Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GTF2A2P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:31263140-31263742  UCSC
Coordinates (T2T) chr1:31115359-31115961  UCSC
Coordinates (hg19) chr1:31735987-31736589  UCSC
Strand -
Parental Sequence NM_001320929.2
Parental seq. overlap 314 bp
Parental seq. overlap (%) 18%
Genomic Region Intragenic (SNRNP40)
Retrocopy Summary GTF2A2P1, located on chr1:31263140-31263742, is a retrocopy of the parental gene GTF2A2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GTF2A2
Full Name general transcription factor IIA subunit 2
Also known as HsT18745|T18745|TF2A2|TFIIA|TFIIA-12|TFIIA-gamma|TFIIAS
Coordinate chr15:59638062-59657515
Strand -
Gene summary Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GTF2A2P1
Bonobo Pan paniscus GTF2A2P1
Gorilla Gorilla gorilla GTF2A2P1
Orangutan Pongo abelii GTF2A2P1
Gibbon Nomascus leucogenys GTF2A2P3
Green monkey Chlorocebus sabaeus GTF2A2P4
Crab-eating macaque Macaca fascicularis GTF2A2P1
Rhesus Macaca mulatta GTF2A2P1
Baboon Papio anubis LOC100999448P1
Golden snub-nosed monkey Rhinopithecus roxellana GTF2A2P3
Marmoset Callithrix jacchus GTF2A2P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GTF2A2P1
AAAATTAATTGAGAAAAACAAAAAGATTCTGTGATAATATGTAGACTTTTGTGAAAATTATGGCCTGTGATGATAAAAATACTGGCTCTAATACTATAGAATGAATAAGGAAAAAATCACATTTTTATGACATCTTCTGTTATTATTCATCACTTTTGAAGAGAAATGTAGAAGTTTTTTTTTATTTATTCTAGCATTGCAGAAAGTTCAGCACAGGACATCAAGGCAAGCTTGAATAAGAAAAACAATTTCTTCTTCCTAAGCCATATCATATCAGTTATACAGAAGTACTACTTTGGGACACAGTCTTCAGGAGAGCCTAGATGAGCTCATAAAATCTCAGCAGTTCACTCAACTTGCCCTTCAAGTTTTACTTCAGTTTGATAAGGCTATAAAGTCATCATTGGCTCAGAGGATTAGGAACAGAGTTGATTTCAGGGGCTCTCTAAATACATACAGATTGTGCCATATg
>NM_001320929.2
CCTTCGCTCCTGGGATCTGCCCGTTACCGACCGTTGCCGGCAAGGCCCCGCGGCCGGCACCGGAGAAGGGCGGCGAGGCGGCGGTGATGGTCGCGTCCCGTGGCGGGAGGCTCGTCGTTCACGGGGCGCCCACAGAACCCACCTAGGGGAGGTCTTCAGCCCACCACCGTATTTTCAGCCAGGACATCAATGCAAGCTTGAATAAGAAAAACAAATTCTTCCTCCTAAGCCATGGCATATCAGTTATACAGAAATACTACTTTGGGAAACAGTCTTCAGGAGAGCCTAGATGAGCTCATACAGTCTCAACAGATCACCCCCCAACTTGCCCTTCAAGTTCTACTTCAGTTTGATAAGGCTATAAATGCAGCACTGGCTCAGAGGGTCAGGAACAGAGTCAATTTCAGGGGCTCTCTAAATACGTACAGATTCTGCGATAATGTGTGGACTTTTGTACTGAATGATGTTGAATTCAGAGAGGTGACAGAACTTATTAAAGTGGATAAAGTGAAAATTGTAGCCTGTGATGGTAAAAATACTGGCTCCAATACTACAGAATGAATAGAAAAAATATGACTTTTTTACACCATCTTCTGTTATTCATTGCTTTTGAAGAGAAGCATAGAAGAGACTTTTTATTTATTCTAGAATTGCAGAAATGACTACACTGTGCTATACCAGAGAATTCCAGTAGAAAGAAACTTGTAACTCTGTAGCCTCTTACATCACCTTTATTATACAGCATGAAAAACCATAACTTTTTTTTAAGGACAAAAGTTGTTGCCTTCCTAAGAACCTTCTTTAATAAACTCATTTTAAAACTCTGAGTAATAACTGGTGAAGCTATTAAGGTAGCAATATGAAGATATTAGATAATGCATTTTCCCATTTCCTTTGCAAGGAACATGATGCCCTTTCAGAATGCTTATTTCAATAAAGTCATGTTTTGTCAGTTGTAACTTTACCTGATGAAAGCATCAGCAGGGGCAAAACCAAACTCTGGATGGAATTTTTTAAGAAAATCCCTTGCTTTTTAAAATACAAAACCAAAGTTAATCATTGGTATAAAAAAACCCAAGTACAACTTGATTAGGAAAAGTTAGACAATCATAGCAAAAACAAAACCAAAAAACTTTCCTTCTTAGACCAGGTAACATGAGGAAGGGGGAAAAAAACCCAAACAAAATAGTCCCCCCACATGACAGGTGTCTTCAGCTTGCCATATTGATCCAAAGTTCATACATTTTATCATGTACAAGATACATTAGACTTACAATAAAGTCTAATTATTAGACTTTTATGTCAGTGGATTGTGCTTGCAGAAATACAGAAGTAACATACTGACCCTAGGTGAGGAGTTTCTTACATGGTTAACTGGATTGACCCAATTGGAGTAAAAGATTTTTGCTGTTACCTCGATGCTCCTGCAGTTGTTACCTCAGCATGCCACTGTAGTCCTTGACTCTCACATTAAAACTAACTTTggctaggtactggtggctcacacctgtaagtaatcccagtactttaggaggctgagactggaggattacttgagtccaggagttggagaccagcctggccaatatagactgtccctacaaagaaaataaaaTTGTTTCATCTTCCAA

Publications

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