Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LDHBP1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:113277286-113277906  UCSC
Coordinates (T2T) chr13:112530945-112531565  UCSC
Coordinates (hg19) chr13:113931601-113932221  UCSC
Strand +
Parental Sequence NM_001174097.3
Parental seq. overlap 543 bp
Parental seq. overlap (%) 34.2%
Genomic Region Intergenic
Retrocopy Summary LDHBP1, located on chr13:113277286-113277906, is a retrocopy of the parental gene LDHB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LDHB
Full Name lactate dehydrogenase B
Also known as HEL-S-281|LDH-B|LDH-H|LDHBD|TRG-5
Coordinate chr12:21635342-21657971
Strand -
Gene summary This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LDHBP1
Bonobo Pan paniscus LDHBP1
Orangutan Pongo abelii LDHBP1
Gibbon Nomascus leucogenys LDHBP1
Green monkey Chlorocebus sabaeus LDHBP1
Marmoset Callithrix jacchus LDHBP1
Gorilla Gorilla gorilla Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LDHBP1
TCTGCCACGGATGGATTTGGGGAGAACACAGTGACTCAAGTGTGGCTGTGTGGAGTAGTGTGAACGTGGCAGGTGTTTCTCTCCAGGAATTGAATCCAGAAATGGGAACTAATGATGATCAGGAAACTTGGAAGGAAGTGTATAAGATAGTGGTTGAAAGTGCCTGTGGTCATCAAGCTAAAAGGATATACCGACTGGGCTCCTGGGTGAAGTGTAGCTGATCTTATTGAATCCACGTTGAAAAATCTGTCCAGGGCTCACCCAGTATCAACAATAGTGAAGGGGATGCAGGGCACCAAGAATGAAGCCCTCTGGAGCCTCCCATGTACCCTCACTGCTCAGGGATTAAACAGTGTTACCAACCACAGCTAAGGGATAATGAGGTTGTTCTGCTCAAGAAAAGTGCAGATACCCCGTGGGACATCCAAAAGGACCTCAAAGACCTGTGACTCCTAAGCTGTAGAAATTTAAAACCACAGTGAGATGAACCCTGAGCCTTCAGTGTTCATCCATATACATGCATCACCGTTTGCTTTTATCTTCTTCAGTATGTGAATTTGGGCTCACAGAATCAAATCCCATGCTTGATTTCATGCTTGCAATCGAGTCCTTGAACAAATA
>NM_001174097.3
CTTGCAGAGCCGGCGCCGGAGGAGACGCACGCAGCTGACTTTGTCTTCTCCGCACGACTGTTACAGAGGTCTCCAGAGCCTTCTCTCTCCTGGTAGGTTTCGGCTCAGGACCCTGAATCCTGGCCCACAGGCAAGCCTGATGGGACGTGCGGGGTAGTACTTGTATGGGGAGACGCGGGAAGGAGGAAGAAGCACATCTGTCCTCCGCGGCCTTTAGCTCTGAGCATCCGGCCGCGGGCCCTGACTTTGCCGCTCAGTTTGGGGCGCAGGGGGGGCCGTGCCCTGGCGGAGGAGCAGAAGGCAGAGGGTAGCAGCTGCGGCTCAGCGGAGAGACTTGTTGCATTTGCAGCTAAAACCAGGCCCTACTTGTCCTTGTGCAAAATGGCAACTCTTAAGGAAAAACTCATTGCACCAGTTGCGGAAGAAGAGGCAACAGTTCCAAACAATAAGATCACTGTAGTGGGTGTTGGACAAGTTGGTATGGCGTGTGCTATCAGCATTCTGGGAAAGTCTCTGGCTGATGAACTTGCTCTTGTGGATGTTTTGGAAGATAAGCTTAAAGGAGAAATGATGGATCTGCAGCATGGGAGCTTATTTCTTCAGACACCTAAAATTGTGGCAGATAAAGATTATTCTGTGACTGCCAATTCTAAGATTGTAGTGGTAACTGCAGGAGTCCGTCAGCAAGAAGGGGAGAGTCGGCTCAATCTGGTGCAGAGAAATGTTAATGTCTTCAAATTCATTATTCCTCAGATCGTCAAGTACAGTCCTGATTGCATCATAATTGTGGTTTCCAACCCAGTGGACATTCTTACGTATGTTACCTGGAAACTAAGTGGATTACCCAAACACCGCGTGATTGGAAGTGGATGTAATCTGGATTCTGCTAGATTTCGCTACCTTATGGCTGAAAAACTTGGCATTCATCCCAGCAGCTGCCATGGATGGATTTTGGGGGAACATGGCGACTCAAGTGTGGCTGTGTGGAGTGGTGTGAATGTGGCAGGTGTTTCTCTCCAGGAATTGAATCCAGAAATGGGAACTGACAATGATAGTGAAAATTGGAAGGAAGTGCATAAGATGGTGGTTGAAAGTGCCTATGAAGTCATCAAGCTAAAAGGATATACCAACTGGGCTATTGGATTAAGTGTGGCTGATCTTATTGAATCCATGTTGAAAAATCTATCCAGGATTCATCCCGTGTCAACAATGGTAAAGGGGATGTATGGCATTGAGAATGAAGTCTTCCTGAGCCTTCCATGTATCCTCAATGCCCGGGGATTAACCAGCGTTATCAACCAGAAGCTAAAGGATGATGAGGTTGCTCAGCTCAAGAAAAGTGCAGATACCCTGTGGGACATCCAGAAGGACCTAAAAGACCTGTGACTAGTGAGCTCTAGGCTGTAGAAATTTAAAAACTACAATGTGATTAACTCGAGCCTTTAGTTTTCATCCATGTACATGGATCACAGTTTGCTTTGATCTTCTTCAATATGTGAATTTGGGCTCACAGAATCAAAGCCTATGCTTGGTTTAATGCTTGCAATCTGAGCTCTTGAACAAATAAAATTAACTATTGTAGTGTG

Publications

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