Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HOMER2P2
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Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:106286091-106287792  UCSC
Coordinates (T2T) chr14:100557592-100559295  UCSC
Coordinates (hg19) chr14:106742686-106744387  UCSC
Strand -
Parental Sequence NM_199330.3
Parental seq. overlap 1468 bp
Parental seq. overlap (%) 73.9%
Genomic Region Intergenic
Retrocopy Summary HOMER2P2, located on chr14:106286091-106287792, is a retrocopy of the parental gene HOMER2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HOMER2
Full Name homer scaffold protein 2
Also known as ACPD|CPD|DFNA68|HOMER-2|VESL-2
Coordinate chr15:82836946-82986176
Strand -
Gene summary This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HOMER2P1
Bonobo Pan paniscus HOMER2P1
Gorilla Gorilla gorilla HOMER2P1
Orangutan Pongo abelii HOMER2P2
Crab-eating macaque Macaca fascicularis HOMER2P1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.511.5
log10(TPM+1)

Related Sequence

>HOMER2P2
GCGGAATGGAGCGGCGCCAGGGCTGAGCCAGGCGCGCAGGGGCCGCCGCACGTGCCGCGCGGGGAGCGGATGCCCAGCGGGCGGAGAGCCAGCGCCAGAGGCCGGGTCGGAGCGGCCGCTGGAGCAGCGTCAGAATGGGAGAACAGCCCATCTTCACCCCCCGAGCGCGGGTCTTCCAGATTGACCCCAACACCAAGAAGAACTGGATGCCTGCGAGCAACAGGCGGTCACCATTTCCTGTTTCTATGATGTCACAAGGAACAGCTATGGGATCATCAGTGTGGACAGCGCCAAGGTGACCATAAACAACACAATTACACAGAATATGACCTTCACCAACACGTCACAGACGTCTGGGCAGTGGGCCGACAGCAGAGCCAACACGGTGTTTGGTTTGGGGTTTTCCTCTGAGCAGCAGCTGACAAAGTTTGCAGAGAAATTCCAGGAGGTGGAAGAAGCGGCCAAGACAGCCAAAGACAAGACCCAGGAGAACATGGAGCCCTCGAGTAATCATCCTGAGAATCAGGGCGTGGAGCCCCATCTTCTACTCCGGCATCCAGTGTCAACGGGACGGACGATGAAAGGCCTCTCAGGCCGCTGCAGCCGACACGCACCTGCAGTCTGGGAACCACAAGCTGAAGGCGGCCTCGACGCAGAGCTGCCCACGGGAAGAGGTGGGAGATGGAGCTGCAGACCCGGCGGGAGACCGACTTCCGGCTGCCCACGGCGCTGCAGGAGTCGACGGCCAGTGCGGAGCAGAGGAAGAGGCCGTGAGTCAGAGTGCGACTGTGTCTCTGAGAAGATGGAGGCGGCAGAGAGAGGATCAAAACCTGGAAGATAAAGTGCGTTCCCTAAAGATAGGCCCTGAGGAGAGCAAATCCCGACAGCGCCACCTGGAGGCGCTTCCTGGTGGCGCTGGACCGGAAGATCCAGGCCTGCATAACTTCCGCCCAGGCCTCCCAGGCTGGGCACCAACAACTAGGGCTGGCAGAGGCCCGGGATCCCCACCGTGAGTCCTAAGTATGTGTGCGAGACCAGATGGCGCTAGGACGTTCCCTGTGTGCGTTGCTTCTGTAAATGCAGGCGCCGTGTGTCGTGTTTCCAAACCAGTTGTGCCATCCACTCACTCCTTTCCAGAATAGAAATCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTGAGGAAACCAGAACCAGGTCTACCTTCAACATTTACGCAGTCAGGCCAGGGATGTTTATATCGTTCATAAGGGTTGTTGGAACCATATGAACTGAAAAAAAGCATTTTCTCATCCAAATATTGATATTCTTTACACCAGGCCATCGGGCTCCTTTTATCCGATAGCATTCAGAGTATTTGAAGGTCCTCCAGGTGCCAGCCTTGGGGGCACAGGGAGAACAACATTCCTCTCCGAAAACATGGGGAAGCTTTAAAATAACTGTTTAGTGGAGACTTACCCAGAGATGGAAAACAGGTTTCTGGTGAGTACATTTTCTGGTTTGGGAATCACCTGCATCCCCGATCCTGCCCCGTGCCCCCCAGTTTGTATGGTTGTGACAATGTTCCATTTCTTTGTTTTAATTTCTGAGCAGTTGACTGTGGTGCGGGAACAGCACACAGTGAGGg
>NM_199330.3
gcGCCTGGCGGCGGTGGCGGCAGTGGCAGCAGTGGCAGCCGCGCAGCCCCGCGGAATGGAGCGGCGCCGGGGCTGAGCCGGGCGCGCACGGGCCGCCGCATGTGCCGCGCGGGGAGCGGCTGCCGAGCGGGCGGAGAGCGAGCGCGAGAGGCCCCGTCGGAGCGGCCGCCGGAGCAGCGCCGGAGATGGGAGAACAGCCCATCTTCACCACCCGAGCGCATGTCTTCCAGATTGACCCCAACACCAAGAAGAACTGGATGCCTGCGAGCAAGCAGGCGGTCACCGTTTCCTACTTCTATGATGTCACAAGGAACAGCTATCGGATCATCAGTGTGGACGGAGCCAAGGTGATCATAAACAGCACAATCACACCGAATATGACCTTCACCAAAACGTCACAGAAGTTTGGGCAGTGGGCCGACAGCAGAGCCAACACAGTGTTTGGTTTGGGGTTTTCCTCTGAGCAGCAGCTGACAAAGTTTGCAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAAGAATCTGGGCGTGAAACCCCATCTTCTACTCAGGCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACACACACCTGAAGTCTGAGAATGACAAGCTGAAGATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAAGTGGGAGATCGAGCTGCAGACCCTTCGGGAGAGCAATGCACGGCTGACCACAGCACTGCAGGAGTCGGCAGCCAGTGTGGAGCAGTGGAAGAGGCAGTTCTCCATCTGCCGTGATGAGAATGACCGGCTCCGCAACAAGATTGATGAGCTGGAAGAACAATGCAGTGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTGAAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGCTCATGTCAGAGTGCGAATATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAGACAGACATTGAGGAGAGCAAATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACCTGCATGACTTCCGCCGAGGGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTGTGTGCGAGACCAGATAGCTCTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGTGCCGTCCACTCACTCCTTTTCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGGAATCCAGAACTAGGTCTACCTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTGAAAAAACACGCATTTTGTAATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAATGTCCACCAGACACCAGCCCCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGAAACTTTCTGAGAGATGGAAAACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCGCCCCCCCAGTTTGTACGGTTGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGAGGgtgcctagcacaatgtctggcacaaagtaggtgcttaataaatatttgttcaattaaa

Publications

PMID - Link Title
No publications available for this retrocopy