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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CLCP2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:114306611-114307186  UCSC
Coordinates (T2T) chr13:113515671-113516246  UCSC
Coordinates (hg19) chr13:115072086-115072661  UCSC
Strand +
Parental Sequence NM_001828.6
Parental seq. overlap 490 bp
Parental seq. overlap (%) 77.2%
Genomic Region Intergenic
Retrocopy Summary CLCP2, located on chr13:114306611-114307186, is a retrocopy of the parental gene CLC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CLC
Full Name Charcot-Leyden crystal galectin
Also known as GAL10|Gal-10|LGALS10|LGALS10A|LPPL_HUMAN
Coordinate chr19:39731255-39738029
Strand -
Gene summary Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gibbon Nomascus leucogenys LOC100591329P1
Green monkey Chlorocebus sabaeus LOC103234682P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CLCP2
AACACAATTCAGAAGAGCCACCCAGAGGGAGACAACAATGTCACAACTACTTGTGCCACACACACAGACTGTGCTCTTGTCTATTGGTTCTACTTGACATCAAAGGGAGGCTAGTTGTTTGTTTCATCAATGAACCACAGCTGCAGGTGGATTTCCACACCAGGATGAATGAAGACTCAGACATCACCTTCCATTTCCAAGTGTTCTTTGGCCGTTGTGTGGTCATGAACAGCGTGAGAATGGGGCCTGGAAGCCTGAGATGAAATCCAAAAATATGCCCTTTCAGAATGGCAAAGAATTTGACCTGAGCATCTTGGTGCTGGACAGTAAGTACCAGGTAATGGTCGATGGCCAATGCTTTTAGAGCTTTGACCATCGAATCCCGCCTGAGTCTGTGAAGATGGTGCAAGTGTGGAGAGATGTCTCCCTGACCAAAGTGAGTGCCTGCAATTGAGGGTGATAACCAGACTTCCTGTTGACAAAGGAATCCGTTTCTGTGTGACCATGGGATTCCCAGAGCCAGCTAACAGCATAATTCCTCCTCACTTCAACCCTTACTCTTGCTCATTAAAACTT
>NM_001828.6
CATTTAAATTCTGCAGCTCAGAGATTCACACAGAAGTCTGGACACAATTCAGAAGAGCCACCCAGAAGGAGACAACAATGTCCCTGCTACCCGTGCCATACACAGAGGCTGCCTCTTTGTCTACTGGTTCTACTGTGACAATCAAAGGGCGACCACTTGCCTGTTTCTTGAATGAACCATATCTGCAGGTGGATTTCCACACTGAGATGAAGGAGGAATCAGACATTGTCTTCCATTTCCAAGTGTGCTTTGGTCGTCGTGTGGTCATGAACAGCCGTGAGTATGGGGCCTGGAAGCAGCAGGTGGAATCCAAGAATATGCCCTTTCAGGATGGCCAAGAATTTGAACTGAGCATCTCAGTGCTGCCAGATAAGTACCAGGTAATGGTCAATGGCCAATCCTCTTACACCTTTGACCATAGAATCAAGCCTGAGGCTGTGAAGATGGTGCAAGTGTGGAGAGATATCTCCCTGACCAAATTTAATGTCAGCTATTTAAAGAGATAACCAGACTTCATGTTGCCAAGGAATCCCTGTCTCTACGTGAACTTGGGATTCCAAAGCCAGCTAACAGCATGATCTTTTCTCACTTCAATCCTTACTCCTGCTCATTAAAACTTAATCAAACTTCA

Publications

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