Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name YWHAZP1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:44290720-44291736  UCSC
Coordinates (T2T) chr14:38481624-38482640  UCSC
Coordinates (hg19) chr14:44759923-44760939  UCSC
Strand -
Parental Sequence NM_145690.3
Parental seq. overlap 875 bp
Parental seq. overlap (%) 17.4%
Genomic Region Intergenic
Retrocopy Summary YWHAZP1, located on chr14:44290720-44291736, is a retrocopy of the parental gene YWHAZ. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name YWHAZ
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Also known as 14-3-3-zeta|HEL-S-3|HEL-S-93|HEL4|KCIP-1|POPCHAS|YWHAD
Coordinate chr8:100916523-100954068
Strand -
Gene summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes YWHAZP7
Bonobo Pan paniscus YWHAZP7
Gorilla Gorilla gorilla YWHAZP7
Orangutan Pongo abelii YWHAZP8
Gibbon Nomascus leucogenys YWHAZP1
Green monkey Chlorocebus sabaeus YWHAZP7
Crab-eating macaque Macaca fascicularis YWHAZP4
Rhesus Macaca mulatta YWHAZP4
Baboon Papio anubis YWHAZP5
Golden snub-nosed monkey Rhinopithecus roxellana YWHAZP3
Marmoset Callithrix jacchus YWHAZP6
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>YWHAZP1
GACACAGAACATTCAGTCATGGGTAAAAATATCCCGGTGCAGAAGGCCAAATGGGCTGAGCAATATGTTGTCACGAAAGACTGCATGATGTCTGTAACTAAGCAAGGAACTGAATTTTTTTTTTATTAGGAGAGGAATCTTCTTTTAGTTGCTTATAAAAATGTTACAGGAGCCTGTAGGTCATCTTGGAGCTTCGTCTCAAGTATTGGGCAAATGACAGAAGCTGCTGAGAAAAACAGCAGATGGCTTGAGAATACAGAGAGAAAATGCAAAGTGAGCTAAGAGCTATCTGTAAATGATGTACTGTCCCTTTTGGAAGAGTTCTTGATCCCCAAAGCTTCACAAGCACAGAGCAAAATCTATTAAAAGCAAAAGGAGTCTACTTTTGTTATTTGGCTCAGGTTGCCGCTAGTGATGATAAGAAAGGGATTGTGGATCAGTCACAACAAGCACATCAAGAAGCTTTTGAAATCAGAAAAAGGAATTGCAATCAACACATCCTATCAGATTGGGTCTGGGCTATAAGCTCTCTGTGTTGTATTGTGAGAATCTGAACTTGCTGGAGAAAGCCTGCTGTCTTGCAAAGACAGCTTTTGATGAAGCCATTGTTGGACTCAATACATTAAGAGTCATATAAAGATAGCATGCTAATAATGCAACTACTGAGAAACTACTTAACATTTTACACATCAGATACCCAAGGAGATGAAGCTGAAGCAGGAGAAGAAGGTGAAAATTAACTGACTTCTCAAATTTGTCTACTTCATTCTAAAACACAGTGGACCATTTGTCATCCATATGTCCTGAATATAATTTTTTTAAAAAGGTATAGGTTACTTCTATTTGAATTTCTGTTTTTTCCTATATGGTTTTTATGTTTTACATTAGAATAGGGCCAATTAAGATTTAGGGAGTTATATGTTTTCATCTTTAGGTGGCCAATATGGGGATGTGAAATTTTCATATAAGCTATAAATGTTTGACATAGTATTTTGCTAAATTGTGGCCTCACAAGGA
>NM_145690.3
GACAGAGTCTCAGCCTcgccgctgctgccgccgccgccgccCAGAGACTGCTGAGCCCGTCCGTCCGCCGCCACCACCCACTCCGGACACAGAACATCCAGTCATGGATAAAAATGAGCTGGTTCAGAAGGCCAAACTGGCCGAGCAGGCTGAGCGATATGATGACATGGCAGCCTGCATGAAGTCTGTAACTGAGCAAGGAGCTGAATTATCCAATGAGGAGAGGAATCTTCTCTCAGTTGCTTATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGGGTCGTCTCAAGTATTGAACAAAAGACGGAAGGTGCTGAGAAAAAACAGCAGATGGCTCGAGAATACAGAGAGAAAATTGAGACGGAGCTAAGAGATATCTGCAATGATGTACTGTCTCTTTTGGAAAAGTTCTTGATCCCCAATGCTTCACAAGCAGAGAGCAAAGTCTTCTATTTGAAAATGAAAGGAGATTACTACCGTTACTTGGCTGAGGTTGCCGCTGGTGATGACAAGAAAGGGATTGTCGATCAGTCACAACAAGCATACCAAGAAGCTTTTGAAATCAGCAAAAAGGAAATGCAACCAACACATCCTATCAGACTGGGTCTGGCCCTTAACTTCTCTGTGTTCTATTATGAGATTCTGAACTCCCCAGAGAAAGCCTGCTCTCTTGCAAAGACAGCTTTTGATGAAGCCATTGCTGAACTTGATACATTAAGTGAAGAGTCATACAAAGACAGCACGCTAATAATGCAATTACTGAGAGACAACTTGACATTGTGGACATCGGATACCCAAGGAGACGAAGCTGAAGCAGGAGAAGGAGGGGAAAATTAACCGGCCTTCCAACTTTTGTCTGCCTCATTCTAAAATTTACACAGTAGACCATTTGTCATCCATGCTGTCCCACAAATAGTTTTTTGTTTACGATTTATGACAGGTTTATGTTACTTCTATTTGAATTTCTATATTTCCCATGTGGTTTTTATGTTTAATATTAGGGGAGTAGAGCCAGTTAACATTTAGGGAGTTATCTGTTTTCATCTTGAGGTGGCCAATATGGGGATGTGGAATTTTTATACAAGTTATAAGTGTTTGGCATAGTACTTTTGGTACATTGTGGCTTCAAAAGGGCCAGTGTAAAACTGCTTCCATGTCTAAGCAAAGAAAACTGCCTACATACTGGTTTGTCCTGGCGGGGAATAAAAGGGATCATTGGTTCCAGTCACAGGTGTAGTAATTGTGGGTACTTTAAGGTTTGGAGCACTTACAAGGCTGTGGTAGAATCATACCCCATGGATACCACATATTAAACCATGTATATCTGTGGAATACTCAATGTGTACACCTTTGACTACAGCTGCAGAAGTGTTCCTTTAGACAAAGTTGTGACCCATTTTACTCTGGATAAGGGCAGAAACGGTTCACATTCCATTATTTGTAAAGTTACCTGCTGTTAGCTTTCATTATTTTTGCTACACTCATTTTATTTGTATTTAAATGTTTTAGGcaacctaagaacaaatgtaaaagtaaagatgcaggaaaaatgaattgcttggtattcattacttcatgtatatcaagcacagcagtaaaacaaaaacccatgtatttaacttttttttaggatttttgcttttgtgatttttttttttttgatacttgcctaacatgcatgtgctgtaaaaatagttaacagggaaataacttgagatgatggctagctttgtttaatgtcttatgaaattttcatgaacaatccaagcataattgttaagaacacgtgtattaaattcatgtaagtggaataaaagttttatgaatgGACTTTTCAACTACTTTCTCTACAGCTTTTCATGTAAATTAGTCTTGGTTCTGAAACTTCTCTAAAGGAAATTGTACATTTTTTGAAATTTATTCCTTATTCCCTCTTGGCAGCTAATGGGCTCTTACCAAGTTTAAACACAAAATTTATCATAACAAAAATACTACTAATATAACTACTGTTTCCATGTCCCATGATCCCCTCTCTTCCTCCCCACCCTGAAAAAAATGAGTTCCTATTTTTTCTGGGAGAGGGGGGGATTGATTAGAAAAAAATGTAGTGTGTTCCATTTAAAATTTTGGCATATGGCATTTTCTAACTTAGGAAGCCACAATGTTCTTGGCCCATCATGACATTGGGTAGCATTAACTGTAAGTTTTGTGCTTCCAAATCACTTTTTGGTTTTTAAGAATTTCTTGATACTCTTATAGCCTGCCTTCAATTTTGATCCTTTATTCTTTCTATTTGTCAGGTGCACAAGATTACCTTCCTGTTTTAGCCTTCTGTCTTGTCACCAACCATTCTTACTTGGTGGCCATGTACTTGGAAAAAGGCCGCATGATCTTTCTGGCTCCACTCAGTGTCTAAGGCACCCTGCTTCCTTTGCTTGCATCCCACAGACTATTTCCCTCATCCTATTTACTGCAGCAAATCTCTCCTTAGTTGATGAGACTGTGTTTATCTCCCTTTAAAACCCTACCTATCCTGAATGGTCTGTCATTGTCTGCCTTTAAAATCCTTCCTCTTTCTTCCTCCTCTATTCTCTAAATAATGATGGGGCTAAGTTATACCCAAAGCTCACTTTACAAAATATTTCCTCAGTACTTTGCAGAAAACACCAAACAAAAATGCCATTTTAAAAAAGgtgtattttttcttttagaatgtaagctcctcaagagcagggacaatgttttctgtatgttctattgtgcctagtacactgtaaatgctcaataaatattgatgatGGGAGGCAGTGAGTCTTGATGATAAGGGTGAGAAACTGAAATCCCAAACACTGTTTTGTTGCTTGTTTTATTATGACCTCAGATTAAATTGGGAAATATTGGCCCTTTTGAATAATTGTCCCAAATATTACATTCAAATAAAAGTGCAATGGAGACCTTGGGGTCTTTATTTCCAGGAGAAAAGATACCTTCTGCATCTAGGGCAACAATCCTTTTCCCTCGCAGCTCTTTCTTTTACCTCACTTACTGATTTCTCCTGACCCCCAAGCCAAGGAGGTAAAATAATtatatatatatatatatatatatatatatatatataAAGTAATTATATTTTATAGCTAGACTGAAGAGGTGGGAAtttttttgttgttttttttttttttggagacaagagtcttgctctgtcacccaggcttgagtgcagtggtgcgatctcggctgagtgcaacctccgcctgctgggttcaagcgattctcctgcctcagcctcccaagtagctgggattacaggtgcccgccaccacacctggctaatttttgtgtttttagtagagacagggtttcaccatgttgtccaggctggtcttgaattcccgacctcaggcaatccgcccatctcaacctcccaaagtgctgggattacaggcataagccaccgcgcccagTAGAGATGTGATATTATTCAAGTAAATAAAACCTGAAACTTGGCACATTTGCCTATTTAATGTGCATCAGTCATCTGAACTAGGTTGATCCTGGAATAATGAAAACACTTCACTAGTATTAACTAATGTTTTCTACATAGTAGTTCCCAATAGATTAAGGAAAATTTCCAACCTGAGATTCTTTGTTTTGGAATTTGAATAATGTGTTTGTAACTATTCCTTGATTGTCCCAAATCCAGGCTTTACGTCTGCTTTTGTCAATGTAACATCCTAGTGCCAGGAAATTGGAAAATCCAATGACTTTTTGTGTGTAAAGTACTGGAAtttttttgttcgtttgtttttaagacggagtgtcaactctcgcccaggctggggtgcagtggcctgatctcggctcactgcaaccttctcctcccaggctgaagtgattctcctgcctcagcctcgcaagtagctgggactgcaggcatgtgccaccactcctggctaattatttgtatttttagtagagagagggtttcaccgtgttagccatgatggtctcattctcctgaccttgtgatccgcccacctcggcctcccaaagtgctgggattacaggcgtgagccactgtgcccACCCTGGTATGTTTTTTTTAAATTGGCCACTTAAGAGTTGTCCTTCAGAAAGTGGAGCAGCAGTGTGATTAGTAAAAACGATGGGCTTTCCTGCAGCTCTGGCTTATGGTCTTTGTTTTTCCAGTTAACAGCTGTTACTTCATGCTGTTATAGGGGGTGGGGGGAGAAAGAGAAAGAATATGTCTAGTGGCTTAATTTTGGGGCTCAATTTGTTTATTATGTTTTTCCTGCAAAAGAGTCACCAGTCTTGTCATGGCTCAATGCATATTTTAAAATGAGTCAAAGCCAATTTGGAAGCTGCTATCTTAGGTTATTTGTAGTCAGGCTTCAAATGGAGAGTGAAACTTTGACTTTGAAAACTGGTGCTCTATGCTCAATGATGGTCTTACACATTCCTCTAGGGAAAGGTCAAGAAATAAATTTGGCTTGATTGTATTCTCTCATTTACCATATAGGAAATACTATGGTAGAACTGAAAATATGTACAATAGTAAAGTGGTGGCTGAGACTGGGCACTTGGAAAATAGACTTGGATTCTTTTCTAAGTGTGAAACTAATTAAATACTTTTATGTGACTGGTAGTAGTCACAGTCTCCTTGATTGATTCTAGTTCCTTTTCAAAGTGGAGAGACCTGAATATAGATTGTAACAGGATGTCCAACCTTGCCAGACAAGCAGGCATATATGTCTCTGGGATGCAGAAGCAGTTACAAGTTAATATATTTAAGCATAATGTTAGCCAATCCTAGGTGATACCAGAGATGTGAATATTTGATCATATTTGAGTTCATTCCTTGAAAGTCCAAACCTAACTGGTCTTAATTGATTACTTCTTAGTATTCCGAATTTTAGAATTTAAAACCCTATGAATTTTCAGTTTGTGCTTACATTTTCTAACATTGGATGTTTGCTTTGGCCA

Publications

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