RCPedia: Rtcs

Summary

Retrocopy Name	MYL9P2	Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr12:7870830-7871626 UCSC
Coordinates (T2T)	chr12:7885099-7885892 UCSC
Coordinates (hg19)	chr12:8023426-8024222 UCSC
Strand	+
Parental Sequence	NM_006097.5
Parental seq. overlap	694 bp
Parental seq. overlap (%)	24.8%
Genomic Region	Intragenic (SLC2A14)
Retrocopy Summary	MYL9P2, located on chr12:7870830-7871626, is a retrocopy of the parental gene MYL9. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	MYL9
Full Name	myosin light chain 9
Also known as	LC20\|MLC-2C\|MLC2\|MMIHS4\|MRLC1\|MYRL2
Coordinate	chr20:36541519-36551447
Strand	+
Gene summary	Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	MYL9P2
Bonobo	Pan paniscus	MYL9P2
Gorilla	Gorilla gorilla	MYL9P2
Orangutan	Pongo abelii	MYL9P2
Gibbon	Nomascus leucogenys	MYL9P2
Green monkey	Chlorocebus sabaeus	MYL9P1
Crab-eating macaque	Macaca fascicularis	MYL9P1
Rhesus	Macaca mulatta	MYL9P1
Golden snub-nosed monkey	Rhinopithecus roxellana	MYL9P1
Marmoset	Callithrix jacchus	MYL9P2
Baboon	Papio anubis	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>MYL9P2
CCCCCACCCACCTGAAGCCAAAATGTTCAGCAAGTGGACCAAAGCCAAGACCACCAAGAAGCGACCACAGCACAAGGGGCCACATCCAATGTCTTCGTGATGTTCGACCAGTTCCACATCCAGGAGTTTAAGGAGGCTTTCAACATGATTGACCAGAACCATGATGGCTTCAATGACAAGGGGGACAGCACGACAAGCTGGCTTCACCGCGGAAGAACCCCATGGATGAATACCTGCAGGGCATGATGAGCGAGGCCCCAGGGCCCATCAACTTCACCACTTCCCTCACCATGTTTGGGGAGAAGCTGAATGGAACAGACCCCCAGGATGTGATCCAAAACGCCTTCACCTGCTTCAACGAGGAATCCTCAGGTTTCATTCATGAGGACCACCTCCAGGAGCTGCTCACCACCATGGGTGACAGCTTCACAGATGAAGAAGTGGATGAGATGTACTGGGAGGCACCCATTGATAAAAAAAGACAAGTTCAACTAGGTGGAGTTCACCTGCATCCTCATACATGGCGCCAAGGGCAAAGATGACTAGGCCACCCCAGCCCTCGCGACACCCTGGCCCCCCCGCCAGTCATCTCCCCACCCCCGGCACACACTGGTCTGTACCAGCTCTCTGCCCACGACCTTCTCTCAGGGGATCCTCCCTTTGAGGGCTTCGGGTCCCAGCTCCCAGTGGAGAAATCACGCCAAGAGAAGTGCAGTGCAGGACTGAGGCAGGTGTTCTCACTGTGACCCTAGGGCCCTGGGCTGGAGTCTCTGACCCCTCCAGGGAAAGACCGCCTT

>NM_006097.5
AGTTCCACGCACCCAGCGAGCCCAAGCGCCTTCTCCGCACCAGGGAAGCCCCACCCACCAGAAGCCAAGATGTCCAGCAAGCGGGCCAAAGCCAAGACCACCAAGAAGCGGCCACAGCGGGCCACATCCAATGTCTTCGCAATGTTTGACCAGTCCCAGATCCAGGAGTTTAAGGAGGCTTTCAACATGATTGACCAGAACCGTGATGGCTTCATTGACAAGGAGGACCTGCACGACATGCTGGCCTCGCTGGGGAAGAACCCCACAGACGAATACCTGGAGGGCATGATGAGCGAGGCCCCGGGGCCCATCAACTTCACCATGTTCCTCACCATGTTTGGGGAGAAGCTGAACGGCACGGACCCCGAGGATGTGATTCGCAACGCCTTTGCCTGCTTCGACGAGGAAGCCTCAGGTTTCATCCATGAGGACCACCTCCGGGAGCTGCTCACCACCATGGGTGACCGCTTCACAGATGAGGAAGTGGACGAGATGTACCGGGAGGCACCCATTGATAAGAAAGGCAACTTCAACTACGTGGAGTTCACCCGCATCCTCAAACATGGCGCCAAGGATAAAGACGACTAGGCCACCCCAGCCCCCTGACACCCCAGCCCCCGCCAGTCACCCCTCCCCGCACACACCCGTCCATACCAGCTCCCTGCCCATGACCCTCGCTCAGGGATCCCCCTTTGAGGGGTTAGGGTCCCAGTTCCCAGTGGAAGAAACAGGCCAGGAGAAGTGCGTGCCGAGCTGAGGCAGATGTTCCCACAGTGACCCCAGAGCCCTGGGCTATAGTCTCTGACCCCTCCAAGGAAAGACCACCTTCTGGGGACATGGGCTGGAGGGCAGGACCTAGAGGCACCAAGGGAAGGCCCCATTCCGGGGCTGTTCCCCGAGGAGGAAGGGAAGGGGCTCTGTGTGCCCCCCAGGAGGAAGAGGCCCTGAGTCCTGGGATCAGACACCCCTTCACGTGTATCCCCACACAAATGCAAGCTCACCAAGGTCCCCTCTCAGTCCCCTTCCCTACACCCTGACCGGCCACTGCCGCACACCCACCCAGAGCACGCCACCCGCCATGGGAGTGTGCTCAGGAGTCGCGGGCAGCGTGGACATCTGTCCCAGAGGGGGCAGAATCTCCAATAGAGGACTGAGCACTGCTTCTGGTCTGTGTGTCTGTGGCTGGGGTGAAGTAAGGGGACCCCGGGCCTGAAACCCTCTCCCACCTTCTCCTGCCATCTCCAGTTACTGCCCTGCTCCTCCCACCCTGGCCCAGGGAAGGACTGGGTGTCCTCCGGCCATATGGTCCCTGAAGCCTCTAGGGACCAGAGTCCCTAGTAAGTGGGCTCTGTGCTCAGCTGAGACCAGCAGGGGACAGGGGACGGAGGGAATGGGCCTCATGGCCTTCTCAGGGCTTGTGGGAAAGGGAGGACCATGGGAATCACCACAGCCAATCCCGTGGAGGGTTCCAGGCCTCTTGGGGGGCAGAGGTCAGGCCACACAGCCCTCAGGACTAAAGCTCCGGGTTCCAGAAGAACAGGGAGGCTCCAACAGTGATGAGGCAGGCGTCCCAGCAGCTCAGGGTTGGAGGTGGGAATGAGGGGTTTCCCAGCCCCAGGCAGGTGGAGGGCGAGTTCAGCCCCAGGACCAACAGCATGGGGGCCACAGCTTTCCATGTCCCTGTGTACGCAGGGCAGGCAGGGCCGGGACCCCTGCTACTGGTGGATGATGGGGACACTGATGGCAGTGCCTGGGGCCTAAGAGGGGCAGAAAGAGCGCTGAATGACTGAGCAGAGAGTCCAGAGGGGCATGGACTGCCTGGGTCACCCAATAGGCCTAGGGAAGAGTGAGGGCCGGACCCACCCCACCTGACCCCAGCGAGTGGACCCAGCTTGGTCCTGAGGCCTTCTCCAGAGGTCACCCAGCGCAGGCAGCCGCAGCACTCAGCAAAGGTCCCAGATCAGGGCCAAGGGGGAGCTGAGCACCAGGGGACCCTGTGCCTGACCAGGAGGCCCTAACCTCCTGCAGGCCTCAACGCCAGGCCCTGCTCAGAGCTCGGCTGAAACTCCTCATCCTGGCTCCAAACAGAGGCCCAAAAGTCCCTGGTATCAACTCCAGAAGGGGCGAGACCCGAACAAGTTCCAAACCAGGCCCAAATAGTATCCCAAACTCAGTCCCAAACACATTCTCACCCCCGGCAGCAGGCTGCAGGCCTCCAGCTACACACACGGCCCTGGGCAACTCTCAGTCTGGCCACCCATTCGATGCTGCCAGCCCCAAGGGTGTGGGAGGGGGGTCTCAGAGTGTCCCAGGGTACTGGCCACACATGCCCGACACCAGGGTCATAAGGTCCTCTCAGCAGAGCCACTGCAGCACCAAAGGCATTTCTGGAAGGAGGCAAGGACGCGTCATCTAGATGTCAAGCCCCAGCGTGCGATTCTGTCACAGTTCACCCCACCTTCACCCCGAGACGGAAGACGGAAGAGCTTCGCACACAGGCGGGAAGAGGTCAGGACCAGTCCAGCCTCACTGGCTTCAGAACTGGCCTGGGGGCTACCTTGACCCACAGGAAGGGAAGAGGAACGTGCTCTGGGCAGGGCAAGGCAGGACCTGCAGCACCCACAGACCAGCAGTAAAGGACCCCCGGAACtttccaagtctagcacaaaacccagaagccacaaaggaaaatactggcagatttaaatgcatgaagtcaacattctttttgtagagctaaagaaaccataagcaaaattaaaagccaaatgcattctgggaggaaa

>NM_006097.5 

AGTTCCACGCACCCAGCGAGCCCAAGCGCCTTCTCCGCACCAGGGAAGCCCCACCCACCAGAAGCCAAGATGTCCAGCAAGCGGGCCAAAGCCAAGACCACCAAGAAGCGGCCACAGCGGGCCACATCCAATGTCTTCGCAATGTTTGACCAGTCCCAGATCCAGGAGTTTAAGGAGGCTTTCAACATGATTGACCAGAACCGTGATGGCTTCATTGACAAGGAGGACCTGCACGACATGCTGGCCTCGCTGGGGAAGAACCCCACAGACGAATACCTGGAGGGCATGATGAGCGAGGCCCCGGGGCCCATCAACTTCACCATGTTCCTCACCATGTTTGGGGAGAAGCTGAACGGCACGGACCCCGAGGATGTGATTCGCAACGCCTTTGCCTGCTTCGACGAGGAAGCCTCAGGTTTCATCCATGAGGACCACCTCCGGGAGCTGCTCACCACCATGGGTGACCGCTTCACAGATGAGGAAGTGGACGAGATGTACCGGGAGGCACCCATTGATAAGAAAGGCAACTTCAACTACGTGGAGTTCACCCGCATCCTCAAACATGGCGCCAAGGATAAAGACGACTAGGCCACCCCAGCCCCCTGACACCCCAGCCCCCGCCAGTCACCCCTCCCCGCACACACCCGTCCATACCAGCTCCCTGCCCATGACCCTCGCTCAGGGATCCCCCTTTGAGGGGTTAGGGTCCCAGTTCCCAGTGGAAGAAACAGGCCAGGAGAAGTGCGTGCCGAGCTGAGGCAGATGTTCCCACAGTGACCCCAGAGCCCTGGGCTATAGTCTCTGACCCCTCCAAGGAAAGACCACCTTCTGGGGACATGGGCTGGAGGGCAGGACCTAGAGGCACCAAGGGAAGGCCCCATTCCGGGGCTGTTCCCCGAGGAGGAAGGGAAGGGGCTCTGTGTGCCCCCCAGGAGGAAGAGGCCCTGAGTCCTGGGATCAGACACCCCTTCACGTGTATCCCCACACAAATGCAAGCTCACCAAGGTCCCCTCTCAGTCCCCTTCCCTACACCCTGACCGGCCACTGCCGCACACCCACCCAGAGCACGCCACCCGCCATGGGAGTGTGCTCAGGAGTCGCGGGCAGCGTGGACATCTGTCCCAGAGGGGGCAGAATCTCCAATAGAGGACTGAGCACTGCTTCTGGTCTGTGTGTCTGTGGCTGGGGTGAAGTAAGGGGACCCCGGGCCTGAAACCCTCTCCCACCTTCTCCTGCCATCTCCAGTTACTGCCCTGCTCCTCCCACCCTGGCCCAGGGAAGGACTGGGTGTCCTCCGGCCATATGGTCCCTGAAGCCTCTAGGGACCAGAGTCCCTAGTAAGTGGGCTCTGTGCTCAGCTGAGACCAGCAGGGGACAGGGGACGGAGGGAATGGGCCTCATGGCCTTCTCAGGGCTTGTGGGAAAGGGAGGACCATGGGAATCACCACAGCCAATCCCGTGGAGGGTTCCAGGCCTCTTGGGGGGCAGAGGTCAGGCCACACAGCCCTCAGGACTAAAGCTCCGGGTTCCAGAAGAACAGGGAGGCTCCAACAGTGATGAGGCAGGCGTCCCAGCAGCTCAGGGTTGGAGGTGGGAATGAGGGGTTTCCCAGCCCCAGGCAGGTGGAGGGCGAGTTCAGCCCCAGGACCAACAGCATGGGGGCCACAGCTTTCCATGTCCCTGTGTACGCAGGGCAGGCAGGGCCGGGACCCCTGCTACTGGTGGATGATGGGGACACTGATGGCAGTGCCTGGGGCCTAAGAGGGGCAGAAAGAGCGCTGAATGACTGAGCAGAGAGTCCAGAGGGGCATGGACTGCCTGGGTCACCCAATAGGCCTAGGGAAGAGTGAGGGCCGGACCCACCCCACCTGACCCCAGCGAGTGGACCCAGCTTGGTCCTGAGGCCTTCTCCAGAGGTCACCCAGCGCAGGCAGCCGCAGCACTCAGCAAAGGTCCCAGATCAGGGCCAAGGGGGAGCTGAGCACCAGGGGACCCTGTGCCTGACCAGGAGGCCCTAACCTCCTGCAGGCCTCAACGCCAGGCCCTGCTCAGAGCTCGGCTGAAACTCCTCATCCTGGCTCCAAACAGAGGCCCAAAAGTCCCTGGTATCAACTCCAGAAGGGGCGAGACCCGAACAAGTTCCAAACCAGGCCCAAATAGTATCCCAAACTCAGTCCCAAACACATTCTCACCCCCGGCAGCAGGCTGCAGGCCTCCAGCTACACACACGGCCCTGGGCAACTCTCAGTCTGGCCACCCATTCGATGCTGCCAGCCCCAAGGGTGTGGGAGGGGGGTCTCAGAGTGTCCCAGGGTACTGGCCACACATGCCCGACACCAGGGTCATAAGGTCCTCTCAGCAGAGCCACTGCAGCACCAAAGGCATTTCTGGAAGGAGGCAAGGACGCGTCATCTAGATGTCAAGCCCCAGCGTGCGATTCTGTCACAGTTCACCCCACCTTCACCCCGAGACGGAAGACGGAAGAGCTTCGCACACAGGCGGGAAGAGGTCAGGACCAGTCCAGCCTCACTGGCTTCAGAACTGGCCTGGGGGCTACCTTGACCCACAGGAAGGGAAGAGGAACGTGCTCTGGGCAGGGCAAGGCAGGACCTGCAGCACCCACAGACCAGCAGTAAAGGACCCCCGGAACtttccaagtctagcacaaaacccagaagccacaaaggaaaatactggcagatttaaatgcatgaagtcaacattctttttgtagagctaaagaaaccataagcaaaattaaaagccaaatgcattctgggaggaaa

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