Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GOT2P3
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:9641669-9643984  UCSC
Coordinates (T2T) chr12:9527912-9530227  UCSC
Coordinates (hg19) chr12:9794265-9796580  UCSC
Strand +
Parental Sequence NM_002080.4
Parental seq. overlap 2096 bp
Parental seq. overlap (%) 85.8%
Genomic Region Intergenic
Retrocopy Summary GOT2P3, located on chr12:9641669-9643984, is a retrocopy of the parental gene GOT2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GOT2
Full Name glutamic-oxaloacetic transaminase 2
Also known as DEE82|KAT4|KATIV|KYAT4|mitAAT
Coordinate chr16:58707131-58734316
Strand -
Gene summary Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GOT2P4
Bonobo Pan paniscus GOT2P4
Gorilla Gorilla gorilla GOT2P4
Orangutan Pongo abelii GOT2P4
Gibbon Nomascus leucogenys GOT2P4
Green monkey Chlorocebus sabaeus GOT2P2
Crab-eating macaque Macaca fascicularis GOT2P3
Rhesus Macaca mulatta GOT2P3
Baboon Papio anubis GOT2P4
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GOT2P3
aGCCCTCTGCTCAGTCCTGCAGCTGCCCACTGCCCTCCTACTGTCCACCGTGGCCCTGCTGCACTCTGGCTGCGTCCTCTCTGGGATCGCTGCCACCTTCCACCTGGGCCTCGCAGCTGCGGCCTCTGCCAGAGCCAGCTCCTGATGGACCCATGTGGAAATGGGACCTCCAGATATCATCCTGGCAGTCATTGAAGACTTTAAGAGGGACACCAATAGCAAAAAGATGAATCTGGGAGTTGGTGCCTACCGGGATGATAACGGAAAGCCTTGGACGTGCTGCCTAGCGTCCCCAAGGCAGAGGCCCAGATTGCCACAAAAAGTTTGGACAAGGAATACCTGTCCACTGGGGGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTTGGTGAGAACAGCGAAGTCTTGAAAAGTGGCCGGTTTGTCATTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATTGGAGCCAGCTTTCTGCAAAGATTTTTTAAGTTCAGCTGAGATGTCTTTCTGCCCAAACCAAGCTGGGGAAATCACACGCCCATCTTCAGGGACACTGGCATGCAGCTACAAGGTTATCGGCTTTATGACCCCAAGACTTGCGATTTTGACTTCACAGGCGCTGTGGAGGGCCTTTCAAAAATACCAGAGCAAAATGTTGTTCTTCTGCATGCCTGCACCCACAATCCCACGGGAGTGGACCCAGGTCTGGAACAGTGGAAGGATACAGCAACAATGGTGAAGAAGAAGAGTCTCTTTGCCTTCTTTGACATAGCCTACCAAGGCTTTACCAGTGGTGATGGTGATAAGGATGCCCGGGCTGTGCACCACTTCTTTGAACAGGGCATTAATGTTTGTCTCTGCCAATCATATGCCAAGAACATGGGCTTATATTGTGAGCGTGTAGGAGCCTTCACTGTAGTATGCAAAGATGCGATGAAACCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCATTCCACGTATGCCAACCGTCCCCACAATGGGGCCCAGATTGCTTCTACCATTCTGAACACCCCAGATTCATGAAAACAATGGTTGCAAGAAGTGAAAGGCATGGCCGACCACATCATTAGCATGCGGACTCAGCTTGTCTCCAACCTCAAGAAGAAGGGTTCCACCCACAACTGGCCACATAGCACTGCCCAAACTGGCATGTTTTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGTGGCTAACCAAGGAGTTCTCCATCTATATGACAAAGGACGGCCGCATTTCTGTGGCAGGGGTCACCTCCGGCAACGTGGGCTACCTTGCCCATGCCATTCACCAGGTCACCAAGTAATGTACCTGGTGCAAGGAAACAGAGACGACCTTTCTGTCTTCAGCCTCTGCTATTGGGAGCTTCACACAGAGGATGAGAGAGAGCGGATGGTGGTGAGTGGATCATTTTCTTCAACCACGGTGTGTAACACTCAGCAATTGAATGTTTCTCAGAAAAGAACGTGTAGTGACACAGGGCAGAGGGATCCGTGGCTGGCGTCTGGAACATTGTGGCTCTAAACCAAATGCTCCCCTGTCCTTTTATCCCCAACTTTTCTCAAAGAGTTTACATGTACAAGAAAGTCACCACACCAAAAAACCTGTCAATTATGCCATTGCAATATTTCAGAAGCTTTAACTGAAGTGTCATATAGTGTCAGGTTCCTCATGAGAAATAGCACACATTAGAGGCTTTGAGAGAAGACCTAGTTCTGTCATGAACACTTGGCCTCATGTCTGTCCTCCCATCATGGAGCAGCCTTATCAACAGACCACATTGCAGAAATTATGTTTTATGAAAACCAGTAAGTCTGCTGCCACTACAGCAAGGAAAGGAATGCAGTTTCCTGTCTTATTTAAGAAAAAGAGAAGGCTCTCTTTTCTCCTTTGCCATTGCTGTTCTTTTCCTTATGCACAAAGATTTTTAATGAATGCAGATTTTTATCTCATTCTACTGCCTGACTATCAACCCCATCCTATTGGGATTTATTTAAGAATAAACATAATTTTCTGCTGATGCCATACCCTCACTTTTCTCAGCAAAGAATAATGGAGAGTAGGTAACTGTACTTTATCTCAGCATCCTCTTGAATGATTTTGTAATCTTCTCTAGTTGTGATGTTGTCTCTGCCCAGTTGTACCTCCTCCTTTGTTGAATGTGGTTGTGCAGTCACTCATCTCACACCGTGAGTCCAGTGGCACAGGGTGGTACCAGGAAAGAGGATATTCTAGGCTTTGTGTGCTGCCAGTTGGGTTCAGGCTTCACCTCCTGGAAA
>NM_002080.4
ACCTTCAGCAGGAGCCGGTTCCCTGTGTGTGTGTCCGCTCGCCCTCTGCTCCGTCCTGCGGCTGCCCACTGCCCTCCTACGGTCCACCATGGCCCTGCTGCACTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGCCTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCTCCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATGAATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTCCGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGGGGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTCTTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATCGGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCAACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGGTATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAAATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGACCCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCGTTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATGCCTGGGCTGTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAACATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAAGCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCCCTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGGCTGCAAGAAGTGAAAGTCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCCAACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATGTTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATCTACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTACCTTGCCCATGCCATTCACCAGGTCACCAAGTAATGTCCCTGGTGCGAGGAAACAGAGACAACCTTTCTGTCTTCAGCCTCTGCTATTGAGAGCTTCACACAGACAATGAGAGAGGGTGGATGGTGGTGAGTGGATCATTTCTTTCAGCCACAGTGTGTAACACTCAGCATTTGAATGTTTCTCAGAAAAGAACATGTAGTGACACAGGGCAGAGGCATCCATGGCTGGCGTCTGGAATATTAAACCAAACTCTCCCCGGTCCTTTTTTCTCCAACTTTTCTCAAAGAGTTTACATGTGCAAGAAAGTCATCGCACCAAAAAACCTGTCAATTATGCCATTGCAATATTTCAGAAGCTTTAACTGAAGTGTCAGGTTCCTCGTGAGAAACAGCACACGTTAGAGGCTTTGAGAGAAGGCCTAGTTCTGTCATGAGTAGTCGGCCTCGTGTCTGTCCTCCCATCTTGGAACAACCTTATCAACAGGCCGCACTGCAGAAATGATGTTTTATGAAAACCAATGAGGCTGCTGCCACTCCAGCAAGGGAAATAATGCAGTTTCCTGTCTTATTTAAGAAAAAGAGAAGGCTCTCTTTTCTCCCTTGTCATTGCCGTTCTTTTCCTTACACGCAAAGATTTTTTAACTATTGCAGATTTTCATCCCATTCTACTGCTTGATTGACCATCAACTCCATCCTATCGAGATTTATTTAAGAATGAAGAACATAATTTTCTGCTGATGCTGTACCCTCACCCTTTTCAGCAAAGAATAGTGGAGAGTAGGAAACTGTACTTTATCTCGGCATCCTCTTGAATGATAGTGCAAGTTTCTCCAGTTGGGATGTTGTCTCTGCCCGGTTGGACCTCCTCCCTTTGTTGAATGTGGTGTGCAGCCTCTCATCTCACACTGTGAGTCCAGCGGCGCAGGGTGGTACCAGGAAAGAGGATATTCTAGGCTTTGCGTGCTGCTAGCTGGGTTCAGGCTTCACCCACTGGAAAGAACCACCATCTGCTCTAACCATGTAGACTTATTGCGGCCTGGTTTCTCTGTTACAATAAAATTACTGTAGACCCAA

Publications

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