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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FABP3P2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:42369260-42369710  UCSC
Coordinates (T2T) chr13:41588978-41589428  UCSC
Coordinates (hg19) chr13:42943396-42943846  UCSC
Strand -
Parental Sequence NM_004102.5
Parental seq. overlap 398 bp
Parental seq. overlap (%) 36.2%
Genomic Region Intergenic
Retrocopy Summary FABP3P2, located on chr13:42369260-42369710, is a retrocopy of the parental gene FABP3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FABP3
Full Name fatty acid binding protein 3
Also known as FABP11|H-FABP|M-FABP|MDGI|O-FABP
Coordinate chr1:31359595-31373618
Strand -
Gene summary The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FABP3P1
Bonobo Pan paniscus FABP3P1
Gorilla Gorilla gorilla FABP3P1
Orangutan Pongo abelii FABP3P1
Gibbon Nomascus leucogenys FABP3P1
Green monkey Chlorocebus sabaeus FABP3P1
Crab-eating macaque Macaca fascicularis FABP3P1
Rhesus Macaca mulatta FABP3P1
Baboon Papio anubis FABP3P1
Golden snub-nosed monkey Rhinopithecus roxellana FABP3P1
Marmoset Callithrix jacchus FABP3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FABP3P2
CCTTGCACACCTGCTCTCTCACAGCTTCTTTCTCAGTCTAGGCCAGCATCACCATGGTAGATGCCTTCCTGTGCACCTGGAAGCTCTCAGACAGCAAGAATTTTGATGACTACATGAAGTTAATCGGTGCAAGTTTTGCTATCAGGCAGGTGGCTAGCATGACAAAGCCTACCACAATCATCAAAAAGAATGGGGACATTATCACCTTAAAAACACAGAGCATGTTCAAGAACACAGAGATCAGCTTTAAGCTGGGGATGGGGTTCGATGAGACAACAGCAGATGACAAAAAGGTCAAGTCCATTGTGACACTGGATGGAAGCAAACTTTTTCACCTGCAGAAGTGTAACGGGCAAGAGAGGACACTTGTGCCAGAGCTAAGTGATGGGAAACTCATCCTGACACTCACCCAGGGCACTGCGGTTTACACTCGCACTTATGAGAAAGAGGT
>NM_004102.5
GCCGTCGGAGCCCTTGCACGCCTGCTCTCTTGTAGCTTCTCTCAGCCTAGCCCAGCATCACTATGGTGGACGCTTTCCTGGGCACCTGGAAGCTAGTGGACAGCAAGAATTTCGATGACTACATGAAGTCACTCGGTGTGGGTTTTGCTACCAGGCAGGTGGCCAGCATGACCAAGCCTACCACAATCATCGAAAAGAATGGGGACATTCTCACCCTAAAAACACACAGCACCTTCAAGAACACAGAGATCAGCTTTAAGTTGGGGGTGGAGTTCGATGAGACAACAGCAGATGACAGGAAGGTCAAGTCCATTGTGACACTGGATGGAGGGAAACTTGTTCACCTGCAGAAATGGGACGGGCAAGAGACCACACTTGTGCGGGAGCTAATTGATGGAAAACTCATCCTGACACTCACCCACGGCACTGCAGTTTGCACTCGCACTTATGAGAAAGAGGCATGACCTGACTGCACTGTTGCTGACTACTACTCTGCCAATCGGCTACCCCTCGACTCAGCACCACATTGCCTCATTTCTTCCTCTGCATTTTGTACAAATCCACGAATTCTTCTGGGGTCAGGTGCCACTGACCGGGATCCAGTTCCAGTTCCCATGGTGTATGTGGttttttttttttttttttAACTGCACTCATAGGGTGCTCTGAGGTCAATAAAGCAGAGCCAAGGCCACCCAGTTGCCTTTTTGCCTTTGGTAACATAACTCTGGGAGTCTTGGTTTATCCTGTGTGTCAGAGAGTGGGCAGAAATAACGGCCTGAAGGTTACTGAGGAAGAAGCACTGGATGGGAGACTGAAATGGACAGTCTCGGAGCCTGTTAATCAGCTGATCACCTTACACATTTAATAATAAAAGAGCTGTACCTACACGTTGCCTTTACACTGCCCCCCCTCCATGGTCAAATGACCTAGTTCAGTCAGTGATGGGGCTTCCCCAGGTTTGGCTATTGAACTGTCACTTCAGGCCCATCCTACACTGAAAGCTCTTGGGTCTGGCTGTTCTCTGTGAAATGCTGTAGTCTCTCCCTTTCCAGAATTCAGGTTCAGGGCACAGAACCCAGGCTTGTACCATGGTG

Publications

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