Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PRDX6P2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:95100529-95101021  UCSC
Coordinates (T2T) chr12:95081239-95081732  UCSC
Coordinates (hg19) chr12:95494305-95494797  UCSC
Strand +
Parental Sequence NM_004905.3
Parental seq. overlap 422 bp
Parental seq. overlap (%) 25%
Genomic Region Intragenic (FGD6)
Retrocopy Summary PRDX6P2, located on chr12:95100529-95101021, is a retrocopy of the parental gene PRDX6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRDX6
Full Name peroxiredoxin 6
Also known as 1-Cys|AOP2|HEL-S-128m|LPCAT-5|NSGPx|PRX|aiPLA2|p29
Coordinate chr1:173477335-173488815
Strand +
Gene summary The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRDX6P3
Bonobo Pan paniscus PRDX6P2
Gorilla Gorilla gorilla PRDX6P2
Orangutan Pongo abelii PRDX6P1
Gibbon Nomascus leucogenys PRDX6P2
Green monkey Chlorocebus sabaeus PRDX6P2
Rhesus Macaca mulatta PRDX6P2
Baboon Papio anubis PRDX6P2
Marmoset Callithrix jacchus PRDX6P7
Crab-eating macaque Macaca fascicularis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PRDX6P2
AGGCTCCCAACTCGGAGGCTAATCGCACTGTTGGCTGTATCTGTTCCCACGACTTTCTAGGAGACTCCTGTGGCATTCTTTTTTCCCACCCTTGGGACTCTAAACCAGTGTGCACTATGGAGCTTGGCAGAGCTGCAAAGCTGGCACCAGAATTCACCAAGAGCAATGTGAAGTTGACTGCCCTTGCAACAGACAGTGCTGAGGACCATCTTGCCTGGAGCAAGGATATCAATGCTTACAATAGTGATGAGCGAACAGAAAAATGCCCTTTTCCCAACATTGATGGTAAGGATCAGGACCTTGCCGTCTTGTTGGGCATGCTGGATCCTCCTGAGTTGGAAGAAAAGGGAATGGGTGTCAGAGCTTATGGTGTTTATTTTTGCTCCTGACAAGAAACTGAAGCTGTCTACCCAGCTACCACTGGCAGGAACTTGGATGAGATTCACGGGGTAGTTATCTCTCTCCAGCTGACAGCGGAAGAGAGGTTGCCACC
>NM_004905.3
GCTTCTTCGCCAGAACCAACCGGTTGCTTGCTGTCCCAGCGGCGCCCCCTCATCACCGTCGCCATGCCCGGAGGTCTGCTTCTCGGGGACGTGGCTCCCAACTTTGAGGCCAATACCACCGTCGGCCGCATCCGTTTCCACGACTTTCTGGGAGACTCATGGGGCATTCTCTTCTCCCACCCTCGGGACTTTACCCCAGTGTGCACCACAGAGCTTGGCAGAGCTGCAAAGCTGGCACCAGAATTTGCCAAGAGGAATGTTAAGTTGATTGCCCTTTCAATAGACAGTGTTGAGGACCATCTTGCCTGGAGCAAGGATATCAATGCTTACAATTGTGAAGAGCCCACAGAAAAGTTACCTTTTCCCATCATCGATGATAGGAATCGGGAGCTTGCCATCCTGTTGGGCATGCTGGATCCAGCAGAGAAGGATGAAAAGGGCATGCCTGTGACAGCTCGTGTGGTGTTTGTTTTTGGTCCTGATAAGAAGCTGAAGCTGTCTATCCTCTACCCAGCTACCACTGGCAGGAACTTTGATGAGATTCTCAGGGTAGTCATCTCTCTCCAGCTGACAGCAGAAAAAAGGGTTGCCACCCCAGTTGATTGGAAGGATGGGGATAGTGTGATGGTCCTTCCAACCATCCCTGAAGAAGAAGCCAAAAAACTTTTCCCGAAAGGAGTCTTCACCAAAGAGCTCCCATCTGGCAAGAAATACCTCCGCTACACACCCCAGCCTTAAGTCTCTTGGAGAAGCTGGTGCTGTGAGCCAGAGGATGTCAGCTGCCAATTGTGTTTTCCTGCAGCAATTCCATAAACACATCCTGGTGTCATCACAGCCAAGGTTTTTAGGTTGCTATACCAATGGCTTATTAAATGAAAATGGCACTAAAAGTTTCTTGAGATTCTTTATACTCTCTGCCTTCAGCAATCAATTCCATTCATACATCAGCACTCTGCTGGTTCTGTTTGAAATATGTTCTGTATTTAAAACTCAAATCTTGTTGGATCTCTGCAGGGCTTGTGACCAATGAAGTCATATTTGTTGATGGTTGACAAAGCTTGCTTCACTCCATCAGAGAATGACTATCAATTTTTTTTTAACTGTCCTATCACGTCCTCTCCTGTCACCCATTTTGAAGAGTGGCAGAACTTGAAGTTCAACTTCCTCTGTAAATATCCAAGTATAAAGCCCAGGAACTTCTAGAATAACCCAGATGCGCTTTAATTTTTTTTAATATGTTTTGATCACAGAACTTCTAGAATAACCCAGATGCTCTTTCATATTCTTTTAATACATCTTGATCACAGCTGGGGGAAAAAAAGCTTTTTAATTCTATACCTTCCTAGTAGATAAGTGAAGAGCAGGGAAAGAGACCTTTAAATATTTTGCTATAAAAAAATTTGTGATAAGTTTCTATCAAAATGGGGAGATTGCAGAAAAGGCTTCCCTTGGCTCCCAAGGAGGTGTAGCAGGTGTGAGCAATATTAGTGCCATGTGCCTTTCACACAGGGTTTGCATTTATCAGTCTGTTTTCCGATGATGTGTACATGAAAGAGTACACCATGTGAAGAGAAGAGAGAATGATTGAAAATGTTTTAGTATAGAACTCTTCTTGCAGTGGGTTGCTATTTTCTAGATTTTACTTTTTAGGGAACAAAATAAAATCCTTTGTTAAAACTGGGTCAGAGAA

Publications

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