Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name PRDX3P2
Wait
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:28526321-28527238  UCSC
Coordinates (T2T) chr1:28368278-28369195  UCSC
Coordinates (hg19) chr1:28852833-28853750  UCSC
Strand -
Parental Sequence NM_006793.5
Parental seq. overlap 486 bp
Parental seq. overlap (%) 30.2%
Genomic Region Intragenic (RCC1)
Retrocopy Summary PRDX3P2, located on chr1:28526321-28527238, is a retrocopy of the parental gene PRDX3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRDX3
Full Name peroxiredoxin 3
Also known as AOP-1|AOP1|HBC189|MER5|PPPCD|PRO1748|SCAR32|SP-22|prx-III
Coordinate chr10:119167720-119178812
Strand -
Gene summary This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRDX3P1
Bonobo Pan paniscus PRDX3P1
Gorilla Gorilla gorilla PRDX3P1
Orangutan Pongo abelii PRDX3P1
Gibbon Nomascus leucogenys PRDX3P4
Green monkey Chlorocebus sabaeus PRDX3P3
Crab-eating macaque Macaca fascicularis PRDX3P1
Rhesus Macaca mulatta PRDX3P1
Baboon Papio anubis PRDX3P1
Golden snub-nosed monkey Rhinopithecus roxellana PRDX3P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>PRDX3P2
CTATCCTTTGGATTTCACCTTTGTGTGTCCTACAGAAATTGTTGCTTCTAGTGACAAAGCTAAGGAATTTCACGATGTGAACTTTGAAGTTGTTGCAGTCTCAGTGGATTCCCACTTTAGCCGTCTTGCCTGGATAAATACACCAAGAAAGAATGGTGCTTTGGGCCACATAAACATCGCACCCTTGTCAGATTTAACTAAGCGAATTTCTCGAGACTTCGGTGTGCTGTTAGAAGGTCCTGGTCTTGCACTAAGAGGTCTCTTCATAATTGACCCCAATGGAGTCATCAAGTTGCACTGAAGATCGCGGCTGCTGTGGGAAGGTTACTCTGAGCATCAGTTGCCCGGCATGTGAGTGCCATTCCTTGGGGGCATTTCTGCCACTGCAGCCCTCAGGCCTGCTGCTTCTGGAAGAACAAGTTTGACAAACATATTGTGGTCTGGTTCCGGTCAAGCAAAATTCTGGTACCAGTTCCTCATACCATGCACCTGATGTCACCCAGCATGCGCCCTATTTTAAGGGTACAGCCGTGGTCAATGGAGAGTTCAAAGACCTAAGCCTTGATGACTTTGAGGGGAAATATTTGGTGCTTTTCTTCTATCCTTTGGAt
>NM_006793.5
GTGGCGCCCGAGTGCACTGAAGATGGCGGCTGCTGTAGGACGGTTGCTCCGAGCGTCGGTTGCCCGACATGTGAGTGCCATTCCTTGGGGCATTTCTGCCACTGCAGCCCTCAGGCCTGCTGCATGTGGAAGAACGAGCTTGACAAATTTATTGTGTTCTGGTTCCAGTCAAGCAAAATTATTCAGCACCAGTTCCTCATGCCATGCACCTGCTGTCACCCAGCATGCACCCTATTTTAAGGGTACAGCCGTTGTCAATGGAGAGTTCAAAGACCTAAGCCTTGATGACTTTAAGGGGAAATATTTGGTGCTTTTCTTCTATCCTTTGGATTTCACCTTTGTGTGTCCTACAGAAATTGTTGCTTTTAGTGACAAAGCTAACGAATTTCACGACGTGAACTGTGAAGTTGTCGCAGTCTCAGTGGATTCCCACTTTAGCCATCTTGCCTGGATAAATACACCAAGAAAGAATGGTGGTTTGGGCCACATGAACATCGCACTCTTGTCAGACTTAACTAAGCAGATTTCCCGAGACTACGGTGTGCTGTTAGAAGGTTCTGGTCTTGCACTAAGAGGTCTCTTCATAATTGACCCCAATGGAGTCATCAAGCATTTGAGCGTCAACGATCTCCCAGTGGGCCGAAGCGTGGAAGAAACCCTCCGCTTGGTGAAGGCGTTCCAGTATGTAGAAACACATGGAGAAGTCTGCCCAGCGAACTGGACACCGGATTCTCCTACGATCAAGCCAAGTCCAGCTGCTTCCAAAGAGTACTTTCAGAAGGTAAATCAGTAGATCACCCATGTGTATCTGCACCTTCTCAACTGAGAGAAGAACCACAGTTGAAACCTGCTTTTATCATTTTCAAGATGGTTATTTGTAGAAGGCAAGGAACCAATTATGCTTGTATTCATAAGTATTACTCTAAATGTTTTGTTTTTGTAATTCTGGCTAAGACCTTTTAAACATGGTTAGTTGCTAGTACAAGGAATCCTTTATTGGTAACATCTTGGTGGCTGGCTAGCTAGTTTCTACAGAACATAATTTGCCTCTATAGAAGGCTATTCTTAGATCATGTCTCAATGGAAACACTCTTCTTTCTTAGCCTTACTTGAATCTTGCCTATAATAAAGTAGAGCAACACACATTGAAAGCTTCTGATCAACGGTCCTGAAATTTTCATCTTGAATGTCTTTGTATTAAACTGAATTTTCTTTTAAGCTAACAAAGATCATAATTTTCAATGATTAGCCGTGTAACTCCTGCAATGAATGTTTATGTGATTGAAGCAAATGTGAATCGTATTATTTTAAAAAGTGGCAGAGTGACTTAACTGATCATGCATGATCCCTCATCCCTGAAATTGAGTTTATGTAGTCATTTTACTTATTTTATTCATTAGCTAACTTTGTCTATGTATATTTCTAGATATTGATTAGTGTAATCGATTATAAAGGATATTTATCAAATCCAGGGATTGCATTTTGAAATTATAATTATTTTCTTTGCTGAAGTATTCATTGTAAAACATACAAAATAAACATATTTTAAAACA

Publications

PMID - Link Title
No publications available for this retrocopy