Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSPA5P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:38708705-38711240  UCSC
Coordinates (T2T) chr1:38575892-38578427  UCSC
Coordinates (hg19) chr1:39174377-39176912  UCSC
Strand +
Parental Sequence NM_005347.5
Parental seq. overlap 2383 bp
Parental seq. overlap (%) 60.3%
Genomic Region Intergenic
Retrocopy Summary HSPA5P1, located on chr1:38708705-38711240, is a retrocopy of the parental gene HSPA5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSPA5
Full Name heat shock protein family A (Hsp70) member 5
Also known as BIP|GRP78|HEL-S-89n
Coordinate chr9:125234853-125241343
Strand -
Gene summary The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSPA5P1
Bonobo Pan paniscus HSPA5P1
Gorilla Gorilla gorilla HSPA5P1
Orangutan Pongo abelii HSPA5P1
Gibbon Nomascus leucogenys HSPA5P2
Green monkey Chlorocebus sabaeus HSPA5P2
Crab-eating macaque Macaca fascicularis HSPA5P1
Rhesus Macaca mulatta HSPA5P1
Baboon Papio anubis HSPA5P1
Golden snub-nosed monkey Rhinopithecus roxellana HSPA5P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSPA5P1
AGACGCCGGCCGAGACAGCGCAGACAGACCGACCGACTGGGGTGTTTCGTGAATGTGAGAGGTAAGCGCCGCGGCCTGCATTTCCAGAGCTGCCCTTCGCCTGGTTCGTGGCGCCTTGTGACCCCTGCCACCTGCAAGTCGGTAACCGCGCTGTGCTCCTGTGCTGCGGCCTGTGGCTGGACTGCCTGGGATGCCCTGCCTGCTGCTGCCCGACTGGCTGGCAAGATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTGCTCAGCGCGGCGCGGGCCAAGGAGGAGGACATGGGCACGGTGGTCGCCATCCACCTGGGGACAACCTACCCCTGTGTCGGCGTGTTCAAGAACGGCCGCATGGAGATCATCGCCAACGATCAGGGCAACCGCATCATGCCGTCCTATGTGGCCTTCACTCCTGAAGGGGAATGTCTGATCGGCGATGCAGCTAAGAACCAGCTCACCTCCAACCCCAAGAACACGGTCTTTGACGCCAAGCGGCTCATCGGCCGCAGGTGGCACGACCCGTCTGTGCAGCAGGACATCGAGTTCCTGCCGTTCAAGGTGGTTGAAAAGAACACTAAATCATACATTCAAATTGATGTTGGAGGTGGGCAAACAAAGACATTTGCTCCTAAAGAAATTTCTGCAATGGTTCTCACTAAAATGAAAGAAAACGCTGAGGCTTATTTGGGAAAGGTTACCCATGCAGTTGTTACTGCACCAGCCTATTTCAATGATGCCCAATGCCAAGCAACCAAGGACGCTGGAACTATTGCTGACCTAAATGTTATGAGGATCATCAATAAGCCTACAGCAGCTGCTATTGCTTATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATCCTGGTGTTTGACCTGGGTGGTGGAACCTTTGATGTGTCTCTTCTCACCATTGACAATGGTGTCTTCAAAGTTGTGGCCACTAATGGAGATACTTATCTGGGTGGAGAAGACTTTGACCAGCGTGTCATGGAACACTTCATCAAACTGTACAAAAAGAAGACTGGCAAAGATGTCAGGAAAGACAATAGAGCTGTGCAGAAACTCTGGCGCAAGGTAGAAAAGGCCAAACGGGCCCTGTCTTCTCAACATCAAGCAAGCAGTAATTGAAATTGAGTCCTTCTATGAAGGAGAAGACTTTTCTGAGACCCTGACTCAGGCCAAATTTGAAGAGCTCAACTGGATCTGTTCCAGTCTACTATGAAGCCTAGCCAGAGAAGTGTTGGAAAGTGTTGGAAGACTCTGATTTGAAGAAGTCTGACATTGATGAAACTGTTCTTGTTGGTGGCTTTACTCAAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAATGGCAAGGAACTATCCCGCGGCATAAGCCCATATGAAGCTGTAGCATATGGTGCTGCTGTCCAGGCTGGTGTGCTCTCTGGTGATCAAGATACAGGTGACTTGGTGCTGCTTGATATATGTCCCCTTACACTTGGTATTGAAACTGTGGGAGGTGTCATGACCAAACTGATTCCAAGGAACACAGTGGTGCCAACCAAGAAGTCTCAGATATTTTCTACAGCTTTTGATAATCAACCGTTACAATCAAGGTCTATGAAGGTAAACAACCCCTGACAAAAGACAATCATCTTCTGGGTACATTTGATCTGACTGGAATTCCTCCTGCTCCTTGTGGGGTCCCACAGATTGAAGTCACCTTTGAGATGGATGTGAGTGATATTCTTCAAGTGACAGCTAAAGACAAGGGTACAAGGTACAAAAATAAGATCACAATTACCAACGACCAGAATCACCTGACACCTGAAGATATTGAAAGGATGGTTAATGATGCTGAGAAGTTTGCTGAGGAAGACAAAAAGCTCAAGGAGTGCACTGATACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATAAAGAAAAGCTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAACTGTAGAAGAAAAGACTGAATGGCTGGAAAGCCACCAAGATGCTGACACTGAAGACTTCAAAGCTAAGAAGAAGGAACTGGAAGAAATTGTTCAACCAATTATCAGCAAACTCTATGGAAGCGCAGGCCCTCCCCCAACTGGGGAAGAGGATACAGCAGAAAAAGATGAGTTGTAGACACTGATCTGCTAGTGCTGTAATATTGTAAATACTGGACTCAGGAACTTTCGTTAGGAAAAAATAGAGAGAACTTAAGTCTCAAATGTAATTGGAATCTTCACCTCAGAGTGGAGTTGAAAATGCTATAGCCCAAGCGGCTGTTTACTGCTTTTCATTAGCAGTTGCTCACATGTCTTTGGACGGGTCAGGAGAAGAAGAATTGGCCATCTTAAAAAGTGGGTAAAAAGCCTGGGTTAGGGTGTGTATTCACCTTCAAAATGTTCTATTTAACAATTGGGTCATGTGCATCTGGTGTAGGAAGTTTTTTCTACCATAAGTGACACCAATAAATGTTTGTTATTTACA
>NM_005347.5
GACGCCGGCCAAGACAGCACAGACAGATTGACCTATTGGGGTGTTTCGCGAGTGTGAGAGGGAAGCGCCGCGGCCTGTATTTCTAGACCTGCCCTTCGCCTGGTTCGTGGCGCCTTGTGACCCCGGGCCCCTGCCGCCTGCAAGTCGGAAATTGCGCTGTGCTCCTGTGCTACGGCCTGTGGCTGGACTGCCTGCTGCTGCCCAACTGGCTGGCAAGATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAGGAGGACAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACCTGGGGACCACCTACTCCTGCGTCGGCGTGTTCAAGAACGGCCGCGTGGAGATCATCGCCAACGATCAGGGCAACCGCATCACGCCGTCCTATGTCGCCTTCACTCCTGAAGGGGAACGTCTGATTGGCGATGCCGCCAAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGACGCCAAGCGGCTCATCGGCCGCACGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAGGTGGTTGAAAAGAAAACTAAACCATACATTCAAGTTGATATTGGAGGTGGGCAAACAAAGACATTTGCTCCTGAAGAAATTTCTGCCATGGTTCTCACTAAAATGAAAGAAACCGCTGAGGCTTATTTGGGAAAGAAGGTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAACGCCAAGCAACCAAAGACGCTGGAACTATTGCTGGCCTAAATGTTATGAGGATCATCAACGAGCCTACGGCAGCTGCTATTGCTTATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATCCTGGTGTTTGACCTGGGTGGCGGAACCTTCGATGTGTCTCTTCTCACCATTGACAATGGTGTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGAGAAGACTTTGACCAGCGTGTCATGGAACACTTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAAGACAATAGAGCTGTGCAGAAACTCCGGCGCGAGGTAGAAAAGGCCAAACGGGCCCTGTCTTCTCAGCATCAAGCAAGAATTGAAATTGAGTCCTTCTATGAAGGAGAAGACTTTTCTGAGACCCTGACTCGGGCCAAATTTGAAGAGCTCAACATGGATCTGTTCCGGTCTACTATGAAGCCCGTCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAATTGTTCTTGTTGGTGGCTCGACTCGAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAATGGCAAGGAACCATCCCGTGGCATAAACCCAGATGAAGCTGTAGCGTATGGTGCTGCTGTCCAGGCTGGTGTGCTCTCTGGTGATCAAGATACAGGTGACCTGGTACTGCTTGATGTATGTCCCCTTACACTTGGTATTGAAACTGTGGGAGGTGTCATGACCAAACTGATTCCAAGGAACACAGTGGTGCCTACCAAGAAGTCTCAGATCTTTTCTACAGCTTCTGATAATCAACCAACTGTTACAATCAAGGTCTATGAAGGTGAAAGACCCCTGACAAAAGACAATCATCTTCTGGGTACATTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTCCCACAGATTGAAGTCACCTTTGAGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAACAAAAATAAGATCACAATCACCAATGACCAGAATCGCCTGACACCTGAAGAAATCGAAAGGATGGTTAATGATGCTGAGAAGTTTGCTGAGGAAGACAAAAAGCTCAAGGAGCGCATTGATACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATAAAGAAAAGCTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAAAAGATTGAATGGCTGGAAAGCCACCAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAGAAGGAACTGGAAGAAATTGTTCAACCAATTATCAGCAAACTCTATGGAAGTGCAGGCCCTCCCCCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAGACACTGATCTGCTAGTGCTGTAATATTGTAAATACTGGACTCAGGAACTTTTGTTAGGAAAAAATTGAAAGAACTTAAGTCTCGAATGTAATTGGAATCTTCACCTCAGAGTGGAGTTGAAACTGCTATAGCCTAAGCGGCTGTTTACTGCTTTTCATTAGCAGTTGCTCACATGTCTTTGGGTGGGGGGGAGAAGAAGAATTGGCCATCTTAAAAAGCGGGTAAAAAACCTGGGTTAGGGTGTGTGTTCACCTTCAAAATGTTCTATTTAACAACTGGGTCATGTGCATCTGGTGTAGGAAGTTTTTTCTACCATAAGTGACACCAATAAATGTTTGTTATTTACACTGGTCTAATGTTTGTGAGAAGCTTCTAATTAGATCAATTACTTATTTTAGGAAATTTAAGACTAGATACTCGTGTGTGGGGTGAGGGGAGGGAGTATTTGGTATGTTGGGATAAGGAAACACTTCTATTTAATGCTTCCAGGGAtttttttttttttttttAACCctcctgggcccaagtgatccttccacctcagtctcccagctaattgagaccacaggcttgttaccaccatgctcggcTTTTGCATTAATCTAAGAAAAGGGGAGAGAAGTTAATCCACATCTTTACTCAGGCAAGGGGCATTTCACAGTGCCCAAGAGTGGGGTTTTCTTGAACATACTTGGTTTCCTATTTCCCCTTATCTTTCTAAAACTGCCTTTCTGGTGGCTTTTTTTAAAATTATTACTAATGATGCTTTTATAGCTGCTTGGATTCTCTGAGAAATGATGGGGAGTGAGTGATCACTGGTATTAACTTTATACACTTGGATTTCATTTGTAACTTTAGGATGTAAAGGTATATTGTGAACCCTAGCTGTGTCAGAATCTCCATCCCTGAAATTTCTCATTAGTGGTACTGGGGTGGGATCTTGGATGGTGACATTGAAACTACACTAAATCCCCTCACTATGAATGGGTTGTTAAAGGCAATGGTTTGTGTCAAAACTGGTTTAGGATTACTTAGATTGTGTTCCTGAAGAAAAGAGTCCAGGTAAATGGTATGATCAATAAAGGACAGGCTGGTGCTAACATAAAATCCAATATtgtaatcctagcactttgggaggccaaggcgggtggatcacaaggtcaagagatagagaccatctttgccaacatggtgaaactccatctctactgaaaatacaaaaattagctgggcgtggtagtgcaagctgaaggctgaggcaggagaatcactcgaacccgggaggcagaggttgcagtgagccgagatcacaccactgtactccagcccggcactccagcctggcgacaagagtgagactccacctcaaaaaaaaaaaaaagaaTCCAATACTGCCCAAGGATAGGTATTTTATAGATGGGCAACTGGCTGAAAGGTTAATTCTCTAGGGCTAGTAGAACTGGATCCCAACACCAAACTCTTAATTAGACCTAGGCCTCAGCTGCACTGCCCGAAAAGCATTTGGGCAGACCCTGAGCAGAATACTGGTCTCAGGCCAAGCCCAATACAGCCATTAAAGATGACCTACAGTGCTGTGTACCCTGGGGCAATAGGGTTAAATGGTAGTTAGCAACTAGGGCTAGTCTTCCCTTACCTCAAAGGCTCTCACTACCGTGGACCACCTAGTCTGTAACTCTTTCTGAGGAGCTGTTACTGAATATTAAAAAGATAGACTTCAA

Publications

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