Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CYP51A1P2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:28720867-28724155  UCSC
Coordinates (T2T) chr13:27944147-27947435  UCSC
Coordinates (hg19) chr13:29295004-29298292  UCSC
Strand -
Parental Sequence NM_000786.4
Parental seq. overlap 2332 bp
Parental seq. overlap (%) 67.9%
Genomic Region Intergenic
Retrocopy Summary CYP51A1P2, located on chr13:28720867-28724155, is a retrocopy of the parental gene CYP51A1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CYP51A1
Full Name cytochrome P450 family 51 subfamily A member 1
Also known as CP51|CYP51|CYPL1|LDM|P450-14DM|P450L1
Coordinate chr7:92112153-92134803
Strand -
Gene summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CYP51A1P2
Bonobo Pan paniscus CYP51A1P2
Gorilla Gorilla gorilla LOC101127636P2
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CYP51A1P2
CTCCCTGCTTCCTCTCTAGAATCCAATTAGGGATGTTTGTTACTACTTATGTTGATTAAAACAGTTAACAAACTTTTTTTCTTTTTAAAATGTGAGATCAGTGAACTCTGGTTTTAATATAATCTGAAACAAGGTCCTTGGGAGTAATATAATTGGTCACATTCTGTAAAGCACATTCTGTTTAGGAATCACTTATCTCAAATTATAACTCAGGGCCTAACTATATGAGATGGCTGAAAAAATACCACATTGTCTGTTTTCACTAGATGATGCCAAAATATTTTGCTTTACGTATATTACAGTTCTTTTTAAAACACTGGAAGACTCATGTTAAACTCTAATTGTGAAGGCAGAAACTCTGCTAATTTTTCACATTAAAATTCTCTTTGAAAAAATGAAAAAGAAACAAAGGAGTACTTTCAGAGTTGGGGAGAAAGTGGAGAAAAAAATGTGTTTGAAGCTCTTTCTGAGCTCATAATTTTAACAGCTAGCCACTGTTTGCATGGAAAGGAAATCAGAAGTCAACTCAATGAAAAGGTAGCACAGCTGTATGCAGATTTGGATGGAGGTTTCAGCCATGCAGCCTGGCTCTTACCAGGTTGGCTGCCTTTGCCTAGTTTCAGATGCAGGGACAGAGCTCATTGGGAAATCAAGGATATTTTCTATAAGGCAATCCAGAAACGCAGACAGTCTCAAGAAAAAATTGATGACATTCTCCAAACTTTACTAGATGCTACATACAAGGATGGGCGTCCTTTGACTGATGATGAAGTAGCAGGGATGCTTATTGGATTACTCTTGGCAGGGCAGCATTCATCCTCAACTACTAGTGCTTGGATGGACTTCTTTTTGGCCAGAGACAAAACACTTCAAGAAAAATGTTATTTAGAACAGAAAACAGTCTGTGGAGAGAATCTGCCTCCTTTAACTTATGACCAACTCAAGGATCTAAATTTACTTGATCGCTGTATAAAAGAAACATTAAGACTTAGACCTCCTATAATGATCATGATGAGAATGGCCAGAACTCCTCAGACTGTGGTAGGGTATACCATTCCTCCAGGACATCAGGTGTGTGTTTCTCCCACTGTCAATCAAAGACCTAAAGACTCATGGGTAGAACGCCTGGACTTTAATCCTGATTGCTACTTACAGGATAACCCAGCATCAGGGGAAAAGTTTGCCTATGTGCCATTTGGAGCTGGGTGTCATCGTTGAATTGGGGAAAATTTTGCCTATGTTCAAATTAAGACAATTTGGTCCACTATGCTTCGTTTATATGAATTTGATCTCATTGATGGATATTTTCCCATCGTGAATTATACAACTATGATTCACACCCCTGAAAACCCACTTATCCATTACAAACGAAGATCAAAATGAAAAAGGTTGCAAGGAACCAATATATGTGATCATCACTGTAAGCCACAAAGGCATTCGAAGAGAATGAAGTGTACAAAACAACTCTTGTAGTGTACTGTTTTTTTTGAGTGTGTAATTCTAAAAGCCAGTTTATGATTTAGTATTTTGTTAACTGAATGGTTCTATCAAATATAATAGCATTTGAAACATTTTCTAATAGCTATGATACTTATACATGTGCTTTCAGGAAGTTCATTAGTAAAACAATTGTTCAGGAGGATCTAGGTAATTGGCAGATTCTAAATAATATAATTTCCAGGTAGTAATTTTAAGAGTACTCTTAGCTCTTGCCAAATAAGTTCAGGGTATTCAAATCTTGGACTAGTCCTGCAAGGTATAAAGAATAAAAATCCCGGTGAGATACTTGGAAACCTCAGGTTATTATTTATCTGGGCAATTATTGTGTGGGTGAGGATGGAAGGGCAGGGAATAATTGAACATCTAAAGCCTTGAATGAGAGAATACTAATTCTTTTGGTATGATGATACTCAGAAATGGAGATGTTGTAGAAAAAAAATATCCTTTGGAATTTTAACTAAAATCACTGAATATAGGAAATTAAGAGATCCGGGACCATATTTGATAAGATTTCCTAAAAATAATGTAATTATTAATGCCAAAAACTGCTCATGTATCTTGATCTAATTACGAAATAATTACATATTTACCTGATAAATATGTATCTAGGTCTTCAAGGTCACATTTATGTGGAAGTCCAAAGTCAAGTCCTTAGGGGATAATTTTGTTTTGGCTCAGTTGTTCCCTGCTTCCTCTCTCTCTCAGTAGGAGACCTGGGGGCCGGAGCCGCCTGTGGACAACCATCCGCCAGCTTCTCTCGCTCCGTCGATTAGGAGGAGTGGTGGCGACCTCGGCCTTCAGTGTCTCCAATGAAGTGAAATGGCGGCAGCGGCGGGGATGATGTTGCTGGGCTTGCTGCAGGCGGGGTGGGTCGGTGCTGGGCCAGGCGATGGAGAAGGTGACAGGAGGCAACCTCTTGTCCATGCTGCTGATCGCCTGCACCTTCACCCTCAGCCTGGTCTACCTGTTCCGTCTGGCCGCCGGCCACTTGGTCCAGCTGCCCGCAGGGGCGAAAAGTCCTCCATACGTTTTCTCCCCAGTTCCATTCCCTGGGCATGCCATAGCATTTGGGAAAAGTCCAGTTGAATTTCTAGAAATGCATATGAGAAGTATGGACCTGTATTTAGTTTTACCATGGTAGGCAAGACATTTACTTACCTTCTGGGGAGTGATGCTGCTGCGCTGCTTTTTAATAGTAAAAATGAAGACCTGAATGCAGAAGATGTCTACAGTCACCTGACGACACCTGTGTTTGGGAAGGGAGTTGCATACGATGTGCCTAATCCAGTTTTCTTGGAGCAGAAGAAAATGTTAAAAAGTGGCCTTAACAAAGCCCACTTTAAACAGCATGTTTc
>NM_000786.4
AGTAGGAGACCTGGGGCAAGGCCCCCTGTGGACGACCATCTGCCAGCTTCTCTCGTTCCGTCGATTGGGAGGAGCGGTGGCGACCTCGGCCTTCAGTGTTTCCGACGGAGTGAATGGCGGCGGCGGCTGGGATGCTGCTGCTGGGCTTGCTGCAGGCGGGTGGGTCGGTGCTGGGCCAGGCGATGGAGAAGGTGACAGGCGGCAACCTCTTGTCCATGCTGCTGATCGCCTGCGCCTTCACCCTCAGCCTGGTCTACCTGATCCGTCTGGCCGCCGGCCACCTGGTCCAGCTGCCCGCAGGGGTGAAAAGTCCTCCATACATTTTCTCCCCAATTCCATTCCTTGGGCATGCCATAGCATTTGGGAAAAGTCCAATTGAATTTCTAGAAAATGCATATGAGAAGTATGGACCTGTATTTAGTTTTACCATGGTAGGCAAGACATTTACTTACCTTCTGGGGAGTGATGCTGCTGCACTGCTTTTTAATAGTAAAAATGAAGACCTGAATGCAGAAGATGTCTACAGTCGCCTGACAACACCTGTGTTTGGGAAGGGAGTTGCATACGATGTGCCTAATCCAGTTTTCTTGGAGCAGAAGAAAATGTTAAAAAGTGGCCTTAACATAGCCCACTTTAAACAGCATGTTTCTATAATTGAAAAAGAAACAAAGGAATACTTTGAGAGTTGGGGAGAAAGTGGAGAAAAAAATGTGTTTGAAGCTCTTTCTGAGCTCATAATTTTAACAGCTAGCCATTGTTTGCATGGAAAGGAAATCAGAAGTCAACTCAATGAAAAGGTAGCACAGCTGTATGCAGATTTGGATGGAGGTTTCAGCCATGCAGCCTGGCTCTTACCAGGTTGGCTGCCTTTGCCTAGTTTCAGACGCAGGGACAGAGCTCATCGGGAAATCAAGGATATTTTCTATAAGGCAATCCAGAAACGCAGACAGTCTCAAGAAAAAATTGATGACATTCTCCAAACTTTACTAGATGCTACATACAAGGATGGGCGTCCTTTGACTGATGATGAAGTAGCAGGGATGCTTATTGGATTACTCTTGGCAGGGCAGCATACATCCTCAACTACTAGTGCTTGGATGGGCTTCTTTTTGGCCAGAGACAAAACACTTCAAAAAAAATGTTATTTAGAACAGAAAACAGTCTGTGGAGAGAATCTGCCTCCTTTAACTTATGACCAGCTCAAGGATCTAAATTTACTTGATCGCTGTATAAAAGAAACATTAAGACTTAGACCTCCTATAATGATCATGATGAGAATGGCCAGAACTCCTCAGACTGTGGCAGGGTATACCATTCCTCCAGGACATCAGGTGTGTGTTTCTCCCACTGTCAATCAAAGACTTAAAGACTCATGGGTAGAACGCCTGGACTTTAATCCTGATCGCTACTTACAGGATAACCCAGCATCAGGGGAAAAGTTTGCCTATGTGCCATTTGGAGCTGGGCGTCATCGTTGTATTGGGGAAAATTTTGCCTATGTTCAAATTAAGACAATTTGGTCCACTATGCTTCGTTTATATGAATTTGATCTCATTGATGGATACTTTCCCACTGTGAATTATACAACTATGATTCACACCCCTGAAAACCCAGTTATCCGTTACAAACGAAGATCAAAATGAAAAAGGTTGCAAGGAACGAATATATGTGATTATCACTGTAAGCCACAAAGGCATTCGAAGAGAATGAAGTGTACAAAACAACTCTTGTAGTTTACTGTTTTTTTAAGTGTGTAATTCTAAAAGCCAGTTTATGATTTAGGATTTTGTTAACTGAATGGTTCTATCAAATATAATAGCATTTGAAACATTTTCTAATAGTTATGATACTTATACATGTGCTTTCAGGAAGTTCCTTGGTGAAACAATTGTTGAGGGGGGATCTAGGTAATTGGCAGATTCTAAATAATATAATTTCCAGATAGTAATTTTAAGAGTACTCATCGCTCTTGCCAAATAAGTTCAGGGTATTCAAATCTTGGACTAGTCCTGCAAGGTATAAAGAATAAAAATCCCAGTGAGATACTTGGAAACCACAGTTTATTATTATTTATCTGGGCAATTATTGTGTGTGTGAGGATGGAAGGGTAGGGAATAATCGAACATCTAAAGCCTTGAATAAGAGAATACTAATTGTTTTGGTATGATGATACTCAGAAATGGAGATATTATAGGAAAAAGAAATCCTTTGGAATTTTAACTAAAATCACTGCATATGGGAAATTAAGAGATCCAGGACCATATTTGATAAGAGTTCCTAAAAATAATGTAATTATTAATGCTAAAGACTGCTCATGTATCTTGATCTAATTACTAAATAATTACATATTTATTTACCTGATAAATATGTATCTAGTTCTACAAGGTCACATTTATGTGGAAGTCCAAAGTCAAGTCCTTAGGGGATAATTTTGTTTTGGCTCAGTTGTTCCCTGCTTCCtttttttttttttttttttgagatggagtctcgctctgttgcccaggctggagtgcagtggtgcgatctcagctcactgcatcctctgcctcccgggttcaagcaattctctgcctcagcctcccaagtagttgggattacaggcacctgccaccatgcctggctaattttttgtatttttagtagagacgggggtttcactatgttggctaggctggtcttgaactcctgacctcgtgatccacccgccttggcctcccaaagtgctgggattacaggcatgagccaccgcacctggccTTCCCTGCTTCCTCTCTAGAATCCAATTAGGGATGTTTGTTACTACTCATATTGATTAAAACAGTTAACAAACTTTTTTCTTTTTAAAATGTGAGATCAGTGAACTCTGGTTTTAAGATAATCTGAAACAAGGTCCTTGGGAGTAATAAAATTGGTCACATTCTGTAAAGCACATTCTGTTTAGGAATCAACTTATCTCAAATTGTAACTCGGGGCCTAACTATATGAGATGGCTGAAAAAATACCACATCGTCTGTTTTCACTAGGTGATGCCAAAATATTTTGCTTTATGTATATTACAGTTCTTTTTAAAACACTGGAAGACTCATGTTAAACTCTAATTGTGAAGGCAGAATCTCTGCTAATTTTTCAGATTAAAATTCTCTTTGAAAAAA

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