Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name USP7P1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:83145577-83146110  UCSC
Coordinates (T2T) chr13:82378449-82378982  UCSC
Coordinates (hg19) chr13:83719712-83720245  UCSC
Strand +
Parental Sequence NM_003470.3
Parental seq. overlap 467 bp
Parental seq. overlap (%) 8%
Genomic Region Intergenic
Retrocopy Summary USP7P1, located on chr13:83145577-83146110, is a retrocopy of the parental gene USP7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name USP7
Full Name ubiquitin specific peptidase 7
Also known as HAFOUS|HAUSP|TEF1
Coordinate chr16:8892097-8963912
Strand -
Gene summary The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes USP7P1
Bonobo Pan paniscus USP7P1
Gorilla Gorilla gorilla USP7P1
Orangutan Pongo abelii USP7P1
Gibbon Nomascus leucogenys USP7P1
Green monkey Chlorocebus sabaeus USP7P1
Crab-eating macaque Macaca fascicularis USP7P2
Rhesus Macaca mulatta USP7P2
Baboon Papio anubis USP7P2
Golden snub-nosed monkey Rhinopithecus roxellana USP7P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>USP7P1
ACATTTCCCCAAAGAGGTCTTCAGAACATTCAGAAACCCATTTTTACTGAGGATGCACCAGGGCGAGCATTTCTGAGAGGTGATTACATGGATCCGGAGCCTGCTGAGCATCCAGGAGAAGGAATTTGAGAAGTTTAAATTAGCATTTGTAATGATGGGCCGACTCCAGTATAAATGAAGACGAGTATGAAGTAAATTTGAAAGACTTTGAGCCACAGCCTGGTAACATGTCTCATCCTCAGCCTTGGATAGGGCTCAACCACTTCAACACAGTCCCAAAGAGGAGTAGCTACACTTACCTTGCACAGGCTATTAAAATCCATAACTGACTTCCAAGCCAGTGTATTCAAGGCAAGGATGGTGTCTGCATGTGCCCCTTAACAGCCAGGGACTTTCGCGCCCGTGCCCTCTAGCCAGAGTCTTCAGCAAGAGGATTTGTTGCTGATGTGAACTTTATTTTATTCAGTCTGTTCAGTCTGGCGTCTCCTTAGCTATTGACTGCCTTTTTGAGCAAAATGAAGGTGTTTCTATAAA
>NM_003470.3
GACATTTCACGCCGCCGCCATTTTGAGAGcgagccgagccgagctgccgggcgccgcgtccgctgccggagccccgacgacgacgccgaGGAGGCGGAGGCCGCGGCTCTCGGAACGCGGCCGGCCCGTCGCCCGCCCGCTCCGCCGCTCCCGCCGGCCCCAGGGCCCGCAGGCCCGCCGCGGCCGGCCAGGCCTCCCGTCCGCCGCGCCCGGCCCGAGGCGGGGCTGACTCCGCGGCCCCCGACCGGCCGCCCTCCGCCCCCGGCCGGCCCGCGGCCCCGCAGCCCCGGCCCCGGCCCCGGCGGCGGGAGGCGGGCCCCGCGGCGGCGGCGGCGGCGGCCGCAGCGAGCGACGAGGCCGCCCGGCCCGGCCCGCCGGCCGCCCGCCCGCCTCGGCGCCGAGATTGGGCGAATCGCGAGCAAGTACGTGCGCGTCTCCCTGCCGCCGCCGCCGCCCGCCGCGGGCCGCCCCGGGGCCGCCGTCGCCGACGACGCGCGGGAGGAGGAGGAGGAGgccgccccgccgccgccgccgccgccgccgccccggctcgccgccgccCGCCCGCCGGGCTCGcagccccggcccccggccgcaggcgaggcccaggccgcggccGACATGAACcaccagcagcagcagcagcagcagaaagcgggcgagcagcagTTGAGCGAGCCCGAGGACATGGAGATGGAAGCGGGAGATACAGATGACCCACCAAGAATTACTCAGAACCCTGTGATCAATGGGAATGTGGCCCTGAGTGATGGACACAACACCGCGGAGGAGGACATGGAGGATGACACCAGTTGGCGCTCCGAGGCAACCTTTCAGTTCACTGTGGAGCGCTTCAGCAGACTGAGTGAGTCGGTCCTTAGCCCTCCGTGTTTTGTGCGAAATCTGCCATGGAAGATTATGGTGATGCCACGCTTTTATCCAGACAGACCACACCAAAAAAGCGTAGGATTCTTTCTCCAGTGCAATGCTGAATCTGATTCCACGTCATGGTCTTGCCATGCACAAGCAGTGCTGAAGATAATAAATTACAGAGATGATGAAAAGTCGTTCAGTCGTCGTATTAGTCATTTGTTCTTCCATAAAGAAAATGATTGGGGATTTTCCAATTTTATGGCCTGGAGTGAAGTGACCGATCCTGAGAAAGGATTTATAGATGATGACAAAGTTACCTTTGAAGTCTTTGTACAGGCGGATGCTCCCCATGGAGTTGCGTGGGATTCAAAGAAGCACACAGGCTACGTCGGCTTAAAGAATCAGGGAGCGACTTGTTACATGAACAGCCTGCTACAGACGTTATTTTTCACGAATCAGCTACGAAAGGCTGTGTACATGATGCCAACCGAGGGGGATGATTCGTCTAAAAGCGTCCCTTTAGCATTACAAAGAGTGTTCTATGAATTACAGCATAGTGATAAACCTGTAGGAACAAAAAAGTTAACAAAGTCATTTGGGTGGGAAACTTTAGATAGCTTCATGCAACATGATGTTCAGGAGCTTTGTCGAGTGTTGCTCGATAATGTGGAAAATAAGATGAAAGGCACCTGTGTAGAGGGCACCATACCCAAATTATTCCGCGGCAAAATGGTGTCCTATATCCAGTGTAAAGAAGTAGACTATCGGTCTGATAGAAGAGAAGATTATTATGATATCCAGCTAAGTATCAAAGGAAAGAAAAATATATTTGAATCATTTGTGGATTATGTGGCAGTAGAACAGCTCGATGGGGACAATAAATACGACGCTGGGGAACATGGCTTACAGGAAGCAGAGAAAGGTGTGAAATTCCTAACATTGCCACCAGTGTTACATCTACAACTGATGAGATTTATGTATGACCCTCAGACGGACCAAAATATCAAGATCAATGATAGGTTTGAATTCCCAGAGCAGTTACCACTTGATGAATTTTTGCAAAAAACAGATCCTAAGGACCCTGCAAATTATATTCTTCATGCAGTCCTGGTTCATAGTGGAGATAATCATGGTGGACATTATGTGGTTTATCTAAACCCCAAAGGGGATGGCAAATGGTGTAAATTTGATGACGACGTGGTGTCAAGGTGTACTAAAGAGGAAGCAATTGAGCACAATTATGGGGGTCACGATGACGACCTGTCTGTTCGACACTGCACTAATGCTTACATGTTAGTCTACATCAGGGAATCAAAACTGAGTGAAGTTTTACAGGCGGTCACCGACCATGATATTCCTCAGCAGTTGGTGGAGCGATTACAAGAAGAGAAAAGGATCGAGGCTCAGAAGCGGAAGGAGCGGCAGGAAGCCCATCTCTATATGCAAGTGCAGATAGTCGCAGAGGACCAGTTTTGTGGCCACCAAGGGAATGACATGTACGATGAAGAAAAAGTGAAATACACTGTGTTCAAAGTATTGAAGAACTCCTCGCTTGCTGAGTTTGTTCAGAGCCTCTCTCAGACCATGGGATTTCCACAAGATCAAATTCGATTGTGGCCCATGCAAGCAAGGAGTAATGGAACAAAACGACCAGCAATGTTAGATAATGAAGCCGACGGCAATAAAACAATGATTGAGCTCAGTGATAATGAAAACCCTTGGACAATATTCCTGGAAACAGTTGATCCCGAGCTGGCTGCTAGTGGAGCGACCTTACCCAAGTTTGATAAAGATCATGATGTAATGTTATTTTTGAAGATGTATGATCCCAAAACGCGGAGCTTGAATTACTGTGGGCATATCTACACACCAATATCCTGTAAAATACGTGACTTGCTCCCAGTTATGTGTGACAGAGCAGGATTTATTCAAGATACTAGCCTTATCCTCTATGAGGAAGTTAAACCGAATTTAACAGAGAGAATTCAGGACTATGACGTGTCTCTTGATAAAGCCCTTGATGAACTAATGGATGGTGACATCATAGTATTTCAGAAGGATGACCCTGAAAATGATAACAGTGAATTACCCACCGCAAAGGAGTATTTCCGAGATCTCTACCACCGCGTTGATGTCATTTTCTGTGATAAAACAATCCCTAATGATCCTGGATTTGTGGTTACGTTATCAAATAGAATGAATTATTTTCAGGTTGCAAAGACAGTTGCACAGAGGCTCAACACAGATCCAATGTTGCTGCAGTTTTTCAAGTCTCAAGGTTATAGGGATGGCCCAGGTAATCCTCTTAGACATAATTATGAAGGTACTTTAAGAGATCTTCTACAGTTCTTCAAGCCTAGACAACCTAAGAAACTTTACTATCAGCAGCTTAAGATGAAAATCACAGACTTTGAGAACAGGCGAAGTTTTAAATGTATATGGTTAAACAGCCAATTTAGGGAAGAGGAAATAACACTATATCCAGACAAGCATGGGTGTGTCCGGGACCTGTTAGAAGAATGTAAAAAGGCCGTGGAGCTTGGGGAGAAAGCATCAGGGAAACTTAGGCTGCTAGAAATTGTAAGCTACAAAATCATTGGTGTTCATCAAGAAGATGAACTATTAGAATGTTTATCTCCTGCAACGAGCCGGACGTTTCGAATAGAGGAAATCCCTTTGGACCAGGTGGACATAGACAAAGAGAATGAGATGCTTGTCACAGTGGCGCATTTCCACAAAGAGGTCTTCGGAACGTTCGGAATCCCGTTTTTGCTGAGGATACACCAGGGCGAGCATTTTCGAGAAGTGATGAAGCGAATCCAGAGCCTGCTGGACATCCAGGAGAAGGAGTTTGAGAAGtttaaatttgcaattgtaatGATGGGCCGACACCAGTACATAAATGAAGACGAGTATGAAGTAAATTTGAAAGACTTTGAGCCACAGCCCGGTAATATGTCTCATCCTCGGCCTTGGCTAGGGCTCGACCACTTCAACAAAGCCCCAAAGAGGAGTCGCTACACTTACCTTGAAAAGGCCATTAAAATCCATAACTGATTTCCAAGCTGGTGTGTTCAAGGCGAGGACGGTGTGTGGGTGGCCCCTTAACAGCCTAGAACTTTGGTGCACGTGCCCTCTAGCCGAAGTCTTCAGCAAGAGGATTCGCTGCTGGTGTTAATTTTATTTTATTGAGGCTGTTCAGTTTGGCTTCTCTGTATCTATTGACTGCCCTTTTTGAGCAAAATGAAGATGTTTTTATAAAGCTTGGATGCCAATGAGAGTTATTTTATGGTAACCACAGTGCAAGGCAACTGTCAGCGCAATGGGGGAGAAGAGGTTAGTGGATCGGGGGTCCCTGGCTCAAGGTCTCTGGGCTGTCCCTAGTGGGCACGAGTGGCTCGGCTGCCTTCCTGGGGTCCCGTGCACCAGCCCTGCAGCTAGCAAGTCTTGTGTTTAGGCTCGTCTGACCTATTTCCTTCAGTTATACTTTCAATGACCTTTTGTGCATCTGTTAAGGCAAAACAGAGAAACTCACAACCTAATAAATAGCGCTCTTCCCTTCATTGTGTGCATTGTCGGCCCTTCCTCGGGTTCTCCTCCTCCAGCTGCCTGGGGGCTTTTTAATAAACTTGTCTCACCTCGTCAGCCACTACTGTCTGCAGCCCCTTTGCAAAGTGGATGCACTGAATACAGTCCGGACAGACATTGTGGGGGTCTTTTTATTAAATCAAGAACATTGTTAAATTCAATTAAGGTTTACTCTGCTGCCTTGGCAGACTTACGATCTCAACAGTTCATACGAGCAGGTGAAAGGATTATAAATAGAATTTCGTTAAAGTGGAACAGACGACAAGAAAGCCTTTTAGCAAGAGGGCATGCTCACTAGTGGTTAGTAAGCTGTCGACTTTGTAAaaaagttaaaaatgaaaaaaaaaggaaaaatgaaTTGTATATTTAATGAATGAACATGTACAATTTGCCACTGGGAGGAGGTTCCTTTTTGTTGGGTGAGTCTGCAAGTGAATTTCACTGATGTTGATATTCATTGTGTGTAGTTTTATTTCGGTCCCAGCCCCGTTTCCTTTTATTTTGGAGCTAATGCCAGCTGCGTGTCTAGTTTTGAGTGCAGTAAAATAGAATCAGCAAATCACTCTTATTTTTCATCCTTTTCCGGTATTTTTTGGGTTGTTTCTGTGGGAGCAGTGTACACCAACTCTTCCTGTATATTGCCTTTTTGCTGGAAAATGTTGTATGTTGAATAAAATTTTCTATAAAAATTATAATTCAGTGAGTTACGTGGAAGTGGAGGAAGATTTCTACTCTCCCTGGAAACAGGCCTGGGAAACCTTGGCATTTGTAACAAGGTTTCACTGAGATGTACTTTTCCTTCTAATTCCGTTTTGCGGGGGCAGGGTCTCttgtttctttttttttttttttttttttttAGCCTCTAACTAGTCACATTTACTCTTAAGAAATGAAAGGTTTTCCAGGAGAGAACTGTGTACAAATAAGGTGACTGGAGATGTGACCTGATGTGTCACGAGGCCCTTCGGGGCGGCAGGCGCTATCGTGGGCGTGGTCCTTGCACCGTCCCATCGGCCTTGCCTTCCAGCTCCGTGGCACGGTTTCCTGGTCTTTGGGCCAGTGTGTACCTTGGAGTGACTTCCTTTCTCAACTTCCACTGCAGTGTGTGTGCCTTCTGCTCTGAGAGCTGCCTTGTGACCCGTGTGATAGAAAGCAGGGAGTGAGGGTCCCCGCGGACCTGGCCCTTCCCTCCTTCCTCCCCCAGAAAGAGGAGTTAGAGCAGGGGTGCGAGAGCCGTTCGCTGTGGGTTTGTCTTTGAACAAACATTAAGGTGTCTTGTTTTTGTTCTGGGCTGGGGGTTGGCTGTAGTCTTAGGTAACTGAAAGTTCCTACTCTCCCTTAAGGTATTAAATGACTCTTTTTCCAAA

Publications

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