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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FKBP1BP1
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Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:41742705-41743449  UCSC
Coordinates (T2T) chr14:35933541-35934285  UCSC
Coordinates (hg19) chr14:42211908-42212652  UCSC
Strand +
Parental Sequence NM_004116.5
Parental seq. overlap 636 bp
Parental seq. overlap (%) 68.2%
Genomic Region Intragenic (LRFN5)
Retrocopy Summary FKBP1BP1, located on chr14:41742705-41743449, is a retrocopy of the parental gene FKBP1B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FKBP1B
Full Name FKBP prolyl isomerase 1B
Also known as FKBP12.6|FKBP1L|OTK4|PKBP1L|PPIase
Coordinate chr2:24033205-24067743
Strand +
Gene summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FKBP1BP1
Bonobo Pan paniscus FKBP1BP1
Gorilla Gorilla gorilla FKBP1BP1
Orangutan Pongo abelii FKBP1BP1
Gibbon Nomascus leucogenys FKBP1BP1
Green monkey Chlorocebus sabaeus FKBP1BP1
Crab-eating macaque Macaca fascicularis FKBP1BP1
Rhesus Macaca mulatta FKBP1BP1
Baboon Papio anubis FKBP1BP1
Golden snub-nosed monkey Rhinopithecus roxellana FKBP1BP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.40.60.8
log10(TPM+1)

Related Sequence

>FKBP1BP1
TGTGTGTAGCGCACTACATAGGGGTGTTCCAAAATGGGAATAAATTTGATTTATCCGAAGACAGAAACAAACCTTTCAAGTTCAAAACTGGTGAACAGGAAGTCATCAGTGGTTTTGAAGAGTACATAGCGCAGATGAGCTTGGGGCAGAAGGTGAAGCTGACCTGCATATGTGATGTGTCATATAGAGCTCCAGGCTACTCTAGTATCATCCCTCCCAGTGCTATCCTATCTTTGACATGGAATTGCTCAACTTAGAGTGAAGGCAGGAAGGAAATCAAGGTGGATGGAGATGGCTGCTGCTCACCCTCCTAGCCTGCTTTGCCACTGGGTTGGCTCCTCCTGTTTGGGGCTCTTGATCAGTGTGCTAACCTCACTGTCTCATGGCATGATCCATTCTTTCTGCCCAAGTTGCTGTGTATGTGTTCATTATTGTTCATGCATATCCTTGCTTGAGGAAATTTTGATTTCATTGAAACATTTCATGTTGTGCATTTTTTTATAAGGCATGTAGTAGCCATTCCTGGTCACAGAAAATAGATTTCTTGCTTGCAAAATCTACATCGCCCTACCTTCACTTAAGCCAGACATGCAAGGTGATCAGATATGAAATATACATGGTGTATGCTAGAGACTTGAGCCAGTTACCTTTGCTTTCACTTTCTATCTTATAAATTCTGTTGGCTGCTCACTTAAACAGTGTCTGCTTTGGAAATAATATGTAAAATAAAGACGCAGTGCTTGAC
>NM_004116.5
GCAGTggcggcgaggaggcgagccggagcgacggcggggctggggccggagccgagccggggtcgggCAGCAGCAGGGACCCCCCAGAGGCGGGGCCTGTGGGACCGCTATGGGCGTGGAGATCGAGACCATCTCCCCCGGAGACGGAAGGACATTCCCCAAGAAGGGCCAAACGTGTGTGGTGCACTACACAGGAATGCTCCAAAATGGGAAGAAGTTTGATTCATCCAGAGACAGAAACAAACCTTTCAAGTTCAGAATTGGCAAACAGGAAGTCATCAAAGGTTTTGAAGAGGGTGCAGCCCAGATGAGCTTGGGGCAGAGGGCGAAGCTGACCTGCACCCCTGATGTGGCATATGGAGCCACGGGCCACCCCGGTGTCATCCCTCCCAATGCCACCCTCATCTTTGACGTGGAGCTGCTCAACTTAGAGTGAAGGCAGGAAGGAACTCAAGGTGGCTGGAGATGGCTGCTGCTCACCCTCCTAGCCTGCTCTGCCACTGGGACGGCTCCTGCTTTTGGGGCTCTTGATCAGTGTGCTAACCTCACTGCCTCATGGCATCATCCATTCTCTCTGCCCAAGTTGCTCTGTATGTGTTCGTCAGTGTTCATGCGAATTCTTGCTTGAGGAAACTTCGGTTGCAGATTGAAGCATTTCAGGTTGTGCATTTTGTGTGATGCATGTAGTAGCCTTTCCTGATGACAGAACACAGATCTCTTGTTCGCACAATCTACACTGCCTTACCTTCACTTAAACCACACACACAAGGTGCTCAGACATGAAATGTACATGGCGTACCGTACACAGAGGGACTTGAGCCAGTTACCTTTGCTGTCACTTTCTCTCTTATAAATTCTGTTAGCTGCTCACTTAAACAATGTCCTCTTTGAGAAAATGTAAAATAAAGGCTCTGTGCTTGACAAA

Publications

PMID - Link Title
No publications available for this retrocopy