Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GPR153P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:6824150-6824447  UCSC
Coordinates (T2T) chr12:6833443-6833740  UCSC
Coordinates (hg19) chr12:6933316-6933613  UCSC
Strand +
Parental Sequence XM_017001251.2
Parental seq. overlap 246 bp
Parental seq. overlap (%) 12.4%
Genomic Region Intragenic (GPR162)
Retrocopy Summary GPR153P1, located on chr12:6824150-6824447, is a retrocopy of the parental gene GPR153. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GPR153
Full Name G protein-coupled receptor 153
Also known as PGR1
Coordinate chr1:6247353-6261098
Strand -
Gene summary This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]

Homology

Species Scientific Name Retrocopy
Rabbit Oryctolagus cuniculus GPR153P1
Tasmanian Devil Sarcophilus harrisii GPR153P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GPR153P1
CTGGAACGAGAGTATCTGCAAGGTCTTCGTGTCCACCTACTACACCCTGGCGCTGGCCACCTGCTTCACGGTCGCCTCCCTCTCCTACCATCGCATGTGGATGGTGCGCTGGCCCGTCAACTACCGCCTCAGCAACGCCAAGAAGCAGGCACTGCATGCCGTCATGGGCATCTGGATGGTCAGCTTCATCCTCTCCACACTGCCCTCCATTGGCTGGCACAACAACGGCGAGCGCTACTATGCCCGCGGCTGCCAGTTCATAGTCTCCAAGATCGGCCTCGGCTTTGGCGTTTGCTTC
>XM_017001251.2
GCATGCCCCGGCCCGCGGGCCGCTCCGCCGCCAGCCACCCCCGCGGCCCTCGGCGGCCTGCGCTCGGCCCGGGggcgcgggaaccgcagccggagccggaggcgggagcagcgagccggagccCCGGGCGCTCGAATGCAGGATGCTCGTGGTCCCCAGCATCCTTGAGCCACCAGGAGTGAGGGCTGCTGCTCCCTGAGACCTGGCTCCAAGGAGGATGCCACAGCCGCCTGCCAGCTCCGGTCTGCACCATGAGTGATGAGCGGCGGCTGCCTGGCAGTGCAGTGGGCTGGCTGGTATGTGGGGGCCTCTCCCTGCTGGCCAATGCCTGGGGCATCCTCAGCGTTGGCGCCAAGCAGAAGAAGTGGAAGCCCTTGGAGTTCCTGCTGTGTACACTCGCGGCCACCCACATGCTAAATGTGGCCGTGCCCATCGCCACCTACTCCGTGGTGCAGCTGCGGCGGCAGCGCCCCGACTTCGAGTGGAATGAGGGTCTCTGCAAGGTCTTCGTGTCCACCTTCTACACCCTCACCCTGGCCACCTGTTTCTCTGTCACCTCCCTCTCCTACCACCGCATGTGGATGGTCTGCTGGCCTGTCAACTACCGGCTGAGCAATGCCAAGAAGCAGGCGGTGCACACAGTCATGGGTATCTGGATGGTGTCCTTCATCCTGTCGGCCCTGCCTGCCGTTGGCTGGCACGACACCAGCGAGCGCTTCTACACCCATGGCTGCCGCTTCATCGTGGCTGAGATCGGCCTGGGCTTTGGCGTCTGCTTCCTGCTGCTGGTGGGCGGCAGCGTGGCCATGGGCGTGATCTGCACAGCCATCGCCCTCTTCCAGACGCTGGCCGTGCAGGTGGGGCGCCAGGCCGACCGCCGCGCCTTCACCGTGCCCACCATCGTGGTGGAGGACGCGCAGGGCAAGCGGCGCTCCTCCATCGATGGCTCGGAGCCCGCCAAAACCTCTCTGCAGACCACGGGCCTCGTGACCACCATAGTCTTCATCTACGACTGCCTCATGGGCTTCCCTGTGCTGGTGGTGAGCTTCAGCAGCCTGCGGGCCGACGCCTCAGCGCCCTGGATGGCACTCTGCGTGCTGTGGTGCTCCGTGGCCCAGGCCCTGCTGCTGCCTGTGTTCCTCTGGGCCTGCGACCGCTACCGGGCTGACCTCAAAGCTGTCCGGGAGAAGTGCATGGCCCTCATGGCCAACGACGAGGAGTCAGACGATGAGACCAGCCTGGAAGGTGGCATCTCCCCGGACCTGGTGTTGGAGCGCTCCCTGGACTATGGCTATGGAGGTGATTTTGTGGCCCTAGATAGGATGGCCAAGTATGAGATCTCCGCCCTGGAGGGGGGCCTGCCCCAGCTCTACCCACTGCGGCCCTTGCAGGAGGACAAGATGCAATACCTGCAGGTGAGCGCAGGGCTGGGGGAGAGGCCGCACCTGCGGGTGACAGGGTGTCCTGAGCTCCCCGAGGCCTCTCCACTCGGAGCCCATCTCACGCCTTCTGCAGTCGCAGGGGTGGCTGTCACCATCCGAGGACGGGCTGTCCAAAGGTCACACAGCTTGTGTGGGTGGGCCCCAACCGCCACCCCCATGGTCCCTGTCACATGAGTTATCTCCTGCCGGCTCAGTATCCTCAACGAGCGCCCTCCCCAACCGACCCCAGCTGTCTGACACAGCCCTGCGGCTCGAAGAGACTGCACCAAACCTCACAGCTCCCAGCCAGACTGCCCCAGCGCGCAGCCTGGTCCCTGACCCACGGAAGGCCTTTCCCCAGGGTGGAGAAGGGTTTGTCCCCGTTTCCCAGGAGGGCAGCTCGGGGTAAAAGCCAGCCGCGTCCTGACAGGTCCCGCCCACGCGGCGCTTCTCCCACGACGATGCGGACGTGTGGGCCGCCGTCCCGCTGCCCGCCTTCCTGCCGCGCTGGGGCTCCGGCGAGGACCTGGCCGCCCTGGCGCACCTGGTGCTGCCTG

Publications

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