Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KRT17P8
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:9127522-9128536  UCSC
Coordinates (T2T) chr12:9109719-9110733  UCSC
Coordinates (hg19) chr12:9280118-9281132  UCSC
Strand +
Parental Sequence NM_002276.5
Parental seq. overlap 844 bp
Parental seq. overlap (%) 60.5%
Genomic Region Intragenic (KLRG1)
Retrocopy Summary KRT17P8, located on chr12:9127522-9128536, is a retrocopy of the parental gene KRT19. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KRT19
Full Name keratin 19
Also known as CK19|K19|K1CS
Coordinate chr17:41523617-41528308
Strand -
Gene summary The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KRT19P5
Bonobo Pan paniscus KRT19P4
Gorilla Gorilla gorilla KRT19P4
Orangutan Pongo abelii KRT19P4
Gibbon Nomascus leucogenys KRT19P5
Green monkey Chlorocebus sabaeus KRT19P3
Crab-eating macaque Macaca fascicularis KRT19P4
Rhesus Macaca mulatta LOC707129P6
Golden snub-nosed monkey Rhinopithecus roxellana KRT19P4
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KRT17P8
AACTTCCTGCAGCTTTCGCCAGTCATTGGCCACTTAGTCCTTTGGGGGCTGGGCAGCGGCTCCGTGCACTTTGGAGTCGGGGGCGCCTTCCTAGAGCCCAGCATCCACTGGGGCTCCGAAGCCGTAGCCTGTCTGTGTCCTCCACCCACTTTGTGCCCTCATCCTCCTCTGGGGCTATGGCAGCGGCGATGCCAGCGTCCTCTGCAGGTCCGACAGGCTGCTGACGGGCACCAAGATCACCACGCAGAACATCCACGACCACTTGGTTCCTACCTGGACAAGGTGCGGGCTCTGGAGGAGGCCGGGTGAGCTGAAGGTGAAGATCTGCGACTGGGCCCCGGGGCCCCGGCAATTACAGCCACTACTTCAAGACCATTGAAGACCTGCGGGACAAGATTCTTGGTGTCACCATTGAGAACTCCCGGATTGTCTTGCAGATTGACACCCGCCGCCTGGCTGCAGATCACTTCCGAACCAAGTCTGAGATGGAGCAGTCTCTGCGAAGGAGCTTGGAGGCAGACATCAAGGCCTGCGCAGGGCGCCCGATGAGCTGACCCCGGCCAGGGCTGACCTGAAGACGCACATCCAAGGCCTGCAGGAGGAGCTGGATCACCTGGAGAAGAACCACAACGAGGAAATCAGTGCTGCGGGTGGCCAGGTCAGTGTGGAGGTGGATTCTGCTCCAGGCATTGGTCTTGCCAAGATCCCGGGCAACACGTGAAGCCAGTATGCGGTCATAACTGAGCAGATGCCCAAGATGCTGAAGCCTGGTCACCAGCCAGACTGAGGATCTGAGCTGGGAGGTCGCTGGCCACACGGAGCAGCTCCAGATGCACAAGTCCGAGTCGCGGACCGGTGGCGTACCCTCCGGGGTCTTGAGATTGAGCTGCAGTCGCAGCTCAGCATGAAAACCGCATTGGAAGACCGTACTGCAGGAACGGAGGCCTGCGTTGAGGCCCAGCTGGTGCGGATCCAGGCTCTGAGCAGCGGTGCCGAAGTCCAGCTGGGCAATGTG
>NM_002276.5
GCTCCTCCCGCGAATCGCAGCTTCTGAGACCAGGGTTGCTCCGTCCGTGCTCCGCCTCGCCATGACTTCCTACAGCTATCGCCAGTCGTCGGCCACGTCGTCCTTCGGAGGCCTGGGCGGCGGCTCCGTGCGTTTTGGGCCGGGGGTCGCCTTTCGCGCGCCCAGCATTCACGGGGGCTCCGGCGGCCGCGGCGTATCCGTGTCCTCCGCCCGCTTTGTGTCCTCGTCCTCCTCGGGGGCCTACGGCGGCGGCTACGGCGGCGTCCTGACCGCGTCCGACGGGCTGCTGGCGGGCAACGAGAAGCTAACCATGCAGAACCTCAACGACCGCCTGGCCTCCTACCTGGACAAGGTGCGCGCCCTGGAGGCGGCCAACGGCGAGCTAGAGGTGAAGATCCGCGACTGGTACCAGAAGCAGGGGCCTGGGCCCTCCCGCGACTACAGCCACTACTACACGACCATCCAGGACCTGCGGGACAAGATTCTTGGTGCCACCATTGAGAACTCCAGGATTGTCCTGCAGATCGACAATGCCCGTCTGGCTGCAGATGACTTCCGAACCAAGTTTGAGACGGAACAGGCTCTGCGCATGAGCGTGGAGGCCGACATCAACGGCCTGCGCAGGGTGCTGGATGAGCTGACCCTGGCCAGGACCGACCTGGAGATGCAGATCGAAGGCCTGAAGGAAGAGCTGGCCTACCTGAAGAAGAACCATGAGGAGGAAATCAGTACGCTGAGGGGCCAAGTGGGAGGCCAGGTCAGTGTGGAGGTGGATTCCGCTCCGGGCACCGATCTCGCCAAGATCCTGAGTGACATGCGAAGCCAATATGAGGTCATGGCCGAGCAGAACCGGAAGGATGCTGAAGCCTGGTTCACCAGCCGGACTGAAGAATTGAACCGGGAGGTCGCTGGCCACACGGAGCAGCTCCAGATGAGCAGGTCCGAGGTTACTGACCTGCGGCGCACCCTTCAGGGTCTTGAGATTGAGCTGCAGTCACAGCTGAGCATGAAAGCTGCCTTGGAAGACACACTGGCAGAAACGGAGGCGCGCTTTGGAGCCCAGCTGGCGCATATCCAGGCGCTGATCAGCGGTATTGAAGCCCAGCTGGGCGATGTGCGAGCTGATAGTGAGCGGCAGAATCAGGAGTACCAGCGGCTCATGGACATCAAGTCGCGGCTGGAGCAGGAGATTGCCACCTACCGCAGCCTGCTCGAGGGACAGGAAGATCACTACAACAATTTGTCTGCCTCCAAGGTCCTCTGAGGCAGCAGGCTCTGGGGCTTCTGCTGTCCTTTGGAGGGTGTCTTCTGGGTAGAGGGATGGGAAGGAAGGGACCCTTACCCCCGGCTCTTCTCCTGACCTGCCAATAAAAATTTATGGTCCAAGGGA

Publications

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