RCPedia: Rtcs

Summary

Retrocopy Name	KRT8P47	Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr1:44103062-44104705 UCSC
Coordinates (hg19)	chr1:44568734-44570377 UCSC
Strand	-
Parental Sequence	NM_001256293.2
Parental seq. overlap	1473 bp
Parental seq. overlap (%)	77.1%
Genomic Region	Intragenic (KLF17)
Retrocopy Summary	KRT8P47, located on chr1:44103062-44104705, is a retrocopy of the parental gene KRT8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	KRT8
Full Name	keratin 8
Also known as	CARD2\|CK-8\|CK8\|CYK8\|K2C8\|K8\|KO
Coordinate	chr12:52897191-52949860
Strand	-
Gene summary	This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	KRT8P4
Bonobo	Pan paniscus	KRT8P4
Gorilla	Gorilla gorilla	KRT8P4
Orangutan	Pongo abelii	KRT8P2
Gibbon	Nomascus leucogenys	KRT8P29
Green monkey	Chlorocebus sabaeus	KRT8P35
Crab-eating macaque	Macaca fascicularis	KRT8P4
Rhesus	Macaca mulatta	KRT8P3
Baboon	Papio anubis	KRT8P3
Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>KRT8P47
GGGCCCAGTGCCTGCATCAGCTCTTAGAGCTTCTCCCTACTGGGCAGCAGCAGCTTCTGGGCTGGCCTGGGCAGAGGCTATGGTGGGACCAGCGGCATGGGAGGCATCACTGCTGTCACAGTCAACCAGAGTCTGCTGAGCCCCCTTAGGAGGTGGATCTCAACATCCAGGCCATGCGCACCCAGGAGAAGGAGCAGATCAAGAACCCCACCAACAAGTTTGCCTCCTTCATCGACAAGGTGCGGTTCCTGGGGCAGCAGAACAAGATTCAGGAGACGAAGTGGAGCCTCCTGCAGCAGCAGCAGACGGCTGGGAGCAACACGGACAACATGTTCCAGAGCTACATCAACAACCTTAGGCGGCAGCTGGAGACTCTGGGCCAGGAGAAGCTGAAGCTGGAGACGGAGCTTGGCAACACGCAGGGGCTGGTGGAGGACTTCAAGAACAAGTACGAGGATGAGATCAATAAGCGTACAGAGATGGAGAATCAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTTACATGAACAAGTTAGAGCTGGAGTCTGGCCTGGAAGGGCTGACTGACGAGATCAACTTCCTCAGGCGGCTGTATGAAGAGAAGATCCGGGAGCTGCAGTCCCAGATCTCCGCCACGTCTGTGGTGCTGTCCATGGACAACAGCCGCTCCATGGACACGGACAGCATCATCGCTGAGGTCAAGGCGCAGTACGAGATCGCCAACCGCAGGCGGGCTGAGGCTGAGAGCATGTACCAGATCAAGTATGAGAAGCTGCAGGCGCTGGCTGGGAGGCACTGGGATGACGTGCAGCATACAAAGACTGAGACCTCCGAGATAAACTGGAACATCAGTGGGCTCCAGGCTGAGACTGAGTGCCTCAAAGGCCAGAGGGCTTCCCTGGAGGCCGCCATCACAGATGCCGAGCAGCCTGAGGAGCTGGCAGTTAAGGGTGCCAACGCCAAGCTGTCCGAGCTGGAGGCCGCCCTCCAGCCGGCCAAGCAGGACATGGCGCGGCAGCTGCGTGAGTACTAGGAGCTGATGAACGTCAAGCTGGCCCTGGACATCGAGATCGAGATCGCCACCTACAGGAAGCTGCTAGAGGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACAGGAGTATCCATACGAAGACCACCAGCAGCTATGCAGGTGCGCTGAGCTCGGCCTATGGGGGCCTCACGAGCCCCGGCCTCAGCTACGGTCTGGGCTCCAGCTTTGGCTCTGGCATGGGCGCCAGCTCCTTCAGCCGCACCAGCTCCACCAGGGCCGTGGTTGTGAAGAAGATCCAGACCTGCAACGGGAAGCCGGTGTCCGAGTCCGGTGTCCGAGTCCTTTGACGTCCTGCCCAAGTGAACAGCCAGGGCAGCCCCTCCCAGCCTGCCCCTCCTGCGGCTGCCCCAGAGTCCGGGAGGGAGGCCGCTGTGCAGGGGAGCACAGGGAACGGGAGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCTGCGGAGGAGTTTACTGCTTGGGGATACCCCCTTGCCCATGTCTCCAGCTACAAAACAATTCAATTGCTTTTTTCTTTTTTGTGTGTCCAAAATAAAACCTCAGCTAGCTCTGA

>NM_001256293.2
CTTTCCTTACCTCCCTCCATGCTGTCCACTTCCTCTGTAAAGCTCTCAACCCTGTCCCCTTCCCCCTCTCTCCTGGGAAAGAGCCCTCCCATGCCTAGCTGCTGCTCTTAGGGACCCTGTGGCTAGGTGCGCGGATGGAAATCCAGGATCTCCGCCTGGTTCGGCCCGCCTGCCTCCACTCCTGCCTCTACCATGTCCATCAGGGTGACCCAGAAGTCCTACAAGGTGTCCACCTCTGGCCCCCGGGCCTTCAGCAGCCGCTCCTACACGAGTGGGCCCGGTTCCCGCATCAGCTCCTCGAGCTTCTCCCGAGTGGGCAGCAGCAACTTTCGCGGTGGCCTGGGCGGCGGCTATGGTGGGGCCAGCGGCATGGGAGGCATCACCGCAGTTACGGTCAACCAGAGCCTGCTGAGCCCCCTTGTCCTGGAGGTGGACCCCAACATCCAGGCCGTGCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATAGACAAGGTACGGTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAGTGGAGCCTCCTGCAGCAGCAGAAGACGGCTCGAAGCAACATGGACAACATGTTCGAGAGCTACATCAACAACCTTAGGCGGCAGCTGGAGACTCTGGGCCAGGAGAAGCTGAAGCTGGAGGCGGAGCTTGGCAACATGCAGGGGCTGGTGGAGGACTTCAAGAACAAGTATGAGGATGAGATCAATAAGCGTACAGAGATGGAGAACGAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTTACATGAACAAGGTAGAGCTGGAGTCTCGCCTGGAAGGGCTGACCGACGAGATCAACTTCCTCAGGCAGCTATATGAAGAGGAGATCCGGGAGCTGCAGTCCCAGATCTCGGACACATCTGTGGTGCTGTCCATGGACAACAGCCGCTCCCTGGACATGGACAGCATCATTGCTGAGGTCAAGGCACAGTACGAGGATATTGCCAACCGCAGCCGGGCTGAGGCTGAGAGCATGTACCAGATCAAGTATGAGGAGCTGCAGAGCCTGGCTGGGAAGCACGGGGATGACCTGCGGCGCACAAAGACTGAGATCTCTGAGATGAACCGGAACATCAGCCGGCTCCAGGCTGAGATTGAGGGCCTCAAAGGCCAGAGGGCTTCCCTGGAGGCCGCCATTGCAGATGCCGAGCAGCGTGGAGAGCTGGCCATTAAGGATGCCAACGCCAAGTTGTCCGAGCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGGACATGGCGCGGCAGCTGCGTGAGTACCAGGAGCTGATGAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACATGAGTATTCATACGAAGACCACCAGCGGCTATGCAGGTGGTCTGAGCTCGGCCTATGGGGGCCTCACAAgccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctccTCCAGGGCCGTGGTTGTGAAGAAGATCGAGACACGTGATGGGAAGCTGGTGTCTGAGTCCTCTGACGTCCTGCCCAAGTGAACAGCTGCGGCAGCCCCTCCCAGCCTACCCCTCCTGCGCTGCCCCAGAGCCTGGGAAGGAGGCCGCTATGCAGGGTAGCACTGGGAACAGGAGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCTGGGGAGTTTACTACCTGGGGACCCCCCTTGCCCATGCCTCCAGCTACAAAACAATTCAATTGCTTTTTTTTTTTGGTCCAAAATAAAACCTCAGCTAGCTCTGCCAA

>NM_001256293.2 

CTTTCCTTACCTCCCTCCATGCTGTCCACTTCCTCTGTAAAGCTCTCAACCCTGTCCCCTTCCCCCTCTCTCCTGGGAAAGAGCCCTCCCATGCCTAGCTGCTGCTCTTAGGGACCCTGTGGCTAGGTGCGCGGATGGAAATCCAGGATCTCCGCCTGGTTCGGCCCGCCTGCCTCCACTCCTGCCTCTACCATGTCCATCAGGGTGACCCAGAAGTCCTACAAGGTGTCCACCTCTGGCCCCCGGGCCTTCAGCAGCCGCTCCTACACGAGTGGGCCCGGTTCCCGCATCAGCTCCTCGAGCTTCTCCCGAGTGGGCAGCAGCAACTTTCGCGGTGGCCTGGGCGGCGGCTATGGTGGGGCCAGCGGCATGGGAGGCATCACCGCAGTTACGGTCAACCAGAGCCTGCTGAGCCCCCTTGTCCTGGAGGTGGACCCCAACATCCAGGCCGTGCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATAGACAAGGTACGGTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAGTGGAGCCTCCTGCAGCAGCAGAAGACGGCTCGAAGCAACATGGACAACATGTTCGAGAGCTACATCAACAACCTTAGGCGGCAGCTGGAGACTCTGGGCCAGGAGAAGCTGAAGCTGGAGGCGGAGCTTGGCAACATGCAGGGGCTGGTGGAGGACTTCAAGAACAAGTATGAGGATGAGATCAATAAGCGTACAGAGATGGAGAACGAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTTACATGAACAAGGTAGAGCTGGAGTCTCGCCTGGAAGGGCTGACCGACGAGATCAACTTCCTCAGGCAGCTATATGAAGAGGAGATCCGGGAGCTGCAGTCCCAGATCTCGGACACATCTGTGGTGCTGTCCATGGACAACAGCCGCTCCCTGGACATGGACAGCATCATTGCTGAGGTCAAGGCACAGTACGAGGATATTGCCAACCGCAGCCGGGCTGAGGCTGAGAGCATGTACCAGATCAAGTATGAGGAGCTGCAGAGCCTGGCTGGGAAGCACGGGGATGACCTGCGGCGCACAAAGACTGAGATCTCTGAGATGAACCGGAACATCAGCCGGCTCCAGGCTGAGATTGAGGGCCTCAAAGGCCAGAGGGCTTCCCTGGAGGCCGCCATTGCAGATGCCGAGCAGCGTGGAGAGCTGGCCATTAAGGATGCCAACGCCAAGTTGTCCGAGCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGGACATGGCGCGGCAGCTGCGTGAGTACCAGGAGCTGATGAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACATGAGTATTCATACGAAGACCACCAGCGGCTATGCAGGTGGTCTGAGCTCGGCCTATGGGGGCCTCACAAgccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctccTCCAGGGCCGTGGTTGTGAAGAAGATCGAGACACGTGATGGGAAGCTGGTGTCTGAGTCCTCTGACGTCCTGCCCAAGTGAACAGCTGCGGCAGCCCCTCCCAGCCTACCCCTCCTGCGCTGCCCCAGAGCCTGGGAAGGAGGCCGCTATGCAGGGTAGCACTGGGAACAGGAGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCTGGGGAGTTTACTACCTGGGGACCCCCCTTGCCCATGCCTCCAGCTACAAAACAATTCAATTGCTTTTTTTTTTTGGTCCAAAATAAAACCTCAGCTAGCTCTGCCAA

Publications

PMID - Link	Title
No publications available for this retrocopy