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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name POLR2KP2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:48134340-48134553  UCSC
Coordinates (T2T) chr13:47354672-47354885  UCSC
Coordinates (hg19) chr13:48708476-48708689  UCSC
Strand -
Parental Sequence NM_005034.4
Parental seq. overlap 183 bp
Parental seq. overlap (%) 19.3%
Genomic Region Intergenic
Retrocopy Summary POLR2KP2, located on chr13:48134340-48134553, is a retrocopy of the parental gene POLR2K. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name POLR2K
Full Name RNA polymerase II, I and III subunit K
Also known as ABC10-alpha|RPABC4|RPB10alpha|RPB12|RPB7.0|hRPB7.0|hsRPB10a
Coordinate chr8:100150636-100154003
Strand +
Gene summary This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes POLR2KP1
Bonobo Pan paniscus POLR2KP1
Gorilla Gorilla gorilla POLR2KP1
Orangutan Pongo abelii POLR2KP2
Gibbon Nomascus leucogenys POLR2KP2
Green monkey Chlorocebus sabaeus POLR2KP1
Rhesus Macaca mulatta POLR2KP3
Baboon Papio anubis POLR2KP3
Golden snub-nosed monkey Rhinopithecus roxellana POLR2KP2
Crab-eating macaque Macaca fascicularis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>POLR2KP2
TGCTGTGTAGGGACTAACAATGGACACCCAGAAGGACATTCAAACCCCAAAGCAGCAGCCAATGGCATATAACTGTAGAGAATGTCACACAGAAAATGACATGAAGTCCAGGGATCCAGTCAAATGTGGAGAATGTGGTTACAGAATAATATATAAGAAAAGGACTGAAATATTGGTGGGTTTTGATGCCCAGTGAAACCTGGGAATTCAGAGA
>NM_005034.4
GGAAGTTGGTCTCGACACCTGGACTAGCCGGGTTGTATTTGGAAACGCGGAGTGAGTTTTTCCGTGCTGTGTAGGGGCTAACAATGGACACCCAGAAGGACGTTCAACCTCCAAAGCAGCAACCAATGATATATATCTGTGGAGAGTGTCACACAGAAAATGAAATAAAATCTAGGGATCCAATCAGATGCAGAGAATGTGGATACAGAATAATGTACAAGAAAAGGACTAAAAGATTGGTCGTTTTTGATGCTCGATGAATGCTGGGAATTCAGAGGAATGTCTTCACTTATACTTGGATTTGCTCTCTTCCCATTTCTGATTGTTGTATAGCTTTCGATTTTGCTTAcagtagttcccccttatcttcgggagatacattccaaggcccccagtgaactcctgaaacctcaaacagtaccaaacctttatacactgttttttccatatatatatacctatgataaagtataatgtataaattaagcatagcaagagattaataataatgtaatagaacaatgataacatactataataaaagttatgtgaatgtggttggtctctcttgctttcaaaatatcttcttgtacagtactcacctattttagaatgtggttgactacaggtaaccaaaaccacagaaagggaaactttggatgaggggggcactactgTACTTAGGAATACAACTATATACATATGATTTTATTTTTAAGACCATATTATATTTGGGTATCTACTAATATTTTGTATAAAGCAATTTTTTGTTCCATTACGTGACTTTTTGTTTTATTGTATATGTAATTTAACACACAATAAAGGGTAAAGTTGCTTCCCCAAACCACACTTTTAATCAAAACCTagaatcatctgcagtccttgttaaaaatgcaggtttctagaaccctctgaagttctgattaaataaatttATTGCAAACCAC

Publications

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