Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2D3P4
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:84020475-84020819  UCSC
Coordinates (T2T) chr13:83253293-83253636  UCSC
Coordinates (hg19) chr13:84594610-84594954  UCSC
Strand +
Parental Sequence NM_181890.3
Parental seq. overlap 282 bp
Parental seq. overlap (%) 7.4%
Genomic Region Intergenic
Retrocopy Summary UBE2D3P4, located on chr13:84020475-84020819, is a retrocopy of the parental gene UBE2D3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2D3
Full Name ubiquitin conjugating enzyme E2 D3
Also known as E2(17)KB3|UBC4/5|UBCH5C
Coordinate chr4:102794383-102868895
Strand -
Gene summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2D3P3
Bonobo Pan paniscus UBE2D3P3
Gorilla Gorilla gorilla UBE2D3P2
Orangutan Pongo abelii UBE2D3P2
Gibbon Nomascus leucogenys UBE2D3P4
Green monkey Chlorocebus sabaeus UBE2D3P1
Crab-eating macaque Macaca fascicularis UBE2D3P4
Rhesus Macaca mulatta UBE2D3P3
Baboon Papio anubis UBE2D3P4
Golden snub-nosed monkey Rhinopithecus roxellana UBE2D3P4
Mouse lemur Microcebus murinus UBE2D3P2
Rabbit Oryctolagus cuniculus UBE2D3P3
Marmoset Callithrix jacchus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2D3P4
CCTTTTTGGCAATTAATTTTTTTACAAACCACCTCTTCAAGCCACCTGAGGTTGAATTTAAAGTAAGAATTTATCATCTAACTATTAGTAATGGCACCATTGGTTGTGATACTCTAAAATCACAATGGCTTCTTGCTTTAACTATTTCTAAAGGTCTTTTATCCATATGTTCACTGCATGTACTCCAAACACAGATGACCCCCCCCCAATGCCAGTGATTGTACAGATCTATAAAACAGACAGAAATAAGAATAACAGAATATCTTAGTAATGAGCTCAGTAGTATAATGTGTGATGCTACCTTCATGTCCAAATAACCTACATTATAGTTGAAATAAGCTTTAA
>NM_181890.3
GCGGCGGACTGCCGAGGCGCGGGAACTGGCGGGTAGCGAGGCCCTCCTCGGAATCTCGTGTGAAGGTGGCCCTCCTCTTGGGCCTTTAACGTCTGTAGATGCTGGAGACCAGCAGAAAGGATACTGTGTGCGatgagataagcatgtgagaatgctttctaaccgaaagtgcctttcaaaaGCGCCTGTGTCTGGCAGAGCTGGTGTGAGACGAGACAATCCTGCCCCGCCGCCGGGATAATCAAGAGTTTTGGCCGGACCTTTGAGCATACACCGAGAGAGTGAGGAGCCAGACGACAAGCACACACTATGGCGCTGAAACGGATTAATAAGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAAGTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTATCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACTTAAGTTCTTCCAGCTTTGGACAATAACTGCTTTTAGAAACTGTAAAGTAGTTACAAGAGAACAGTTGCCCAAGACTCAGAATTTTTAAAAAAAAAAATGGAGCATGTGTATTATGTGGCCAATGTCTTCACTCTAACTTGGTTATGAGACTAAAACCATTCCTCACTGCTCTAACATGCTGAAGAAATCATCTGAGGGGGAGGGAGATGGATGCTCAGTTGTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTGTTTAAGCCTTCCACTGTTAGAGATTTGAGGTTACATGATATGCTTTATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGAATTTATAGCATCAGCAGAACAGAAAATGTGATGTATTTTATGCATGTCAATAAAGGAATGACCTGTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAACACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAATTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTCCAATACACTGTTTAATATAGCACTGAATAAATGATGCAAGTTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTATTTTTCTTCAATAAAGTTGCATAAACCAATGAGTTAGCTGCCTGGATTAATCAGTATGGGAAACAATCTTTTGTAAATGCAAAGCTGTTTTTTGTATATACTGTTGGGATTTGCTTCATTGTTTGACATCAAATGATGATGTAAAGTTCGAAAGAGTGAATATTTTGCCATGTTCAGTTAAAGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTGATTTATGCAGAATTAATAAGCTATTTGGATAGTGTAGCTTTAATGTGCTGCACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTTTGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTTTCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACCTTGTACACTTGACAGCTGAAAAAAAACAACATGGGAGTAATAATGGGTCAAAATTTGCAAAATAAAGTACTGTTTTGGTGTGGGAGTTGTCATGAGGCTGTGTTGAAGTGACTTATCTATGTGGGATATTGAGTATCCATTGAAATGGATTTGTTCAGCCATTTACATTAATGAGCATTTAAATGCAACAGATATCATTTCAGGTGACTTAACATGAATGAATAAAAGTCAATGCTATTGGATTGTTTTTTGTTTGACAAGTGCTATCTGTGCCACTGATTTAACTTCTGTAGTAACAAGGGCATTACCATTCTTCACCTTTCCTAATTCTGATCCCATAGTTTTACATTTTTCCTGTTTATTTTGATTTTGTTCACTGCTTTATTTCTTAAAGTTCTAGCACATCTGTGACTCCTCCACTTCCACATTTTTGCACTGCTTACACTTACGTGCAATCTTATTCCTTGTCTGCACACACATGTGGAAAGCTAGAAATAAATGTTAAAACTTACTTTTTATAAACATTTTAATATGTAGTTTGGACATGATTTATTGACTTAAGGTTCTTCTCTAAACTGGAAGTGAAATGCATGCCTTCTGAAGATGTTCTGGCTTTGTTAATTCTGTAATCATTTCATTGGGGAAAAAACCAGCTACGCAGTTTTTCCAATGAGTGAATTTTTTCATTTTGTGTTTTGCTTAAAACGGCTCCTTCAGGGTAGATGTCATACTGCATAACTTTTTTGGATTCAAATTATGAATGAGAAATTAGTTAACATTCTGCTCCACAAGGTAAGAAAAACTGCTCTTTGGCTCTATTTTCAAAATTACTTCTGAGATGCATATAGTCTCAAAATAACAGCTTTAGTAGGCATATCACTTCTTGAAAGCCAAACATGAGTGTAAGACACTTTTATGAAACACGGTGGATCCCTAACTGGCTTTCAAATTGACCTTTATAGCCTTAGACAACCCTTAGGTATTTACGGAGATGACTTCTTTGATTGTCATAACAATTAGTGGATGTGTCCAGTTCTCTGTATCTTTGACTTGATGCTTTATACATCATTTCATTTGTTGCTTCTAAGGGAATAAGCCATAGAGGCTTCTCCAGGTTTAAAAGAACAGTAAAGTACCTGGAAAACCAACATTTTTGAATGTATGGACACTGGACATGAGATATGTACAATGAAATCTTAAAAGAATCTAAGAATTTGCCCTCTTTGCCCCACTCCACCCAGTAATTTGACATTACTAGTGCCATGTATAGGACCCAACTGAGTATTAGAATCAGTTTTGACTATGTCTTTGTATTTCCTAAATCTTTTAATGCATAAACCGAATTAGGGTCCAGTTGGCCTGTTAATGGTAAATTTACATTTTAAATGACTCAGTTTGTTTTTCCTGGGCGAGTTTGCAATGTGATAATCAGATTTTTTAAAACTGATTAATTTGCTTTCTTGTGTGGGTGTACTCACATTTTAAAGTATGAACCACAGTTAACTAGTGGTCTCAGGGGTAGTGAAACACTCACttttttttttgtttgtttttttttgtttgttGAAATGGCTTAGTTGAAGTATACTTAAGGTACTGATCATGCTGTGTTAGTAATTTGGGCGGGGAGGGGGGTAACTCAGCCATGTTTTGTGTTGGCATAACAAAACTGTTAATGATTGTTGATTACACTTTTAAGTGAATTTGTCTTTTATGAGGAACCCAGTGCAAGTCACTAAATATTGTCTAATAGTGACATCTGCATAAGACTTGTAATAGCTGAAGTTAATTGAGCTTAAAGGAATTGTTACCATTAAAGTCTGTGTTTAAAGACA

Publications

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