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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TULP3P1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:96947719-96948226  UCSC
Coordinates (T2T) chr13:96151809-96152316  UCSC
Coordinates (hg19) chr13:97599973-97600480  UCSC
Strand -
Parental Sequence NM_001160408.2
Parental seq. overlap 431 bp
Parental seq. overlap (%) 21.8%
Genomic Region Intergenic
Retrocopy Summary TULP3P1, located on chr13:96947719-96948226, is a retrocopy of the parental gene TULP3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TULP3
Full Name TUB like protein 3
Also known as HRCDF|TUBL3
Coordinate chr12:2890891-2941138
Strand +
Gene summary This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla TULP3P1
Green monkey Chlorocebus sabaeus TULP3P1
Crab-eating macaque Macaca fascicularis TULP3P1
Rhesus Macaca mulatta TULP3P1
Golden snub-nosed monkey Rhinopithecus roxellana TULP3P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TULP3P1
CCTGGAGGACTTTTAAGCATAGTCCTGCCCCTTGAAGTGTCACAGTAAGATGTCATATAATCAGGGATAAAAAAAGGAATGGATTGGGGCCCCTGCTCCACTTACTGTATATACTTGGAAAAAGAAGAAAATCAGAAGACATTTCTTCTTACAGCTAGAAAGCGGGAAAAGAGCAAATCATCCAACTGCCTTATCTCCACTGATCCAACTGATTTATCTCGTGAAGGAGAAAGGTATACTGGCAAACTTAGATCTAACCTCAGGGGAACCAAGTTTACAGTTTATGACCGCGGCGTCTGCCCCATCATGGCCGGAGTCTGGTAGGGAAGGCTCACACACGGCAGGAGCTGGCTGTCGTTTCCTGTGAAACAGGTGAAGTGGGATCTGAAGGTCCTAGGAAAATGTCTGTGATCATTCCCGGAATGACGGTGAATCACGAGCAGATCCCATTTCAGCCACGAAATAACGACGGCAGCTTGTTCTCAAGATGGCAGAACAAAACTATGGT
>NM_001160408.2
ACTCTAGCGACGGCGGGGAAGAGTGTGTACGTGGTGGGGGCTTCCTCGGTGGCGGGCATGGAGGCTTCGCGCTGCCGGCTCAGTCCCAGCGGCGACAGTGTCTTCCATGAAGAAATGATGAAGATGCGACAGGCTAAGCTGGATTATCAGAGGCTACTACTTGAGAAGAGGCAAAGGAAAAAGCGCCTTGAGCCATTTATGGTGCAGCCCAATCCAGAAGCCAGGCTACGTCGGGCAAAGCCAAGGGCCAGTGATGAGCAGACTCCCTTGGTGAACTGTCATACTCCCCACAGCAATGTCATCTTACATGGTATTGATGGTCCAGCTGCTGTCCTGAAACCAGACGAAGTTCATGCTCCATCAGTAAGCTCCTCTGTTGTGGAAGAAGATGCTGAAAACACCGTGGATACTGCTTCCAAGCCAGGACTTCAGGAGCGTCTCCAAAAGCATGATATCTCTGAAAGTGTGAACTTCGATGAGGAGACTGATGGAATATCCCAGTCAGCATGTTTAGAAAGACCCAATTCTGCATCAAGCCAGAATTCAACCGATACAGGCACTTCCGGTTCTGCTACTGCCGCCCAACCAGCTGATAACCTCCTGGGAGACATAGACGACCTGGAGGACTTTGTGTATAGTCCTGCCCCTCAAGGTGTCACAGTAAGATGTCGGATAATCCGGGATAAAAGGGGAATGGATCGGGGTCTCTTCCCCACCTACTATATGTACTTGGAAAAAGAAGAAAATCAGAAGATATTTCTTCTTGCAGCTAGAAAGCGGAAAAAGAGCAAAACAGCCAACTACCTTATCTCCATTGATCCAGTTGATTTATCTCGTGAAGGAGAAAGTTATGTCGGCAAGCTTAGATCCAACCTCATGGGGACCAAGTTTACAGTTTATGACCGTGGCATCTGCCCCATGAAGGGCCGGGGTTTGGTAGGAGCGGCCCACACCCGGCAGGAGCTGGCTGCCATCTCCTATGAAACAAACGTACTTGGATTTAAAGGTCCTAGGAAAATGTCTGTGATCATTCCTGGAATGACACTGAATCATAAGCAGATCCCCTATCAGCCACAAAACAACCATGACAGTTTGCTCTCAAGGTGGCAGAACAGAACTATGGAAAATCTGGTTGAGCTGCACAACAAGGCCCCCGTCTGGAACAGTGACACTCAGTCCTATGTCCTCAACTTCCGTGGCCGGGTCACTCAGGCGTCTGTGAAGAACTTCCAGATAGTCCACAAAAATGACCCTGATTATATAGTCATGCAGTTTGGACGTGTGGCAGATGACGTGTTCACACTGGATTACAACTACCCACTTTGTGCAGTACAGGCCTTTGGCATCGGTCTTTCTAGCTTTGACAAATGTATCCAAACCTTGAGAATGCAGGAGCTCTGTGAGCTCCACCGTCAGCACCATTCAGCTGCATCCCTTGTGCACAGAACTGTTTGCCAGCGTTGGGTGGGACACCCGTGGCGGCTGCTCCCTCAGACCTCCCTTCTGTGGACTGACCTCTCACCTCCGCCTGTTGTTCCTGCACCACATCAGATAAGCATGTGAAGGAGGGCCAACTGGCAGCTGCGGGACCCTTGGCTTGTCCCCCACCGACAAGTCCCACCTGCTGGGTGAGGACGAGACTGTTTCCATCTCAGGCATGTATCCCACCAAGTGCCTCCCTCACAGCCATGCCCAGAAGCCTCACACCTCGTCACCACCACCACCCCCCACCCCATCCTGAGGCACTGCCTGGCAGATAACCCTGGTTGGCCACAGAAGCTATTAATACACGACAGCATGTGGGGAAGGACTTATGGTGGGCCAGGTGGACCTCATCCTGCTTCTTCCTCCCTCTGGTTTAAAGAGATATATAAACTAATTTCACATAATTTGTGTGTGCAGGTGATTGGTTTTTACATAAGTCCTATTTATACCTTTTATATGTTACAGAAATAAAAGTTAATTTATATAAAAA

Publications

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