Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LGMNP1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:64957572-64959518  UCSC
Coordinates (T2T) chr13:64176711-64178657  UCSC
Coordinates (hg19) chr13:65531704-65533650  UCSC
Strand -
Parental Sequence NM_005606.7
Parental seq. overlap 1727 bp
Parental seq. overlap (%) 85.9%
Genomic Region Intergenic
Retrocopy Summary LGMNP1, located on chr13:64957572-64959518, is a retrocopy of the parental gene LGMN. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LGMN
Full Name legumain
Also known as AEP|LGMN1|PRSC1
Coordinate chr14:92703809-92748627
Strand -
Gene summary This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LGMNP1
Bonobo Pan paniscus LGMNP1
Orangutan Pongo abelii LGMNP1
Gibbon Nomascus leucogenys LGMNP1
Green monkey Chlorocebus sabaeus LGMNP1
Golden snub-nosed monkey Rhinopithecus roxellana LGMNP1
Gorilla Gorilla gorilla Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LGMNP1
ACGATCGCTTATCACAGGTTTCTGCAGTTGAACTCCAAAGTGCAGAAGGCTTTGGAAAGTAGCTGTATTCCTCAGCGTGGCACTGGGCACTGGTGCTGTTCCCATAGATGATCCTGAAGATGGACGCAAGCACTGGGTGGTGATCGTGGCGGGTTCAAATGGCTGGTATAATTACAGGCACCAGGCAGCTGCGTGCCATGCCTACCAGATCATTTACTGGAATGGGATTCCAGACGAGCACATCATTGTTATGATGTACGATGACACTGCTCACTCTGAAGACAATCCCACTCCAGGAATTGTGATCAACAGACCCAATGGCACGGATGTCTATCAGGGATTCCCGAAGGACTGACTACACTGGAGAGGATGTTACCCCACAAAATTTCCTTGCTGTGTTGACAGGCGATGCAGAAGCAGTGAAGGGCATAGGAACCGGGAAAGTCCTGAAGAGCGGTCCCCAGGATCATGTATGTGTTCGTTTACTTCACTGACCATGGATCTACTGGAATACTGGTTTTTCCCAATGAAGATCTTCATGTAAAGTACCTGAATGAGACCATCCATTACATGTACATACATAAAATGTACCAAAAGATGGTGTTCTATATTGAAGCCTGTGAGTCTGGGTCCATGATGAACCACCTGCCTGGTGATACTAATGTTTATGCAACTACTGCTGCCAACCCCAGAGAGTCGTCCTACACCTGTTACTATGATGAGAAGAGGTCGACGTACCTGGGGGACTGGTACAGCGTCAACTGGATGGAAGACTCGGACGTGGAAGATCTGACTAACCAGACCCTGCACAAGCAGTGCCGCCTGGTAAAATCATACACCAATACCAGCCACATCATGCAGTACGGAAACGAAACGATCTCCACATTAAAGTGATGCAGTTTCAGAGTATGAAACACAAAGCCAGTTCTCCTATCTCCCTGCCTCCAGTCACACACCTTGACCTCACCCCCAGCCCTGATGTGCCCCTCATGATCGTGAAAAGGAAACTGATGAACACCAACGATCTGGAGGACTCCAGGCAGCTCACAGAGGAGATCCAGCGGCATCTGGATGCCAGGCACCTCATTGAGAAGTCAGTGCGCAAGATCGCCTCCTTGCTGGCAGCGTCCGAGGCTGAGGTGGAGCAGCTCCTGTCTGAGAGAGCCCCGTTCACGGGGCATAGCTGCTACCTGGAGGCCCTGCTGCACTTCCAGACCCACTGCTTCAACTGGCACTCCCCCACGTGCGAGTATGCGTTGAGACATTTGTACGTGCTGGCCAACCTTTGTGAGAAACCGTATCCGCTTCACAGGATAAAATTGTCCATGGACCACGTGTGCCTCGGTCGCTACTGAAGAGCTGCCTCCTGGAAGCTTTTCCAAGTGGAAGCACTCCCCCGAATGTGTGCTAATCAGAGACTGAAGAGGTGGAGTGAGAAGTCCCCGCTGCTCCGGGCCCTCCTGGGGAGTCCCCACTCTAGGGCTCGCTCCAGGACCTTCCTCACAGGATGACTTGCTCGCTGTTACCTACTTCCCCAGTCTTCTCTGAAAACCTACAAATTGGAGTGGGGAAAGCTCTGTATTGAGAAGGGTCATATTTGCTTTCTAGGAGGTTTTTTTGTTTTGTTTTTGTTTTGCCCATTAGTTTTAAGGAGCAGGAAGTTCATGGGGGCTTCTGTAGCCCCGCTCAAAAGGAGTCTTTATTCTGAGAAATTTGAAGCTGAAACCCCTTTAAATCTTCAGAATGATTTTATTGAAGGGGGCCGCAAGCCCCAAATGGAAAACTATTTTTAGAAAATATTATGATTTTTTATTGCTTTTGTATTTAGTTCTGCCAGTGTTCAAGTACTAAAAAATAAAGATTTATAACAGAGTTCTCACGGTCc
>NM_005606.7
AATCACAGCAGTGCCGACGTCGTGGGTGTTTGGTGTGAGGCTGCGAGCCGCCGCGAGTTCTCACGGTCccgccggcgccaccaccgcggtcactcaccgccgccgccgccaccactgccaccacggtcgcctgccACAGGTGTCTGCAATTGAACTCCAAGGTGCAGAATGGTTTGGAAAGTAGCTGTATTCCTCAGTGTGGCCCTGGGCATTGGTGCCGTTCCTATAGATGATCCTGAAGATGGAGGCAAGCACTGGGTGGTGATCGTGGCAGGTTCAAATGGCTGGTATAATTATAGGCACCAGGCAGACGCGTGCCATGCCTACCAGATCATTCACCGCAATGGGATTCCTGACGAACAGATCGTTGTGATGATGTACGATGACATTGCTTACTCTGAAGACAATCCCACTCCAGGAATTGTGATCAACAGGCCCAATGGCACAGATGTCTATCAGGGAGTCCCGAAGGACTACACTGGAGAGGATGTTACCCCACAAAATTTCCTTGCTGTGTTGAGAGGCGATGCAGAAGCAGTGAAGGGCATAGGATCCGGCAAAGTCCTGAAGAGTGGCCCCCAGGATCACGTGTTCATTTACTTCACTGACCATGGATCTACTGGAATACTGGTTTTTCCCAATGAAGATCTTCATGTAAAGGACCTGAATGAGACCATCCATTACATGTACAAACACAAAATGTACCGAAAGATGGTGTTCTACATTGAAGCCTGTGAGTCTGGGTCCATGATGAACCACCTGCCGGATAACATCAATGTTTATGCAACTACTGCTGCCAACCCCAGAGAGTCGTCCTACGCCTGTTACTATGATGAGAAGAGGTCCACGTACCTGGGGGACTGGTACAGCGTCAACTGGATGGAAGATTCGGACGTGGAAGATCTGACTAAAGAGACCCTGCACAAGCAGTACCACCTGGTAAAATCGCACACCAACACCAGCCACGTCATGCAGTATGGAAACAAAACAATCTCCACCATGAAAGTGATGCAGTTTCAGGGTATGAAACGCAAAGCCAGTTCTCCCGTCCCCCTACCTCCAGTCACACACCTTGACCTCACCCCCAGCCCTGATGTGCCTCTCACCATCATGAAAAGGAAACTGATGAACACCAATGATCTGGAGGAGTCCAGGCAGCTCACGGAGGAGATCCAGCGGCATCTGGATGCCAGGCACCTCATTGAGAAGTCAGTGCGTAAGATCGTCTCCTTGCTGGCAGCGTCCGAGGCTGAGGTGGAGCAGCTCCTGTCCGAGAGAGCCCCGCTCACGGGGCACAGCTGCTACCCAGAGGCCCTGCTGCACTTCCGGACCCACTGCTTCAACTGGCACTCCCCCACGTACGAGTATGCGTTGAGACATTTGTACGTGCTGGTCAACCTTTGTGAGAAGCCGTATCCGCTTCACAGGATAAAATTGTCCATGGACCACGTGTGCCTTGGTCACTACTGAAGAGCTGCCTCCTGGAAGCTTTTCCAAGTGTGAGCGCCCCACCGACTGTGTGCTGATCAGAGACTGGAGAGGTGGAGTGAGAAGTCTCCGCTGCTCGGGCCCTCCTGGGGAGCCCCCGCTCCAGGGCTCGCTCCAGGACCTTCTTCACAAGATGACTTGCTCGCTGTTACCTGCTTCCCCAGTCTTTTCTGAAAAACTACAAATTAGGGTGGGAAAAGCTCTGTATTGAGAAGGGTCATATTTGCTTTCTAGGAGGTTTGTTGTTTTGCCTGTTAGTTTTGAGGAGCAGGAAGCTCATGGGGGCTTCTGTAGCCCCTCTCAAAAGGAGTCTTTATTCTGAGAATTTGAAGCTGAAACCTCTTTAAATCTTCAGAATGATTTTATTGAAGAGGGCCGCAAGCCCCAAATGGAAAACTGTTTTTAGAAAATATGATGATTTTTGATTGCTTTTGTATTTAATTCTGCAGGTGTTCAAGTCTTAAAAAATAAAGATTTATAACAGAACCCAAA

Publications

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