Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PCNPP5
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:48326377-48328500  UCSC
Coordinates (T2T) chr13:47546691-47548814  UCSC
Coordinates (hg19) chr13:48900513-48902636  UCSC
Strand -
Parental Sequence NM_020357.3
Parental seq. overlap 1609 bp
Parental seq. overlap (%) 62.3%
Genomic Region Intragenic (RB1)
Retrocopy Summary PCNPP5, located on chr13:48326377-48328500, is a retrocopy of the parental gene PCNP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PCNP
Full Name PEST proteolytic signal containing nuclear protein
Also known as -
Coordinate chr3:101574094-101594465
Strand +
Gene summary Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PCNPP5
Bonobo Pan paniscus PCNPP5
Gorilla Gorilla gorilla PCNPP5
Orangutan Pongo abelii PCNPP5
Gibbon Nomascus leucogenys PCNPP2
Green monkey Chlorocebus sabaeus PCNPP1
Crab-eating macaque Macaca fascicularis PCNPP3
Rhesus Macaca mulatta PCNPP3
Baboon Papio anubis PCNPP5
Golden snub-nosed monkey Rhinopithecus roxellana PCNPP7
Marmoset Callithrix jacchus PCNPP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PCNPP5
ACAACTGAGATGAATGTCTTTAATAAAATACCAATAAATTTGTACGAACTTTTTTTTTAATGTGACAGTTAAACACATCTTTAAAAGCACAGTCACAGACAAAAAAAAATACAGTATAAAAATTTCCTTGAAAACTCCTACTACAATATTGTATTTGGAGGCAGCTTCAGACCGTTTTATTGGTGGTAACTGCTCGCTGAGCTCTTTTAGTCGGTAATAACTCAGAGAAGCAACCTGTGTATATTCCTAACTCTTTGTTAACTAGTATTTAAGTTTAGAATAAGCCCCAGGTAAAACAATGGAAATGTATATAGAACTCTTAGTTCTTATATGATTTAATTATATCAAGATACTTGAATTTAACTCACTTTAATGTAGGCAAACTATCCATTTTTGTCCATTTTCCTGTTTGTTAAAATAACATACAGTAATGGAGAGGAAAGTTCCAGCCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCAGACCTCCAACAAAGCCTGCAAAGATCTCCAACTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCACCCATATCCATCAAACTTGGATCAAGTAAGCCTAAAGAAACTGTTCCAACTCTTGCTCCAAAAACTCTTTCAGTAGCAGCAGCTTTTAATGAAGATGAAGATAGTGAATCAGAGGAAAGGCCTCCAGAAGCAAAGATGAGGATGAAGAATATTGCAAGGGATACACCAACATCAGCTGGACCAAACTCCTTCAATAAAGGAAAGCATGGGTTTTCTGATAACCAGAAGCTATGGGAGTGGAATATAAAATCTCATCTTCGAAATGTCTATGACCAAGACAATTAAATGATGTTTTGAAATTGGGGTGTGGGTGGGTATAAAGTTAAAAAGAACAGTTTCCTTTTTTTAAGAATGGTATAAGACTACCTTTGGAGCCACTTTTTTTTTCTTTTTCATCTTTTTAAAAGATTGAGTGGTACACCAATAAATGAGAGTTTGAAATTAGAGGTAATTTATGTTTTGTATACAGATTTCAAGACATTTGCTAATTTGGTAGTTTTGTGTGATTAGTTTCCAAAGTTTACAGATAATAAAGAAATCAGAAATGGTACCTTTTTAAGAATTGCCTATTTTTTTAGACACAACTATTAGCACATTAAGAGGGAAGCAAAAAGTTAATTGTCTATTTAAAACTGCAAGCAGTTACTCTCTTAACTCCCTTATTACCTAAACTTGTCTGGCTCCCAGGAATAGCCTTATAGAGAGAGGGAGTATTGTATTGGGAGGAAAATGTTACTGAACTATTGACTGAAAGTACATTTAGATAAAATTAAAATACAGCTTTTTTCTTCATGGGCATTTGTTTTCTTTCAAGTCATCATAAACTAGGTGTTGCATTGCTATCAGTGGATACAGACGCTTAGCTCTTAAAATAACTTTTTTATATGTAAACTGTTGAATATTTGAAATAGCCCACTTCACCTTAATGGGTCTTGTCTATCTTCATTAATCTTCAAAGAAAAACCATTTGCTACCAAAGTAAATCAGTATTTTGAATGTGCTTCTCTTGTTTTTTGTTTATTAGCTAGTTCCTGTAAGCATTTCCACCAGAACTTGAAGCGAATCATAAGAAAACTGTTTCTTTTAAAATACAAACCACCACCAAAAATTTAAATGTACATATTGCTTAAGTATTTGGCTGCTTTTATTTTTTAAAAGGTATAAACACCAAAAAAAAAAAATTTAACATTGTATGAAGATGGAAAACAAGAAGATGCACTTTCTGTAACTTTGTCCAAGGATTTAAATTACTAACTTGTGAAATCCAATTTGAATTGAACTTAACTACTGGCTTTCTTACTAGTAAAATTATATGGTTTATTTTAAATGTATACATATTGACCAATGGCCTCTCAAAAAGCACATTTTAGATACTGAAATAGAAGGAAAGAAAATGCATCTTCAAACATTTTTTGGAATCTCACCACACATACTTTGTGAATTTGt
>NM_020357.3
CTTGGCGTGGCTGCAGGGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTGAAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCAGCCATATCCATCAAACTTGGATCAAGTAAGCCTAAAGAAACTGTTCCAACTCTTGCTCCAAAAACTCTTTCAGTAGCAGCAGCTTTTAATGAAGATGAAGATAGTGAACCAGAGGAAATGCCTCCAGAAGCAAAGATGAGGATGAAGAATATTGGAAGGGATACACCAACATCAGCTGGACCAAACTCCTTCAATAAAGGAAAGCATGGGTTTTCTGATAACCAGAAGCTGTGGGAGCGAAATATAAAATCTCATCTTGGAAATGTCCATGACCAAGACAATTAAATGATGTTTTGAAATTGGGGTGTGGGGTGGGTGTAAAGTTAAAAGGAACAGTTTCCTTTTTTAAAGAATGGTATAAGACTATCTTTGGAGCCGCtttttttttctttttcatttttttAAAAGATTGAGTGGTACACTAATAAATGAGAGTTTGAAATTAGAGGTAATTTATGTTTTATATACAGATTTCAAGACATTTGCTAATTTTGTAGTTTCATGTGATTAGTTTCCAAAGGTTACAGATAATAAAGAAATCAGAAATGGTACCTTTTTAAGAATTGCATATTTTTTTAGACACAACTATTAGTACATTAAGAGGGAAGCAAAGTTACTGTCTATTTAAAACTGCAAGCAGTTAACTCTCTTAACTCCCTTATTACCTAAACTTGTCTGGCTCCCAGGAACAGCCTTATAGAGAGAGGGAGTATTGTATTGGGAAGAAAATGTTACTGAACTATTGACTGAAAGTAAATTTAGATAAAATACAGCTTTTTTCCTTATGGGCATTTGTTTTGTTTCAAGTCATCATAAACTAGGTATTGCATTGCTATCCGTGGATACAGACGCTTAGCTCTTAAAAGATTTTTTTTTTATGTAAACTGTTGAATATTTGAAATAGTCCACTTCACCTTAATGGGTCTTGTCTATCTTCATTAGTCTTCAAAGAAAAACCATTTGCTACCAAAGTAAATCAGTATTTTGAATGTGCTTCTCTTGTTTTTTGTTTATTAGCTAGTTCCTGTAAGCATTTCCACCAGAACTTGAGGCAAATCGTAAGGAAGCTGTTTCTTTTAAAACACAAACCACCACCAAAAATTTAAATGTACATATTGCTTAAGTATTTGGCTGTTTTTATTTTTTAAAAGGTATAAACACCAAAAAAAAAATTAACATTGTATGAAGATGGAAAATAAGAAGATGCACTTTCTGTAACTTTGTCTAAGGATTTAAATTACTAACTTATGAACTCCAATTTGAATTGAACTTAACTATCGGCTTTCTTACTGGTAAAATTATATGGTTTATTTTAAATGCGTACATATTGACCAATGGCCTCTGAAAAAGCACATTTTAGATACTGAAATTGAAGGAAAGAAAATGCATCTTCAAACATTTTTTGGAATCTCACCACATATACTTTGTTAGATTTGtgtattgtagggtgtttgttttgtatttttgtattgtatATGAACTTTTTTTAAATGTGACAGTTAAACACATCTTTAAAAGCATAGTCACAGACAAAAGCATACAGTATAAAAATTTCCTTGAAAACTCCTACAATATTATATTTGGAGGCAGCTTCAGACTGTTTTATTGGTGGTAGCTGCTTGCTGAGGTCTTTTAGTTGGTAATAACTCCAGAGAAGCAGCCTGTGTATATTCCTAACACTTTGTTCACTAGCATTTAAGTTTAGAATAAGCCCAAGTAAGACAATGGAAATGTATATAGAACTCTTAGTTCTTACATGATTTAATTATATCGATACATGAATTTAACTTACTTTAATGTAGGCAAACTATCAATTTTTTGTCCATTTTCCTGTTTGTTAAAATAACATACCTCTCCTACGTATTATTTTCTTGACCCAAATGAAATATTAACCTAAGGTCAAGCTGGGAGAGAGAAATGACTGAGATGAATGTCTTTACTAAAGTACCAATAAATTTGTCAAACTCAATAGTGTTTTTATTTTCTATTCCATTTAA

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