Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NUS1P4
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:98609287-98610829  UCSC
Coordinates (T2T) chr13:97818951-97820488  UCSC
Coordinates (hg19) chr13:99261541-99263083  UCSC
Strand -
Parental Sequence NM_138459.5
Parental seq. overlap 1036 bp
Parental seq. overlap (%) 21.3%
Genomic Region Intergenic
Retrocopy Summary NUS1P4, located on chr13:98609287-98610829, is a retrocopy of the parental gene NUS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NUS1
Full Name NUS1 dehydrodolichyl diphosphate synthase subunit
Also known as C6orf68|CDG1AA|MGC:7199|MRD55|NgBR|TANGO14
Coordinate chr6:117675469-117710727
Strand +
Gene summary This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NUS1P3
Bonobo Pan paniscus NUS1P3
Gorilla Gorilla gorilla NUS1P5
Orangutan Pongo abelii NUS1P3
Gibbon Nomascus leucogenys NUS1P1
Green monkey Chlorocebus sabaeus NUS1P1
Crab-eating macaque Macaca fascicularis NUS1P1
Rhesus Macaca mulatta NUS1P1
Baboon Papio anubis NUS1P1
Golden snub-nosed monkey Rhinopithecus roxellana NUS1P1
Marmoset Callithrix jacchus NUS1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NUS1P4
GCATTCTGTGTTGAAAGGAGCTCCAGAGGAATGAAGTTCTGTGTTTCTCCCATGTTAAAAACTTTCTCACCTTCAGAACAGAAGGAATACAGATCTTCAGATATCAGTCCATTTTCTTCTCTTCGTTATGGTCAAACAGTGTGATTTGAGAGTGTCGTTCTGGTGTCTGGGTTCCTTCTCGGACATCACACGCCTCGTGCTGTGGTGTATGGCCGTGGCCGTCTCCTACATTCACGTTTACGGCCACCAATCTTTTCAAAAGAAATATTTCCATATTGATGGATGAAATTTTAAAACAGCAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAGTTTGCAAATAGGAACGACAAAGGTGATCAAGTTCTAAATTGCCGTTTGGCAGTGAAGGTGCTGTCCCCGGTAGATGGAAAAGCAGATATTCTGAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGTGACCCACAGATTTGGAAGGAGCTATGTTAGGCAGTTTACTTAGTTCAAATGGTTCTCCTGATCCTGATTTAGTATTGAAGTTTGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCCGGCACATCAGATTTACTGAGATTGTCTCTTTGCCTGCCCACTTAAACATCAGTTATGACGACTTTTTCTCTGCCCTACATCAGTATGCAGCCTGTGGCCAGCGTGAGGAAAAGCAGTAGTTATTGGTTGCATAATTGGATTTTAGGCTTTTAGAGAAAAGGACTCAAGTGACTCTGATGTTCACAAAGCACCTATGAAACCCTGTACACACCTAGTCCATAATCCTCATAATTTATCAACAAACACAAGTGTCTGATGTCTGACTTGAGAGAATGTGTGTATGTGTGTCTGTGTGTGCATGCGTGAGTGCACATATGTGCACCTTTGTATGTATGGAAATAAACTTATACATGGGGACGTACTGGAGAGGGAAATACATAGACATAGAACTTGGAGCAAATAGCAGCGATGTTGTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCCGCCAACTTTCCTGTTTTTGTGGGGAGAAGGGGGCCTGATTAGAGCTGCTCTGGTTGTGTCTGGCGGGAGGTGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAATTTTTAAGAATAGGATATTGACTTGTTGAATTGAAGGATTCTGTGAGGTTTt
>NM_138459.5
GTACTACTGGGGGCGGGGCTGCCAAGGGAGGAGGAAGATGGCGGCGGGGGCGAGGTGAGGTGTTGGCAGTGGAAAGGGGTTCGGGCTCGGGGGGCGGGGGGACGCGGAGCGATGGCCCGCGCCGGCCGCAGGGGCGGATAAAAAGCCGTCGCGCTGCGGGAGTGGGCGGGAGGGAGAGGGGGTGTCTGAGGGCCACAAGAGTATGACGGGGCTGTACGAGCTGGTGTGGCGGGTGCTGCACGCGCTGCTCTGTCTGCACCGCACGCTCACCTCCTGGCTCCGCGTTCGGTTCGGCACCTGGAACTGGATCTGGCGGCGCTGCTGCCGCGCCGCCTCTGCCGCGGTCCTAGCGCCGCTCGGCTTCACGCTCCGCAAGCCCCCGGCAGTCGGCAGGAACCGCCGTCACCACCGGCACCCGCGCGGGGGGTCGTGCCTGGCAGCCGCACACCACCGGATGCGCTGGCGCGCGGACGGTCGTTCCTTGGAGAAGCTGCCTGTGCATATGGGCCTGGTGATCACCGAGGTGGAGCAGGAACCCAGCTTCTCGGACATCGCGAGCCTCGTGGTGTGGTGTATGGCCGTGGGCATCTCCTACATTAGCGTCTACGACCACCAAGGTATTTTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAAGATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATTGTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTGTCCTGATCCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTGACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAACAGCGTCTGGGAAAGTAGTGGTCATTGGTTGCATAATTTGATTTGAGGCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGCACCTATGAAACCCTGTACACACCTAGTTCATAATCCTCATAATTTATCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAgtgtgtgtgtgtgcgtgtgcacgtgcacacatgtgcacgtttgtatgtaTGGAAATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGACCTACAACTTTGAGCAAATAGCAGTGATGTTTTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGGGGAGAAGAGGGCCTGATTAGAACTGTTCTGGTTGTGTTTGGCGGGAGGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAATTTTTAAGAATAATATATTGACTTACTGAACTGAAGCATTCTGAGTTGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGTTAAAATCTTGCTCACCTTCAGAGCAGAGGGAATACCTATCTTCAGATATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTATTCTGGGTTCTGAAGTCTGGTATTCTGGTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTATTCTGAGAGTTGCTCTGTATTCTGGGTTCTGAAGATTATTTGAAAAATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACATTGGATTAGGCAGTCAAAAAAACCAAGCAAGCATAAAAGGTCAATAAGTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGAAAGAAAGTTTTATTTCCTTTTTTGTTTGATGGGCAGTATGCCATATTATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTTATTTAAAATAAACATTTGAGGGAAGTTACCAAGGCAGCTTTTTTCCTCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGCATGGTTAATACCTGAGATTTTTACTCAGTAAATCCTGATGGTTACTGTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGGAATAAAATATTACCAAAGTCTATAAAAATAAATTTTACATGTTCTCTTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGAATAATTGATTTCTTGATAGGTGTTTAATATTTCTTCCCTCACTGCTGATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTTCAGAAAACCCTTATCAACAAGTGTACAATACTTATCTAAAACTATACATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGAAAAATAGCAAAGAAGACTGGATTTGGAAAGCATGGTCTACAATTGGTTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGGATTATGAAACCCCATTTATGATTTTTTAAATACACTTGAAATAAAAATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGCATAATCCATTATACGTTGTACGACTTTTTTTTTTTGTTTTAATTTATTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGAATTTCTGATTCCTTATACTGTGATTATATTATATTGAGGCATTTGTAGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAGGTATAAATGTCTTATAAACATTCTGGAGTATGTATAGCTTTAATGAATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTTGTTAAAGTTAAGTTAGTCAAATAAATTACCTACTGGAATATAGCCCAAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTTCTCCTTCCATTCATAAGTATATACTTGAAAGTACATCTGTAGCCTATGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAACTACTAGGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCATTGGTTGTTCTGTAATTCCTGCCAAAAGCATCACAAGTTGTACATCATCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAACAAAAGTATGTGTCTTTATTTGTATTGGAAAATACTGTCTTTAAATTGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTAAACCTGTTTTATGGATGGCAGCTTGGAGCATAGCAAGAAGTTGGAGGATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAAAACTATAATAATCGGTTACTGTTATAAAGTTTAAAAGGTGGTTTTAATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAATGCCTGTCTTTGAGAGGAAGGTGTTATAATATTAATGAACAGTGCCAAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTTACTGGATTAGCTCCCTCCTCCTGTGTGATGGTACCATGCATAGAGTCAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGTAAATAATGTGTAAAGCCAGTTTTTATGATTAAGGAATCAAATTTATTGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAAAACCAATAAAAGAATATACTCTTTTCATTGACTATAGTATTATGTGAATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAATAAGAAATGCATATGACTAGATAGCAATAGTGTTTTTTTTAGATGGTATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAACATTTGGAATCTTATAATGTTACTTGCTTTTTGATAGATAATAGTGAAATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACAGTAATTAAAATTTGAATTTTTACCGAATATGAAATTTCCAAATTAAAAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTTGTCAAATGAGAAAATTTAAAGGTAAGAGTTATGGTTTGTCTTATGCTGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGACAATTGTTTTTTTGTGCATAGTTTTCATCTAAAATTAAGTTTACCAAAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTACTATAAAGTTCAGGACAGTTTGAAATAAAACCCAGGAAACAAGATTAATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACTATGATGCAATGGATAGGAAAAGGTAGTGCAAAAAGAATTTCTTAAGGTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGAGAAACAAAGGAATGTAACCTTATTGATTACATTTTTGGTGATCACCGAGAATTTTTTGTACTATATTTTAAAAAATGTATTCTACTGTAACAAGTTAATAAAGAGATTTTTTAAAAAACTATAAACTAGAAATTGAGAGTCTTGCATTCTCTTTTGTATTTGATTATTGTGTCTGGATATAAATTACAATAGCACATGAAAATAAAATGTTTTAAAAAA

Publications

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