Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name POLR3KP1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:59071110-59071625  UCSC
Coordinates (T2T) chr13:58290868-58291383  UCSC
Coordinates (hg19) chr13:59645244-59645759  UCSC
Strand -
Parental Sequence NM_016310.5
Parental seq. overlap 431 bp
Parental seq. overlap (%) 31.3%
Genomic Region Intergenic
Retrocopy Summary POLR3KP1, located on chr13:59071110-59071625, is a retrocopy of the parental gene POLR3K. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name POLR3K
Full Name RNA polymerase III subunit K
Also known as C11|C11-RNP3|HLD21|My010|RPC10|RPC11|RPC12.5
Coordinate chr16:46407-53608
Strand -
Gene summary This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus POLR3KP1
Gorilla Gorilla gorilla POLR3KP1
Orangutan Pongo abelii POLR3KP1
Gibbon Nomascus leucogenys POLR3KP1
Green monkey Chlorocebus sabaeus POLR3KP1
Golden snub-nosed monkey Rhinopithecus roxellana POLR3KP1
Chimpanzee Pan troglodytes Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>POLR3KP1
GAGCAACTGCCTAGGAGAATGTCCACTGTCCTGCCCAGCCATGTCCCCAGTGCGAACACCCTCCTGTTCACTTCATGCAGCACAAGACTCACCCTGCAGATGAGCCAATGACTGCCTTCTACAAGGGCAGCAGTGCTCAGTGTGGACACTGCTGGGGGAATTAGGGCCAGGATGGCCCAGCTGCCTCAGTGTCTGCTTACCTTGTCCCCCAGGGTGGATTCTCAGCTGGGAGTATGAATTGTGGGTACTGAGGATCTTTTCTGGTGGAAAGCTAACTCTTTTAGAGTGAAGAGCCAAAGTCTTAGTAACTGTAGCCTATCTGCCAGTCAGGGAGTTTTTGTGTGTGGAGAGGAGACCCATAGCTAAGTAAGCTCTGTTTAAAGTCCTGTTCTTTCACCTTTCATATTTATTGGCAGTTGACATTTCCTCACCACCAGTCAACATTCTTAAATACTTGTACTGTTTCCACAACTTAGTACACTGTCCCTAAATATTTAACTATTAATTGTAAACTTA
>NM_016310.5
GGAGCCTGCGGAGTTCGAGACCATGCTGCTGTTCTGCCCCGGCTGCGGGAACGGGCTGATCGTGGAGGAGGGACAACGCTGCCACCGCTTCGCCTGCAACACGTGCCCCTACGTGCACAACATCACCCGCAAGGTAACAAATCGGAAGTACCCAAAACTGAAAGAAGTGGATGATGTGCTTGGTGGAGCAGCTGCCTGGGAGAATGTTGACTCTACTGCAGAGTCGTGTCCCAAATGCGAACATCCTCGTGCTTACTTCATGCAGCTTCAGACCCGCTCTGCAGATGAGCCGATGACCACCTTCTACAAGTGCTGCAATGCTCAGTGTGGACACCGCTGGAGGGATTAGGGCCAGGATGGCCCAGCTGCCCTAGTGTGTGCTTGCCTTGTCCCTCGGGGTAGATGCTTAGCTGGCAGTATGAGTTGTGTGTCCTGAGGGTCTTTGCTAGTGTGGTGGAAAGATAAACCTTTTGAGGTGAAGAGCCAGGGGGTCAGGAAATATGGCCTATCTGCCAGGCAGGGTGGATGAAGTCATGAATGTCTGGGAGTTTTTCTGTGTGGGGAGGAGACAGAGACCCATAACTAAATATGCTCTGTGTAAAGTCCTATTCTTTCATCTTCCACTTTATTGGCAGTTGACATTCCCTTACTCCCAATCAACACTCTTAAATATTTGTACTGTTTGTAAAACTTAGTACATGTCCCTAAATATTTAACTGTTACTTGTAAACTTGTGTAATTTATTATTTATTTTAATCAAAATTCTGAATATTTCATTTAAATGAAAGTTGGAATATTGCCTTCTCAGTGTTTTAAATAGCTTAAGAGGTAGAAAGCAAACCCCAAATCACAGTGATCCCAGAATAGACTACATACTTACATTTGAACAGGCTACGAAAATGTTAATCACCGGGATTTCAATTTCTTTCTTTATTCCTATTCTTACTCCCTTATTCATTTTTTTGAACCTCCCCTGATTTGCTTCCTCGGGTTGCTTTAAATGTATAAGATACtatttatttatttatttattttatttatttatttatttatttaagacagagtcttgttctgtcgcccaggctggagtgcagtggtacgaattcagctcactgcaacctctgccttccgggttcaagggattctcctgtctcagcctcccaagcagctgggactacaggcatgcaccaccacacctgggtaattttgcatttttagtagagatggggtttctccatgttggtcgggctggtctccaactcctgacctcagataatctgtctgcctcggcctcctaaagtgctgggattacaggcgtgagccactgtgtccCACCAATCTTTACATTTAATATGACTATTTTCTTATTGTT

Publications

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