Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name PLA2G12AP2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:38902304-38902782  UCSC
Coordinates (T2T) chr13:38119019-38119497  UCSC
Coordinates (hg19) chr13:39476441-39476919  UCSC
Strand +
Parental Sequence NM_030821.5
Parental seq. overlap 393 bp
Parental seq. overlap (%) 7.5%
Genomic Region Intergenic
Retrocopy Summary PLA2G12AP2, located on chr13:38902304-38902782, is a retrocopy of the parental gene PLA2G12A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PLA2G12A
Full Name phospholipase A2 group XIIA
Also known as GXII|PLA2G12|ROSSY
Coordinate chr4:109709989-109730070
Strand -
Gene summary Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PLA2G12AP2
Bonobo Pan paniscus PLA2G12AP2
Gorilla Gorilla gorilla PLA2G12AP2
Orangutan Pongo abelii PLA2G12AP2
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PLA2G12AP2
ATCCTGCTTCTCTTCCTGGCCTCTGCTTTCAGGTGCCAGAAGCAGGCCCAGACCACTGATTGCAGGGCCAGCCTGAAGACCACAGGAATGGTATTCACCAGATAGACACATACCCAAGTGCCACCTTGGACCTCTGGGAGGCAAGGATGGGTTCTGCCAGCATGAGTGCCTTTCCCACATTGCAATTATAAACCCTCCTGCTGAATGGACGGGGCTCTCCACTATCTGGAGTTCGTCTTAACATTGGCATTGCTTCCCAGACTGAGTGCTGCAACTACTGTGACAGGTGCTATGAGACTGGGGGCAAAAGCAAGAACAACTGGGAAGAGAAGTTCCAGTATTTATTGCCTCTTTAACATCTGCCAAAATGTGCAGAAAACACTGGGACTGGCTCAGCATGTTCAGGCTTGTGAAACAACAATGCAGCTCTTGTTTGACAGTGTTAGACATTTAGGCTGTAAACCACACCTGGACAGCCA
>NM_030821.5
GCACAGGGGACGGTTGCTGGCCCAGGTGAGCGGGCGCGCTGGTCCAGGTGAGCGGGCGCGTCCCCGCGACGGCGCTGCCTGCCCGAGGCGGTTCACGTAAAGACAGCGAGATCCTGAGGGCCAGCCGGGAAGGAGGCGTGGATATGGAGCTGGCTGCTGCCAAGTCCGGGGCCCGCGCCGCTGCCTAGCGCGTCCTGGGGACTCTGTGGGGACGCGCCCCGCGCCGCGGCTCGGGGACCCGTAGAGCCCGGCGCTGCGCGCATGGCCCTGCTCTCGCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGTCAGGTGCCAGGAGCAGGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAACGGCGTTCATAAGATAGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGACGGTCTCTGCCAGTATAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAACCCTCCCCACCGAATGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATCCCTTCCCTGACAAAGTGTTGCAACCAACACGACAGGTGCTATGAGACCTGTGGCAAAAGCAAGAATGACTGTGATGAAGAATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAGAAAACACTAGGACTAACTCAGCATGTTCAGGCATGTGAAACAACAGTGGAGCTCTTGTTTGACAGTGTTATACATTTAGGTTGTAAACCATATCTGGACAGCCAACGAGCCGCATGCAGGTGTCATTATGAAGAAAAAACTGATCTTTAAAGGAGATGCCGACAGCTAGTGACAGATGAAGATGGAAGAACATACCTTTGACAAATAACTAATGTTTTTACAACATAAAACTGTCTTATTTTTGTGAAAGGATTATTTTGAGACCTTAAAATAATTTATATCTTGATGTTAAAACCTCAAAGCAAAAAAAGTGAGGGAGATAGTGAGGGGAGGGCACGCTTGTCTTCTCAGGTATCTTCCCCAGCATTGCTCCCTTACTTAGTATGCCAAATGTCTTGACCAATATCAAAAACAAGTGCTTGTTTAGCGGAGAATTTTGAAAAGAGGAATATATAACTCAATTTTCACAACCACATTTACCAAAAAAAGAGATCAAATATAAAATTCATCATAATGTCTGTTCAACATTATCTTATTTGGAAAATGGGGAAATTATCACTTACAAGTATTTGTTTACTATGAAATTTTAAATACACATTTATGCCTAGAAGGAACGGACTTTTTTTTTCTATTTTAATTACACATAATATGTAATTAAAGTACAACATAATATGTTGTTTCTCTGTAGCCCGTTGAGCATATGAGTAAGTCACATTTCTATTAGGACTACTTACAAGGACAAGGTTTCCATTTTTCCAGTTGTAAAATTGGAACCATCAGCTGATAACCTCGTAGGGAGCAACCCCAGGATAGCTAAGTGTTATGTAATATGCCTAGAAGGTGATGTGAATGCGATTCAGAAGCATAGCCACTCCCATTTTATGAGCTACTCACATGACAAATGTCATCTTTTGCTATAACCTTTGCCAAGTTAGAGAAAAGATGGATTTAATGAGATAAATGAAAAGATATTTAACCTAATATATCAAGGCACTATTTGCTGTTATGCTTTGTTATTTATTTCCCAGCACTTGTTCCTTATTGTAGATTTTTTAAAGACTGTAACCTTTTACTAACTGTGGTCTTACTAAAATTTGTGCTTGATACTGCTTTTCAAAAAGCCTTTAATTAGAGCCAAAAGGATGGAAAAGGCAAGATATAAATGCCTTTTATAGATCTCTTATTTACATTGAAAATTATTACCATATGTTTAGAGCAAATCCAAGAAAACTTCAACAGCTTCTGAAGATGTCTATGAATGTTGAAAACTTTTCAATCTCTTGGAATGCTCAGTTATGTTCCTAGACCGGTCTTTGCTGACTACTGGTTGTTAACCTTTCCCTAGCCTGGGACCTCAAGCCATATATATCCTTTGGGTGACCCATGGCCAAAGTTATTAAGATGAACTGACTTTCAAAGTCAGAGAAGGACAGCATAGGGAGAGGCGGTTATTTGTAAGTCATTACAGGTAGAACAGGGCAGAAGGAAAAGTATGTTCTGGAGAAAGGGCCATGTTCCTAACTTTGGAGATATGTCATTGCCGGGAACCTAGTATCTTCCAACTTGAATTGGTGGCAGCTGTTCCAGTGAGACAAGGCACATGTATGCCTTGTGGCTAAGTGAGCAAACTGGGTTTCCACTTAAATGTTTGGGACCCTCAATTGATTCTTTATTTCAAACCTTTATAAAAGGTACAGTTTTGTAAGCCATTATTAATAATTAATGCTTATCggctgggcacagtggctcacacctataatcccagcactttgggaggctgaggcggttggatcacttgaggtcaggagtttgagaccagctggccaacatggtgaaacagcgtctctactaaaaatacaaaaatttgccgggcgtggtggcgcatgcttatagtctcagctactcaggaagctgaggtacgagaatcacttgaacccaggaggtggaggttgcagtgagctgagattgtgccactgcactgcagcctgggcaacagagcaagactctaaaaaaaaaaTGGTTTATCAATATTTACTATTGAAATATTTGTCCAGGTAACTTTACACTTACAATGAATTCATGGATTTTGTTAGCAGCATTGGCTTTCTCAAAAGGACAAACTCAATATCGTTATAAAATATAATTCGTGATCACAAATTATACAAAAATCAGTAGAAACAGTTTTTTATGTTCAGATTAAAAAAAAAAACttgggataattttagatttacagaaaagttgcaaagatacatggagagcttctgtgaccactcacccagttcccccagtgttaaccttttatttaaccatgaagcatttgtcagaagctaagtaaccagcaatggcaattactattaacggaactttgactttatttttcagattgtactagttttttaattaatgtcatttttcttttccaggatccaatctaggataccacactgaattagtcgtcatgcctaattagcctctggtctgtgatagttccacagtctttctttttcataaccttgacagttttgaggagtactggtcaggtgttttgtagaatattcctcaatttgggtttgtctgatgttttcctcatggttagagtggggttatagatttttaggaagaataccagaggtgaaggtccttctcactgcatcatgtcaggagttacatgctatcagcttgatggtgtattaactttggacacttggttaaggtagtgtgtgttggttttttgctgctgaaaattactgttattttccctttccatacttctgttctttggaaaacagtcactaagtccagtcatgggaggtggtgggtgggaaagattacattcaaccccctggaagtgggaatatccatatgtagtatttggaatttttctatatggaaaatttgtttctccctcccaccctaatttgtttacatcagtatggactcatgtatattttgtattttgggtaacacagtatttattttgttgcttaagttgtccagcttggctattaggagttctgccaggttggctactatgtccctttgatgtgcccatccttttgatttttgagcacttcttactttctggcactacaagatgctccaggttcatcttggatattccctgccccaaccctagaatccctagaatcaacccctgctccaaagagccctggttccttttgttggagaatcatacttagaaaccaagatctgggcattagatgtgcttgttgctactgggatgtcactgtttgtagcagagttgagaaatatgtatgtatattaatccatgcatatgtacacatctataattatttatgtgtgtacaaagctaaacatgagtttgtactgccgtcttcaactcaaaATTTGTCCCAAAATTTTGTGGCATATGTTTAGATTTTAAAGTTGATATTTTCCCTATTGACAGAATAAACTCATTaaaagagcaaaaaaaaaaaaaaaaaaaaaaaGGCAAGAACTAACTGTCAGCAGCTCTTTGCAAGAAATGTAATATTGATACTTTAAAATAATACTGCCTTCAAATGATGCCTGTCTCTTTAAAATCTTTTGACATAGTTCTTCcagggacagatatggctgtatttatttcatagatggagaaactgagcacagagCTGTAATGAAGACAGAATTGAGATATAAGGGCAAAAGCTAATTAAACGCATCCTCACAGGTAGCCTTTCTTTCAGTGAACCTGTAGACTAGTCCAGTAATACTTATTAAAATTAGTTGTTAGAggctgggcatggtggttcaagcctgtaatctcagcactgtgggaggccaaggcggacagatcactcaaagtcagaagttcgagaccagcttggccaacatggcaaaaccctgtctctactaaaaatacaaaaattagttgggtgtggtggcacatgcctgtaatcccagccactcgggaggtgaaggcacaagaattggttgaacctgggaagcagaggttgcagtgagctgagattgcactgctgcactccagcataggcgtcagaataagactctgtcttggaaagaagaaaaaaaaTTGTTAGCCTAAAACCAACTCTCTCTAAATTTAAAAGAGTGATTATTTATCTTAGTATTTATAGAAGTATGAGATTATCAGAAGGTGCGATGCACAATGCTCATTATTTTATCCTAGTACAAGACACGTATAACATCTAACAGTAAAGAAGATGGAATCTTTCTATAAAAACAATTCTGTTATTAATAGTTGACTGACTTCAGTAACTTTGAGGAGTAGAATGAAACTTATTAGGCAAGATCTTTCCACATACACTACATTGTATTGTTCAAAATTCATAGAAATTACTTGCAATATATTGATTTAAGCCTTATGTAGTGACTGTTGCTATATTTGAAGTAGCATTTTTAGTTTGCTGTTTTTCCTCACTGCTTAATCCTACAAAAACCAGCCATCTGCCTAAAAAATAAAAGAGCAAAAATGAATCAGTGCAACCGGTATACGAAAAATAATAATTATTAATAAAACTGTAAAGGGA

Publications

PMID - Link Title