAAGGAAAGAAGCTGTTGCATTACTGGGATTTTAAAAGTTTGATTTACATTTATATTCCTTTTCTGGTTCCCATGTTTTGTCACTCATGTGCACATTGCTTCGCCATTGGGCCTCCAGTGTATTGTTCTGCAGTGTTGAAACAGAATGGAAATGACAAGAAATATCTGCAGTTATCCAGGAGAAAGTATAATGGCAAAATTATTGGTTTCTTTCTTTACTTTGTGCTTGTTTTTATCCCCTTGGGTTGTTTTTCTCTGATTTTTAAATAAACTTAAGAAATTTAGATTACAGAGTATGCATGACTGTAAGAAAAAGAAATTGAGAGGAAGTGATCATAGCAAATTAAAGAAGTCTTTTCCTCCCAGAACTTAAAGTAaaataaaaaataaataaataaataaaATCTTTTCCACAGAGAAAGGCAACTGTGATGATAAAATTTAACGTTCCCCCAAACACTGAGTCAATGAGATTTTTCTCAGGAGATACTTTACCTATAACAACGCCGTTAAATCCAAATCTCTTCTAAACGATGGCATTCTATGTAATGCCTTTCCTGGACTTTTTTGGCCACTGCCCTGGACTAGTGAAAGAATGGACTCTATCTTTATCTGCAAGAGGAACTAAGGCCTTCTCTCAGACTGCCTGGCCAGCCTGGGGCACTGAAAATACGGCTCATGTTAATGAGTTACATTATCAGCCAGCCCAGCCTTGCCCACCATTTAAGAAATATCACAGAGCCACTAGATCTCATATGATCTTCTTCAAGCCATTATTTTAACTCAAGAAAACTCTAGAGAAGAAAAGTGAAGAAGTCATGTTGAAGAAGATGTAAGAATGTGTCAAGACCATCCAGAAATGATATGAGAAATACTGATATTTTAAATGGTTGACATCATCCAGCGAAATGAATCTACATTAAATGTTGTTTTAACTGCGCTATGATTAAAACCATTCATATAGAGTTAGTCTTTACAACTACTATTCTGTTATTTTTTTTTTTAATCTGACAACATTTGTCCTAAGTAAGATAAGCAAAAAAATTCTTCAACTCCTTTTGGCAAGAAAACTGTAACAGAAAATAAATTTTGAATGTGTACTTAAGTCTTTATTATATTTGAAGCAATTTTTTTTCAATTTTAAAAGCTGAATGAAGACAACTTAGGTTGCTAACCTAGTTCAAAATGAAATTATTTAGATACCAATTTTTAAAATACTGGAGAGAATTTATATGTCTTTTTCCAGAGTTCTGATGATAAGCATTTGGAGTGCATTTATTCCTCCAGATAATAAATGTGTGTTCAGAACTTTTTGTGTTTTTTAAGGCATTAATAAAGCCTTCGATAATATTAAATACAAAA

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