Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name CSNK1A1L
Wait
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:37103269-37105282  UCSC
Coordinates (T2T) chr13:36322451-36324464  UCSC
Coordinates (hg19) chr13:37677406-37679419  UCSC
Strand -
Parental Sequence NM_001892.6
Parental seq. overlap 1814 bp
Parental seq. overlap (%) 33.8%
Genomic Region Intergenic
Retrocopy Summary CSNK1A1L, located on chr13:37103269-37105282, is a retrocopy of the parental gene CSNK1A1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CSNK1A1
Full Name casein kinase 1 alpha 1
Also known as CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975
Coordinate chr5:149492982-149551439
Strand -
Gene summary Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CSNK1A1P4
Bonobo Pan paniscus CSNK1A1P4
Gorilla Gorilla gorilla CSNK1A1P4
Orangutan Pongo abelii CSNK1A1P3
Gibbon Nomascus leucogenys CSNK1A1P3
Green monkey Chlorocebus sabaeus CSNK1A1P2
Crab-eating macaque Macaca fascicularis CSNK1A1P5
Rhesus Macaca mulatta CSNK1A1P5
Baboon Papio anubis CSNK1A1P5
Golden snub-nosed monkey Rhinopithecus roxellana CSNK1A1P5
Marmoset Callithrix jacchus CSNK1A1P1
Mouse lemur Microcebus murinus CSNK1A1P3
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.51
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth012
log10(TPM+1)

Related Sequence

>CSNK1A1L
CCCAGCCTCCATCTTTGCCTCTCAGGATGACAAACAACAGCGGCTCCAAAGCCGAACTCGTTGTGGGAGGGAAATACAAACTGGTGCGGAAGATCGGGTCTGGCTCCTTTGGAGACGTTTATCTGGGCATCACCACCACCAACGGCGAGGACGTAGCAGTGAAGCTGGAATCTCAGAAGGTCAAGCACCCCCAGTTGCTGTATGAGAGCAAACTCTACACGATTCTTCAAGGTGGGGTTGGCATCCCCCACATGCACTGGTATGGTCAGGAAAAAGACAACAATGTGCTAGTCATGGACCTTCTGGGACCCAGCCTCGAAGACCTCTTTAATTTCTGTTCAAGAAGGTTCACCATGAAAACTGTACTTATGTTAGCCGACCAGATGATCAGCAGAATTGAATACGTGCATACAAAGAATTTTCTACACCGAGACATTAAACCAGATAACTTCCTGATGGGTACTGGGCGTCACTGTAATAAGTTGTTCCTTATTGATTTTGGTTTGGCCAAAAAGTACAGAGACAACAGGACCAGGCAACACATACCGTACAGAGAAGATAAACACCTCATTGGCACTGTCCGATATGCCAGCATCAATGCACATCTTGGTATTGAGCAGAGCCGCCGAGATGACATGGAATCCTTAGGCTACGTTTTCATGTATTTTAATAGAACCAGCCTGCCGTGGCAAGGACTAAGGGCTATGACAAAAAAACAAAAATATGAAAAGATTAGTGAGAAGAAGATGTCCACCCCTGTTGAAGTTTTATGTAAGGGGTTTCCTGCAGAATTCGCCATGTACTTGAACTACTGTCGTGGGCTGCGCTTTGAGGAAGTCCCAGATTACATGTATCTGAGGCAGCTATTCCGCATTCTTTTCAGGACCCTGAACCACCAATATGACTACACATTTGATTGGACGATGTTAAAGCAGAAAGCAGCACAGCAGGCAGCCTCTTCCAGTGGGCAGGGTCAGCAGGCCCAAACCCAGACAGGCAAGCAAACTGAAAAAAACAAGAATAATGTGAAAGATAACTAAGCGTGAATGAGGAACAGAAGAAGCAGAGCAGATGATTCGAGCAGCATTTGTTTCTCCCCACATCTAGAAATTGTAGTTCATATGTACACCAGCTAGTGGCTGTGAACAACCATTTAGTTGGTGTAAAAAACTTTATTTCAATATAAACTGACTCTGGGGAGCGTTGGTGATGCTGTATCCCAAAGTGTAGCCTCTGTAATTGTGAATATTAACTGAGGTAGTGAAACGTGGTGTCTGGTTTTCTATTGCATTTATTCAAGTAGAAAAGTTAACTAAATGGTTGACACACACGAATTGGTGGAGACATTGTCCATATGCCAATTTTTTGTTAAAACCTTTTATTTTGAACTAGACTGCTTTGAGATATCATTTCAGAAGGACAGTATTCAGCCACAGCTGCAAAGGTTGTAAATGCTTATGATTGAGCATTTTTAGGGTTTCTCCATCCCTGGGGTTTGCAAATTGTTCACATAAAGAGCATTCTTAAAATGGTTGGCTTCTTGTCTGTAAGCCAGCTGATCTAGTAGTAACCAAAAATTCCAGTTTTGAGAATAGGAAAGATTCCGCCTGCTTACCTGTGAAGACATAAGAAAATCTTAGTAACTACCAGATTATCTTTAGAATTCCACATTAACTATATCATGTTCTCGGTATTTTAAAAACAACAACAACCATATTTGTCACAGAAATTTAGTTAACATCTTACAACTGAACATGTATGTACATGGCTTAGATAAATGTAATCACCGTAAACACCCATATGATCTGGGATTTTGTTCATATTTTGAAATGGGAGCTTTTATGTTTTACAAGTTCACTAAAATCTGAAAACTGTTTCTATAAGGAAATAATACTTTTTTAAACAACAACCAAAAAATGCCTTGCTGATTCACTAGGAAATAAAAATCTCCCCAATTTTTTGATAGTCAACTTCGAGCCATTTGTTACATGATATTCCCTTGCAAGTAAATTTT
>NM_001892.6
CCCAGAGTGCTCTGCGCCGTGAAGAAGCGGCTCCCGGGGACTGGGGGCATTTTGTGTTGGCTGGAGCTGGAGTAACAAGATGGCGTCGTCCGCGGAGTGACAGGGGTCCCTCTGGGCCGGAGCCGGCGGCAGTGGTGGCAGCGGTATCGCCGCCCTAGCTCACCGCGCCCCTTTTCCAGCCCGCGACGTCGCCGCGCAAGCGAGGCAGCGGCGGCCGCCGAGAAACAAGTGGCCCAGCCTGGTAACCGCCGAGAAGCCCTTCACAAACTGCGGCCTGGCAAAAAGAAACCTGACTGAGCGGCGGTGATCAGGTTCCCCTCTGCTGATTCTGGGCCCCGAACCCCGGTAAAGGCCTCCGTGTTCCGTTTCCTGCCGCCCTCCTCCGTAGCCTTGCCTAGTGTAGGAGCCCCGAGGCCTCCGTCCTCTTCCCAGAGGTGTCGGGGCTTGGCCCCAGCCTCCATCTTCGTCTCTCAGGATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTACGGAAGATCGGGTCTGGCTCCTTCGGGGACATCTATTTGGCGATCAACATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAGAGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATGGATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATGATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGTAATAAGTTATTCCTTATTGATTTTGGTTTGGCCAAAAAGTACAGAGACAACAGGACAAGGCAACACATACCATACAGAGAAGATAAAAACCTCACTGGCACTGCCCGATATGCTAGCATCAATGCACATCTTGGTATTGAGCAGAGTCGCCGAGATGACATGGAATCATTAGGATATGTTTTGATGTATTTTAATAGAACCAGCCTGCCATGGCAAGGGCTAAAGGCTGCAACAAAGAAACAAAAATATGAAAAGATTAGTGAAAAGAAGATGTCCACGCCTGTTGAAGTTTTATGTAAGGGGTTTCCTGCAGAATTTGCGATGTACTTAAACTATTGTCGTGGGCTACGCTTTGAGGAAGCCCCAGATTACATGTATCTGAGGCAGCTATTCCGCATTCTTTTCAGGACCCTGAACCATCAATATGACTACACATTTGATTGGACAATGTTAAAGCAGAAAGCAGCACAGCAGGCAGCCTCTTCCAGTGGGCAGGGTCAGCAGGCCCAAACCCCCACAGGCAAGCAAACTGACAAAACCAAGAGTAACATGAAAGGTTTCTAAGCATGAATTGAGGAACAGAAGAAGCAGAGCAGATGATCGGAGCAGCATTTGTTTCTCCCCAAATCTAGAAATTTTAGTTCATATGTACACTAGCCAGTGGTTGTGGACAACCATTTACTTGGTGTAAAGAACTTAATTTCAGTATAAACTGACTCTGGGCAGCATTGGTGATGCTGTATCCTGAGTTGTAGCCTCTGTAATTGTGAATATTAACTGAGATAGTGAAACATGGTGTCCGGTTTTCTATTGCATTTTTTCAAGTGGAAAAGTTAACTAAATGGTTGACACACAAAAATTGGTGGAGAAATTGTGCATATGCCAATTTTTTGTTAAAACCTTTTGTTTTGAACTATACTGCTTTGAGATCTCATTTCAGAAGAACGGCATGAACAGTCTTCAGCCACAGTTGTGATGGTTGTTAAATGCTCACAATTGTGCATTCTTAGGGTTTTTCCATCCCTGGGGTTTGCAAGTTGTTCACTTAAAACATTCTTAAAATGGTTGGCTTCTTGTCTGCAAGCCAGCTGATATGGTAGCAACCAAAGATTCCAGTGTTTGAGCATATGAAAGACTCTGCCTGCTTAATTGTGCTAGAAATAACAGCATCTAAAGTGAAGACTTAAGAAAAACTTAGTGACTACTAGATTATCCTTAGGACTCTGCATTAACTCTATAATGTTCTTGGTATTAAAAAAAAAGCATATTTGTCACAGAAATTTAGTTAACATCTTACAACTGAACATGTATGTATGTTGCTTAGATAAATGTAATCACTGTAAACATCTATATGATCTGGGATTTTGTTTTTATTTTGAAATGGGAGCTTTTTTGTTTACAAGTTCATTAAAAACTAAAAACTGTTTCTGTAAGGAAATGAGATTTTTTTTAAACAACAAAAAATGCCTTGCTGACTCACTATTAAATAAAAATCTCCCCAATTTTTTGATAGACTACTTCAAGCCATTTGTTACATGGTATTCCTTTGCAAGTCAATTTAGGTTTCGTGTTATAACTTTTCCTCTTTTTTTAAGAAAAATGAAAAAAGTAATTCTTTTGTCTGAAGGGGAAAGGCAttctttcatttttttctttttttttttttttttttATGACTTGCAGGCACAATATCTAGTACTGCAACTGCCAGAACTTGGTATTGTAGCTGCTGCCCGCTGACTAGCAGCTGGACTGATTTTGAATAAAAATGAAAGCATTAAAGGGTTTCCCTACAAAACATTTTTCTTTAAAATACTTTTGAAATGGCTATAAGCAGTTGACTTTCACCCTTGGAGAGCATCACACTGTGTGAGGTTCAGTGATTGTTGACCCTCCCCAGCCCCTCCTGCTTCTTTAAGTTATCTGTGTGCGTGCGCTTCCTCTCAATCTTCTTTGCACGCTCATTTCTTTTTCTCTGACCCATGAGAAAGGAAAACTTACTGATGATAATTTTTAAATAGTGTAATTTATTCATTTATAGCATGTCAGGATAAATTAAAAGAACATTTGTCTGGAAATGCTGCCGGGAGCCTATTGTGTAAATGTAGGTATTTTGTAAAATAACCTTGAAATTGTAAATTGACACGTGTTTGGTCAGATTGTGTCAAGTTTAAtttgttttgttttcttttttcttttttttatttGAAAACTACTTTAGCAATAATTAATTCCATGATTATCACATTCTGCCATTAAGGGATATTAGTACCGTAATACTGAAGAAATTTTATTAAGTCTGAACTTCTGGGGTAGGCAGCTTCTTTGTTTCTTTTCTATCCACCCTTGTCGGTTGAGGTATTTGTTTCTTGACTAATAAACCCTTTGATACTTTTAGCCAGAAATCAGTCTCATAAAGCTATTTTTGAGTATAGTTTGTGTAAAATAAAAATGTTTAGCTTTGGTAATAACTTCCAAGCTGAACTCCCTCTAGCAAGATATTTTTCAGTGCTTTTATTTACTATGCACTTAGACTATGCACTTTTTCTGAAATATTTTTGTAACACTTTTTTGTATTTTTGCCATTTGAAAAGGTTGTGGTGTAGTTGGTCTGTAATTAAGTTGCAGATTTAAAACTGCTGTTAGCTTTGTAAATCAAAATATAGGTGTTTTTTGTCCTGGTATATCGTCATTCCATCTGCAGCTGGAGCTGGAATCCCATTGATCTTCTAGCTACCATTCATTTTCTTCACTGTTCACAAAAGAAGAGTGTGAAATTCAGTGAATGCTGTTACTAATCCTGTTACGAGATGAATCTCATTTCACCAAAATTAAATTATGTTTTTCCGCTAAAATGATGATACAAGTTGAAGACACATCACTCTGAAATTGGAAGACCTCACCACTTAAGGCTCCACAGTGGCTTACTCAGCTGAACTCTAGGTTACTACTCTTTACTTTGTTCACCCATTGGGGGGTGCAGTTTTTTTAAAATGTTGGGAGATGGCCATTCTAACTACTGTTGAATGTCTCTGTTTTGGGAAGGTATAACAAGAAATAAAAAAGAATATATATGAAGGGAGAGACTGGTTATCTCCTCCCATATGGTTGTGCTTATCCTCTTATGGCTTACAAATGAATATTTGGAGGTTTGCTTTCACAATGATTTCCCATCAACAAATATTTTTAGTAGGATTTTTCCTGTTTCTGTTAGTCCTTGCAGTACTCATAAATGTTTTAAGCTGAGCATACTGTAATAGTCATAAGTTTAATTTCATTATAATAAAAATAATCAAACAAAAGGACTTTAGAACCCAAGACAATGAGCTAGTTTTCCCTAAAGTTTGCTGAACTATTAAGGAATATGTTCTTATAGCTTTTGACTAGAATGAGTCATGGGAATTCTAAGAAGGGATGGCCTAGACATTTTTAGCTCAGTTAAATTCAGCATTTAATGCAGGTGAGTTCCTGGGTCGTTTTCCAACTAGTCTGGAACAGTCTGGTTCTGACTCAAACTGGTATAAAGCATTATTTTAGGTTTTCTCTTTGCCAGTTTTTAAGCAGTTATAACCATGTAAATCAAGATGTGAGGACATCTATATGAAGTATAGTAAAGAAGTGGTGTCAGCAGATCAATATGTGTGTCCTGGGTGTGCTGCTCTCTTAAGTGAGACTTTGTGAGACTATACTTTAAATGCATTATTACCATTGCTTACATTTTGGGGGATTTTCTTCCTCCTCAAAACTTCCATTTCTATTGTAATATTCTTAATGACAATCTTTTTTTTTTTTTAGCAGTGTATGTTTGAAACAGCCAAAGATGGCGATGAACCAAGTGTAAATTGATCTAAGCAGCCCATGCAGTTTGTGTTGAATCAACAAACAGTGTATTGTTGAAGTGAAATTATTTTCTGAAATGACTTGTTAGACCAGTTTTGAGGACATACTCAAAAGTAGAGTAATAATGGCTCctgggatggagaaatatgagatgaacctggaacattctattatggtgccacaaaggaaatctaaaaaaaaaaaaaaaaaaaaaagtggttggctaggagcagtggcacacgcctgtgattccagcactttgggaggccgaagtgggcaggagttcaagaccagcctggccaacatagtgaaaccctgtctctactaaaaatacaaaaattagccgggtgtggtggcgggcgcctgtaatcccagcttttcaagaggctgaggcagaagaatcgcttgaacccgggagatggaggttgcagtgagctgagatcgtgccactgcactccagcctgggcgttgcagtgagactccgtctcaacaacaacaaaaaggtggatacatgtcaaaagggcacaggagccacttgaaggattatacttgctaaatctgtgtcaattatcaaaataaactggtagcaacgtta

Publications

PMID - Link Title
37257767Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src.
36736316Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.
36215168TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.
35563538Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling.
35271311OpenCell: Endogenous tagging for the cartography of human cellular organization.
33961781Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
31980649Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
31586073The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.
31152661The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing.
29523541Peli1 Modulates the Subcellular Localization and Activity of Mdmx.
29229926Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.
28675297A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
28514442Architecture of the human interactome defines protein communities and disease networks.
28380382A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
27637333Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.
26885983The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.
26186194The BioPlex Network: A Systematic Exploration of the Human Interactome.
25720964FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.
24332808PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
23362303Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
21988832Toward an understanding of the protein interaction network of the human liver.
21873635Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
20360068Systematic analysis of human protein complexes identifies chromosome segregation proteins.
17620599Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
15489334The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11708798The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.
8051045Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.