Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PARP1P1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:110936702-110940232  UCSC
Coordinates (hg19) chr13:111589049-111592579  UCSC
Strand +
Parental Sequence NM_001618.4
Parental seq. overlap 3166 bp
Parental seq. overlap (%) 79.4%
Genomic Region Intergenic
Retrocopy Summary PARP1P1, located on chr13:110936702-110940232, is a retrocopy of the parental gene PARP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PARP1
Full Name poly(ADP-ribose) polymerase 1
Also known as ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PARS|PPOL|Poly-PARP|pADPRT-1
Coordinate chr1:226360691-226408093
Strand -
Gene summary This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla PARP1P1
Orangutan Pongo abelii PARP1P1
Green monkey Chlorocebus sabaeus PARP1P1
Golden snub-nosed monkey Rhinopithecus roxellana PARP1P2
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PARP1P1
CGCGTGTCTCCAGGTCGTCGCGTCGGGCTCCTGGGATTTGGCGGCAACTGTGGGAGGATGGCAGAGTCCTCGGATAAGCTCTACTGAGTGGAGTACACCAAGAGCGGGCGCACCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTGCGGATGGCCATCATGGTGCAATAGTCCATGTTTGATGGAGAAGTCCCACACTGGTACCACTTCTCCTGCTTGCGGAAGGTGGGCCACTCCATGCGGCACCCTGACGTTGAGGTGGATGGATTCTCTGAGCTTTGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCTGACGCTGGAGGAGTGACGGGCAAAGGCCAGAATGGAATTGGTAGCAAGGCAGAGAAGACGCTGGGTGACTTTGCAGCAGAGTAGGCCAAGTCCAGCAGAAGCAAGTGCAAGAGGTGTTATGGAGAAGATAGAAAAGGGCCAGATGCGCCTATCCAAGAAGATGCTGGACCCTGAGAAGCCTCAGCTAGGCATGATTGACCCCTGGTACCACCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCAGCCTGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTCGCTGCAGAGGATAAAGAAACCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAGAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCCAAGAAGAAATCTAAAAAAGAAAAAGACGAGGATGGTAAGCTTGAAAAGGCCCTAAAGGCCCAGAACGACCTGATCTGGAACATCAAGGACGAGCTAATGAAAGTGTGCTCTATTAATGACCTGAAGGAGATGCTCATCTTCAACAGGCAGCAGGTGCCTTCCGGGGAGTCGGCGATCTTGGACCGAGTAGCTGACAGCATGACGTTCGGTGCCCTCCTTCCCTGTGAGGAATGCTCAGGTCAGCTGGTCTTCAAGAGCGACACTTATTACTGCACCGGGGACGTCACGGCCTGGACCAAGTGTATGGTCAAGACATGGACACCCAACCAGAAGGAATAGGTGATCCCACCGAGAAATCTCTTAACTCAAGAAATTTAAGGTTAAAAAGCAGGACCGTATATTCCCCCCAGAAACCAGTGACCCAGTGGCGGCCATGCCCCCACCCTCCACAGCCTCCGAGCCTGCTGCCATGAACGCCTCTGCTCCAGCAGATAAGCCGTTATCCAACATGAAGATCCTTACTCTTGGGAAGCTCTCCCGGAACAAGGATGAAGTGAAGGCCACGATTGAGAAACTCGGGGGAAAGTTGATGGGGACGGCCAACAAGGCTTCTCCGTGCATCAGCACTACCAACATCTGAGCTGTGTCTGAGGACTTCCTCCAGGACTTCTCTGCCTCCACCAAGGGGCTCCAGGAGTTGTTCTCAGCGCACATCTTGTCCCCCTGGGGGGCAGAAGTGAAGGCAGAGCCTGTTGAAGTCGTAGCCCCAAGAGGGAAGTCAGGAGCTGTGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGACTCTGGTCTGGAACACTCTGCACATGTTCTGGAGAAAGGTGGGAAGGTCTTCAGTGCCACCCTCAGCCTGGTGGACGTCGTTAAAGGAACCAACTCCTATTACAAGCTGAAGTTGCTGAAGGATGACAAGGAAAGCAGGCATTGGATATTCAAGTCCTGGGACCGTGTGGGCACGGTGATCGGTAGCAACAAACTGGAACAGATGCTGTCCAAGGAGGACACCACTGAACACTTCATGAAATTATATGAAGAAAAACTAGGAATGCTTGGCACTCCAAAAATTCACAAAGTATCCCAAAAAGTTCTACCCCCTGGAGATTGACTACGGCCAGGACAAAGAGGCGGTGAAGAAGCCGACAGTAAATCCTGGCACCAAGTCCATGCTCCCCAAGCCAGTTCAGGACCTCATCAAGATGATCTTTGATGTGGAAAGTATGAGCAAAGCCATGGTGGGGTGTGAGATCGACCTTCAGATGCCCTTGGGGAAGCTGAGCAAAAGGCAAATCCAGGCCGCGTACTCCATCCTCAGGTCCAGCAGGTGGTGTCCCAGGGCAGCAGCGACTCTCAGATCCTGGATTTCTCAAATCGCTTTTACATCCTGATCCCCCACGACTTTGGGATGAAGGATCCTCTGCTCCTGAACAATGCAGACAGTGTGCAGGCCAAGGTAGAAATGCTGGACAACCTGCTGGACATTGAGGTAGCCTACGGTCTGCTCAGGGGAGGGTCTCACGATAGCAGGAAGGACTCCATCGATGTCAACTATGAGAAGCTCAAAACTGACATTAAGGTGGTTGACAGAGATTCTGAAGAAGCTGAGATCATCAGGAAGTATGTTAAGAACACTCATGCAACCAACCACACACGATGCATATGACTTGGAAGTCATTGATAGCTTTAAGATAGAGTGTGAAGAGGAGTGCCAGCACTACAAGCCCTTTAAGCAGCTTCATAACTGAAGGTTGCTGTGGCATGGGTCCAGGACCACCAACTTTGCTGGGATCCTGTCCCTGGGTCTTTGGATAGCCCTGCCTGAAGCACCTGTGATGGGCTACATGTTTGGTAAAGTGATCTATTTCGCTGATCTTGTCTCCAAGAGTGCCAACGACTGCCATACATCTTAGGAAGACCCAATAGGGTTAATCCTGTCGGAAGAAGTTGCCCTTGGAAACGTGTGTGAACTGAAGCATGCTTCACATATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGTTTGGGCAAAACTACTCCTGACCTTTCAGCTAGTATCCCACTGGATGGTGTAGAGGTTCCTCTTGGGACCAGGGTTTCATCTGGTGTGAATGACACCTGTCTACTGTATAATGAGTACATTGTCTATGATATTGCTCAGGTAAATCTGAAATATCTGCTGAAACTGAAATTCAATTTTAAGACCTCCTTGTGGTAATTGGGAGAGGTGGCTGAGTCACACACGGTGACTCTGGTATTAATTCACCCTAAGCGCTTCTGCACCAACTCACCTGGCTGGCTAAGTTGCTGGTGGGTAGTACCTGTACTAAACCTCCTCAGAAAGGATTTTGCAGAAATGCATTAAAAGCTTTTTCCCAAATTTTTTAGTCTCtTTTTCTTGCCAGGTAGATAAAACTGACAAGCTGGAGAGAGATTCTGTTTGCATGGATTAGTCCTCTGGAAAAAACCAAGCTGTGCTACAATATCTGCCTTAGTGGTTTCCCCAGGGAAGAAAAAATATGTTTCCACCCTTTTTTTTTGTTTGTTTGTCTTTAGTTTTGATTTTGGAAAGATGTTAAGCATTTATTTTTAGTTAAAAATAAAAATTGATTTCATACTA
>NM_001618.4
AGCAATCTATCAGGGAACGGCGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCGTGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAGTACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCCATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGATGGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATTGGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATAGAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAAGAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAGAAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTAAAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGAGTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACTGGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATCTCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCCACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCCCGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACCAAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTCTCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTTGTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTCTTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGGTATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAGCACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTCATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGATCGACCTTCAGAAGATGCCCTTGGGGAAGCTGAGCAAAAGGCAGATCCAGGCCGCATACTCCATCCTCAGTGAGGTCCAGCAGGCGGTGTCTCAGGGCAGCAGCGACTCTCAGATCCTGGATCTCTCAAATCGCTTTTACACCCTGATCCCCCACGACTTTGGGATGAAGAAGCCTCCGCTCCTGAACAATGCAGACAGTGTGCAGGCCAAGGTGGAAATGCTTGACAACCTGCTGGACATCGAGGTGGCCTACAGTCTGCTCAGGGGAGGGTCTGATGATAGCAGCAAGGATCCCATCGATGTCAACTATGAGAAGCTCAAAACTGACATTAAGGTGGTTGACAGAGATTCTGAAGAAGCCGAGATCATCAGGAAGTATGTTAAGAACACTCATGCAACCACACACAATGCGTATGACTTGGAAGTCATCGATATCTTTAAGATAGAGCGTGAAGGCGAATGCCAGCGTTACAAGCCCTTTAAGCAGCTTCATAACCGAAGATTGCTGTGGCACGGGTCCAGGACCACCAACTTTGCTGGGATCCTGTCCCAGGGTCTTCGGATAGCCCCGCCTGAAGCGCCCGTGACAGGCTACATGTTTGGTAAAGGGATCTATTTCGCTGACATGGTCTCCAAGAGTGCCAACTACTGCCATACGTCTCAGGGAGACCCAATAGGCTTAATCCTGTTGGGAGAAGTTGCCCTTGGAAACATGTATGAACTGAAGCACGCTTCACATATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGTTTGGGCAAAACTACCCCTGATCCTTCAGCTAACATTAGTCTGGATGGTGTAGACGTTCCTCTTGGGACCGGGATTTCATCTGGTGTGAATGACACCTCTCTACTATATAACGAGTACATTGTCTATGATATTGCTCAGGTAAATCTGAAGTATCTGCTGAAACTGAAATTCAATTTTAAGACCTCCCTGTGGTAATTGGGAGAGGTAGCCGAGTCACACCCGGTGGCTCTGGTATGAATTCACCCGAAGCGCTTCTGCACCAACTCACCTGGCCGCTAAGTTGCTGATGGGTAGTACCTGTACTAAACCACCTCAGAAAGGATTTTACAGAAACGTGTTAAAGGTTTTCTCTAACTTCTCAAGTCCCttgttttgtgttgtgtctgtggggaggggttgttttggggttgtttttgttTTTTCTTGCCAGGTAGATAAAACTGACATAGAGAAAAGGCTGGAGAGAGATTCTGTTGCATAGACTAGTCCTATGGAAAAAACCAAGCTTCGTTAGAATGTCTGCCTTACTGGTTTCCCCAGGGAAGGAAAAATACACTTCCACCCTTTTTTCTAAGTGTTCGTCTTTAGTTTTGATTTTGGAAAGATGTTAAGCATTTATTTTTAGTTAAAAATAAAAACTAATTTCATACTATTTAGATTTTCTTTTTTATCTTGCACTTATTGTCCCCTTTTTAGTTTTTTTTGTTTGCCTCTTGTGGTGAGGGGTGTGGGAAGACCAAAGGAAGGAACGCTAACAATTTCTCATACTTAGAAACAAAAAGAGCTTTCCTTCTCCAGGAATACTGAACATGGGAGCTCTTGAAATATGTAGTATTAAAAGTTGCATTTGAAATTCTTGACTTTCTTATGGGCACTTTTGTCTTCCAAATTAAAACTCTACCACAAATATACTTACCCAAGGGCTAATAGTAATACTCGATTAAAAATGCAGATGCCTTCTCTA

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