Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NEK2P5
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:18698045-18700120  UCSC
Coordinates (T2T) chr14:13201424-13203499  UCSC
Coordinates (hg19) chr14:19474522-19476597  UCSC
Strand -
Parental Sequence NM_002497.4
Parental seq. overlap 1944 bp
Parental seq. overlap (%) 90.2%
Genomic Region Intergenic
Retrocopy Summary NEK2P5, located on chr14:18698045-18700120, is a retrocopy of the parental gene NEK2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NEK2
Full Name NIMA related kinase 2
Also known as HsPK21|NEK2A|NLK1|PPP1R111|RP67
Coordinate chr1:211658256-211675625
Strand -
Gene summary This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NEK2P2
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NEK2P5
AAACGGGGCCGAAGGCAGGGGTGGCAGGTCAGTGTTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGCTCCCGGTCCCTGGAGCTCCGCACTTGGGGGCACAACCTGCATGAGGCAGCGCCACTCTGGTGACTGGCCGGCCATGCCATCCCGGGCTGAGAACTATGAAGTGTTGTACACCATTGGCACAGGCTCCTATGGCCGCTGCCAGAAGATCCAGCGGAAGAGTGACGGCAAGATACTAGTTTGGAAAGAACTTGATTATGGCTTCATGACAGAAGCTGAGAAACAGATGCTTATTTCTGAAGTGAATTTGCTTTGTAAACTGAAAAATCCAAACATCGTTCATTACTATGATCGTATTATTGACCGGACCAACACAACACTGTACGTTGTAATGGAATATTGTGAAGAAGGAGACCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGACGACTCAGTTGACTCTGGCCCTGAAGTAATGCCACAGACGAAGTGGTGGTGATCATACTGTAGTGCGTCGGGATCTGAAACCAGCCAGTGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGATTTGGGGCTAGCCAGAATATTAAACCACGACACGAGTTTTGCAAAAACATTTGTTGGCATACCTTATTACATGTCTCCTGAACAAACGAATCACATGTCCTACAATGAGAAACCAGATATCTGGTCATTGGGCTGCTTGCCGTATGAGTCACGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCTATACCGTTACTCTGATGAATTGAATGAAATTATTATGAGGATGTTAGAGGATTACCATCAACCTTCTGTTGAAGAAATTCTCGAGAACCCTTTAATAGCAGATTTGGTTGCAGAAGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATTGCTGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTAAAGGAAATTCAGTTAGAGGAGCAAGAGCGAGCTCTCAAAGCAGGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTTGTGAGAGACTAGCAGAGGACAGACTGGCTATACCAGAAAATCTGTTGAAGAATTACAGCTTGCTAAAGGAACAGAAGTTCCTGTCTCTGGCAAGTAGTCCAGAACTTCTTAATCTTCCATCCTCAGTAATTAAGAAGAAAGTTCATTTCAGTGGGGAAAGTAAAGAGAATGTCATGAGGAGTGAGAATCCTGAGAGTCAGCTCACATCTAAGTCCAAGTGCAAGGACCTGAAGGTCCTTGCTTCATGCTTCATGCTGCCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTATCAACTAAAAAGCAGAGAGATCCTGGGCATGCGCTAGCCGGGTAGAGAGACACAGAGCTGTGTACAGGATGTAATATCACCAACTTTTAGAGACTGATGTTCAAATGCTGTAGCGTTATATACTTGGTTCCATGAGCCGTGCCTTTTTGCATAGTCCACATGATATTTCAGAATTGGTGTTGCTGTTCTTTAGCAACTGTTGTACAAAATGTTCACATTTAATTTTTCTTTCTTCTTTTAAGAACACATTATAAAAAGAATACTTTCTTGTTTGGTTGGGCTTTTAATCCTGTGTGTGATTACTAGTAAGAACATGAGATGTGACATTCTAAATCTTGGGAGAAAAAAATAACACGAAAAAAAATTTAATGAGGAGTAGCACTCACTGCATAGTTTTAAATGACTGAGTGGTGTGCTTACAATTGTCATGTCTAGATTTGAATTTTAAGTCTGAGATTTTAAATGTTTTTGAGCTTAGAAAACCTAGTTGGATGCCATTTGGTCATTAATACCATGACATCTTGCTTATGAATATTCCATTGCTCTGTAGTTCAAATCTGTTAGCTTTGTGAAAGTTCATCACCGTGATGTCTGTATTCTTTTTTCCTTTTTATTCTGTTTAACAGAATAA
>NM_002497.4
AAACGGGGCCCAAGGCAGGGGTGGCGGGTCAGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACTTGGCGGCGCAACCTGCGTGAGGCAGCGCGACTCTGGCGACTGGCCGGCCATGCCTTCCCGGGCTGAGGACTATGAAGTGTTGTACACCATTGGCACAGGCTCCTACGGCCGCTGCCAGAAGATCCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCATCCTCAGTAATTAAGAAGAAAGTTCATTTCAGTGGGGAAAGTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTAAGTCCAAGTGCAAGGACCTGAAGAAAAGGCTTCACGCTGCCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGAAAAGCAGACAGATCCTGGGCATGCGCTAGCCAGGTAGAGAGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGATATTCAAATGCTGTAGTGTTGAATACTTGGTTCCATGAGCCATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTCTTCAGCAACTATTGTACAAAATGTTCACATTTAATTTTTCTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCTTTTAATCCTGTGTGTGATTACTAGTAGGAACATGAGATGTGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTATGCAGGAAGAGTAGCACTCACTGAATAGTTTTAAATGACTGAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGATTTTAAATGTTTTTGAGCTTAGAAAACCCAGTTAGATGCAATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCTGTAGTTCAAATCTGTTAGCTTTGTGAAAATTCATCACTGTGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTGTCATTTACCTACTTCTTTCCCACTAAATAAAAGAATTCTTCAGTTTCCCTGTA

Publications

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