Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RIPPLY3P1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:38973734-38973970  UCSC
Coordinates (T2T) chr14:33162403-33162639  UCSC
Coordinates (hg19) chr14:39442938-39443174  UCSC
Strand -
Parental Sequence NM_018962.3
Parental seq. overlap 189 bp
Parental seq. overlap (%) 9%
Genomic Region Intergenic
Retrocopy Summary RIPPLY3P1, located on chr14:38973734-38973970, is a retrocopy of the parental gene RIPPLY3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RIPPLY3
Full Name ripply transcriptional repressor 3
Also known as DSCR6
Coordinate chr21:37006150-37019662
Strand +
Gene summary Predicted to be involved in embryonic pattern specification and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RIPPLY3P1
Bonobo Pan paniscus RIPPLY3P1
Gorilla Gorilla gorilla RIPPLY3P1
Gibbon Nomascus leucogenys RIPPLY3P1
Green monkey Chlorocebus sabaeus RIPPLY3P1
Crab-eating macaque Macaca fascicularis RIPPLY3P1
Rhesus Macaca mulatta RIPPLY3P1
Baboon Papio anubis LOC116274611P1
Orangutan Pongo abelii Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RIPPLY3P1
CGTGGAGACCTGTGATCCTGACACCTGCAGATGCTGAGCTGACCAGAACTGGAAGCCAATTTAAACCTGGGGGAGATCAAGAAACTTTTGGATTAAAGGAAGTCTTCAGGTTTCTGCATCCTGTAAGACTTTACTTACCCTTTTTGAAATGTCAATAATATTTGCAGTGTTCTGGGGAAAAAGTGCTGGTCAGTTTTCCAGTGCAAGCCATGATATACTTCTATAACGATGAGTCTG
>NM_018962.3
GTTAGCCCGAGTGGATCTAGGCGCGCTCGTAGGCCGGCGCCGCAGCAAGGGGCGCGGGCTCCGCCGGCACCATGGAGCCCGAAGCGGCGGCCGGAGCCCGGAAGGCGCGGGGGCGCGGCTGTCACTGCCCCGGGGACGCTCCCTGGAGGCCTCCGCCACCGCGCGGGCCGGAGAGCCCCGCGCCGTGGCGACCTTGGATCCAGACACCTGGAGATGCTGAGCTGACCAGAACTGGAAGGCCGCTTGAACCTAGGGCTGACCAACACACTTTTGGATCAAAGGGAGCCTTTGGGTTTCAGCATCCTGTAAGAGTCTATTTACCCATGTCAAAGCGTCAAGAATACCTGCGGAGTTCCGGGGAGCAAGTACTGGCCAGTTTCCCAGTGCAAGCCACGATTGACTTCTACGACGATGAGTCTACTGAGTCTGCTTCCGAAGCTGAAGAGCCAGAGGAAGGACCCCCACCCCTCCATCTTCTGCCCCAGGAGGTGGGAGGTCGGCAGGAAAATGGCCCAGGGGGAAAGGGCAGAGACCAGGGCATCAACCAAGGGCAGCGATCCTCAGGAGGGGGTGACCACTGGGGGGAGGGTCCGCTCCCTCAAGGTGTCTCCTCAAGGGGTGGCAAGTGCTCCTCATCCAAATGAATCAGTCTCTGTCTCCTGGGCCCTGCTCTGGGACCTGCCCCTCACGTTCTCTTGGGGACACCCGAGCCAGGACACTACGCATCCCTGCTGAGTGTGCAGAGGCTAGAGGCTTCTCGGGCAGCCCCTGGCCTGCACACTACTCATGACAGAAAGTCAGCTTTTACTTTTCTTTCCCCTGGCAATTCGTTTTTGGTGCACTCATGCATGCCTTTGAGAAAGGATTCTAGGAGAAAGAGAAGGTCTATGTCAACAGAGTTGTTATCTCATAGAGCCAGTTTTCAAAGCTCCTTCTGCATTGTCACTCACTGATCAGGTGATGAATTCTTCCTAGATAGTCGCCCACTCCACCTCCTACTTAACCTGAGACTCATTATTTAGCTATTTCTGCTTTTGTAAAAATAATTCAGATATTAAACTCCAATTTTAATCTATCATCCAAGGGTAGATGTAGTTGCTTAGTAGCATTTTGGAAAAAAAAGAAAAAAAGGTTTGGTTTGGttttgtgacggagttttgctcttgtctcccaggctggagtgcagtgacacaatctcggctcactgcaacctccacttcttgggttcaagtgattctcctgtctcagcctcccaagtagctgggattacaggcatgagctaccacgcctggctaattttttgtatttttagtagagactcggtttcaccatgttggtcaggctggctttgaactcctgacctcaggtgatccacccgccttggcctcccaaagtgctgggattacaggcgtgagccactgagcccggccAAAAAAAAATGTATTTATTAAAAAAAAATTTTTTTAACCCGCCGAATAATTCCCATAAGAGTAACAAAAAGgaccagcctgaccaacgtggagaaactctgtctctactaaaaatacaaaattagccaggcgtgatggctcatgcctgtaatcccagctactcgggaggctgaggcaggagaatggctagaacccgggaggcggaggttgccgtgagtcgagatcgcaccattgcattccagcctgggcaacaagagcgaaactccgtctcaaaaaaaaaaaaaaaaaaaaagaaagaaaaGAGTAACAGAAAGATAGGGATTTTTAGGAGACAATTAGATAAAAATGTATGTGATGACTGTATAAGGAGGCCTGTGTGTATGAATTTATAGGGAGTAGAACCGTCTCTCTTCTTAGTTGGTGACTGTTTGGGGCCTGGTATTTTAATAGATGAACACTACTTTTTTAATTTTTTATTTTTTTAACCCTACCCTTAACCCATGAACACTATTTTTAATTAAAGTATCTGATGTAAAATTATTTTGAGTTTTTAATATTTTGATAAACGTGTATTCCTGAAACTTTTTGACTTACTTATCTTACATGTGGTGTCTTCCTGTATATAGTACATTATATCAATTTCTACTTGAAATAAATATTTTGAAAGAA

Publications

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