Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name PGDP2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:75600044-75601564  UCSC
Coordinates (T2T) chr12:75575046-75576566  UCSC
Coordinates (hg19) chr12:75993824-75995344  UCSC
Strand +
Parental Sequence NM_001304451.2
Parental seq. overlap 1191 bp
Parental seq. overlap (%) 50.9%
Genomic Region Intergenic
Retrocopy Summary PGDP2, located on chr12:75600044-75601564, is a retrocopy of the parental gene PGD. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PGD
Full Name phosphogluconate dehydrogenase
Also known as 6PGD
Coordinate chr1:10399064-10420511
Strand +
Gene summary 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PGDP2
Bonobo Pan paniscus PGDP2
Gorilla Gorilla gorilla PGDP1
Orangutan Pongo abelii PGDP1
Gibbon Nomascus leucogenys PGDP2
Green monkey Chlorocebus sabaeus PGDP1
Crab-eating macaque Macaca fascicularis PGDP1
Rhesus Macaca mulatta PGDP1
Baboon Papio anubis PGDP1
Golden snub-nosed monkey Rhinopithecus roxellana PGDP1
Marmoset Callithrix jacchus PGDP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PGDP2
ACCATGGCCCAAGCTGGCATTGCACTGATTGGACTGGCTGTCATGGGCCAGAACTTAATATTGTGCATGAATGACCATGGCTTCATGGCCTGTGCTTTTAATAGTACAGTCTCCAAAGTTGATGATTTCTTGGCAACAAGGCAAAGGGAACCAAAGATGTTGATGTTCAGTCCTTGACGGAGATGGTCTCCAAACTGAAAAAGCCACAGGCGTATCATCCCTCTTGTGAAGGCTGGTCAAGCTGTTGATGATTTCATGAAAAAATTAGTACCATTGTTGCACACTGGTGATGTCATCATTGATGGAGGAAATTCTGAATATAGGGATGACACAAGACGATGTAGATACCACAAGGCCAAGAAAATTTTATCAGTGGAGAGCAAAGTTAGTGCTGGAGGAAAAGGATCCCAGTATGGCCTATCACTCATGCCAAGAGGGAACAAAAGCTGGCCCCTATCAAGGCAATCTTCTAAGGCATCACTGCAAAAGAAAGAACTGAGGAACTTTTCTCTGACTGGGTGGGAGAGGAGGGAGCAGGCCACGTTGTAAAGATGGTGTACAATGGGATACAGTATGGGGATATGCAGCTGATCTGTGGGGCTTACCACCTGATGAAACATGTGCTGGGCATGGAGCAAAACAAGATGGCACAGGATTTTAAGGATTGGAATAAGACAGAGCTCGACTCATTCTTGAATGAAATCAAAACAAGATGACGGAGGCCTTTGAGGACTAGAATAAGACAGAGCTCGATCCATTCTTGATTGAAATCACAGCCAATATTCTAAGATACTGATAGCAAATACCTGCTGCCAAAGATCAGGGACAGCACAGGACAGAAGGGCACCAGAAAGTGGACCACCATCTCCACCCTGGAAGATGGCATTCCTGTCACCTTCATTGGAAAAGCTATCTTTGCTCGGTGCTTATCCTCTCTGAAGGATGAAAGAATTCAAGCTAGCAAAAAGCTGAAGGGTTCCCAAAAGATCTAGTTTGATGGTGATAAGAAATCATTCCTAGAAGACATTCGGAATGACCTCTATGCTTCCAAGATCATCTCTTATGCTCAAGGCTTTATACTGCTAAGACAGGCAACCACTGAATTTGGCTGGACCCTCAATTATGGTTGTATTGTCCTGTTGTGGAGGAGGGAGGCTGCATCATCAGAGGTGTATTTCTAGGAAAGATAAAGGATGCATTTCATCAACGCCCAGAACTTGAGAACCTATTATTAGACGACTTCTTTAAGTTGGCTGTTGAAAACTGCCAGGACTGCTGGTGGTGGGTGGTCAGCACTGGGGTCCAAGCTAGCATTCCCATGCCCTGTTTCACCATTGCTGTCTCCTTCTGTGATGGATATAGACACGAGATGCTCCCAGCCAACCTCATCCAGACTCAGCGGGATTACTTCGGGGCTCACACTTATGAAGGCTTAGAAAAACAGGGACAGTTTACCCACACCAATTGGACAGGCCATGGTGGCAGTGTGTCATGCTCTTCACATAATGCCTAATCATGCTG
>NM_001304451.2
CCCTCACTCGTCCTCCGCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCTGTGCTTTTAATAGGACTGTCTCCAAAGTTGATGATTTCTTGGCCAATGAGGCAAAGGGAACCAAAGTGGTGGGTGCCCAGTCCCTGAAAGAGATGGTCTCCAAGCTGAAGAAGCCCCGGCGGATCATCCTCCTGGTGAAGGCTGGGCAAGCTGTGGATGATTTCATCGAGAAATTGAGACGGTGCCGAGACCTCAAGGCCAAGGGAATTTTATTTGTGGGGAGCGGAGTCAGTGGTGGAGAGGAAGGGGCCCGGTATGGCCCATCGCTCATGCCAGGAGGGAACAAAGAAGCGTGGCCCCACATCAAGACCATCTTCCAAGGCATTGCTGCAAAAGTGGGAACTGGAGAACCCTGCTGTGACTGGGTGGGAGATGAGGGAGCAGGCCACTTCGTGAAGATGGTGCACAACGGGATAGAGTATGGGGACATGCAGCTGATCTGTGAGGCATACCACCTGATGAAAGACGTGCTGGGCATGGCGCAGGACGAGATGGCCCAGGCCTTTGAGGATTGGAATAAGACAGAGCTAGACTCATTCCTGATTGAAATCACAGCCAATATTCTCAAGTTCCAAGACACCGATGGCAAACACCTGCTGCCAAAGATCAGGGACAGCGCGGGGCAGAAGGGCACAGGGAAGTGGACCGCCATCTCCGCCCTGGAATACGGCGTACCCGTCACCCTCATTGGAGAAGCTGTCTTTGCTCGGTGCTTATCATCTCTGAAGGATGAGAGAATTCAAGCTAGCAAAAAGCTGAAGGGTCCCCAGAAGTTCCAGTTTGATGGTGATAAGAAATCATTCCTGGAGGACATTCGGAAGGCACTCTACGCTTCCAAGATCATCTCTTACGCTCAAGGCTTTATGCTGCTAAGGCAGGCAGCCACCGAGTTTGGCTGGACTCTCAATTATGGTGGCATCGCCCTGATGTGGAGAGGGGGCTGCATCATTAGAAGTGTATTCCTAGGAAAGATAAAGGATGCATTTGATCGAAACCCGGAACTTCAGAACCTCCTACTGGACGACTTCTTTAAGTCAGCTGTTGAAAACTGCCAGGACTCCTGGCGGCGGGCAGTCAGCACTGGGGTCCAGGCTGGCATTCCCATGCCCTGTTTTACCACTGCCCTCTCCTTCTATGACGGGTACAGACATGAGATGCTTCCAGCCAGCCTCATCCAGGCTCAGCGGGATTACTTCGGGGCTCACACCTATGAACTCTTGGCCAAACCAGGGCAGTTTATCCACACCAACTGGACAGGCCATGGTGGCACCGTGTCATCCTCGTCATACAATGCCTGATCATGCTGCTCCTGTCACCCTCCACGATTCCACAGACCAGGACATTCCATGTGCCTCATGGCACTGCCACCTGGCCCTTTGCCCTATTTTCTGTTCAGTTTTTTAAAAGTGTTGTAAGAGACTCCTGAGGAAGACACACAGTTTATTTGTAAAGTAGCTCTGTGAGAGCCACCATGCCCTCTGCCCTTGCCTCTTGGGACTGACCAGGAGCTGCTCATGTGCGTGAGAGTGGGAACCATCTCCTTGCGGCAGTGGCTTCCGCGTGCCCCGTGTGCTGGTGCGGTTCCCATCACGCAGACAGGAAGGGTGTTTGCGCACTCTGATCAACTGGAACCTCTGTATCATGCGGCTGAATTCCCTTTTTCCTTTACTCAATAAAAGCTACATCAGACTGATGCTCTTTCTCCAGATTCTTAGTCTCACCTCGGCCACATGGAGCCATTATCCCCATTGGCAGAAAGATTTTTCTTTAAAAAAAAAGACTAGAATAACACAAGAAACCACATTTAGGATTATGCTTCACTCAgaggaggcaggcagggaggacacaccaggggctttaatacactgggcatgttttctttctccaattgggcaatgggtacatggacgttcactgtaACGTGCtttttctttcgtcttttttttttttttttttttttttGCTCCTGGCAAGCTGTGCGTGACATTCTTTATGGCTTTTTGTATGTCAAATACTTCATACTAAACTTTCTAGAGAATTAAACTTTAATGATGGGCTCA

Publications

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