Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2CP1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:30682868-30683629  UCSC
Coordinates (T2T) chr14:24880686-24881447  UCSC
Coordinates (hg19) chr14:31152074-31152835  UCSC
Strand -
Parental Sequence NM_007019.4
Parental seq. overlap 670 bp
Parental seq. overlap (%) 83.1%
Genomic Region Intragenic (SCFD1)
Retrocopy Summary UBE2CP1, located on chr14:30682868-30683629, is a retrocopy of the parental gene UBE2C. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2C
Full Name ubiquitin conjugating enzyme E2 C
Also known as UBCH10|dJ447F3.2
Coordinate chr20:45812644-45816952
Strand +
Gene summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2CP3
Bonobo Pan paniscus UBE2CP2
Gorilla Gorilla gorilla UBE2CP2
Orangutan Pongo abelii UBE2CP2
Gibbon Nomascus leucogenys UBE2CP5
Green monkey Chlorocebus sabaeus UBE2CP6
Crab-eating macaque Macaca fascicularis UBE2CP5
Rhesus Macaca mulatta UBE2CP5
Baboon Papio anubis LOC116268818P3
Golden snub-nosed monkey Rhinopithecus roxellana UBE2CP5
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2CP1
CCGAGTTCCTGTCTCTGCCAGCACCGCCTGGATGGCCTCCCAAAATTGCGACCCAGCCACCACTAGCATCGCAGCCTCCCACAAAGGAGCAGAGCCAAGCTGGGGTGCCGCTGGGGGTCCCATGGGCAAAACAACAGGAGCTCATGACTCATAATGTGTGGCAGCAAGGGCATTTCTGCCTTCCCTGAATCAGACCACCTTTTCACATGGGTAGGGGCCATCCATGGAGCAGCTGCCACAATATATGAAGACCTGAGGTATAAGCATAAGCTCTCACTAGAGTTCCCCAGTGACTACCCTTACAATGCACCCAGGTGAAATTCCTCACACCCTGCTACTATCCCAGTGTGGACACCCAGGGTAACATATGCCTGGACATCCTGAAGGACAAGTGGTCTGCCCTGTATGACATCAGGACCATTCTGCTCTCCATCCAGAACACTCTCCATCTCCAGCCTACTAGGAGAACCCAACATTGATAGCCCCTTGAACACACATGCTGCCAAACCCTGGAAAAACCCCACAGCTTTTAAGAAGTATCTGCAAGAAACCTACTCAAAACAGGTCACCAGTCAGGAGCCCTGACCCAGGCTGCCCAGCCTGTCCTTGTGTCGTCTTTTTAACTTTTCCTTAGATGGTCTGTCTTTTTTTGTGATTTCTGTATAGACTCTGTATCATGAGCTGTGATATTATTTTTGTTTTTGTCTTTTAAATTAAGCCTCAGTTGAGCCCTTGTGATGTATATTAAATAAATACATTTTG
>NM_007019.4
GCAGTTGCAGTCGTGTTCTCCGAGTTCCTGTCTCTCTGCCAACGCCGCCCGGATGGCTTCCCAAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCTGAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGATGACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTCAAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTATATGAAGACCTGAGGTATAAGCTCTCGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTTCCTCACGCCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGCCTGGACATCCTGAAGGAAAAGTGGTCTGCCCTGTATGATGTCAGGACCATTCTGCTCTCCATCCAGAGCCTTCTAGGAGAACCCAACATTGATAGTCCCTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACAGCTTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCCTGACCCAGGCTGCCCAGCCTGTCCTTGTGTCGTCTTTTTAATTTTTCCTTAGATGGTCTGTCCTTTTTGTGATTTCTGTATAGGACTCTTTATCTTGAGCTGTGGTATTTTTGTTTTGTTTTTGTCTTTTAAATTAAGCCTCGGTTGAGCCCTTGTATATTAAATAAATGCATTTTTGTCCTTTTTTA

Publications

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