Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TM2D3P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:85781758-85782412  UCSC
Coordinates (T2T) chr12:85762424-85763078  UCSC
Coordinates (hg19) chr12:86175536-86176190  UCSC
Strand -
Parental Sequence NM_078474.3
Parental seq. overlap 550 bp
Parental seq. overlap (%) 39.3%
Genomic Region Intergenic
Retrocopy Summary TM2D3P1, located on chr12:85781758-85782412, is a retrocopy of the parental gene TM2D3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TM2D3
Full Name TM2 domain containing 3
Also known as BLP2
Coordinate chr15:101632977-101652381
Strand -
Gene summary The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TM2D3P1
Bonobo Pan paniscus TM2D3P1
Gorilla Gorilla gorilla TM2D3P1
Orangutan Pongo abelii TM2D3P1
Gibbon Nomascus leucogenys LOC100600805P1
Green monkey Chlorocebus sabaeus TM2D3P1
Crab-eating macaque Macaca fascicularis TM2D3P1
Rhesus Macaca mulatta TM2D3P1
Baboon Papio anubis TM2D3P1
Golden snub-nosed monkey Rhinopithecus roxellana TM2D3P1
Marmoset Callithrix jacchus TM2D3P1
Mouse lemur Microcebus murinus TM2D3P1
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TM2D3P1
AGCAATGGTTTGTGTAGCAGGTATTCTGCAGAATTTATAGACTGCACAACAAATGTCCTCTGTGTCTATGGGAAGCTAGTCACTTTTGACTGTACAGTGAAACCTTCTGTTGCCTGTGTTGATTAGGAGTTAAAATCCCAAAGTAACTTTCTCATCAACATGACTTGATTTTGATGGAAGCCTCCAGAAACAGAATATGAATGTTTCAATTCTACCAGCTGCATGAGGTCCTGTCCTCAACGGCATTATGCTGCCAAATACATGATAAACACATTCATGACTTGGGTAACTACTTTTTTCAAAATGCTGCACTGAAATTGGGCTGGAGGCTATAAGTGGTCTATTGCTCTGGCTCTAAGCATCACCCTTGGTGGCTTTGGAGCAGACCATTTCCACCTCAACCAGTGGCAAGAAGGCCTTGGCAAGCTCTTCAGCTTCAGTGGCCTGGAAATATAGACACTAATAGACATCTTGCTAATTGGAGTTGGCTACATTGGACCAGCAGATGGCTCTTGATACATTTAGCTTGTGATTATGTGCTTTGAAGAGGAGTAATGTTTAGTAAAAGCCCTTTTGCCTGTAGGAGTTGATGTGGTGTGAGTGATGTATTTGTATATTTTTAATGTGCAGCACTTGTACTTTGATTGTCTTGATG
>NM_078474.3
AGTGCGCAGGCGCTGGCAAGATGGCGGGAGGGGTGCTCCCGCTGAGGGGCCTCCGCGCCTTGTGTCGCGTGCTGCTCTTCCTCTCGCAGTTCTGCATTCTGTCGGGCGGTGAGCAATCGCAGGCGCTGGCTCAGTCAATAAAGGATCCGGGCCCAACACGCACATTCACAGTAGTTCCCAGGGCAGCAGAAAGTACTGAAATCCCACCTTATGTGATGAAGTGTCCGAGCAATGGTTTGTGTAGCAGGCTTCCTGCAGACTGTATAGACTGCACAACAAATTTCTCCTGTACCTATGGGAAGCCTGTCACTTTTGACTGTGCAGTGAAACCATCTGTTACCTGTGTTGATCAAGACTTCAAATCCCAAAAGAACTTCATCATTAACATGACTTGCAGATTTTGCTGGCAGCTTCCTGAAACAGATTACGAGTGTACCAACTCCACCAGCTGCATGACGGTGTCCTGTCCTCGGCAGCGCTACCCTGCCAACTGCACGGTGCGGGACCACGTCCACTGCTTGGGTAACCGTACTTTTCCCAAAATGCTATATTGCAATTGGACTGGAGGCTATAAGTGGTCTACGGCTCTGGCTCTAAGCATCACCCTCGGTGGGTTTGGAGCAGACCGTTTCTACCTGGGCCAGTGGCGGGAAGGCCTCGGCAAGCTCTTCAGCTTCGGTGGCCTGGGAATATGGACGCTGATAGACGTCCTGCTCATTGGAGTTGGCTATGTTGGACCAGCAGATGGCTCTTTGTACATTTAGCTGTGGTGTGTGCTTCAGAAAGGAGCAGGGCTTAGAAAAAGCCCTTTTGTCCGTAGGAGTTGATGTGGTGTGAGTGATATATTTCTATGTTTTTAATGTACAGCATCTGTACTTTGTTTGCCTTGATAAAGGTAAGATAAATGAAACGCTGAACTATGCTAATCTGGAATTTGTTTTTATTTGCCTGAAATATATTTTTTTCTGTGAAAAAATTAAAACGTACTTAAGCCAGGAGAATGAATTATACAGTGATTGAAAATCCATTTAATTCCTATGACTTTTGTTTTGTATTGCCCAAGTCAAACTACATCACTTGTATCTCCAGCCCAAATGTAGTCTGCCTTGAAAAGTCTTTCAGCTGTGACTGCAGGAAGTGGGAGTGTTTTTATTGTTAGCTAATTGCTGTGACTGCAGGAAGTGGGAGTGTTTCTGTTGTTGGCTAATTGAAGTTATTAGGCTCAGCTTCAGTCATGTGTAAGTTTTGCAGTGTAATACATATGTAGTCTGGTCTGTATATATGAAAATTTGAATTAAACTGCAGAATGTTTATGTCTAGTTATGGTTTAAATTTTCTTAGTAGTATATAAAAGGTAAGAGTACTGAAAAATTAATAAAATTGCAAGTTAAGAAA

Publications

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