Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SNX19P2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:18890816-18895740  UCSC
Coordinates (T2T) chr13:18085558-18090482  UCSC
Coordinates (hg19) chr13:19464956-19469880  UCSC
Strand -
Parental Sequence NM_014758.3
Parental seq. overlap 4511 bp
Parental seq. overlap (%) 28.7%
Genomic Region Intergenic
Retrocopy Summary SNX19P2, located on chr13:18890816-18895740, is a retrocopy of the parental gene SNX19. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SNX19
Full Name sorting nexin 19
Also known as CHET8
Coordinate chr11:130866250-130916486
Strand -
Gene summary Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. [provided by RefSeq, Dec 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SNX19P1
Bonobo Pan paniscus SNX19P1
Gorilla Gorilla gorilla SNX19P1
Gibbon Nomascus leucogenys SNX19P1
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SNX19P2
GTCGCCAGTGGCCGGCAGGCTGGCAGCCCTAACACAGGCAGGGCTGCGAGTGCAGTCACCCAGGTCTGCAGGAGCAGCAGGCCGAGGCCAGCGGAGATGACCCCGATGAGCCCACTTCAGGTCGGGGCTGAGTGTGGGCGCATGGTTCCCGGCAGCGTGTGACCCAGTCCTGGCCCTCCGCCGTCCTCTGCATGTGTAAGTGTCCATGGGCCCCAGGGCCACAAAGGGGCCTTCTGCCTGGGGCAGTATCAAGGCTGCAGAGTTTTCCTCCAAAGCCACACCTCCACTGGAAAGGGCGAGTTCAAGGACTCTGTGGGTGGTAGCCATGGGCAAATGCAGAGCTGCTGCTGTCGCTTTGCAGTGCCTGTAGGACTTCGAGGGCCTGGAGCCTCGGTTCCCTGAACAGCACCCAGATCACCCTGTATCAGGGATACAGTTCCTTCCCACCTTCCCTAACTCTGGAGTAAAATCTTGAGGCTGTCATCTGGGGAAGCCACCTTGTCCGTTCAGCCATGAAGACAGAAACAGTGCCATCGTTCCGGGAGACTCCAGCTGGATCCAGCTGTCACCTTAATAACCTGTTGAGTAGGCGAAAGGTGATGGCTGTGGGGGTCTTGCTTGCTGGCTCCTGGCCATACACCTTCTGGTCAGCGTGTGGCTGCTGTGCCTTCTGTCTGCATTGCTAGTGGTGCTGGGAGGATGGCTGGGCTCCAGTGTCTCTGGAGTGGCTTCAAGTCCACTGCTCCTGGAAGGCTTCATCCCATTGGCCACCTGTCCTCTATGCCCTGAGGCAGAAAGACAGCTGGAACAGGAGATCAACCGCACCATCCAGATGTGATTATTTGAGATTTTATATTATCCTTGTACCGTTCTGTGAGCCAGGAGCCAGCCTTTGCGGAGGAAATGGAGGCAGCCATGAAAGAGTTGGTCCAGGAGCTTCAGAGGAGGATGAGCATGATGGACCATCATGCTCTTGCCCAGAGTGTTCTGCCTCTCTGTCGTTTTTCACCTGCAGAGCTACATTCAGGCAAAGGAGGCCACTACAGGGAAGAATGGTCCAGTTGAGCCTTCCCACCTCTGGGAGGCTTACTGCCAGGCTACTGCCCCACATCCTGCTGTGCACAGCCCCAATGCTGAAGCCACCTATACATGTGGTATTGTGAATTTGTTGCTTCAAGGGCTGGTGCCCAAGTCCCACTTGGAGACTCATACTGGATGCCATGTAGTGGTTGAACTCATCATATGCAGTGTAGTCTTACCACTGATCAGCCGGCTGTCAGATCCTGACTGGATCCACCTTGTCCTCATGGGTATCTTTTCCAAGGCCAGAGATCCAGCACCCTGCCCAGCCAGTACCCCTGAACAGCCCTCAGTGCCCACATCTCTGCCACTGATTGCTGAGGTACAGCAGCTTCCAGAAGGGAGGGCTCCTTCTCCAGTAGCAGCCCCAGGGTTCCTAAGTAAACAGTGAGCCAGAGATTCCTGCAGGCCCCTCCTCAGAGGTTGAAGGTGGCCAGGAAGCTGTAGAGGGAGATTTGGGTGGAATGTCTGAAAAAAGAAAAGTAGGAAACAACTCATCTCATTTCCTACAGCCAAATATTCGAGGCCCCCTGTTCTTATGTGGAGACTCAGAGCTGGAGTCTCTGCTGTCTGAAGTAGGCTAAGAAACCATCATGCTAGACTCCAGGCCACTTTCTGTCTGACAGGATTCAGGATGCCCTGTGTGCCCTAGAGGGTTCCCAGGCTCTGGAACCCAAAGGTGGTGAGGGATCTGAAGGAGCAGAGGCTGAGGAGGGTCCAGGGACAGAAACAGAGACAGGCCTGCCTGTCTCCACACTGAACTTCTGCCCAGAGATCCAGATTGACACAGCAGACAAGGAGATAGAACAAGGAGAAGTTACCACCTCTGTTACAGCTTTGCTGGAGGGGCTGGAAAAGACCTGCTCCTCACGGCCCTCATGCTTAGAGAAGGATCTCACCAATGATGTGACCTACCTTGATCCTAGTCTGCCACCACTTCTGCTTTCCTCCTCTTCACCTGGTCCTCTCAGCTCAGCCACCTTCAGCTTTGAACCCCTAAGCAGTCCAGATGGCCCAGTTGTCATCCAGAACCTTCATATCACTGGCACCATTACAGCCCGAGAGCACAGTGGCACCAGATTGCACCCATGCACACGCTGTACTGTGAAGTATGAGACATCCCTTGTCGGTGAAAACAGCAGCCTGCAGCAGCTGGCCTACCACATTGTGAATCACCGCTATTGGGAGTTCTTGAATCTGCAGGCCGTCAGGAGAAGAAACCAGATCTATGAAAGTTCATTAGAAATGTGAAGGGTCCTAAAAAGCTCTTTCCAGATCTTCCATTTGGAAACATGGACAGTGACAGAGTAGAAGCCTGTAAGAGCCTCCTATAATAATTCCTGAAGCAACTGTATGCCATTCCAGCGATTGCTAACAACAGTGAGGAGGTGCAGGAGTTTCTTGCTGTGAACACAGATGCTCGCATTTCCTTTGTCAAGAAACCATTTATGGTCTCTAGAATAGAGAAGATGGTGTTGAGTGCCATTGTGGACACCTTGAAGACAGCGTTTCCTTGCTCTGAATCCCAGAGCCCCACAGAGAAGCTGAGTGAGGCCGAGACTGAAAGCAAGTCCCATATAGAAGGCAAGAAGGCTAGCAAGTCCAGGCTGAGGTTCTTACCCAGTAAAATATCTCCAGCACTAAGTGTGACTGAAGCACAAGACAAGATTCTTTATTGTCTCCAGGAAGGCAATGTGGAGTCCAAGACCCTATCCATGTCTGGGATGGAATCTTTTATTGAAAAACAGACAAAGTTACTGGAGATGGAGGCAACAGAAGCCCCAGAAAAAGATCCTGAACAACTTCCCAAAGGACATGTGGACAGCTGCTTGTCAGATGCAGCTGTGCCAGCCCACGATCCAGCAACGACGGTTCAGGAACAGAGACAGAGTTAGCTGACACAGCCGTGAATCTGCTTCTCTTGCTACTAACAGAACAGTGGAAATGGCTGTGTACTGAAAACATGTAGATGTTTCTTCATCTTATCTTTGGTACCCTAGTTTAAAGGTGGCTAGACGTGCAGGTAGCTAATTTAACAAGTCCACAGTGCTGGGTGCAGTACCTCTGGCTTCTTCTGGAGTCCATCTGGCCTGGTGGAGTTTTGCCTAAGTTTCCACGGCCTGTAAGGACCCAGGAGCAGAAACTGGCTGCTGAGAAACAGGCTTTGCAGAGCCTAATGGGAGTCCTCCCAGATCTCATAGTAGAAATTCTTGGGGTGAACAAATGCCAGCTGAGTGTCTAGTCTTGGAGTCACTACAACAACCACTCATCAACAGGCATTTGATTTACTGCCTTGGGGACATTATCCTGGAATTCTTGGATCTCAGTGCCTCTGTTGAGGAGTCCGCTGCTACCACCTCTGCTTCAGATACCCCAGGCAGCCCTAAGAGGCTGGGTGTCTCCTTTTAGCTGGTTATTCCCGCATCCTTCCCAGGTCAGGGAAGTAGAGTTACTCGGCCACCCAGAGACCAGTGAGGAAGCCCGTGCCCTCTGGAAGTAGGCTACAGCTCAGAAGGCCTAGGCTCTCAGTGGCTCAATTCTCTCCCACTTCTGCTCCATTTGTAGCAGGTGACACGGGGTATGTGTCCCAGTTGCATGCACATTTATTTCCATGTCCCTTTTGTGGTGTTGGGATTGTTGTTGGTGAGTAGATTCTGTTTCCTTTGGGAAAAGAAGATGTGAGGTAGAGGAACAATCCCCCTTTGCTTCTCCTTTTGCTGTCCTCCCTGAGATTGTTTGCCAGAACCCGGCCCTGTGCACAGATGTACTTAATCCACCAGCACACAAGCTCTGGATAGAACAGGAAAAAAGCTATGGCCAGATTTCTCTGGAGGAAAAAACAACCTTCTGAGCTCTCTGTTCCTACCTGGAAACTAAAAATTCATTCCAGGCCATTCTCAAAAACCAGACTCCTGGGTCTTATCTAGTTTCCCAACAGTTCCAGAAGAAGAAGGAGGGAAGAAAATTTTTCAAGGGACTTCTTGCTCATGTGTTGCTATTTCCCAACACATCAGCCTTATGGAAGATGTCATCAGGCTGCTTCCCTGGAAGGCTACACTTTTCCTTTCCAGAAGACTTCAAAGCTGATTGCAAAAGCTTCTGGTAAATCCACCCCACCTTTCACACGCTTTCCTGAGAGGCATTTGTACCACACATTTTATTTTTGTCTCTCCTCCCAACCCCCTGCCCTAGAGCAACTGGATTTTTGAATTTGTGACCCTCCCATTATCTTCAGCAAATTTGCATGACAACTTGCATATTCAGCCTCAGCTTTTCCCAGGAGAAGGTAAAGCACTTGCCTCCTGTCTTAACAATGCAAAAAGAGTAGGAATAGCAAGCTGGGGGAATGAAATCTCCCCTCATAAGTCTTTGATGGGGAACTTTTATTGCTCTGAACAGATAAGATTAGCAAACTTACAAGGAATAGCTTCTTATTTCCTGTTCCTTATGGTTATAATTAGCCTTTAAAGAACTCCAGCAAAATGTTCTGTCAGGCCACAACATCTACTGGAAAGGCAAAGAAATTAGGAATTGCTGGAGGAGAAGGATAAATCAGGAGGAATTGCTGGTAGAAGAGGATGCAGACAGTCACAGGGAAGTGGTATATATTAAATACATGTGAATAGCTGGCAAAAAGGTGTCAGGGATGTTACTCGGAGCCATTTGGCTTCACACTTGCCTGTTAGTGCCTTGCTTTCGCTGAATTACCAGAGCCTACCACTTGGAAGAAGGTCTTGGAGTTAGACTAATGAGAAGGCAATGGGGTGCCAAAAACAAGTGTCAGAGTTCTCTTAGATTCTGAAGTAGGTGGTGAGCACACAATTAAAGTGGTTTATGGAAGAAAA
>NM_014758.3
AGCTGTCGCCGGCGGCCGGCCGGCGGTCAGCCTTCACACAGGCCCGGCTGCGGAGCGCAGTCGCCCAGGTTTACGGCGGCAGAGGGCCGAGGCTCCCGGAGAGGACCGCGATGAGTCCACTTCAGGTCGGGGCTGAGTGTGGGCGCGCGGTTCCCGGCGGCGTGTGACCCAGTCTTCGCCGGCCGCTGCCCGCTGCGTGTGTAAGTGTCCGTGGGCCCCAGGGCCTTGCAGCGCCCGCCCCGAGGCCCCGAAGAGGCCTTCCGCCTGGGGCAGTGTGAAGGCCACAGAGTTTTCCTCCAAAGCCACACCTCAGCTGGAAGGGGCGAGTTGGAGGGCTCTGTTAGTGGTAGCCATGGGGAGACGCGGAGCTGCAGCTGTCGCTTTGCAGTGCCTGTAGGACTTTGAGGGCCTGGAGCCCCGGTTCCCTGAACAGCACCCAGATCGCCCCATATCTGAGACACAGTTCATGCCCCCCTTCCCTAACTCTGAAGTAAAATCTTGAGGGCTGTCATCTGGGGAAGCCACCTTGTCCGTTCAGCCATGAAGACAGAAACAGTGCCACCGTTCCAGGAAACTCCAGCTGGATCGAGCTGTCACCTCAATAACCTGTTGAGTAGCCGGAAGCTGATGGCTGTGGGGGTCTTGCTTGGCTGGCTCCTGGTCATACACCTTCTGGTCAACGTGTGGCTGCTGTGCCTTCTGTCGGCATTGCTAGTGGTGCTGGGAGGATGGCTGGGCTCCAGCCTCGCTGGAGTGGCTTCAGGTCGACTGCATCTGGAACGCTTCATCCCGTTGGCCACCTGTCCTCCATGCCCTGAGGCAGAAAGGCAGCTGGAACGGGAGATCAACCGCACCATCCAGATGATTATTCGAGATTTTGTGTTATCTTGGTACCGTTCCGTGAGCCAGGAGCCAGCCTTTGAGGAAGAAATGGAGGCAGCCATGAAAGGGTTGGTCCAGGAGCTTCGGAGAAGGATGAGCGTGATGGACAGTCATGCTGTTGCCCAGAGTGTTCTGACTCTCTGCGGTTGTCACCTGCAGAGCTACATTCAGGCAAAGGAGGCCACTGCAGGGAAGAATGGTCCAGTTGAGCCTTCCCACCTCTGGGAGGCTTACTGCCGGGCGACTGCCCCACATCCTGCTGTGCACAGCCCCAGTGCTGAAGTCACCTATACGCGTGGCGTTGTGAATTTGTTGCTTCAAGGGCTGGTGCCCAAGCCCCACTTGGAGACTCGTACCGGACGCCATGTAGTGGTCGAACTCATCACATGCAATGTAATCTTACCACTGATCAGCAGGCTGTCAGATCCTGACTGGATCCACCTTGTACTCGTGGGTATCTTTTCCAAGGCCAGAGATCCAGCACCCTGCCCAGCCAGTGCCCCCGAACAGCCCTCAGTGCCGACATCTCTGCCACTGATTGCTGAGGTAGAGCAGCTTCCAGAAGGGAGAGCTTCTCCAGTAGCAGCCCCAGTATTCCTAAGTTACAGTGAGCCAGAGGGTTCTGCAGGCCCCTCTCCAGAGGTTGAAGAAGGCCACGAAGCTGTAGAGGGAGATTTGGGTGGGATGTGTGAAGAAAGAAAAGTAGGAAACAACTCATCTCATTTCCTACAGCCAAATGTTCGAGGTCCCCTGTTCTTATGTGAAGACTCAGAGCTGGAGTCTCCGCTGTCTGAACTGGGCAAAGAAACCATCATGCTCATGACTCCAGGCAGCTTTCTCTCTGACAGGATTCAGGATGCCCTGTGTGCCCTAGAGAGTTCCCAGGCTCTGGAACCCAAAGATGGTGAGGCATCTGAAGGAGCAGAGGCTGAGGAGGGTCCAGGGACAGAAACAGAGACAGGCCTGCCGGTCTCCACACTGAATTCCTGCCCAGAGATCCATATTGACACAGCAGACAAGGAGATAGAACAAGGAGATGTTACCGCCTCTGTTACAGCTTTGCTGGAGGGGCCAGAAAAGACCTGCCCCTCACGGCCGTCATGCTTAGAGAAGGATCTCACCAATGATGTGAGCTCCCTTGATCCTACTCTGCCACCAGTTCTGCTTTCCTCCTCTCCACCTGGTCCTCTCAGCTCAGCCACCTTCAGCTTTGAGCCCCTAAGCAGTCCCGATGGTCCAGTTATCATCCAGAACCTTCGTATCACTGGCACCATTACAGCCCGAGAGCACAGTGGCACTGGATTCCACCCATACACACTCTATACTGTGAAGTACGAGACAGCCCTTGACGGTGAAAACAGCAGCGGCCTGCAGCAGCTGGCCTACCACACTGTGAATCGTCGCTATCGGGAGTTCTTGAATCTGCAGACCCGTCTGGAGGAGAAACCAGATCTACGAAAGTTCATCAAAAATGTGAAGGGTCCTAAAAAGCTCTTTCCAGATCTTCCATTGGGAAACATGGACAGTGACAGAGTAGAAGCCCGTAAGAGCCTCCTAGAATCATTCCTAAAGCAACTCTGTGCCATTCCGGAGATCGCTAACAGTGAGGAGGTGCAGGAGTTCCTTGCTCTGAACACAGATGCTCGTATTGCCTTTGTCAAGAAACCATTTATGGTCTCTAGAATAGACAAGATGGTGGTGAGTGCCATTGTGGACACCTTGAAGACAGCGTTTCCTCGCTCTGAACCCCAGAGCCCCACAGAGGAGCTGAGTGAGGCCGAGACCGAAAGCAAGCCCCAGACAGAAGGCAAGAAGGCTAGCAAGTCTAGGCTGAGGTTCTCATCCAGTAAAATTTCTCCAGCACTAAGTGTGACTGAAGCACAAGACAAGATTCTTTATTGTCTCCAGGAAGGCAATGTGGAGTCTGAGACTCTATCCATGTCTGCGATGGAATCTTTTATTGAAAAACAGACAAAGTTACTGGAAATGCAGCCAACAAAAGCCCCAGAAAAAGATCCTGAACAACCTCCCAAAGGACGTGTGGACAGTTGCGTGTCAGATGCAGCCGTGCCAGCCCAAGACCCCAGCAACAGCGATCCAGGAACAGAGACAGAGTTAGCTGACACAGCCCTGGATCTGCTCCTCTTGCTACTAACAGAACAGTGGAAATGGCTATGTACCGAAAACATGCAAAAGTTTCTTCGTCTTATCTTTGGGACCCTAGTTCAAAGGTGGCTAGAGGTGCAGGTAGCTAATTTAACAAGTCCACAGCGCTGGGTGCAGTACCTCCTGCTTCTTCAGGAGTCCATCTGGCCTGGTGGAGTTTTGCCTAAGTTTCCACGGCCCGTAAGGACCCAAGAGCAGAAACTGGCTGCTGAGAAACAGGCTTTGCAGAGCCTGATGGGAGTCCTCCCAGATCTCGTAGTAGAAATTCTTGGGGTGAACAAATGCCGGCTGAGCTGGGGTCTAGTCCTGGAGTCACTACAACAACCCCTCATCAACAGGCATTTGATTTACTGCCTTGGGGACATCATCCTGGAATTCTTGGATCTCAGTGCCTCTGTTGAGGAGTCTGCTGCTACCACCTCTGCCTCAGATACCCCAGGCAACTCTAAGAGGATGGGTGTCTCCTCTTAGCTGGTTATTCACGCCTTCTTCCCAGGTCAGGGAAGTAGAGTTACTCGGCCACCAGAGACCAGTCAGGAAGCCCGTGCCCTCTTCAAGTAGGCTACAGCTAAGAAGGCCTAGGTTCTCGGTGGCTCACTTCTCTCCCACTTCTGCTCCATTTGTAGCAGGTGACAGGGGTCTGTGTGTCCCAGTTGTATGCACGTTTATTTCCCTGTTCCTTTTGTGATGTTGGGATTGTTGCTGGTGAGTAGATCCTGTTTCCTTTGGGAAAAGAAGCTGTGAGGTAGAGGAATGAACCCCTTTTGCTTCTCCTTTTGCCATCCTCCCTGAGATTGTTTGCCAGAATCCTGGCCCTGTGCACACATGTGCTTAATCCACCAGCACACAAGCTCTAGATAGAACAGGAAAAAAACTGTGGCCAGATTTCCTTGGAGGAGAAAACAACCTTCTCAGCTCTCTGTTCCTACCCGGAAACTAAAAATTCATTCAGGGCCATTCTCAAAAACCAGACTCCTGGGTCTAATCTAGTTTCCCAACAGTTCCAGAAGAAGAAGGAGGGAAGAAAATTTTTCAAGGAACTTCTTGCTCATGTGTTGCTGTTTCCCAACACATCAGCCTTATGGAAGATGTCATGAGGCTGCTTGCCTGGGAGGCTACACTTTCCTTTCCAGAAGACTTCAAAGCTGACTGCCAAAGCTTCTGGTAAATCCACCCCACCCTTCACACCCTTTCCTGAAAGGCATTTATACCACCCATTTTATTTATTGGCTTTGCTCCCAACCCCCTGCCCTAGAGCAATTGAGTTTTTGAATTTTTGACCCTCTCTCTGTCTTCAGCAAAACTGCATGACAAGCTGCATATTCAGCCTCAGTTTTTCCAAGGAGAATGGAAAGCACTTGCCTCCTGTCTTAAGAATGCACAAAGAGTAGGACTAGCAAGGCTGGGGGATGAAATCTCCCTTCCTAAGTCTTTGACAGAGAACTTTTATTATTCTGAACAGATAAGATTAGCAAACTTACAAGGAATAGCTTCTTATTTCCCATTCCTTACGGTTATAATCAGTCCTTTAACAACACCAGCATGAAGGCAAAGGTGTTTTGTCAGACTGCAACATCTATTAGAAAGGCAAGGCAACTGGGAATTGCTGGAGAAGGATAAATCAGGAGGAATTGCTGGTAGAAAAGGCTGCAGACAGTCACAGGGAAGTGCTGTATATTAAATGCATGTGAATAGCTGGCAAAAAGATGTCAAGGATGTCACTGGGAGCCCTTTGGCTTCACACTCGCCTGTTAGCGCCTTGCTTTCGCTGAATTACCAGAGCCTACCACTCGGAGGAAGGTCTTGGAGTTAGACTGATGAGAAGGCAATGGGGTGTCAAAAACAAGTGTCAAAGTTCTCTTAGATTCTGAAGTCGGTGATGAGCACACAATTAAAGTGGTTTGTGGAAGAAAGTTGTAAAATCTTTTTACTTTTTTGCCCCTCTGGAGGCTTTTAACCCTAAATTGTGTCTGATGTATTCGGGAGGCTTAGGTGTGCAATTCTTGCCCAAAGGCAAGGAGATGAATGAGATGTCTCATGGCCTCTTCTAGCCTTAAAAGTTGACCATTACAGTGACTTTATGGCTCCAAAGTTCTTGAAGCATCTCCAGCCCTAGACTTTGACAAGAAAAGGTAGCTCAGCATCTCTACTTTCCGTGAGTACCTGCAGGAGTCCAGCCAATGTATTAGAGCTGATCATTAAGCTCCTTCAGTGAGGGCTAAGATCCTATTCTCGATGAGCATAGGGGGACAGCCTTGTTTTATGCCACTTTTCTCTCCCCATACCTACCTTCCCCTCATGTGTACTTAGCCACCTGTGTTGCTTTGAATCTGCTGCCAGTTCTGGCTCAAATGTGGCACAAAATCAGTACATCAGACACACCATGAAATCCCTGTGGCTATAAATTCTAAGGAATCTTTTGACACTTCCAGCCCAAAGAACTTATTTTTATTTCGTATTATATAAGAGTCCCCACCTCTACTCCACGTACCCCAAAAAGATAAGCTGTCCTCAGATCCTCCTTCTACCCAGGAGGGAAATAATGGATATTGCCAAGGGAACAATCAGAACTCATCTGGCTTTGAAAACGACCTGCCAAGTTTGGCTAGCAGGTTCAGACAACAAGAGAGTAACAATTGGTAGAGAGCCACAGGTAGAAAAGATACTCCCAGCTGACAGGGTGATAAAAGGCAGGGAAGAATTGGGCCTGTGCTGATCCAGGAAGGTTTTATTGTTTGCTTGTTTTTTGTATTTACTCGTGACTAAATTTTATTCATTTAAGTCAGAATTTTGATATTTGAAATAAGACTACTTTCCCTTTTCTTACTATCTATAAAAAAGACGAGGCAGGGATGCTGTGTTCTTTCTGTCAAATTCTAAATGTGATCTTTGCCATTGCTTATTTGAATTCAAGAAAGCTATACTTTTTCATCACATATAACTCACAGTTTCATTTTTGCATTGTTGGATTAGACTTAATAAAACCTAAATGGAAAATAAATTCCTAAATCTGAGCCTAGGAGCATGTATAAATTTTAtttttattattattatacattaagttctagggaacatgtgcacaacatgcaggtttgttgcatatgtatacatgtgccgtgttggtgtgctgcacccgttaactcgtcatttacattaggtatatctcctgatgctatcccttccccctcccccgacctcacaacaggccccagtgtgtgatgttcaccttcctgtgtccaagtgttctcattgttcaattcccacctatgagtgagagcatgTATAAATTTTAAAATCAATACAAGCTACTCCAATTTCCATTTTGGAAATTTCCAGTTTACAAGGTGATTttcttattgttgtaaagaaacacataatgtgagatctaccctcttaagtgtacagtacattatttatttattttgagacggtacattattaactagaagcagcacagtgctttgtagcagactgctacaagtttttcatcttgcataaccaaaagtttatacccattgaacagccactcctcgtttcccctcccaccagcctctggcaatcactgttctactttctgcttctgtgagtttgactactttgaacgcctcatataagtggaatcatgcagtgtttgtcctttgactggcttatttcacttagcataatgtcctccaggttcatccacgttacagcatgtgacagaattttctttttaaggctgaaaacattccattgtatggctatgccacattttctttgttcattcattgagggacatttaggttggctccgcgccttgattgttgaaaacaatgctgcagtgaacatgggagtgtgactgtttcttcgaggccctgcttttaattattttagataaatacccagaagtaggattgctggatcatatattgttctgtttttaattctttgaagaccttcatactgttttccatagtgactagaccattttacattcccaccaacaatgtacaagggttccagtttctccacatcctctccaacacttgtaatgttttgttttttcataatggcatcttaaaaggtattaggtgatattactatctcatggttttgatttgcatAGCCTAGAACATTTTTGAGTCTTCCTGTGTCCTACCCAGGTTATTCATTTCCAGCTACTGCTCTTCCTTTGCTCATAGCACACAACACCAGTTGTTAGGTCCTGGAGGAAGTAAAAATATGTGTAACTATGGTCCCTGGCTATATGAATCAGGATGCTCTGGACAAGAAttaaattatgaggaaaatttattttatttcataacattagtacgtgagtaggtaagcccaggagtttggtgattcagcaactctgagacctcttaaggggcctgaattctttccatctttcttccttgccattctaattaggtcagctgtgctctcagactgcctgccttcctgctgctgcagtttcaggcatcacacccagagataacattcataaaagaacaggagcatctcttctgtgttttcttctaaggaatgaaggaaccatttcccagaagtccttcaagaatcctcttctaggccgggcacagcggctcacacctataatctcaacactttgggaggccaaggttgggggattgtttgagtccaggagtttaagaccagcctggaacatagcaagaccctgtctctacaaaaaatataaaaaatgagcggggcatggtggctctcgcctgtggttccacctactagggaggctgaggcaggaggatcacttgagcccaggaatttgaggctgcagtgagctacgatcacaccactgcattctagccttaagtgacagagtgagaccccaaataaaaaaaaaaaaaacaaaaaacctcttatgactcattggctagaaccacccacctcatgccaatccactgacactgagaatggcattgtgattggctttcaatagtattttcccccagagatgaggtcatcttccatgaaggtcagatatctacagaaataattgatgttagcaaggaagaagcagagaatgggtattgatagacaatgtctgcTCTAGGGATGGGTCATTCTGCCAACATTCAGCAGATCCCCTATCTACTCCCAAAATGCCTGGTACCAGCTAATAGTTAACATCTTCTGAGAgcattacttaaagtctttacatatcttcacttatttaacccacaaatcaacccttaaaggtaggttctgatgtagtgggttggtgcaaaagtaattggagttttgccattttaatgcaattacttttgcaccaatctaatatatccccattttctaggtggggaacatgaggcacagagtggttatgtcttacccacagtcatttgcaagggagtggcagagcctagatacaaaccatgtcaatctgcctctgagtctacgtagtatatccactatactaaactgCCCTTCTACCTtacaaagcagaacaagatcaggttctcacttttaaggagtctacagtctagtATaggagccagcaaactttctctgtaaaggtctggagactaaatactaggttttgcagcagtatggtctctgttgtaactactcagcttttccactgtagcgtaaaaacagttgtagacaattcataaacaagtgtggctgtgttccaataaaacttgatttacaaaaataggcagctggccgggtttgtcccatgagtcagtttgtggaccTGCGGTCTAGTGAGTTAGAATACtgcttaccaaattttaatgtgtgtgtgattcacgtgggatcgggttaaaatgcaaattttgattcaataggtccggagtgaggcctAGTAAAAGTGTAAGTGCTATGCTCTAAAAATGTTGACAGCATGATTATCACACTCCTCTGCTGTTTGAGGGGCAGGGAGCATTTGGAGATGCCTTGTTTCAGGAACCCATTCAGCCAAGTTGTCCTGGCAAGCCGTACCTCCCACAGCCCCCTCCACACCGGCTGTTTGTCCAATCTAACTTTGCACTGGAGCAAGATGTGTTTTCCCAGGATGAGGAAAGGAAGGTTAGCCCACACTGCTGGATGTGGAAGGGGATGGGAACCAGGGAAAGAATGGTAACTGGGGAGGAAGGGAAACCATGATACTTTTGTAGTCGAAGGCCTAACTGGGCGCACTCTGCCATAACTTGGCCCCTCTGCTTCCTTTCCACTGGGAGTGCCAGAAATCACAGGGCAGCAGTCGCTCACCCTGCCTTTGTAGACAAGAAAATGAAACCATCGAAGGGTGAATTTCAGCTAGCATATTGCCATCACTCTTTTATGGTATAAAGGATGAGAGAGGCGGTGAGGGAGACATTGCCCCAAACATGATGTCCACATCCTAAGACTTACCTGATATTTCTTATTACACAAAGACAACATTGACTGGTTTAAGAGAGAAAAAAAAAAAGGAAATCCAGAAGAATGTTTTAATTGTCAAGCGTGAAACAAGTGAAAATCATCAGAATCTTTTTCCTTCTGTGACTTGGTAGCAACAGTGTGTAAAGCCAAGGCCACCGTGAAGCGGTGGGGGAAATTTGGGCACCCGCAGACCTTGGCAGACACACTATGCTATTTTCAGACTTGCGGAGCCTTTGCACTGCCTCCCTGTCATCCTCACCTGTCTCTGGTCTGAAAGTCCATTTTAACTCTGCTTTCTTGGAGGCAGAAACAAGCATGTGACAGGATGCAGAGAATTACTCCTGGCTTTGATGTCTCTTCAACAGCTTGATGAAACCTGGTTTTTCCACCTGTCTTCACTTCTCCAAGCCTTACCTGCAAGCGCTTCCGTGAAAGCCCCCAGCACACCATCTCTGGGATGTGGAAGCTTAGGAGGGGAGAATTAAAAAAACAAAACGAAGGTAACAGTAATCAAGATCCAAACTTAGAAAACATTTCTTGAAGTGACATTATCTGCTCCTTTTAACCCAAtccctttgtcaccagtcagtgtttgtttaggaagtgtaagctaattttaatattaaagtgttgtagtgattaagaaggtaagtttgTGAATAATGTATGAATCATCCACACTTTTGTCTTTTTTCCCACCTTATGTTCCATGTTACTGCTGCACCCTGTTATAAGCAAAGAAGAGTTGGCTGTGATTACTTCCAGAAACTTTGATTAACCCATGAGAGTAAAGATGTAGCTAGATAAACACAGAACTCCCTGATTGCAGACAAAAGGACTCAAATGTCGACAGAAGCAATGGCTTGTTTATACTGTGTTGAACTGGATTTGGTGACTTGTGAGCATAGGTAATCAGCCCTTTTGCCCGTGCCCCTGGGTGAAGAATCATCCTGCTCCTGTAACTATCAAAAAGATTAACCATGAACGTTGATATGAAATACTGCTTTTCATACCTTGACACCAAGAAGAATAGACCTTATTAAGGGAGGAAAAACACTTTTGGAGTTTACCTCCTTTACACATCCTGCTTGCATGGAATCCAAATTCAGTGAGCTGACGGCAGGCCAGTTCCTTGCCACTTTATGCAGTTGTGTTTAAAGTTTACCCTCTGTTATCTATAAATGCAAGTGGCTTTTTCAAGAATAGTGAGGGCAGCTTTCATTAAGGACTCATGCATCTCTAGGAGAATCACATGGGCTTAGTTGGCAGTAGAGCATTTTCTTGGGGACAGAATGTATTATAGATGGTTTAGGCAGGAGGTTAGACGAGAAACTTCCAAAAAAATCTAGGGATTTTTTATTCTGCCCAAACCAGCATGttccttcctgctttcatttttttgttcatgtccttccttccACGTGGTAGATTACCTTCTCTTCTCCAGCTGGGCAAGTAGGCTACCTCTGCCCATAAGGACCAATTCAAGTTCCATTTTCAAGAAGCACTGTCTGATTGCACCAGCCAAAACTCTTCCCACTTTCTTTTCAGTTATTTACACTGCCTCTCTAGTCAATGTGCATGTATATGAAGTCCTCAGTAAGAGACTATAATTCTTCAAGGGCAACGAACATATCTTTTATCTTTTTTAGTCCTATTATGTCCTTATGCCCCCCCCCCAACTATATGTATATACCTAGTGCATGATAGGTACAAAATAAATATTAAAGTTTACTTAATTAAAGATTATGTTTATTTAAGAGGCAAAATTTGTGAATAAGTCTGGATCTTGATACTGTTACTTTCATTTTGTTGATTCCTTTCTCCCAACCTTCCACATCCCAGAGACAGGGTGCTGGTGACTTTTATGGAAAGGCTTGAAGGGTGAAGATATGTGGAGAAACCACCGTAAACCTCTTTGAGATTAACCACTTATTCCAGTGGAGGGCACTGGCTAGTCTGTACCAGACCTGCCCCAGACAGCTTTGTACATCTTGCGTGTGGGTGGGAACCCAAAAAGTTTCCTTTTCAGTGGATCTGTTTAGGTGAGGTAAAGAAATCCATTACTCAAATGTTTCATCAGAGGCTACCCCCTGTTCAGGTGTGCACCCTGCACCCATGTGGGTTTGCGGATGGCATATAACACTTGCAGCAGCAGAGCTCGTTGCCACACATCCAAGGGAAGTAAGTGTGCATATGTGGATGCGGCGGGAATACCTGCGGTCTTTCTGCTGAAGAGCAGGGTTATACACCTCCTTTTAGCAATCTGGAGAGGACTGAGGCAAGAGCTTGTATTGAAACACAAGCAAGCTCCACGTATGGTTTTGGACATGGAAGAAAGAGTACTGTTGGGGTGGAATGACCTAAGTTTTTAATAGGATTAGGATTTCTGTGGATTTTTCCCAAGTGATAGAAGTTTTCTTCATCTAGCAGGGAGCCTCACCCAATTGCTTCTCTATGTTCATTTCTGAAACTCCTTTGTTAAAACTAAATAGCAACAGAGAAGAAACTTTCTTCAAAAAACTCTTCATATCTGTCATTTCTCCTATTCTTATGGAACTTCACAATTGCTTTTTCTTTATTCCTTTTTTTTTTTCTATATCAGCTCATCAGTCTTTGTGGGTGACTTGGCTACCCCACTAATCTAATTGCCTTTTTGATAGTTAAATCAATATGGACATCAACTTAAGGCTATATGTGAACCTTAAATGCATGATATTCCCTATACTTGATTCCACAATTGATATTCTGTGAGGAAAGTTGGCCAGATATTCCCTTCTGTGAAGTCAGAATAACTACCGACCCTAAGAATAAACATTTTGACCAATTCTTTATATGTTGCAAACTATTCACACAACTAGAAAGTTTAGCCATTCACATCTCTTCCCCTGATTTTAAGTCCCAGATTCTGAGACTCAGAAAGTTTAGTGACTTGTTGAGCTTTCTGTGGAAAATCTGTTGTAAAAACAGTTCAGACATTGGAAAATATAAAATAGCCCCTAGAGATCCCAATAAAGCTTCCTCTCCCCAAATCCCTCTACAAGTTTATCCTCGAAAAACTTTCTGAAAACTGATGAGAAAATACTGAGTAATTAATGCTCAAATGGGAAAGATGACATGTAAAAGCAAAAACCTGTTAATGGCATCTGTTCATATAGTTCCATGTGCCTTTTTACTTAACTGCACTGATAGGCAATGTAATGAAGAAGTTTCCTTTTAAAACGTAAAATGTAATTAAACAGAGTTTATCTTAAATTGGCTGGACCCGCACAGCTTGACTGAGACATACACAGCTGTCTTCATTTTGAAGCACCTACACTAGTCAAGCTTCTttctaacccgcccttagggtttgcctgttggtctgtcttccctactgggctgttaatcccttggaggcagattgtcttgtttcccagagtttttccagcATATACCATGGCAGACAATTTTCACCTTATCTATTCTAACTCGTAAGCCTCAGCTAGTGCCTCCATCCTCGGGTGCATAGCCCAGTGACAGGCATGTAACAGACTTTGCCTACAAGCAGTTGCTGATCCATAAATGACGTTGGCAACCTTCTTGTGGCAGTGAGTAACATATTTCTTTCCTCCTGATAGGCTTGGAATCCTCATCCCCATCTGGCAATTTTCTTTCCATCTTTCCTACACTCACAATGGAGCCCACACGCCTCACAACCCCCTTGACTAAACCAGATGACAGCAAGAATGCCTAGTTCCAAGTGAGCAAGGGTGAAGCCTTAGGCCCTTGTCTCCTCCAGACCTCCTCTCTGCTCTAAGAGTATACTGGGCATGGGGTGTGGTCGGGGGGTTGGGGGCGGAGGAGTACTTAACCTCAAACTGAGAAAAAGGGTGTCCTGAGCAAGTTTCATAGCGTAGCAGCTTCCATTTGAAATGTGAAGCTTTGAAGGCCTGTTGCTACAGTAACCAGCTAGCTCCTGACTCCAATGCCTGTCTAATCTAAGGTGGAAATGTCCCAGAAACAGACCCCAGGCTGGCAGCTCTTAACTATGACCCATCTCATAAGCACATATCCAGCTGTAGCCTCTTGGTTGCTGGGGTGAAGGGGCCTCTGTATCGCCACAGGAAAAAAAATCTGATAAATTACGGGCTCAAGAAGGGTGTTGCTTTTTTTTCCACTAACAGACTTTGCAACCCAGTTCCTGGTGAAAGGGCTCCGCACCCACCCGTTTTGTGTGTATAATGCTGAGCTAAAGTGGGAAGGAGCAGTAACACCAAAGGAGGCTAATTCTCTTCCTGTCAGTAGGAGAGAGTGTCTGCCCCCAGTGTGTGAAAAGGGAAGGCATGAGAAGTGAAAAATCAGCCTTCTGGAAGCACCTTCTTACCACGAGAAAACAGGTGATTCTTACTATCTTTGAGACTCATCCAGATTGTGTCTGTTTAACTCTTCAGGCAATATGAAGGCAGAGAAGCCATTTCAGAGAAGAGATTTTTTAAAAAATCATTTCGTTCTTTGGCATTGTCACAGGATTATGATGTGGGTTCTCATAAAAATTTCACTCCCCCCAAAGCCACCCAAAGGAAAGGCAGTGAAATGGGGAGGAACACACATTTGCCTGGCATCGCAAGAGCTGCCTTGTAGTCATGGGTTCCAgtgatcttggaccgatctcttcacttccctggacctcagtttcttccatacaaagaagttgaactggatcatagaaaagatgctgtccagctTGGTAATATCAGATAGGGAGCAGAAGCTGTCTCTTAGCACATGGCCAGATTCCGGAACAACGATGATGGTCTCCATGTTTGTCCTAAAAATGCATCTCATCTCAGTAGAGATTTTCTTCCACCTCATTTGGGTCTCAATTTAAGGAAGGAAGAAAGGAAAGAAACCCGGGGATTCTCTTCTTGAAAGGAATATACTTCACTTTCTCTAGGCTTCTAGGATAAAAACTTCCTATCCTTCATTTTTCCTCTTTAAACCTGCCAAAATCAAGTTGAGTAAAGATACCATACAGATATGAAAAAGAAGCCACATCCTTAAATTTTCATGGAGTCCAAGAGCCTGCTCACCGCCAGTTAGCTTTTCCCAGGATGGTGGTGGCACTGATCATCTAGGTTGCACTTTTATGTTCATGTCCCAGAGCGTTTCCCATCAGCCATCTCATTTCATCTTTTCATCATTCCTCTGAGGAAAAGActtcacacatgtataggactttctatatcacaaagtatttcatatccaatgtcttatttagatcttgacaatcactgtttaaggtaatttggcaagttattaatactcatgtcctcattttactgaagaggaaactgaaatgcagagagcttgtcttttgcccaggatcactcacccagtttattgggaggcagcagcacggggattaagaacatgggttatgccgacaaccaaccaggcagaattccagctctgtcagtagttagctgtctggccttaggaaagggatttcacacctctgtggcttagtttccttgtccattaaatgctcataagaatagagctttcctcacagagattgggtgggcacgggagctaaatgagctcatacgtttaagaacaacctctagcacacagtgcataataaatgtcattattattagcaaagccaggacctgggtcttccagcttctagctcagtggcatttctgctgccccacacCAGGACTATCCTTCGTATACAGGTATGAACCTAAAGCCTTCAGTGTTTCAATGAAAAGTTCACCCAAGGTCTTTCTGTTCAGTAAGTCTAGAGCTAAGGGCTCCTGGCACTCTGTTCAGTCCTTTCGCTGGTAAACCACGCTGCCCTCCGTTGCTCTGGGCAGAATGTCAAACCTTCTTATGTTTTTAAAATTTATAAATCAAGCACTCTTATTTAATATTACTGACAGCCCGAAGGCAGACGCTCCCACTCTCCTGGGGAAGAGGGTCTTCTAATCTGCCATCTTAAGGAGGTAAAAGGGCTTGATTGGGTAACTCATTGCAATGGGCACGTATTTATTACTGTCTCCCGGCCTTTTCTCATGCTGTTTGTCTGCTGGAATTACCACTAGTGCCAGGCCATTTGAATATTTGACCATTTGTCTTAGAATTCTCTGAATACAAATGTTTTTCATACCTTTACTATGTACTTTTTAAGAATGAAGACTATGTTGCATGTTGGTTTGTACTCTCTCCTGCACATAAAAAATGCTTAGTAAATAGATACACAAATGTT

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