Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IPO7P2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:24121034-24123815  UCSC
Coordinates (T2T) chr13:23328056-23330837  UCSC
Coordinates (hg19) chr13:24695173-24697954  UCSC
Strand -
Parental Sequence NM_006391.3
Parental seq. overlap 2289 bp
Parental seq. overlap (%) 36%
Genomic Region Intragenic (SPATA13)
Retrocopy Summary IPO7P2, located on chr13:24121034-24123815, is a retrocopy of the parental gene IPO7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IPO7
Full Name importin 7
Also known as Imp7|RANBP7
Coordinate chr11:9384652-9448127
Strand +
Gene summary The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IPO7P2
Bonobo Pan paniscus IPO7P2
Gorilla Gorilla gorilla IPO7P2
Orangutan Pongo abelii IPO7P2
Gibbon Nomascus leucogenys IPO7P2
Green monkey Chlorocebus sabaeus IPO7P1
Baboon Papio anubis IPO7P2
Golden snub-nosed monkey Rhinopithecus roxellana IPO7P3
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IPO7P2
CTATGTAGATTATTGGTCATTTATTGTAGCACTACATAACTGATTATAAAAATCAGGAAATGAATTGGCACTTTCATATTGAAACAAGCCTGCTAGCCTATGTATAAAATAGCAAAATGTTTGCTGTTTATAAAAAGATGTAATGGGGTGTGAGGCAAGGGTAATTTCAAGTTATTAATTGAAAAACGAACTAGCAATTTTGTACCTGCTGACTTTGTGGTGCGCTCACCTCTGATAGTGACTTGAATTCGGTATGTAAAAAGGGTTTAGTGGTATTTCATTGCTGCTAAAAATGACAGCTCCCTCTGTGTCCTCTTTTCTTAAAGCTGTCAGTGTACAAGTGGGTATTTGAATACCAGACCTTACTGTAAAAAATAAGAAAGGTGGTATCTAGAGCATTTAATTGGATATAAAGTTCTACTCTTAAGAGTTGATCTAAGGGTATGGCTGAACATCTATATATGCAATCTATTAAAAGAACTTAATTCATAACGATCAGATGGAATGCATGTTGCAGAATCATGTACTCCCCCTCTTCAGCAGTGAACTAGGCTACATGAGAGCAAGGGCTTGCTGGGTAATTCACTATTTCTGTGAAGTGAAGTTCGAAAGTGATCAGAACCTTCAAACAGCCTTAGAGCTGACAAGAAGATGTCTGATTGATGATAGAGAAATGCCTGTGAAAGTGGAAGCTGCCATTGCCCTTCAAGTATTGATCAGCAATCAAGAAAAAGCTAAAGAATATATCACACCATTCATCAGACCTGTAATGCAGGCTCTTCTTCATATTATCAGAGAAACAGAAAATGATGACCTTACCCATGCAATTCAGAAAATGATCTGTGAATATAGTGAAGAATTTACTCCTATTGCAGTAGAAATGACACAACATTTGGCAATGACATTTAACCAAGTAATCCAGATGGGGCCAGATGAAGAAGGTAGTGATGACAAAGCAGTTACTGCTATGGGAATTCTGAATACACCTGACACGCTTCTTAGTGTAGCTGAAGATCATTAAGAGATAACCCAACAGCTCGAGGGAATCTGCTTACAGGTCGTTCCTACTGTTTTACAACAGCATGTCTTAGAATTCTATGAGGAGATCTTCTCTTTAGTGCACAGTTTGACATGACAACGAGAGTCTCCACAGATGTGGCAGCTACTTCCCCTTGTATTTGAAGTCTTCCAGCAAGATGGCTTTGATTACTTTACAGATATGATGCTCCTCCTTCGTAATTATGTAACAGTTGATACAGACACACTTCTGTCTGTCACCAAGTATCTTGAAGTGATATACAGTATGTGCAAAAAGGTTCTTACAGGAGTTGCAGGAGAAGATGCAGAGTGTCATGCAACAAAATTGTTAGAGGTCATCGCTCTGCAGTGCAAAGGGCGTGGCACTGACCAGAGGAACCGGGGAGTGATGAAGATGATATTGATGAAGATGGGCAAGAATATTTGGAGATTCTGGCTAAGCAGGCTGGTGAAGATGGAGACGATGAAGACTGGTAAGAAGATGATGCGGAAGAGACTGCTCTGGAAGGCTATTCCACAATCATTGATGATGAAGATAACCCTGTTGATGTGTATCAGATATTTAAAGCTATCTTTCAAACTATTCAAATCGATAGTTTGAATAGTTTCAAACTATCTTTCAAACTATTCAAAATCGTAATCCTGTGTGGTATCAGGCTCTGACTCACCATCTTTCTGAAGAACAAAGAAAACAGTTACAGTATATAGCAATGCTGGCTGATCAAAGAAGAGCAGCCCATGAATCCAAAATGATTGAGAAGCATGGAGGATACAAATTCAGTGCTCCAGTTGTGCCAAGTTCTTTCAATTTTGGAGGCCCAGCACCAGGGATGAATTGAGTTATCTCTTTCTTTCCTGCTGTGTGATTGTAGTGAAGAGCTTGTGTTCGTCCTAGCAGTGGTTCCAGAAGTGGTTCATGTTATCTACTCTAAACTAATGATGAATAGATGGACAAAAGAAACAACAACCCCAGGAGATGGGACCCGATCATGCAACCTGGCACTGGAAAAGAAACCAGCGGGATTTTGGGGGATCGAGGGGGATGGGAGGTACCTTAGGGGGCATATTTCTTTATTTTTTGAAGAAAGGAAGATCCTGACTGTGAAGCTTCAAAGTGACACTGTGGAAATCTGAAACACGAGGGGATGTCATGAAGGCAGCTTTTCTTTTTCTGAGGAAAGAATAGGCAAGGGCTACAGGACTATTTAAAATGTCTCATTTGCAGTATAAAACTCAAAGGTAGATGTAATTTTTACACCTATGAGCATTTGTCCAATTTCTGTCTCTTCCTCACCATTGGGTATCTATTCTTTATATGTCAATAAGATAAGGTAATCTGATAGTATTAATCAAGGAGTTTCTCATGCTCTCACCTGGAAGAATCCAAAGCCCCATATACAAGGCATTATCCAAGATGTTATTTTTCCACTGATGTGCTATACAGATGCTGATGAGGAACTTTGGCAAGAAGACCCTTACGAATATATATGCATGAAGTTTGATGTGTTTGAAGATTTCATTTCTCCTACCACTGCTGCCCAGACACTTTTGTTTACAGCCTGTAGTAAGAGGAAAGAGGTACTGCAAAAGACTATAGGATTTTGTTACCAGATTCTTACAGAACCAAATGCTGACCCTCGAAAAAAAGATGGAGCCCt
>NM_006391.3
CCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCTATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCACTATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAGCACACAAGTCTCTGAATTTTGTCTCAACACTGCTCCAGATTACTATGTCGGAACAGCTGGATTTACCTGTGAGACAGGCAGGTGTTATCTATCTGAAAAATATGATAACACAGTATTGGCCTGATCGAGAAACAGCACCAGGGGATATATCCCCTTATACTATTCCAGAAGAAGATCGCCATTGTATTCGAGAAAATATTGTAGAAGCCATTATCCATTCTCCTGAGCTCATCAGGGTACAGCTTACTACATGCATTCATCACATCATCAAACATGATTATCCAAGCCGCTGGACTGCCATTGTGGACAAAATTGGCTTTTATCTTCAGTCCGATAACAGTGCTTGTTGGCTAGGAATTCTTCTTTGCCTTTATCAGCTTGTGAAAAATTATGAGTATAAAAAACCAGAGGAGCGGAGTCCATTGGTAGCAGCAATGCAGCATTTTCTGCCAGTTCTAAAGGATCGTTTTATCCAGCTTCTTTCTGACCAGTCTGATCAGTCTGTCCTCATCCAGAAACAGATATTCAAGATCTTCTATGCTCTTGTTCAGTATACACTACCACTGGAACTGATAAACCAACAGAACCTGACAGAATGGATAGAAATTTTAAAGACTGTTGTGAACAGGGATGTACCTAATGAAACACTTCAAGTTGAAGAAGATGATCGACCTGAGTTACCATGGTGGAAATGCAAGAAGTGGGCCTTACATATTTTAGCAAGACTTTTTGAAAGATATGGAAGCCCTGGCAATGTTTCCAAGGAGTATAATGAATTTGCTGAAGTATTTCTGAAGGCATTTGCTGTTGGTGTCCAGCAAGTTTTATTGAAGGTGTTATATCAGTACAAGGAGAAGCAATATATGGCTCCTCGAGTTTTACAACAGACATTAAATTATATTAATCAAGGAGTTTCTCATGCTCTCACCTGGAAGAATCTGAAGCCCCATATACAAGGCATTATCCAAGATGTTATTTTTCCATTGATGTGCTATACAGATGCTGATGAGGAACTTTGGCAAGAAGACCCTTACGAATATATACGCATGAAGTTTGATGTGTTTGAAGATTTCATTTCTCCTACCACTGCTGCCCAGACACTTTTGTTTACAGCCTGTAGTAAGAGGAAAGAGGTACTGCAAAAGACTATGGGATTTTGTTACCAGATTCTTACAGAACCAAATGCTGACCCTCGAAAAAAAGATGGAGCCCTGCATATGATTGGCTCTTTAGCTGAAATACTTCTGAAGAAAAAGATCTATAAAGATCAGATGGAATACATGTTGCAGAATCATGTATTCCCTCTCTTCAGCAGTGAACTAGGCTACATGAGAGCAAGGGCTTGCTGGGTACTTCACTATTTTTGTGAAGTGAAGTTCAAAAGTGATCAGAACCTTCAAACAGCCTTAGAGCTAACAAGAAGATGTCTGATTGATGATAGAGAAATGCCTGTGAAAGTGGAAGCTGCCATTGCCCTTCAAGTATTGATCAGCAATCAAGAAAAAGCTAAAGAATATATCACACCATTCATCAGACCTGTAATGCAGGCTCTTCTTCACATTATAAGAGAAACAGAAAATGATGACCTTACCAATGTAATTCAGAAAATGATCTGTGAATATAGTGAAGAAGTTACTCCTATTGCAGTAGAAATGACACAACATTTGGCAATGACATTTAACCAAGTAATCCAGACGGGGCCAGATGAAGAAGGTAGTGATGACAAAGCAGTTACTGCTATGGGAATTCTGAATACAATTGATACACTTCTTAGTGTAGTTGAAGATCATAAAGAGATAACCCAACAGCTTGAGGGAATCTGCTTACAGGTCATTGGTACTGTTTTACAACAGCATGTCTTAGAATTCTATGAGGAGATCTTCTCTTTAGCGCACAGTTTGACATGTCAACAAGTGTCTCCACAGATGTGGCAGCTACTACCCCTTGTATTTGAAGTCTTTCAGCAAGATGGCTTTGATTACTTTACAGATATGATGCCCCTCCTTCATAATTATGTAACAGTTGATACAGACACACTTCTGTCTGACACCAAGTATCTTGAAATGATATACAGTATGTGCAAAAAGGTTCTTACAGGAGTTGCAGGAGAAGATGCAGAGTGTCATGCAGCAAAATTGTTAGAGGTCATCATTCTGCAGTGCAAAGGGCGTGGCATTGACCAGTGCATTCCCTTATTCGTGGAAGCAGCCTTAGAAAGACTGACAAGAGAGGTTAAGACAAGTGAACTTCGAACTATGTGTCTGCAAGTTGCAATTGCAGCTTTGTATTATAATCCACACCTACTACTCAATACCTTAGAAAATCTTCGCTTCCCTAATAATGTTGAACCAGTTACAAATCATTTTATTACACAGTGGCTTAATGATGTTGACTGTTTCTTGGGGCTTCATGACAGAAAGATGTGTGTTCTCGGACTCTGTGCTCTTATTGATATGGAACAGATACCCCAAGTTTTAAATCAGGTTTCTGGACAGATTTTGCCGGCTTTTATCCTTTTATTTAACGGATTGAAAAGAGCATATGCCTGCCATGCAGAACatgagaatgacagtgatgatgatgatgaagctgaagatgatgatgaAACCGAGGAACTGGGGAGTGATGAAGATGATATTGATGAAGATGGGCAAGAATATTTGGAGATTCTGGCTAAGCAGGCTGGTGAAGATGGAGATGATGAAGATTGGGAAGAAGATGATGCTGAAGAGACTGCTCTGGAAGGCTATTCCACAATCATTGATGATGAAGATAACCCTGTTGATGAGTATCAGATATTTAAAGCTATCTTTCAAACTATTCAAAATCGTAATCCTGTGTGGTATCAGGCACTGACTCACGGTCTTAATGAAGAACAAAGAAAACAGTTACAGGACATAGCAACTCTGGCTGATCAAAGAAGAGCAGCCCATGAATCCAAAATGATTGAGAAGCATGGAGGATACAAATTCAGTGCTCCAGTTGTGCCAAGTTCTTTCAATTTTGGAGGCCCAGCACCAGGGATGAATTGAGTTATCTCTTTCTTTCCTGCTGTGTGCTTGTAGTGAAGAGCTTGTGTTCCTCCTAGTAGTGGTTCCAGAACTGGTTCATGTTATCTATTCTAAACTAATAATCAATAGATGGACAAAAGAAACAACAACCCCAGGAGATGGGACCTGATCATGCAACCTGGCACTGGAAAAGAAATCAGCGGGATTTTGGGGGTGGGGGGGGATGGGAGGTACCTTAGAGGGAGTATTTTCTTTATTTTTTGAAGAAAGTAAGATCCTGACTCTGAAGCTTCAAAGTGACACTGTGGAAATCTGAAACGAGGGGATGTCATGAAGGCAGCTTTTCTTTTTCTGAGGAAAAAATAGGCATGGGCTACAGGACTATTTAAAATGTCTCATTTACAGTATAAAACTCAAAGGTAGATGTAATTTTTACACCTATGAGTATTTGTCCAATTTCTGTCTCTTCCTCACCATTGGGTATCTATTCTTTATATGTAAATAAGATAAGGTCATCTGATAGCCTTATTCAGTCTTCATCATTTTCATCATTGTTCCTATGTAGATTATTGGACATTTATTGTAGCACTACATAACTGATTATAAAAATCTGTAAATGAATTAGCACTTTCATATTGAAACAAGCCTGCTAGCCTATGTATAAAATAGCAAAATGTTTGCTGTTTATAAAAAGATGTAATGGGGTGGGGGGCAGGGGTAATTTCAAGTTATTAATTTAAAAATGAACTAGCAATTTTGTACCTGGTGACTTTGTGGTGCACTCACCTCTGATAGTGACTTGAATTCGGTATGTAAAAAGGGGTTAGTGGTATTTCATTGCTGCTAAAAATGACAACTCCCTCTGTGTCCTGTTTTTCTTAAAGCTGTCAGTGTACAAGTGGGTATTTGAATACCAGACCTTACTGTAAAAAATAAAAAAGGTGGTATCTAGAGCATGTAAATTGGATATAAAGTTCTGCTCTTAAAGAGTTGATCTAAGAGTATGGCTAAACATCTATATATGCAATCTATTAAAAGAACTTAATTCGGCTATTATGTCTTGATTTGATTGCAGTTTTTTCCTAATTATAACAAATTTTTCCTCATTGGCCTGTTTTTAATCCTGTGCCTAGAAGGAGTACAAAATGCACACTTTACAAAATTGATATTTAACACTTACCCACTCCCCTTTCCCCATCTCTTCTACCGCTCTTGTTGATCGTGGTATCTGATCTTGACTAGATAGGCTGAAGGCACATGGTTCCCTCCAAAAACCACTATTGATACCACTACAAAAACAAGCCAGCAAAAAGATACTGTAGAGAGGTTGGCTTGCTTCCCTCTCTTCCTAACTGCATGTTGAAAAATAAGCCGTTATTGATCTTAAACATCGGTCAGATGAGTCATACATTGGGTTATTTTTTATATACATGTATACACAAAATATTTCAAATTGAAAGCAACATCTTAATGGATTCAAAACTATTACAAGCTGTTGTCTAAAACAGGTGAGAAAAAAATTTATAACTGTAAAAACAAATGCACATATTGATATTTAAAATGCGTAATTAAGAAAACCCATTGTTGTTGTGTTTTTCTTGTATACCAATAATTAAGCCACTACTGTTGGCACTGTTTGGTTTTCTATTTTAACACTGAAGGAGTGAAAGTATTTCCTATATTTATGAATTTACTACTAAAATCTTGGCAAAAAAAGAAAAAAATTGTCTAACGTGTGTGGGTGAAAACTGTTAATCAAGTGTTTCTACTCCCCCCCGAAAATCCCCTGAAAGTTGGACACCAACTGTATACCCTAGGTTGCTTAAAGGGATTTCACTATTATATAAAGTCAATAAAAATGAAGTAGTTGTATATATGCAACATTGTGTACAGAGGGGAAATAATGAATAGTATTAAAGAAACATTCTCGTCTTCCTTTACCTTTAATCCCCTAATACCTAGTCTACTTTTTAAATTTTCAGACTTCACTGCTTTTTGAATTCATAATTCTAATTTTCACATTATTGTTAATGGAAAATCATATCTAATAAAGGTTTTAGTTATTCCCATGCACAGTATGAAAATTCTCATTTGCTGAGGTTTTGTTTCAAGAAAATGTATTGGCATGTCTTTGAGAACATGTTTTATTGTCTCCTGTGTCATATAATCCAAACTAATCTCCGTTTACAGACTTTAACTTGAAATTAGACCTTATAATTAAACTATTTAAATAGTGTTCAAATGATAGTTTCTAATGCATCAAATATATACCTCAGTTTTCATGATTTCCTTTAACATTATAATTTGGTATAGATCAAGAATCTTAACATGTATCAGTTTCTAGATGAGGCTGCAGGATTTTTGGAAAACTTTTTGAATGTATTTACAATATTCTCTTGTAATTAGCTACATAGGGACTTGTCTTTTTTTCTTTTTACATACAGCTTTTCCTACAGTTTTATTACCCTGTAATTTTTTTTTAGTTGTAGAAGTTAATTCTGATTTTGTGTGGATTTCAGTATTTGTCTTTGTTAATGGCACATATTAGCATAAATCACTTTTGTAAATGTAAGCTTTCTTTTTTTTTCTTGAAAAAGCCTTTCTATTTATCAGTATTAAATAAAGGAAGTTAATCTGTTTCTCTGCAGGTAATAAAATAGTGACACACTGTATTAAGATAGTGACTGCTATACTCAACTCTGGAAGAGACTAGAGTATAGAGCATGAGTGGCAAAACCACAGCCCTTGGGCCATATGCTGCTATTCAGTCCCAGATGTAGCCCCTGAAGCAAGCATAAAGAAAAATGAATTAAAAATTAAATTAATATGGAAAGTTAAAAAATGGATTACATTAGTATGACTAAACCATGTCTTTGGCAAAGATCTAACACAATGTCTTAAGTATAATAGGTAGTCTCTGTTTGTAAAATAAATGACTTAAATTTAAAACATCA

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