Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name YTHDF2P1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:39215063-39217159  UCSC
Coordinates (T2T) chr14:33403725-33405821  UCSC
Coordinates (hg19) chr14:39684267-39686363  UCSC
Strand +
Parental Sequence NM_016258.3
Parental seq. overlap 1992 bp
Parental seq. overlap (%) 72.6%
Genomic Region Intergenic
Retrocopy Summary YTHDF2P1, located on chr14:39215063-39217159, is a retrocopy of the parental gene YTHDF2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name YTHDF2
Full Name YTH N6-methyladenosine RNA binding protein 2
Also known as CAHL|DF2|HGRG8|NY-REN-2
Coordinate chr1:28736624-28769775
Strand +
Gene summary This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes YTHDF2P1
Bonobo Pan paniscus YTHDF2P1
Orangutan Pongo abelii YTHDF2P1
Gibbon Nomascus leucogenys YTHDF2P1
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>YTHDF2P1
CATGGTTGATGGACAGTCAGCTTTTGCCAATGAGACCCTCAGTAAGGCTCCTGGCATGAATGCTATAGACCAAGGGATGGCAGCACTGAAGTTGGGTAGCACAGAAGTTGCAAGCAATGTTCCAAAAGTTGTAGGTTCTGCTGTTGGTAGCGGGTCCATTACTAGTAACATCATGCTTCCAATAGTTTGCCTCCAGCCACCATTGCTCTCCAAAACCAGCATCTTGGGCTGATATTGCTAGCAAGCCTGCAAAACAGCAACCTAAACCGAAGACCAAGAATGGCATGCAGGGTCAAGTCTTCCGCCACCCCCGATAAAGCATAACATGGATATTGGAACTTGGGATAACAAGGGTCCATTGCAAAAGCCCCCTTACAGGCTTTGGTTCAGAATATAGGTCAGCCAACCCAGGGGTCTCCTCAGCCTGCAGGTCAGCAGGCTAACAATAGCCCACCAGTGGCTCAGGCATCAGTAGGGCAACAGACACAGCCATTGCCTCCACCTCCACCACAGCCTGCCCAGCTTTCAGTCCAGCAACAGGCAGCTCAGCCAACCCGCTGGGTAGCACCTCGGAACCATGGCAGTGGGTTCGGTCATAATGGGATGGATGGTAACGGAGTAGGACAGTCTCAGGCTGGTTCTGGATCTACTCCTTCAGAACCCCACCCTGTGTTGGAGAAGCTTCGGTCCATTAATAACTATAACCCCAAAGATTTTGACTGGAATTTGAAACATGGCCGGGTTTTCATCATTAAGAGCTACTCTGAGGACGATATTCACCGTTTCACTAAGTATAATATTTGGTGCAGCACAGAACATGGTAACAAGAGACTGGATGCTGCTTATCGTTCCATGAACGGGAAAGGCTCCTTTTACTTACTTTTCAGTGTCAACAGCCGTGGACACTTCTGTGGCGCTGCAGAAATGAAATCTGCTGTGGACTACAACACATGTGCAGGTGTGTGGTCCCAGGACAAATGGAAGGGTCGTTTTGATGTCAGGTGGATTTTTGTGAAGGACATTCCCAATAGCCAACTGCGACACATTCGCCTAGAGAACAATGAGAATAAACCAGTGACCAACTCTAGGGACACTCAGGAAGTGCCTCTGGAAAAGGCTAAGCAGGTGTTGAAAATTATAGCCAGCTACAAGCACACCACTTCCATTTTTGATGACTTCTCACACTATGGGAAACGCCAAGAGGAAGAAGAAAGTGTTAAAAAGGAACGTCAAGGTCATGGGAAATAAAAGGCAGTTCTACACAGACTGCAGCAACGGTTGCATCTGCATATCCTAAGAGGAAAAAATGACCTTCAAGAGAATTAGGACTTTTTTCTTAATTTCACTGACTTCAGCGACGATTGCAGACTTGCAGTTTAAGTATTGGAATTTCACAAAAGACATAGGACTTAACTGGaTCCCTCTAGGTAGTTTAGGTGAAAAATGTCCCTTTTATTTTGGCTTTGGTTGTGATTTCAGAGCATAATGCTTTGTTTTTTTGTCTTTTTACTATGTTTTTCAGATTTTTAAGTCCGTAAGTGCATACAGTTTTCTCTAATTTTTAAACCCTTTCCTCCTCCCATTTTGACATTTGCACTTGGAGAACACTTGAGTTGTGAAGGTTTTGGGCATCCACCCCAGAAAGTGGGAATTTGATTTTATCCTTCCGAACTGGAAGAACATTTTTATGAAGAATTTTTGTCTAGGAGAATATAACAGTGTTACCCAAGCTTGTGTCTTTAAGGGTGGTTCATTTTCTCTGATCTTTTGTTACTCAAAATAAAGTACTAGGAGTCCTAAGAAATGTTCTGTTCTTGTACATTCTACTGATTAAGTCAGGATTAATTTGATTTCAAAGCTAAGAACAGTGGTAAAAACTTGTTTACAGAAATGCATTTTGGAAGAGAAAAATACTGTAAAACGTGTAGTGAATGTTTCTTCAGTTTCTTGTTCAGCCAATGAGGAAAGGGCATTGCCTTTCTTTTTACCATTAATCACTTCTCAATAAATGTGAGATCCTGTTGAGCAT
>NM_016258.3
AGAGCGTCGCCGAGTCGGAGCCGGAGCCTGAGCCGCGCGCTGTGTCTCCGCTGCGTCCGCCGAGGCCCCCGAGTGTCAGGGACAAAAGCCTCCGCCTGCTCCCGCAGACGGGGCTCATCTGCCGCCGCCGCCGCGCTGAGGAGAGTTCGCCGCCGTCGCCGCCCGTGAGGATCTGAGAGCCATGTCGGCCAGCAGCCTCTTGGAGCAGAGACCAAAAGGTCAAGGAAACAAAGTACAAAATGGATCTGTACATCAAAAGGATGGATTAAACGATGATGATTTTGAACCTTACTTGAGTCCACAGGCAAGGCCCAATAATGCATATACTGCCATGTCAGATTCCTACTTACCCAGTTACTACAGTCCCTCCATTGGCTTCTCCTATTCTTTGGGTGAAGCTGCTTGGTCTACGGGGGGTGACACAGCCATGCCCTACTTAACTTCTTATGGACAGCTGAGCAACGGAGAGCCCCACTTCCTACCAGATGCAATGTTTGGGCAACCAGGAGCCCTAGGTAGCACTCCATTTCTTGGTCAGCATGGTTTTAATTTCTTTCCCAGTGGGATTGACTTCTCAGCATGGGGAAATAACAGTTCTCAGGGACAGTCTACTCAGAGCTCTGGATATAGTAGCAATTATGCTTATGCACCTAGCTCCTTAGGTGGAGCCATGATTGATGGACAGTCAGCTTTTGCCAATGAGACCCTCAATAAGGCTCCTGGCATGAATACTATAGACCAAGGGATGGCAGCACTGAAGTTGGGTAGCACAGAAGTTGCAAGCAATGTTCCAAAAGTTGTAGGTTCTGCTGTTGGTAGCGGGTCCATTACTAGTAACATCGTGGCTTCCAATAGTTTGCCTCCAGCCACCATTGCTCCTCCAAAACCAGCATCTTGGGCTGATATTGCTAGCAAGCCTGCAAAACAGCAACCTAAACTGAAGACCAAGAATGGCATTGCAGGGTCAAGTCTTCCGCCACCCCCGATAAAGCATAACATGGATATTGGAACTTGGGATAACAAGGGTCCCGTTGCAAAAGCCCCCTCACAGGCTTTGGTTCAGAATATAGGTCAGCCAACCCAGGGGTCTCCTCAGCCTGTAGGTCAGCAGGCTAACAATAGCCCACCAGTGGCTCAGGCATCAGTAGGGCAACAGACACAGCCATTGCCTCCACCTCCACCACAGCCTGCCCAGCTTTCAGTCCAGCAACAGGCAGCTCAGCCAACCCGCTGGGTAGCACCTCGGAACCGTGGCAGTGGGTTCGGTCATAATGGGGTGGATGGTAATGGAGTAGGACAGTCTCAGGCTGGTTCTGGATCTACTCCTTCAGAACCCCACCCAGTGTTGGAGAAGCTTCGGTCCATTAATAACTATAACCCCAAAGATTTTGACTGGAATCTGAAACATGGCCGGGTTTTCATCATTAAGAGCTACTCTGAGGACGATATTCACCGTTCCATTAAGTATAATATTTGGTGCAGCACAGAGCATGGTAACAAGAGACTGGATGCTGCTTATCGTTCCATGAACGGGAAAGGCCCCGTTTACTTACTTTTCAGTGTCAACGGCAGTGGACACTTCTGTGGCGTGGCAGAAATGAAATCTGCTGTGGACTACAACACATGTGCAGGTGTGTGGTCCCAGGACAAATGGAAGGGTCGTTTTGATGTCAGGTGGATTTTTGTGAAGGACGTTCCCAATAGCCAACTGCGACACATTCGCCTAGAGAACAACGAGAATAAACCAGTGACCAACTCTAGGGACACTCAGGAAGTGCCTCTGGAAAAGGCTAAGCAGGTGTTGAAAATTATAGCCAGCTACAAGCACACCACTTCCATTTTTGATGACTTCTCACACTATGAGAAACGCCAAGAGGAAGAAGAAAGTGTTAAAAAGGAACGTCAAGGTCGTGGGAAATAAAAGGCAGTTCTACACAGACTGCAGCAACGGTTGCATCTGCATATCCTAAGAGGAAAAAATGACCTTCAAGAGAATTAGGACTTTTTTCTTAATTTCACTGACTTCAGAGACGATTGCAGACTTGCAGTTTAAGTATTGGAATTTCACAAAAGACATAGGACTTAACTGgaaaatgaaaaaaaaaagaaaaagaaaaaactaaacaaaaaaTCCCTCTAGGTAGTTTAGGTGAAAAATGTCCCTTTTATTTTGGCTTTGGTTGTGATTTCAGAGCATAATGCTATGTTTTTTTGTCTTTTTACTATGTTTTTCGGATTTTTAAGTCCGTAAGTGCATACAGTTTTCTCTAATTTTTAAACCCTTTCCTCCTCCCATTTTGACATTTGCACTTGGAGAACACTTGAGTTGTGAAGGTTTTGGGCATCCACCCCAGAAAGTGGGAATTTGATTTTATCCTTCCGAACTGGAAGAACATTTTTATGAAGAATTTTTGTCTAGGAGAATATAACAGTGTTACCCAAGGTTGTGTCTTTAAGGGTGGTTCATTTTCTCTGACCTTTTGTTACTCAAAGTAAAGTACTAGGAGTCCTAAGAAATGTTCTGTTCTTGTACATTATACTGATTAAGTCAGGATTAATTTGATTTCAAAGCTGAGAACAGTGGTAAAAACTCGTTTACAGAAATGCATTTTGGAAGAGAAAAATACTGTAAAACGTGTCGTGAATGTTTCTTCAGTTTCTTGTTCAGCCAATGAGGAAAGGGCATTGCCTTTCTTTTTACCATTAATCACTTCTCAATAAACGTGAGATCCTGTTGAGCATCA

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