Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name PEX12P1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:89991349-89992897  UCSC
Coordinates (T2T) chr13:89195778-89197326  UCSC
Coordinates (hg19) chr13:90643603-90645151  UCSC
Strand +
Parental Sequence NM_000286.3
Parental seq. overlap 1396 bp
Parental seq. overlap (%) 53.2%
Genomic Region Intergenic
Retrocopy Summary PEX12P1, located on chr13:89991349-89992897, is a retrocopy of the parental gene PEX12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PEX12
Full Name peroxisomal biogenesis factor 12
Also known as PAF-3|PBD3A
Coordinate chr17:35574795-35578571
Strand -
Gene summary This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PEX12P1
Bonobo Pan paniscus PEX12P1
Gorilla Gorilla gorilla PEX12P1
Orangutan Pongo abelii PEX12P1
Gibbon Nomascus leucogenys PEX12P1
Green monkey Chlorocebus sabaeus PEX12P1
Crab-eating macaque Macaca fascicularis PEX12P1
Rhesus Macaca mulatta PEX12P1
Baboon Papio anubis PEX12P1
Golden snub-nosed monkey Rhinopithecus roxellana PEX12P1
Marmoset Callithrix jacchus PEX12P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PEX12P1
TCTGGGGTCAGTGAGCAAGAGTGGGCACTGGTGGGGATACTCAAAGCAGACAGCTGCAGCCAGTCCTTGTGTCTGGGACTCACACTGGCACTTCTGAATCCTCAGAATCCGCTGGCTTTTGAGCTCTCATTTTTGGTGGTGGGGGTGGGATTCCTGGTTTGCAGGTCCAGGGGATCGTGCTCCTTCCCTGACACATGTCCCACACAGCCACGTTCTGCCCTGAGATGCAGCATTTGATAACTTACCCCCTTACCACATACCACTTCCACCCACGTCCGAGTCAACTTTGTTCTTAACCTCCTTGAGACTCCGTCTGCCTCGAGAACAGATCTTTTTTTTCCCAGTTCATTGAGTTTGGAGTTTTGGATACCATGCAGAAAGTTTACCTTTAAGACTGAGCACCATTTTGATACCCTTCCTCCCCAAAACGTTCATGCTCACGAGTTTGTGGGAAAAGTGAAAGCCAGTACCCACAGAAAACTATGGCTGAACACAGGCTCACATCACGACTGCTTCTGTGGCTGTTGACCAGCCATCCATCTTTGCGGTAGTAGCACAAGACAGTTTAATGACAGCAGTGAGACTTGCTCTTCAGCATGTGTTCAAGGTTCTTGCAGAATCACATCCCACCCACTATGGCTTCTTGTGGAGGTGGTTTGATGAAATCTTTGCTACATCTTCTGCTCCAGCAGTATTATCTGTCTACAACCAGTGCCTCATTTTCTGAAAACTTTTGTGGCTTGAAGAGCATAGTAATGGGGGACACTCACAAGTGTCACAGATTGGCTAGTGCTGGTCTCCTAAAGGAGCAGCTTTGGAAATCAATTATGTCCCTGGTTCTTCTTTTCTATCTGAAAGTGAAGCTGGAGAAGCTGGTTTCTAGCTGAGAGAAGAGGATGAATATTCTATTCATCCCCCTTCTTCCAACTGGAAATGATTTTACAGACCCTTCCTGGCAGCCTACCCATTTGTTAACATGGCCTGGGAAGGATGGTTTCTTGTACAGCTTCGATACATCCTAGGAAAATCTCAGCATCACTCACCACTGCTGAAGCTGGCTGGAGTTCAGCTAGGTCAACTGACAGTTGAGGATATACAAGCTCTGGAGCATAGACCAGCTGAAGCCAGCATGATACAGCAACCAGCCAGAAGTGTTAGTGAGAAGATGAAGTCAGCTCTGAAGAAAGCTGTGAGGGATGTTGCCTTTTCCCTGTCTACTGGCCTTTCTGTCAGTGCATTCTTCTTGCAGTTCCTTGACTGGTGGTGCTCATCTGAAAACCAAGAAACCATCAAGTCATTGACCGCCCCGCCTACTCCACCACCACCTGTCCACCTAGACTATAACTCTGATTGTTCCCTTACCCAAAATGCAGACTGTGTGCCCCTTGTGTTGTAAAACCCAGGTGAATGATACTGTTCTTGCCACTTTTAGCTATGTGTTTCATTACGGCTGTGTGTTTCATTATATGAGGAGTCACCAAGCTTGTCCCATTACAGGTTATCCAACAGAAGTACATCTGATTAAATTCTACTCCCCTGAGAACTGAAA
>NM_000286.3
GTCATAAAGCGGAGACCTCCCTTCAAACGTGGCGTCGTGGGTTGTTTGCGCCTCGCCTGGGGTCAGCGAGCAAGGACGGGCGCGGGCGGGGATACTCAAAGCCAACAGCTGGAGTCAGCCCTTGTGTCCCGGGCTCACAGTGGCACGACTGAATCCTCAGAGTCGGCTGGCTTTTGAGCTCTCACGATTGGGGAGGAGGGGGCGTTTCTGGTTCGCAGCTCCAGAGGATTGCGTTCCTTCCCCCATACCTGTCCCCCACAGTCACGCTCTGCCCTGACGTGCAGCATTTGACAAGTTACCCCCTCGCCACATACTACTTCCACCCACGTCCGAGTTAACTTTGTTCTTAACCTTCTTGAGACTACCCTCGGCCTCCAGGTCTTTTTTTCCCAGTTCATTTTTGCCCATAAGATTGAGTTTCGAGTTTCAGATATCATGCAGAAAGTTTACCTTTAAGACTGAGCACCCATCTGATACTCTTCCTCCCGAAAAAGTTCATGCTCACGAGAGAGTTTGTGGGAAAAGTGAAAGCCAGTACACGCAGGAAACTATGGCTGAGCACGGGGCTCACTTCACAGCTGCTTCTGTGGCCGATGACCAGCCATCCATCTTTGAGGTGGTAGCACAGGACAGTTTAATGACAGCAGTGAGACCCGCTCTTCAGCATGTGGTCAAGGTTCTTGCAGAATCAAATCCCACCCACTATGGCTTCTTGTGGAGGTGGTTTGATGAAATCTTTACTCTGCTAGATCTTCTGCTCCAGCAACATTATCTGTCTAGAACCAGTGCCTCATTTTCTGAAAACTTTTACGGCTTAAAGAGAATTGTAATGGGGGACACTCACAAGTCTCAGAGATTGGCTAGTGCTGGTCTCCCAAAGCAGCAGCTTTGGAAATCTATTATGTTCCTGGTTCTTCTTCCCTATCTGAAAGTGAAGCTGGAGAAGCTGGTTTCTAGCCTGAGAGAAGAGGATGAATATTCTATTCATCCCCCTTCTTCCCGCTGGAAACGATTTTACAGAGCTTTCCTGGCAGCCTACCCATTTGTGAACATGGCCTGGGAAGGATGGTTTCTTGTACAACAACTTCGATACATCCTAGGAAAAGCTCAGCATCACTCACCACTGCTGAGGCTGGCTGGAGTTCAGCTAGGTCGACTGACAGTTCAGGATATACAAGCTCTGGAGCACAAACCAGCTAAGGCCAGCATGATGCAGCAACCAGCCAGGAGTGTTAGTGAGAAGATAAACTCAGCTCTGAAGAAAGCTGTTGGGGGTGTTGCCTTATCCCTGTCTACTGGCCTTTCTGTGGGTGTATTCTTCTTGCAGTTCCTTGACTGGTGGTACTCATCTGAAAATCAAGAAACCATCAAGTCATTGACTGCCCTGCCTACTCCACCACCACCTGTACACCTAGACTATAACTCTGATTCTCCCCTCTTACCCAAAATGAAGACTGTGTGCCCACTGTGTCGTAAAACCCGGGTGAATGATACTGTTCTTGCCACCTCTGGCTATGTGTTTTGTTACCGCTGTGTGTTTCATTATGTGAGGAGTCACCAAGCTTGTCCCATCACAGGTTATCCAACAGAAGTACAACATCTGATTAAACTCTACTCCCCTGAGAACTGAAAGGGAATCATGTCTTATCCTCACAACAAAAGTATTGCGCTGTAATGTCACAGAGCTGGTTTCAGCATGGTATTGAGTTGACACTTCTCAGCCTCAATTCATAACTATATGAACTTTAAATGATTATATGGATTTCTTTAAAAGGATATGCCCATTTGATCCTAACCTTTTAGCCTGCTCTCTAGAACCCTACTTACAGTTGACCAAGCTGCTTAAAGTAGAAGGATCAGGACTGGCAGGGGATATGAGGGCCAGTGTAGAGATTAAACAGAATAATGAGTACACAAGTTTTTGCCTATCCCTTTCCTTAAAATATAAGAAATAAAGGAGCTCTTACGAAAAACCCAGGTTAGACCGCATAAAAAATAAAGTGAACAGTGAGGTGGTAGCAAGACTTCTTTTTAGAAAAGAAAGCATTTACCTGCCTGTCTGTAAGGTGGAAATTTCATCAGTTTGCAAACGATAAGAAATGCAGACTTGCTCTTGATAGAAATGCTTAGAAACACTCTGGGGGGGAAAAAAGCTCCTTCCATATACTGTGAGACATTTGTTAAGTGACATCTATTGTTTATCAGCTTTTAAGGATAAAAAAGGTATTTTAAAAGTTGGATATTTAGGATATTTGAGGATATTCCTTTATGAGCTCTCCATATCCTTCTTGAGAAACTGGTTAAAAAAGGAATAGGGGTTGAGTGTTACAGAGAGTAGTCTGAAGATTCCTGTGTAAAAGCAAAGCTAACAAGCAATGAAGACATGAAGCAAAATACTAATCTAATTGTGTAAAGAAAGGATATTTTAATAAGTTCTTTCTGCTTGCTGCTAAGAGTTTGCTAAAGTGTCATGAATTATTCTGGTTATTACTAAAGTTTCTATGAAACACTTAAGTAGATTTTAAGAATAAATGTTTCTGGAAAAGAACTATGTTATGATTTTGTAGAAATGTAAAGATTACTTGAGGTGTTTAAAATAAATTTTTCATTCAGACTA

Publications

PMID - Link Title