Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MKRN9P
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:87782890-87784704  UCSC
Coordinates (T2T) chr12:87764430-87766241  UCSC
Coordinates (hg19) chr12:88176667-88178481  UCSC
Strand -
Parental Sequence NM_013446.4
Parental seq. overlap 1579 bp
Parental seq. overlap (%) 50.4%
Genomic Region Intergenic
Retrocopy Summary MKRN9P, located on chr12:87782890-87784704, is a retrocopy of the parental gene MKRN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MKRN1
Full Name makorin ring finger protein 1
Also known as RNF61
Coordinate chr7:140453033-140479505
Strand -
Gene summary This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MKRN1P5
Bonobo Pan paniscus MKRN1P5
Gorilla Gorilla gorilla MKRN1P5
Orangutan Pongo abelii MKRN1P5
Gibbon Nomascus leucogenys MKRN1P2
Golden snub-nosed monkey Rhinopithecus roxellana MKRN1P6
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MKRN9P
TGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTATAAGGAAGGAGATAACTGTTGCAAGTTGCATGACCTCTCTGACAGTCCGTATAATGTAGTGTACAAGAGTTTGCAGCCAGGGTACTGTATTTATGGAGACTGCTGCAGATATGAACATAGCAAGCCATTGAAACAGAAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCATGGATAGTCGGACCACTTGTTGAAATGAATACGGGTGAAGCTGAGTCAAGAAATTCAAACTTTGTAACTGTAGGAGCAGGTTCAGAGGGCTGGGTGAATGCTGTTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGCACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACTGCCGTGGAAACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATATCGGGAGAACTTGTGTGTATATGGAGATTCGTGTGACATGTGTGGCTGCAGGTCCTGCATCTGATGGATGCTGCCCAGAGATCACAGCATATAAAATCATGCTTTGAGGCCCATGAGAAAGACAGGGAGCTCTCATTTGCTGTGCAGCGCAGCGAGGAAATGGTGTGTGAGAGCTGCATGGAGATGATCTATGAGAAAGCCAACCCCAGACAGCACCGCTTCGGGATCCTCTCCAACTGCAACCACACCTACTGTCTTAAGTGCATTCGCAAGTGGAGGAGTGCTAAGCAGTTTGAGAGCAAGATCATAAAGTCCTGCCCAGAATGTCGGATCACATCTAACTTTGTCGTTCCAAGTGAGTACTGTGTGGAGGAGAAAGAAGAGAAGCAGAAACTCATTCTGAAATACAAGGAGGCAATGAGCAACAAGGCGTGCAGGTATTTTGATGAAGGACATGGGAGCTGCCCGTTTGGAGGGAACGGTTTTTATAAGCATGTGTACCCTGATGGCCGTAGAGAGGAGCCACAGAGACAGAAGGTGGGAACATCAAGCAGATACCCGGCCCAATGAAGGAACCACTTCTGGGAACTCATTGAGGAAAGAGAGAACAGCAGCCCCTTTGACAACGATGAAGAAGAGGTTGTCACCTTTGAGCTGGGTGAGTTGTTGCTTATGCTTTTGGCTGCAGTTGGGGACGATGAACTAACAGACTCTGAAGATGAGAGCGACTTGTTTCATGAGGAGCTGGAAGATTTTTATGACTTGGATCTATAGCAACCTTGTGTGGCGTGTGAACTGGTCTGCTGACCCCAGACAGCAGCTGTTCCCTGTGGTGGTGTGGCAGTGCCTGTGTTCTCTCCTAGGCAGGCCTGTCAACTCCAGGTGCTGGCATAAGAATTTTTACCCAGGGCCTGTCTTTTCAACCCCTCACCTTTCCCCAAGGAGTGTGTTGTTTTCCCTCTTGAAAAAAAGTTAGAAAAATAAATCTTAAAGTTAGTTTTCCTCCCCTACCAGGATCCCCACAGTCACCATTCTGTCCCCAAGCAGGCAGGGACTGAGCGGGTGCCTCAGTGTCCTACCCCTCCCTTCGCCGGGCCTCTCAGTCCTCTCCCAGCAGCTGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTTCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAGCTCTCAGACCAACAGCCACAACATCAGGg
>NM_013446.4
GAGAGCGCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGagcaggagcggcagcggcgacggcggcagcagcCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTgggggcgggcggagggggcggcggcagcgacggcagcggcggcggcTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAGCATATCAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCATTTGCCGTGCAGCGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCCCAGTGAGCGCCGCTTCGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGCATTCGCAAGTGGAGGAGTGCTAAGCAATTTGAGAGCAAGATCATAAAGTCCTGCCCAGAATGCCGGATCACATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAGGAGAAAGAAGAGAAGCAGAAACTCATTCTGAAATACAAGGAGGCAATGAGCAACAAGGCGTGCAGGTATTTTGATGAAGGACGTGGGAGCTGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGATGGCCGTAGAGAGGAGCCACAGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAACGAAGGAACCACTTCTGGGAACTCATTGAGGAAAGAGAGAACAGCAACCCCTTTGACAACGATGAAGAAGAGGTTGTCACCTTTGAGCTGGGCGAGATGTTGCTTATGCTTTTGGCTGCAGGTGGGGACGACGAACTAACAGACTCTGAAGATGAGTGGGACTTGTTTCATGATGAGCTGGAAGATTTTTATGACTTGGATCTATAGCAACCTTGCGTGGCGTGTGAACTGGTCTGCTGACCTCAGACAGCAGCTGTCCCCTGTGGTGGTGTGGCAGTGCCTGTGTTCTCTCCTAGGCAGGCCTCTCAACTCCAGGTGCTGTCCTAAGAATTTTTACCCAGGGCCTGTCTTCTCAACCCCTCACCTTTCCCTGAGGAGTGTGTTGTTTTCCCTGTTGAAAAAAGTTACAAAAATAAATCTTAAAGTTAGTTTTTTGTAACACGAATTTAACTGTCAGACAGTTAGTGTAGGTGTGTTGCGTCATCTGTTTTCAACCAGATTGCATTTATGGACTTTTCACACACTCATTTTGAGGACCCCAGGTTCAAAAGTAAAAGCAGTGGCCCTGCTTTGGGGTCCAAGAATAGGAGTGATGGGTGAAGGGACCTAAGCTGGCCAATAGCCCTCTGCCCCAGACATGGGATGTGGATCCTTGAGGTTTCTGGTGAAATCTGCACATCTGTGTTTTTATATCTGTTCCCTACCCTGTAATCCCTACCACGTGCACTTGTTCTGTGGTTTTGGTCTCTTGTTTAATTGCACACAAGTAATACTACTGGGTAACCAGAATCAGGTGTGAATGTGTTGAGATTTTTTACTGTTTTGCATGATAGGAAAATTGAGAAAGAATACGTATAAAAGATAGAGAGGCATAACATCAATGCAGAGTTGGAAGTTGGCTCCCAAGGGCTGACATGGTGTGAGTGTGTGGGTGTGTGATAAGCTTCTCATCCCTGCATAGATGCAGTATTCTTAGCCTTAGTAGAAAAACCTGGTTTAGTGGTTTAAGCCTTGTGTGGCAGATAGATCTTAAAGGGCAAAGCAGTATATTGGTAGTTGTCAATATAGCAGTGCTAGCTCTGTCTATATAAATAGAGAAATGGGGTTAGCCATAGAGGTTAAAACTACCTGGTTATCCCATATAATAACACAAACTGGGTCTTGGATACACAGTTGTATTTAATGTTTTACGATCTAGCCTTTCCAGTACAGGCACTTTCTGAGAAACCTTTGTCCTCACTTGAGGCATTTTGTTGTCGGGTTTTTGTGTTTGTTTTTGTGGGTATTTGCCTCATTCCACCCCTGAGCTTTCAGGTAGACAGACGTGATTCAAAACTCTGTTCTAAGGTGTTTATTGTAGTGGAGTAATGGGTTTGCAGTGATAAGTCATACTTTTCCACCGAAAGGGAGGGCTTGGGAATCCCTGAGATTAGCTAAAGTTAAGTTGTTGGAAGAATTCCTTGATTGGAAATTGTACCTTTGTGTTTTGTTGCTCTGTTTCCTGAAAATAACTCGGGGATGCTCCTGGTTTGTCCATCTACTGCTTTGATTCCTTGGATCCCACCCATTCTTTCACTTTAAGAAAAAACAAATAATTGTTGCAGAGGTCTCTGTATTTTGCAGCTGCCCTTTTGTAAGAAGCACTTTTCCCAAATAAAACAATTAAAAAAAAAGTTGGCTGTTCTGTGTAA

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