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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DDX39AP1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:22704753-22704954  UCSC
Coordinates (T2T) chr13:21902823-21903024  UCSC
Coordinates (hg19) chr13:23278892-23279093  UCSC
Strand -
Parental Sequence NM_005804.4
Parental seq. overlap 174 bp
Parental seq. overlap (%) 11.6%
Genomic Region Intergenic
Retrocopy Summary DDX39AP1, located on chr13:22704753-22704954, is a retrocopy of the parental gene DDX39A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DDX39A
Full Name DExD-box helicase 39A
Also known as BAT1|BAT1L|DDX39|DDXL|URH49
Coordinate chr19:14408798-14419341
Strand -
Gene summary This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DDX39AP1
Bonobo Pan paniscus DDX39AP1
Gorilla Gorilla gorilla DDX39AP1
Orangutan Pongo abelii DDX39AP1
Gibbon Nomascus leucogenys DDX39AP1
Green monkey Chlorocebus sabaeus DDX39AP1
Crab-eating macaque Macaca fascicularis DDX39AP1
Rhesus Macaca mulatta DDX39AP1
Baboon Papio anubis DDX39AP2
Golden snub-nosed monkey Rhinopithecus roxellana DDX39AP1
Marmoset Callithrix jacchus DDX39AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DDX39AP1
TCAACATCGTCTTAACTATGGCATGCCTGAAGACTCGGACACCTACCTCCACCCAGTGGCCTGTGCAGGTTGCTTTGGCACTAAAGACCTGGCCATCACTTTTGTGTCTGAGGAGAATGATGCCAAAGCCCTCAATGACATCTAAGACCAGTTTGACGTTAATGTGACAGAGCTTCTGGAGGAAAGCAACATCTCCACATAT
>NM_005804.4
GTCTGAGCGCCCGGCGGAAAACCGAAGTTGGAAGTGTCTCTTAGCAGCGCGCGGAGAAGAACGGGGAGCCAGCATCATGGCAGAACAGGATGTGGAAAACGATCTTTTGGATTACGATGAAGAGGAAGAGCCCCAGGCTCCTCAAGAGAGCACACCAGCTCCCCCTAAGAAAGACATCAAGGGATCCTACGTTTCCATCCACAGCTCTGGCTTCCGGGACTTTCTGCTGAAGCCGGAGCTCCTGCGGGCCATCGTGGACTGTGGCTTTGAGCATCCTTCTGAGGTCCAGCATGAGTGCATTCCCCAGGCCATCCTGGGCATGGACGTCCTGTGCCAGGCCAAGTCCGGGATGGGCAAGACAGCGGTCTTCGTGCTGGCCACCCTACAGCAGATTGAGCCTGTCAACGGACAGGTGACGGTCCTGGTCATGTGCCACACGAGGGAGCTGGCCTTCCAGATCAGCAAGGAATATGAGCGCTTTTCCAAGTACATGCCCAGCGTCAAGGTGTCTGTGTTCTTCGGTGGTCTCTCCATCAAGAAGGATGAAGAAGTGTTGAAGAAGAACTGTCCCCATGTCGTGGTGGGGACCCCGGGCCGCATCCTGGCGCTCGTGCGGAATAGGAGCTTCAGCCTAAAGAATGTGAAGCACTTTGTGCTGGACGAGTGTGACAAGATGCTGGAGCAGCTGGACATGCGGCGGGATGTGCAGGAGATCTTCCGCCTGACACCACACGAGAAGCAGTGCATGATGTTCAGCGCCACCCTGAGCAAGGACATCCGGCCTGTGTGCAGGAAGTTCATGCAGGATCCCATGGAGGTGTTTGTGGACGACGAGACCAAGCTCACGCTGCACGGCCTGCAGCAGTACTACGTCAAACTCAAAGACAGTGAGAAGAACCGCAAGCTCTTTGATCTCTTGGATGTGCTGGAGTTTAACCAGGTGATAATCTTCGTCAAGTCAGTGCAGCGCTGCATGGCCCTGGCCCAGCTCCTCGTGGAGCAGAACTTCCCGGCCATCGCCATCCACCGGGGCATGGCCCAGGAGGAGCGCCTGTCACGCTATCAGCAGTTCAAGGATTTCCAGCGGCGGATCCTGGTGGCCACCAATCTGTTTGGCCGGGGGATGGACATCGAGCGAGTCAACATCGTCTTTAACTACGACATGCCTGAGGACTCGGACACCTACCTGCACCGGGTGGCCCGGGCGGGTCGCTTTGGCACCAAAGGCCTAGCCATCACTTTTGTGTCTGACGAGAATGATGCCAAAATCCTCAATGACGTCCAGGACCGGTTTGAAGTTAATGTGGCAGAACTTCCAGAGGAAATCGACATCTCCACATACATCGAGCAGAGCCGGTAACCACCACGTGCCAGAGCCGCCCACCCGGAGCCGCCCGCATGCAGCTTCACCTCCCCTTTCCAGGCGCCACTGTTGAGAAGCTAGAGATTGTATGAGAATAAACTTGTTATTATGGAAGCCTGGCTCCCACCCCATCTA

Publications

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